Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 30, 2008, Pages 10396-10401

  Ohtsubo, Motoaki ^a   Yasunaga, Shin'Ichiro ^a   Ohno, Yoshinori ^a   Tsumura, Miyuki ^a   Okada, Satoshi ^a,b   Ishikawa, Nobutsune ^a,b   Shirao, Kenichiro ^a,b   Kikuchi, Akira ^b   Nishitani, Hideo ^c   Kobayashi, Masao ^b   Takihara, Yoshihiro ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c UNIVERSITY OF HYOGO   (Japan)

Author keywords

DNA replication licensing; HSCs; Rae28; Scmh1; Ubiquitination

Indexed keywords

BMI1 PROTEIN; GEMININ; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVITY; CELL CYCLE; DNA REPLICATION; ENZYME ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; GENE REPRESSION; GENETIC CODE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; CELL CYCLE PROTEINS; DNA REPLICATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEMATOPOIETIC STEM CELLS; HUMANS; INSECTS; MICE; MODELS, GENETIC; NUCLEAR PROTEINS; REPRESSOR PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

HEXAPODA; MUS;

EID: 48749092149     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0800672105     Document Type: Article

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