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Volumn 14, Issue 9, 2013, Pages

Inhibition of HSP90 molecular chaperones: Moving into the clinic

Author keywords

[No Author keywords available]

Indexed keywords

ALVESPIMYCIN; AT 13387; BORTEZOMIB; CISPLATIN; CRIZOTINIB; CYTARABINE; DOCETAXEL; GANETESPIB; GELDANAMYCIN; GEMCITABINE; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; IMATINIB; IPI 493; IRINOTECAN; KW 2478; LUMINESPIB; NVP HSP990; PACLITAXEL; PLACEBO; PROTEASOME; PURINE DERIVATIVE; RESORCINOL DERIVATIVE; RETASPIMYCIN; SORAFENIB; SUNITINIB; TANESPIMYCIN; TRASTUZUMAB; UBIQUITIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84880787644     PISSN: 14702045     EISSN: 14745488     Source Type: Journal    
DOI: 10.1016/S1470-2045(13)70169-4     Document Type: Review
Times cited : (320)

References (91)
  • 1
    • 25844494542 scopus 로고    scopus 로고
    • Sick chaperones, cellular stress, and disease
    • Macario AJ, Conway de Macario E Sick chaperones, cellular stress, and disease. N Engl J Med 2005, 353:1489-1501.
    • (2005) N Engl J Med , vol.353 , pp. 1489-1501
    • Macario, A.J.1    Conway de Macario, E.2
  • 2
    • 34447507818 scopus 로고    scopus 로고
    • Inhibitors of the heat shock response: biology and pharmacology
    • Powers MV, Workman P Inhibitors of the heat shock response: biology and pharmacology. FEBS Lett 2007, 581:3758-3769.
    • (2007) FEBS Lett , vol.581 , pp. 3758-3769
    • Powers, M.V.1    Workman, P.2
  • 3
    • 25844519550 scopus 로고    scopus 로고
    • HSP90 and the chaperoning of cancer
    • Whitesell L, Lindquist SL HSP90 and the chaperoning of cancer. Nat Rev Cancer 2005, 5:761-772.
    • (2005) Nat Rev Cancer , vol.5 , pp. 761-772
    • Whitesell, L.1    Lindquist, S.L.2
  • 4
    • 84855457952 scopus 로고    scopus 로고
    • Hsp90 molecular chaperone inhibitors: are we there yet?
    • Neckers L, Workman P Hsp90 molecular chaperone inhibitors: are we there yet?. Clin Cancer Res 2012, 18:64-76.
    • (2012) Clin Cancer Res , vol.18 , pp. 64-76
    • Neckers, L.1    Workman, P.2
  • 6
    • 0036606332 scopus 로고    scopus 로고
    • Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3'-kinase-AKT-dependent pathway
    • Münster PN, Marchion DC, Basso AD, Rosen N Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3'-kinase-AKT-dependent pathway. Cancer Res 2002, 62:3132-3137.
    • (2002) Cancer Res , vol.62 , pp. 3132-3137
    • Münster, P.N.1    Marchion, D.C.2    Basso, A.D.3    Rosen, N.4
  • 7
    • 44649083135 scopus 로고    scopus 로고
    • Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance
    • Shimamura T, Li D, Ji H, et al. Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Res 2008, 68:5827-5838.
    • (2008) Cancer Res , vol.68 , pp. 5827-5838
    • Shimamura, T.1    Li, D.2    Ji, H.3
  • 8
    • 1642541150 scopus 로고    scopus 로고
    • 17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells
    • Fumo G, Akin C, Metcalfe DD, Neckers L 17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells. Blood 2004, 103:1078-1084.
    • (2004) Blood , vol.103 , pp. 1078-1084
    • Fumo, G.1    Akin, C.2    Metcalfe, D.D.3    Neckers, L.4
  • 9
    • 30444441778 scopus 로고    scopus 로고
    • V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors
    • Grbovic OM, Basso AD, Sawai A, et al. V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors. Proc Natl Acad Sci USA 2006, 103:57-62.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 57-62
    • Grbovic, O.M.1    Basso, A.D.2    Sawai, A.3
  • 10
    • 2342625412 scopus 로고    scopus 로고
    • Ubiquitination and proteasomal degradation of nucleophosmin-anaplastic lymphoma kinase induced by 17-allylamino-demethoxygeldanamycin: role of the co-chaperone carboxyl heat shock protein 70-interacting protein
    • Bonvini P, Dalla Rosa H, Vignes N, Rosolen A Ubiquitination and proteasomal degradation of nucleophosmin-anaplastic lymphoma kinase induced by 17-allylamino-demethoxygeldanamycin: role of the co-chaperone carboxyl heat shock protein 70-interacting protein. Cancer Res 2004, 64:3256-3264.
    • (2004) Cancer Res , vol.64 , pp. 3256-3264
    • Bonvini, P.1    Dalla Rosa, H.2    Vignes, N.3    Rosolen, A.4
  • 11
    • 0031909866 scopus 로고    scopus 로고
    • The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent
    • Whitesell L, Sutphin PD, Pulcini EJ, Martinez JD, Cook PH The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent. Mol Cell Biol 1998, 18:1517-1524.
    • (1998) Mol Cell Biol , vol.18 , pp. 1517-1524
    • Whitesell, L.1    Sutphin, P.D.2    Pulcini, E.J.3    Martinez, J.D.4    Cook, P.H.5
  • 12
    • 48849083229 scopus 로고    scopus 로고
    • Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras
    • Park Y, Kubo A, Komiya T, et al. Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras. Cell Cycle 2008, 7:2384-2391.
    • (2008) Cell Cycle , vol.7 , pp. 2384-2391
    • Park, Y.1    Kubo, A.2    Komiya, T.3
  • 13
    • 0036530301 scopus 로고    scopus 로고
    • VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition
    • Dias S, Shmelkov SV, Lam G, Rafii S VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition. Blood 2002, 99:2532-2540.
    • (2002) Blood , vol.99 , pp. 2532-2540
    • Dias, S.1    Shmelkov, S.V.2    Lam, G.3    Rafii, S.4
  • 14
    • 0035844136 scopus 로고    scopus 로고
    • Stable association of hsp90 and p23, but not hsp70, with active human telomerase
    • Forsythe HL, Jarvis JL, Turner JW, Elmore LW, Holt SE Stable association of hsp90 and p23, but not hsp70, with active human telomerase. J Biol Chem 2001, 276:15571-15574.
    • (2001) J Biol Chem , vol.276 , pp. 15571-15574
    • Forsythe, H.L.1    Jarvis, J.L.2    Turner, J.W.3    Elmore, L.W.4    Holt, S.E.5
  • 15
    • 0035146685 scopus 로고    scopus 로고
    • The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins
    • Connell P, Ballinger CA, Jiang J, et al. The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat Cell Biol 2001, 3:93-96.
    • (2001) Nat Cell Biol , vol.3 , pp. 93-96
    • Connell, P.1    Ballinger, C.A.2    Jiang, J.3
  • 16
    • 0037593900 scopus 로고    scopus 로고
    • Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone
    • Lotz GP, Lin H, Harst A, Obermann WM Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. J Biol Chem 2003, 278:17228-17235.
    • (2003) J Biol Chem , vol.278 , pp. 17228-17235
    • Lotz, G.P.1    Lin, H.2    Harst, A.3    Obermann, W.M.4
  • 17
    • 13244295625 scopus 로고    scopus 로고
    • Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei
    • Alekseev OM, Widgren EE, Richardson RT, O'Rand MG Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei. J Biol Chem 2005, 280:2904-2911.
    • (2005) J Biol Chem , vol.280 , pp. 2904-2911
    • Alekseev, O.M.1    Widgren, E.E.2    Richardson, R.T.3    O'Rand, M.G.4
  • 18
    • 3042856481 scopus 로고    scopus 로고
    • Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones
    • Hatakeyama S, Matsumoto M, Yada M, Nakayama KI Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones. Genes Cells 2004, 9:533-548.
    • (2004) Genes Cells , vol.9 , pp. 533-548
    • Hatakeyama, S.1    Matsumoto, M.2    Yada, M.3    Nakayama, K.I.4
  • 19
    • 0028913971 scopus 로고
    • Cyclophilin-40: evidence for a dimeric complex with hsp90
    • Hoffmann K, Handschumacher RE Cyclophilin-40: evidence for a dimeric complex with hsp90. Biochem J 1995, 307:5-8.
    • (1995) Biochem J , vol.307 , pp. 5-8
    • Hoffmann, K.1    Handschumacher, R.E.2
  • 20
    • 0034968225 scopus 로고    scopus 로고
    • Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40
    • Pirkl F, Buchner J Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. J Mol Biol 2001, 308:795-806.
    • (2001) J Mol Biol , vol.308 , pp. 795-806
    • Pirkl, F.1    Buchner, J.2
  • 21
  • 22
    • 33646176246 scopus 로고    scopus 로고
    • Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex
    • Ali MM, Roe SM, Vaughan CK, et al. Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature 2006, 440:1013-1017.
    • (2006) Nature , vol.440 , pp. 1013-1017
    • Ali, M.M.1    Roe, S.M.2    Vaughan, C.K.3
  • 23
    • 0042815093 scopus 로고    scopus 로고
    • Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
    • Brychzy A, Rein T, Winklhofer KF, Hartl FU, Young JC, Obermann WM Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. EMBO J 2003, 22:3613-3623.
    • (2003) EMBO J , vol.22 , pp. 3613-3623
    • Brychzy, A.1    Rein, T.2    Winklhofer, K.F.3    Hartl, F.U.4    Young, J.C.5    Obermann, W.M.6
  • 24
    • 74249108175 scopus 로고    scopus 로고
    • Alternate strategies of Hsp90 modulation for the treatment of cancer and other diseases
    • Brandt GE, Blagg BS Alternate strategies of Hsp90 modulation for the treatment of cancer and other diseases. Curr Top Med Chem 2009, 9:1447-1461.
    • (2009) Curr Top Med Chem , vol.9 , pp. 1447-1461
    • Brandt, G.E.1    Blagg, B.S.2
  • 25
    • 4444311881 scopus 로고    scopus 로고
    • Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity
    • Mimnaugh EG, Xu W, Vos M, et al. Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity. Mol Cancer Ther 2004, 3:551-566.
    • (2004) Mol Cancer Ther , vol.3 , pp. 551-566
    • Mimnaugh, E.G.1    Xu, W.2    Vos, M.3
  • 26
    • 26644473193 scopus 로고    scopus 로고
    • Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone
    • Murphy PJ, Morishima Y, Kovacs JJ, Yao TP, Pratt WB Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. J Biol Chem 2005, 280:33792-33799.
    • (2005) J Biol Chem , vol.280 , pp. 33792-33799
    • Murphy, P.J.1    Morishima, Y.2    Kovacs, J.J.3    Yao, T.P.4    Pratt, W.B.5
  • 27
    • 28244444919 scopus 로고    scopus 로고
    • Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin
    • da Rocha Dias S, Friedlos F, Light Y, Springer C, Workman P, Marais R Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin. Cancer Res 2005, 65:10686-10691.
    • (2005) Cancer Res , vol.65 , pp. 10686-10691
    • da Rocha Dias, S.1    Friedlos, F.2    Light, Y.3    Springer, C.4    Workman, P.5    Marais, R.6
  • 28
    • 0141484615 scopus 로고    scopus 로고
    • A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
    • Kamal A, Thao L, Sensintaffar J, et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 2003, 425:407-410.
    • (2003) Nature , vol.425 , pp. 407-410
    • Kamal, A.1    Thao, L.2    Sensintaffar, J.3
  • 29
    • 0028064940 scopus 로고
    • Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation
    • Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci USA 1994, 91:8324-8328.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8324-8328
    • Whitesell, L.1    Mimnaugh, E.G.2    De Costa, B.3    Myers, C.E.4    Neckers, L.M.5
  • 30
    • 84857039457 scopus 로고    scopus 로고
    • Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers
    • Jhaveri K, Taldone T, Modi S, Chiosis G Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers. Biochim Biophys Acta 2012, 1823:742-755.
    • (2012) Biochim Biophys Acta , vol.1823 , pp. 742-755
    • Jhaveri, K.1    Taldone, T.2    Modi, S.3    Chiosis, G.4
  • 31
    • 26444482073 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models
    • Banerji U, Walton M, Raynaud F, et al. Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models. Clin Cancer Res 2005, 11:7023-7032.
    • (2005) Clin Cancer Res , vol.11 , pp. 7023-7032
    • Banerji, U.1    Walton, M.2    Raynaud, F.3
  • 32
    • 0033579175 scopus 로고    scopus 로고
    • DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90
    • Kelland LR, Sharp SY, Rogers PM, Myers TG, Workman P DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90. J Natl Cancer Inst 1999, 91:1940-1949.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1940-1949
    • Kelland, L.R.1    Sharp, S.Y.2    Rogers, P.M.3    Myers, T.G.4    Workman, P.5
  • 33
    • 23044441106 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies
    • Banerji U, O'Donnell A, Scurr M, et al. Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies. J Clin Oncol 2005, 23:4152-4161.
    • (2005) J Clin Oncol , vol.23 , pp. 4152-4161
    • Banerji, U.1    O'Donnell, A.2    Scurr, M.3
  • 34
    • 20044384168 scopus 로고    scopus 로고
    • Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer
    • Goetz MP, Toft D, Reid J, et al. Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer. J Clin Oncol 2005, 23:1078-1087.
    • (2005) J Clin Oncol , vol.23 , pp. 1078-1087
    • Goetz, M.P.1    Toft, D.2    Reid, J.3
  • 35
    • 20144375312 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors
    • Grem JL, Morrison G, Guo XD, et al. Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors. J Clin Oncol 2005, 23:1885-1893.
    • (2005) J Clin Oncol , vol.23 , pp. 1885-1893
    • Grem, J.L.1    Morrison, G.2    Guo, X.D.3
  • 36
    • 33750711384 scopus 로고    scopus 로고
    • A phase I trial of twice-weekly 17-allylamino-demethoxy-geldanamycin in patients with advanced cancer
    • Nowakowski GS, McCollum AK, Ames MM, et al. A phase I trial of twice-weekly 17-allylamino-demethoxy-geldanamycin in patients with advanced cancer. Clin Cancer Res 2006, 12:6087-6093.
    • (2006) Clin Cancer Res , vol.12 , pp. 6087-6093
    • Nowakowski, G.S.1    McCollum, A.K.2    Ames, M.M.3
  • 37
    • 34250160933 scopus 로고    scopus 로고
    • Phase I and pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with refractory advanced cancers
    • Ramanathan RK, Egorin MJ, Eiseman JL, et al. Phase I and pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with refractory advanced cancers. Clin Cancer Res 2007, 13:1769-1774.
    • (2007) Clin Cancer Res , vol.13 , pp. 1769-1774
    • Ramanathan, R.K.1    Egorin, M.J.2    Eiseman, J.L.3
  • 38
    • 34250197902 scopus 로고    scopus 로고
    • Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer
    • Solit DB, Ivy SP, Kopil C, et al. Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer. Clin Cancer Res 2007, 13:1775-1782.
    • (2007) Clin Cancer Res , vol.13 , pp. 1775-1782
    • Solit, D.B.1    Ivy, S.P.2    Kopil, C.3
  • 39
    • 79955551254 scopus 로고    scopus 로고
    • Tanespimycin pharmacokinetics: a randomized dose-escalation crossover phase 1 study of two formulations
    • Burris HA, Berman D, Murthy B, Jones S Tanespimycin pharmacokinetics: a randomized dose-escalation crossover phase 1 study of two formulations. Cancer Chemother Pharmacol 2011, 67:1045-1054.
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 1045-1054
    • Burris, H.A.1    Berman, D.2    Murthy, B.3    Jones, S.4
  • 40
    • 59449108495 scopus 로고    scopus 로고
    • A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer
    • Heath EI, Hillman DW, Vaishampayan U, et al. A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer. Clin Cancer Res 2008, 14:7940-7946.
    • (2008) Clin Cancer Res , vol.14 , pp. 7940-7946
    • Heath, E.I.1    Hillman, D.W.2    Vaishampayan, U.3
  • 41
    • 58149340657 scopus 로고    scopus 로고
    • Phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with metastatic melanoma
    • Solit DB, Osman I, Polsky D, et al. Phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with metastatic melanoma. Clin Cancer Res 2008, 14:8302-8307.
    • (2008) Clin Cancer Res , vol.14 , pp. 8302-8307
    • Solit, D.B.1    Osman, I.2    Polsky, D.3
  • 42
    • 33747691089 scopus 로고    scopus 로고
    • A phase II trial of 17-(Allylamino)-17-demethoxygeldanamycin in patients with papillary and clear cell renal cell carcinoma
    • Ronnen EA, Kondagunta GV, Ishill N, et al. A phase II trial of 17-(Allylamino)-17-demethoxygeldanamycin in patients with papillary and clear cell renal cell carcinoma. Invest New Drugs 2006, 24:543-546.
    • (2006) Invest New Drugs , vol.24 , pp. 543-546
    • Ronnen, E.A.1    Kondagunta, G.V.2    Ishill, N.3
  • 43
    • 36849055007 scopus 로고    scopus 로고
    • Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study
    • Modi S, Stopeck AT, Gordon MS, et al. Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study. J Clin Oncol 2007, 25:5410-5417.
    • (2007) J Clin Oncol , vol.25 , pp. 5410-5417
    • Modi, S.1    Stopeck, A.T.2    Gordon, M.S.3
  • 44
    • 79960985354 scopus 로고    scopus 로고
    • HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab
    • Modi S, Stopeck A, Linden H, et al. HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab. Clin Cancer Res 2011, 17:5132-5139.
    • (2011) Clin Cancer Res , vol.17 , pp. 5132-5139
    • Modi, S.1    Stopeck, A.2    Linden, H.3
  • 45
    • 77955141041 scopus 로고    scopus 로고
    • Tanespimycin monotherapy in relapsed multiple myeloma: results of a phase 1 dose-escalation study
    • Richardson PG, Chanan-Khan AA, Alsina M, et al. Tanespimycin monotherapy in relapsed multiple myeloma: results of a phase 1 dose-escalation study. Br J Haematol 2010, 150:438-445.
    • (2010) Br J Haematol , vol.150 , pp. 438-445
    • Richardson, P.G.1    Chanan-Khan, A.A.2    Alsina, M.3
  • 46
    • 79957539428 scopus 로고    scopus 로고
    • Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: results of a phase 1/2 study
    • Richardson PG, Chanan-Khan AA, Lonial S, et al. Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: results of a phase 1/2 study. Br J Haematol 2011, 153:729-740.
    • (2011) Br J Haematol , vol.153 , pp. 729-740
    • Richardson, P.G.1    Chanan-Khan, A.A.2    Lonial, S.3
  • 47
    • 79952734485 scopus 로고    scopus 로고
    • A phase I study of the heat shock protein 90 inhibitor alvespimycin (17-DMAG) given intravenously to patients with advanced solid tumors
    • Pacey S, Wilson RH, Walton M, et al. A phase I study of the heat shock protein 90 inhibitor alvespimycin (17-DMAG) given intravenously to patients with advanced solid tumors. Clin Cancer Res 2011, 17:1561-1570.
    • (2011) Clin Cancer Res , vol.17 , pp. 1561-1570
    • Pacey, S.1    Wilson, R.H.2    Walton, M.3
  • 48
    • 77950929054 scopus 로고    scopus 로고
    • Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia
    • Lancet JE, Gojo I, Burton M, et al. Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia. Leukemia 2010, 24:699-705.
    • (2010) Leukemia , vol.24 , pp. 699-705
    • Lancet, J.E.1    Gojo, I.2    Burton, M.3
  • 49
    • 77951907072 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an inhibitor of heat-shock protein 90, in patients with advanced solid tumors
    • Ramanathan RK, Egorin MJ, Erlichman C, et al. Phase I pharmacokinetic and pharmacodynamic study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an inhibitor of heat-shock protein 90, in patients with advanced solid tumors. J Clin Oncol 2010, 28:1520-1526.
    • (2010) J Clin Oncol , vol.28 , pp. 1520-1526
    • Ramanathan, R.K.1    Egorin, M.J.2    Erlichman, C.3
  • 50
    • 72449185268 scopus 로고    scopus 로고
    • Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies
    • Kummar S, Gutierrez ME, Gardner ER, et al. Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies. Eur J Cancer 2010, 46:340-347.
    • (2010) Eur J Cancer , vol.46 , pp. 340-347
    • Kummar, S.1    Gutierrez, M.E.2    Gardner, E.R.3
  • 51
    • 84880839464 scopus 로고    scopus 로고
    • First use of an oral Hsp90 inhibitor in patients with solid tumors: alvespimycin administered QOD or QD
    • abstr 2502.
    • Flaherty KT, Gore L, Avadhani AN, et al. First use of an oral Hsp90 inhibitor in patients with solid tumors: alvespimycin administered QOD or QD. Proc Am Soc Clin Oncol 2008, 26(suppl 15). abstr 2502.
    • (2008) Proc Am Soc Clin Oncol , vol.26 , Issue.SUPPL. 15
    • Flaherty, K.T.1    Gore, L.2    Avadhani, A.N.3
  • 52
    • 84866375177 scopus 로고    scopus 로고
    • A phase I dose-escalation trial of trastuzumab and alvespimycin hydrochloride (KOS-1022; 17 DMAG) in the treatment of advanced solid tumors
    • Jhaveri K, Miller K, Rosen L, et al. A phase I dose-escalation trial of trastuzumab and alvespimycin hydrochloride (KOS-1022; 17 DMAG) in the treatment of advanced solid tumors. Clin Cancer Res 2012, 18:5090-5098.
    • (2012) Clin Cancer Res , vol.18 , pp. 5090-5098
    • Jhaveri, K.1    Miller, K.2    Rosen, L.3
  • 53
    • 51449118446 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 (Hsp90) with the novel agent IPI-504 in metastatic GIST following failure of tyrosine kinase inhibitors (TKIs) or other sarcomas: clinical results from phase I trial
    • abstr 10503.
    • Wagner AJ, Morgan JA, Chugh R, et al. Inhibition of heat shock protein 90 (Hsp90) with the novel agent IPI-504 in metastatic GIST following failure of tyrosine kinase inhibitors (TKIs) or other sarcomas: clinical results from phase I trial. Proc Am Soc Clin Oncol 2008, 26(suppl 15). abstr 10503.
    • (2008) Proc Am Soc Clin Oncol , vol.26 , Issue.SUPPL. 15
    • Wagner, A.J.1    Morgan, J.A.2    Chugh, R.3
  • 54
    • 82255196140 scopus 로고    scopus 로고
    • A phase 1 study of IPI-504 (retaspimycin hydrochloride) in patients with relapsed or relapsed and refractory multiple myeloma
    • Siegel D, Jagannath S, Vesole DH, et al. A phase 1 study of IPI-504 (retaspimycin hydrochloride) in patients with relapsed or relapsed and refractory multiple myeloma. Leuk Lymphoma 2011, 52:2308-2315.
    • (2011) Leuk Lymphoma , vol.52 , pp. 2308-2315
    • Siegel, D.1    Jagannath, S.2    Vesole, D.H.3
  • 55
    • 84870009855 scopus 로고    scopus 로고
    • Safety and activity of IPI-504 (retaspimycin hydrochloride) and docetaxel in pretreated patients (pts) with metastatic non-small cell lung cancer (NSCLC)
    • abstr 7516.
    • Riely GJ, Gettinger SN, Stoller RG, et al. Safety and activity of IPI-504 (retaspimycin hydrochloride) and docetaxel in pretreated patients (pts) with metastatic non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2011, 29. abstr 7516.
    • (2011) Proc Am Soc Clin Oncol , vol.29
    • Riely, G.J.1    Gettinger, S.N.2    Stoller, R.G.3
  • 56
    • 80052330412 scopus 로고    scopus 로고
    • Multicenter phase II trial of the heat shock protein 90 inhibitor, retaspimycin hydrochloride (IPI-504), in patients with castration-resistant prostate cancer
    • Oh WK, Galsky MD, Stadler WM, et al. Multicenter phase II trial of the heat shock protein 90 inhibitor, retaspimycin hydrochloride (IPI-504), in patients with castration-resistant prostate cancer. Urology 2011, 78:626-630.
    • (2011) Urology , vol.78 , pp. 626-630
    • Oh, W.K.1    Galsky, M.D.2    Stadler, W.M.3
  • 57
    • 79951885125 scopus 로고    scopus 로고
    • Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer
    • Sequist LV, Gettinger S, Senzer NN, et al. Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer. J Clin Oncol 2010, 28:4953-4960.
    • (2010) J Clin Oncol , vol.28 , pp. 4953-4960
    • Sequist, L.V.1    Gettinger, S.2    Senzer, N.N.3
  • 58
    • 84993702727 scopus 로고    scopus 로고
    • Final results from a phase III study of IPI-504 (retaspimycin hydrochloride) versus placebo in patients (pts) with gastrointestinal stromal tumors (GIST) following failure of kinase inhibitor therapies.
    • 2010 Gastrointestinal Cancer Symposium; Orlando, FL, USA; Jan 22-24, 2010. Abstract 64.
    • Demetri GD, Le Cesne A, Von Mehren M, et al. Final results from a phase III study of IPI-504 (retaspimycin hydrochloride) versus placebo in patients (pts) with gastrointestinal stromal tumors (GIST) following failure of kinase inhibitor therapies. 2010 Gastrointestinal Cancer Symposium; Orlando, FL, USA; Jan 22-24, 2010. Abstract 64.
    • Demetri, G.D.1    Le Cesne, A.2    Von Mehren, M.3
  • 59
    • 84870009855 scopus 로고    scopus 로고
    • Safety and activity of IPI-504 (retaspimycin hydrochloride) and docetaxel in pretreated patients (pts) with metastatic non-small cell lung cancer (NSCLC)
    • abstr 7516.
    • Riely GJ, Gettinger SN, Stoller RG, et al. Safety and activity of IPI-504 (retaspimycin hydrochloride) and docetaxel in pretreated patients (pts) with metastatic non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2011, 29(suppl). abstr 7516.
    • (2011) Proc Am Soc Clin Oncol , vol.29 , Issue.SUPPL.
    • Riely, G.J.1    Gettinger, S.N.2    Stoller, R.G.3
  • 60
    • 82555180241 scopus 로고    scopus 로고
    • An open-label phase II study of the Hsp90 inhibitor ganetespib (STA-9090) as monotherapy in patients with advanced non-small cell lung cancer (NSCLC)
    • abstr 7500.
    • Wong K, Koczywas M, Goldman JW, et al. An open-label phase II study of the Hsp90 inhibitor ganetespib (STA-9090) as monotherapy in patients with advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2011, 29. abstr 7500.
    • (2011) Proc Am Soc Clin Oncol , vol.29
    • Wong, K.1    Koczywas, M.2    Goldman, J.W.3
  • 61
    • 84876977183 scopus 로고    scopus 로고
    • The GALAXY Trial (NCT01348126): a randomized IIB/III study of ganetespib (STA-9090) in combination with docetaxel versus docetaxel alone in subjects with stage IIIB or IV NSCLC
    • abstr TPS7613^.
    • Goss GD, Manegold C, Rosell R, et al. The GALAXY Trial (NCT01348126): a randomized IIB/III study of ganetespib (STA-9090) in combination with docetaxel versus docetaxel alone in subjects with stage IIIB or IV NSCLC. Proc Am Soc Clin Oncol 2012, 30. abstr TPS7613^.
    • (2012) Proc Am Soc Clin Oncol , vol.30
    • Goss, G.D.1    Manegold, C.2    Rosell, R.3
  • 62
    • 84866382273 scopus 로고    scopus 로고
    • Phase II study of the HSP90 inhibitor AUY922 in patients with previously treated, advanced non-small cell lung cancer (NSCLC)
    • abstr 7543.
    • Garon EB, Moran T, Barlesi F, et al. Phase II study of the HSP90 inhibitor AUY922 in patients with previously treated, advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2012, 30. abstr 7543.
    • (2012) Proc Am Soc Clin Oncol , vol.30
    • Garon, E.B.1    Moran, T.2    Barlesi, F.3
  • 63
    • 84856032294 scopus 로고    scopus 로고
    • Efficacy and safety of retaspimycin hydrochloride (IPI-504) in combination with trastuzumab in patients (pts) with pretreated, locally advanced or metastatic HER2-positive breast cancer
    • abstr 590.
    • Modi S, Saura C, Henderson CA, et al. Efficacy and safety of retaspimycin hydrochloride (IPI-504) in combination with trastuzumab in patients (pts) with pretreated, locally advanced or metastatic HER2-positive breast cancer. Proc Am Soc Clin Oncol 2011, 29. abstr 590.
    • (2011) Proc Am Soc Clin Oncol , vol.29
    • Modi, S.1    Saura, C.2    Henderson, C.A.3
  • 64
    • 79961009295 scopus 로고    scopus 로고
    • A phase I dose-escalation study of the Hsp90 inhibitor STA-9090 administered once weekly in patients with solid tumors
    • abstr 2529.
    • Goldman JW, Raju RN, Gordon GA, Vukovic VM, Bradley R, Rosen LS A phase I dose-escalation study of the Hsp90 inhibitor STA-9090 administered once weekly in patients with solid tumors. Proc Am Soc Clin Oncol 2010, 28(suppl 15). abstr 2529.
    • (2010) Proc Am Soc Clin Oncol , vol.28 , Issue.SUPPL. 15
    • Goldman, J.W.1    Raju, R.N.2    Gordon, G.A.3    Vukovic, V.M.4    Bradley, R.5    Rosen, L.S.6
  • 65
    • 84857042166 scopus 로고    scopus 로고
    • A phase I dose-escalation study of the Hsp90 inhibitor ganetespib (STA-9090) administered twice weekly in patients with solid tumors: updated report
    • abstr 3051.
    • Cho DC, Heath EI, Cleary JM, et al. A phase I dose-escalation study of the Hsp90 inhibitor ganetespib (STA-9090) administered twice weekly in patients with solid tumors: updated report. Proc Am Soc Clin Oncol 2011, 29. abstr 3051.
    • (2011) Proc Am Soc Clin Oncol , vol.29
    • Cho, D.C.1    Heath, E.I.2    Cleary, J.M.3
  • 66
    • 84873124387 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of multiple schedules of ganetespib (STA-9090), a heat shock protein 90 inhibitor, in combination with docetaxel for subjects with advanced solid tumor malignancies
    • abstr 3094.
    • Kauh JS, Harvey RD, Owonikoko TK, et al. A phase I and pharmacokinetic study of multiple schedules of ganetespib (STA-9090), a heat shock protein 90 inhibitor, in combination with docetaxel for subjects with advanced solid tumor malignancies. Proc Am Soc Clin Oncol 2012, 30. abstr 3094.
    • (2012) Proc Am Soc Clin Oncol , vol.30
    • Kauh, J.S.1    Harvey, R.D.2    Owonikoko, T.K.3
  • 67
    • 84857055228 scopus 로고    scopus 로고
    • An open-label phase II study of the Hsp90 inhibitor ganetespib (STA-9090) in patients (pts) with metastatic and/or unresectable GIST
    • abstr 10011.
    • Demetri GD, Heinrich MC, Chmielowski B, et al. An open-label phase II study of the Hsp90 inhibitor ganetespib (STA-9090) in patients (pts) with metastatic and/or unresectable GIST. Proc Am Soc Clin Oncol 2011, 29. abstr 10011.
    • (2011) Proc Am Soc Clin Oncol , vol.29
    • Demetri, G.D.1    Heinrich, M.C.2    Chmielowski, B.3
  • 68
    • 84880819427 scopus 로고    scopus 로고
    • Phase II study of ganetespib, an hsp-90 inhibitor, in patients with refractory metastatic colorectal cancer
    • abstr 467.
    • Cercek A, Shia J, Gollub M, et al. Phase II study of ganetespib, an hsp-90 inhibitor, in patients with refractory metastatic colorectal cancer. Proc Am Soc Clin Oncol 2012, 30(suppl 4). abstr 467.
    • (2012) Proc Am Soc Clin Oncol , vol.30 , Issue.SUPPL. 4
    • Cercek, A.1    Shia, J.2    Gollub, M.3
  • 69
    • 79960983822 scopus 로고    scopus 로고
    • AUY922, a novel HSP90 inhibitor: final results of a first-in-human study in patients with advanced solid malignancies
    • abstr 2528.
    • Samuel TA, Sessa C, Britten C, et al. AUY922, a novel HSP90 inhibitor: final results of a first-in-human study in patients with advanced solid malignancies. Proc Am Soc Clin Oncol 2010, 28(suppl 15). abstr 2528.
    • (2010) Proc Am Soc Clin Oncol , vol.28 , Issue.SUPPL. 15
    • Samuel, T.A.1    Sessa, C.2    Britten, C.3
  • 70
    • 84857036694 scopus 로고    scopus 로고
    • Use of biomarkers and imaging to evaluate the treatment effect of AUY922, an HSP90 inhibitor, in patients with HER2+ or ER+ metastatic breast cancer
    • abstr e11024.
    • Schroder CP, Pedersen JV, Chua S, et al. Use of biomarkers and imaging to evaluate the treatment effect of AUY922, an HSP90 inhibitor, in patients with HER2+ or ER+ metastatic breast cancer. Proc Am Soc Clin Oncol 2011, 29(suppl). abstr e11024.
    • (2011) Proc Am Soc Clin Oncol , vol.29 , Issue.SUPPL.
    • Schroder, C.P.1    Pedersen, J.V.2    Chua, S.3
  • 71
    • 84880770193 scopus 로고    scopus 로고
    • A phase I dose-escalation study of the HSP90 inhibitor AUY922 and erlotinib for patients with EGFR-mutant lung cancer with acquired resistance (AR) to EGFR tyrosine kinase inhibitors (EGFR TKIs)
    • abstr 3083.
    • Johnson ML, Yu HA, Hart EM, et al. A phase I dose-escalation study of the HSP90 inhibitor AUY922 and erlotinib for patients with EGFR-mutant lung cancer with acquired resistance (AR) to EGFR tyrosine kinase inhibitors (EGFR TKIs). Proc Am Soc Clin Oncol 2012, 30. abstr 3083.
    • (2012) Proc Am Soc Clin Oncol , vol.30
    • Johnson, M.L.1    Yu, H.A.2    Hart, E.M.3
  • 72
    • 84875533868 scopus 로고    scopus 로고
    • Phase IB/II study of the HSP90 inhibitor AUY922, in combination with trastuzumab, in patients with HER2+ advanced breast cancer
    • abstr 530.
    • Kong A, Rea D, Ahmed S, et al. Phase IB/II study of the HSP90 inhibitor AUY922, in combination with trastuzumab, in patients with HER2+ advanced breast cancer. Proc Am Soc Clin Oncol 2012, 30. abstr 530.
    • (2012) Proc Am Soc Clin Oncol , vol.30
    • Kong, A.1    Rea, D.2    Ahmed, S.3
  • 73
    • 84866414054 scopus 로고    scopus 로고
    • First-in-human phase I study: results of a second-generation non-ansamycin heat shock protein 90 (HSP90) inhibitor AT13387 in refractory solid tumors
    • abstr 3028.
    • Mahadevan D, Rensvold DM, Kurtin SE, et al. First-in-human phase I study: results of a second-generation non-ansamycin heat shock protein 90 (HSP90) inhibitor AT13387 in refractory solid tumors. Proc Am Soc Clin Oncol 2012, 30. abstr 3028.
    • (2012) Proc Am Soc Clin Oncol , vol.30
    • Mahadevan, D.1    Rensvold, D.M.2    Kurtin, S.E.3
  • 74
    • 84872212504 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of the heat shock protein 90 inhibitor AT13387 in patients with refractory solid tumors
    • abstr 3069.
    • Shapiro G, Kwak EL, Dezube BJ, et al. Phase I pharmacokinetic and pharmacodynamic study of the heat shock protein 90 inhibitor AT13387 in patients with refractory solid tumors. Proc Am Soc Clin Oncol 2010, 28(suppl 15). abstr 3069.
    • (2010) Proc Am Soc Clin Oncol , vol.28 , Issue.SUPPL. 15
    • Shapiro, G.1    Kwak, E.L.2    Dezube, B.J.3
  • 75
    • 84880850083 scopus 로고    scopus 로고
    • Phase l study assessing a two-consecutive-day (QD × 2) dosing schedule of the HSP90 inhibitor, AT13387, in patients with advanced solid tumors
    • abstr 3087.
    • Do KT, Speranza G, Chen AP, et al. Phase l study assessing a two-consecutive-day (QD × 2) dosing schedule of the HSP90 inhibitor, AT13387, in patients with advanced solid tumors. Proc Am Soc Clin Oncol 2012, 30. abstr 3087.
    • (2012) Proc Am Soc Clin Oncol , vol.30
    • Do, K.T.1    Speranza, G.2    Chen, A.P.3
  • 76
    • 84880825123 scopus 로고    scopus 로고
    • First-in-human phase I study: results of a second-generation non-ansamycin heat shock protein 90 (HSP90) inhibitor AT13387 in refractory solid tumors
    • abstr 3028.
    • Daruka Mahadevan, Diane M Rensvold, Sandra E Kurtin, et al. First-in-human phase I study: results of a second-generation non-ansamycin heat shock protein 90 (HSP90) inhibitor AT13387 in refractory solid tumors. Proc Am Soc Clin Oncol 2012, 30(suppl). abstr 3028.
    • (2012) Proc Am Soc Clin Oncol , vol.30 , Issue.SUPPL.
    • Daruka, M.1    Diane, M.R.2    Sandra, E.K.3
  • 77
    • 55249118494 scopus 로고    scopus 로고
    • BIIB021, an oral, synthetic non-ansamycin Hsp90 inhibitor: phase I experience
    • abstr 2503.
    • Elfiky A, Saif MW, Beeram M, et al. BIIB021, an oral, synthetic non-ansamycin Hsp90 inhibitor: phase I experience. Proc Am Soc Clin Oncol 2008, 26(suppl 15). abstr 2503.
    • (2008) Proc Am Soc Clin Oncol , vol.26 , Issue.SUPPL. 15
    • Elfiky, A.1    Saif, M.W.2    Beeram, M.3
  • 78
    • 84871563835 scopus 로고    scopus 로고
    • Phase II study of the HSP90-inhibitor BIIB021 in gastrointestinal stromal tumors
    • Dickson MA, Okuno SH, Keohan ML, et al. Phase II study of the HSP90-inhibitor BIIB021 in gastrointestinal stromal tumors. Ann Oncol 2013, 24:252-257.
    • (2013) Ann Oncol , vol.24 , pp. 252-257
    • Dickson, M.A.1    Okuno, S.H.2    Keohan, M.L.3
  • 79
    • 84880844536 scopus 로고    scopus 로고
    • Phase 1 dose-escalation study of the heat shock protein 90 inhibitor BIIB021 with trastuzumab in HER2+ metastatic breast cancer.
    • CTRC-AACR San Antonio Breast Cancer Symposium; San Antonio, TX, USA; Dec 8-12, Abstract P3-14-02.
    • Modi S, Ismail-Khan R, Munster P, et al. Phase 1 dose-escalation study of the heat shock protein 90 inhibitor BIIB021 with trastuzumab in HER2+ metastatic breast cancer. CTRC-AACR San Antonio Breast Cancer Symposium; San Antonio, TX, USA; Dec 8-12, 2010. Abstract P3-14-02.
    • (2010)
    • Modi, S.1    Ismail-Khan, R.2    Munster, P.3
  • 80
    • 78649593334 scopus 로고    scopus 로고
    • MPC-3100, a fully synthetic, orally bioavailable Hsp90 inhibitor, in cancer patients
    • abstr e13112.
    • Yu MK, Samlowski WE, Baichwal V, et al. MPC-3100, a fully synthetic, orally bioavailable Hsp90 inhibitor, in cancer patients. Proc Am Soc Clin Oncol 2010, 28. abstr e13112.
    • (2010) Proc Am Soc Clin Oncol , vol.28
    • Yu, M.K.1    Samlowski, W.E.2    Baichwal, V.3
  • 81
    • 84880799099 scopus 로고    scopus 로고
    • A phase I study of Debio 0932, an oral HSP90 inhibitor, in patients with solid tumors
    • abstr 3026.
    • Isambert N, Hollebecque A, Berge Y, et al. A phase I study of Debio 0932, an oral HSP90 inhibitor, in patients with solid tumors. Proc Am Soc Clin Oncol 2012, 30. abstr 3026.
    • (2012) Proc Am Soc Clin Oncol , vol.30
    • Isambert, N.1    Hollebecque, A.2    Berge, Y.3
  • 82
    • 80455162319 scopus 로고    scopus 로고
    • A phase I study of PF-04929113 (SNX-5422), an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumor malignancies and lymphomas
    • Rajan A, Kelly RJ, Trepel JB, et al. A phase I study of PF-04929113 (SNX-5422), an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumor malignancies and lymphomas. Clin Cancer Res 2011, 17:6831-6839.
    • (2011) Clin Cancer Res , vol.17 , pp. 6831-6839
    • Rajan, A.1    Kelly, R.J.2    Trepel, J.B.3
  • 84
    • 45849105629 scopus 로고    scopus 로고
    • Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target
    • Gallegos-Ruiz MI, Floor K, Roepman P, et al. Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target. PLoS One 2008, 3:e0001722.
    • (2008) PLoS One , vol.3
    • Gallegos-Ruiz, M.I.1    Floor, K.2    Roepman, P.3
  • 85
    • 34248195608 scopus 로고    scopus 로고
    • High HSP90 expression is associated with decreased survival in breast cancer
    • Pick E, Kluger Y, Giltnane JM, et al. High HSP90 expression is associated with decreased survival in breast cancer. Cancer Res 2007, 67:2932-2937.
    • (2007) Cancer Res , vol.67 , pp. 2932-2937
    • Pick, E.1    Kluger, Y.2    Giltnane, J.M.3
  • 86
    • 84866553587 scopus 로고    scopus 로고
    • Biomarkers that predict sensitivity to heat shock protein 90 inhibitors (HSP90i)
    • abstr 10618.
    • Jhaveri KL, Iyengar NM, Corben A, et al. Biomarkers that predict sensitivity to heat shock protein 90 inhibitors (HSP90i). Proc Am Soc Clin Oncol 2012, 30. abstr 10618.
    • (2012) Proc Am Soc Clin Oncol , vol.30
    • Jhaveri, K.L.1    Iyengar, N.M.2    Corben, A.3
  • 87
    • 50349096803 scopus 로고    scopus 로고
    • Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis
    • Powers MV, Clarke PA, Workman P Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis. Cancer Cell 2008, 14:250-262.
    • (2008) Cancer Cell , vol.14 , pp. 250-262
    • Powers, M.V.1    Clarke, P.A.2    Workman, P.3
  • 88
    • 84857095821 scopus 로고    scopus 로고
    • Optical imaging with her2-targeted affibody molecules can monitor hsp90 treatment response in a breast cancer xenograft mouse model
    • Van de Ven SM, Elias SG, Chan CT, et al. Optical imaging with her2-targeted affibody molecules can monitor hsp90 treatment response in a breast cancer xenograft mouse model. Clin Cancer Res 2012, 18:1073-1081.
    • (2012) Clin Cancer Res , vol.18 , pp. 1073-1081
    • Van de Ven, S.M.1    Elias, S.G.2    Chan, C.T.3
  • 89
    • 0034710542 scopus 로고    scopus 로고
    • Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone
    • Clarke PA, Hostein I, Banerji U, et al. Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone. Oncogene 2000, 19:4125-4133.
    • (2000) Oncogene , vol.19 , pp. 4125-4133
    • Clarke, P.A.1    Hostein, I.2    Banerji, U.3
  • 90
    • 0344393470 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino, 17-demethoxygeldanamycin (17AAG) in human colon cancer models
    • Chung YL, Troy H, Banerji U, et al. Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino, 17-demethoxygeldanamycin (17AAG) in human colon cancer models. J Natl Cancer Inst 2003, 95:1624-1633.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1624-1633
    • Chung, Y.L.1    Troy, H.2    Banerji, U.3
  • 91
    • 84858008290 scopus 로고    scopus 로고
    • Hsp90 inhibitors and drug resistance in cancer: the potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugs
    • Lu X, Xiao L, Wang L, Ruden DM Hsp90 inhibitors and drug resistance in cancer: the potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugs. Biochem Pharmacol 2012, 83:995-1004.
    • (2012) Biochem Pharmacol , vol.83 , pp. 995-1004
    • Lu, X.1    Xiao, L.2    Wang, L.3    Ruden, D.M.4


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