메뉴 건너뛰기




Volumn 4, Issue SEP, 2014, Pages

The PTEN/PI3K/AKT Pathway in vivo, cancer mouse models

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

EID: 84907062975     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2014.00252     Document Type: Article
Times cited : (184)

References (147)
  • 1
    • 0043244937 scopus 로고    scopus 로고
    • Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. Cancer Res
    • Abate-Shen, C., Banach-Petrosky, W. A., Sun, X., Economides, K. D., Desai, N., Gregg, J.P. et al. (2003). Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. Cancer Res 63: 3886-3890.
    • (2003) , vol.63 , pp. 3886-3890
    • Abate-Shen, C.1    Banach-Petrosky, W.A.2    Sun, X.3    Economides, K.D.4    Desai, N.5    Gregg, J.P.6
  • 2
    • 0037050234 scopus 로고    scopus 로고
    • Delayed mammary gland involution in MMTV-AKT1 transgenic mice. Oncogene
    • Ackler, S., Ahmad, S., Tobias, C., Johnson, M. D., Glazer, R. I. (2002). Delayed mammary gland involution in MMTV-AKT1 transgenic mice. Oncogene 21: 198-206.
    • (2002) , vol.21 , pp. 198-206
    • Ackler, S.1    Ahmad, S.2    Tobias, C.3    Johnson, M.D.4    Glazer, R.I.5
  • 3
    • 79953297489 scopus 로고    scopus 로고
    • Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation. Cancer Res
    • Adams, J.R., Xu, K., Liu, J. C., Agamez, N. M., Loch, A. J., Wong, R. G. et al. (2011).Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation. Cancer Res 71: 2706-2717.
    • (2011) , vol.71 , pp. 2706-2717
    • Adams, J.R.1    Xu, K.2    Liu, J.C.3    Agamez, N.M.4    Loch, A.J.5    Wong, R.G.6
  • 4
    • 84860586275 scopus 로고    scopus 로고
    • Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis. J Clin Invest
    • Anderson, P. D., McKissic, S. A., Logan, M., Roh, M., Franco, O. E., Wang, J. et al. (2012).Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis. J Clin Invest 122: 1907-1919.
    • (2012) , vol.122 , pp. 1907-1919
    • Anderson, P.D.1    McKissic, S.A.2    Logan, M.3    Roh, M.4    Franco, O.E.5    Wang J.et, al.6
  • 5
    • 9644253003 scopus 로고    scopus 로고
    • The PI 3-kinase/Aktsignaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells. Oncogene
    • Asano, T., Yao, Y., Zhu, J., Li, D., Abbruzzese, J. L., Reddy, S. A. (2004). The PI 3-kinase/Aktsignaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells. Oncogene 23:8571-8580.
    • (2004) , vol.23 , pp. 8571-8580
    • Asano, T.1    Yao, Y.2    Zhu, J.3    Li, D.4    Abbruzzese, J.L.5    Reddy, S.A.6
  • 6
    • 0035733762 scopus 로고    scopus 로고
    • Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet
    • Backman, S. A., Stambolic, V., Suzuki, A., Haight, J., Elia, A., Pretorius, J. et al. (2001).Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet 29: 396-403.
    • (2001) , vol.29 , pp. 396-403
    • Backman, S.A.1    Stambolic, V.2    Suzuki, A.3    Haight, J.4    Elia, A.5    Pretorius, J.6
  • 7
    • 16644393213 scopus 로고    scopus 로고
    • The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther
    • Bachman, K. E., Argani, P., Samuels, Y., Silliman, N., Ptak, J., Szabo, S. et al. (2004). The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther 3: 772-775.
    • (2004) , vol.3 , pp. 772-775
    • Bachman, K.E.1    Argani, P.2    Samuels, Y.3    Silliman, N.4    Ptak, J.5    Szabo, S.6
  • 8
    • 31944444234 scopus 로고    scopus 로고
    • Cancer-specific mutations in PIK3CA are oncogenic in vivo. Proc Natl Acad Sci U S A
    • Bader, A. G., Kang, S., Vogt, P. K. (2006). Cancer-specific mutations in PIK3CA are oncogenic in vivo. Proc Natl Acad Sci U S A 103: 1475-1479.
    • (2006) , vol.103 , pp. 1475-1479
    • Bader, A.G.1    Kang, S.2    Vogt, P.K.3
  • 9
    • 33846004477 scopus 로고    scopus 로고
    • PTEN enters the nuclear age. Cell
    • Baker, S. J. (2007). PTEN enters the nuclear age. Cell 128: 25-28.
    • (2007) , vol.128 , pp. 25-28
    • Baker, S.J.1
  • 10
    • 27144480288 scopus 로고    scopus 로고
    • Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Curr Biol
    • Bayascas, J. R., Leslie, N. R., Parsons, R., Fleming, S., Alessi, D. R. (2005). Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Curr Biol 15: 1839-1846.
    • (2005) , vol.15 , pp. 1839-1846
    • Bayascas, J.R.1    Leslie, N.R.2    Parsons, R.3    Fleming, S.4    Alessi, D.R.5
  • 11
    • 35148885729 scopus 로고    scopus 로고
    • A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
    • Berns, K., Horlings, H. M., Hennessy, B. T., Madiredjo, M., Hijmans, E. M., Beelen, K. et al.(2007). A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer cell 12: 395-402.
    • (2007) Cancer cell , vol.12 , pp. 395
    • Berns, K.1    Horlings, H.M.2    Hennessy, B.T.3    Madiredjo, M.4    Hijmans, E.M.5    Beelen, K.6
  • 13
    • 34547838420 scopus 로고    scopus 로고
    • PTEN, more than the AKT pathway. Carcinogenesis
    • Blanco-Aparicio, C., Renner, O., Leal, J. F., Carnero, A. (2007). PTEN, more than the AKT pathway. Carcinogenesis 28: 1379-1386.
    • (2007) , vol.28 , pp. 1379-1386
    • Blanco-Aparicio, C.1    Renner, O.2    Leal, J.F.3    Carnero, A.4
  • 14
    • 77949527599 scopus 로고    scopus 로고
    • Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models
    • e9305
    • Blanco-Aparicio, C., Canamero, M., Cecilia, Y., Pequeno, B., Renner, O., Ferrer, I. et al.(2010). Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models. PLoS ONE 5: e9305.
    • (2010) PLoS ONE , vol.5
    • Blanco-Aparicio, C.1    Canamero, M.2    Cecilia, Y.3    Pequeno, B.4    Renner, O.5    Ferrer, I.6
  • 16
    • 84857921336 scopus 로고    scopus 로고
    • Mutational characterization of individual breast tumors: TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes. Breast cancer research and treatment
    • Boyault, S., Drouet, Y., Navarro, C., Bachelot, T., Lasset, C., Treilleux, I. et al. (2012).Mutational characterization of individual breast tumors: TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes. Breast cancer research and treatment 132: 29-39.
    • (2012) , vol.132 , pp. 29-39
    • Boyault, S.1    Drouet, Y.2    Navarro, C.3    Bachelot, T.4    Lasset, C.5    Treilleux, I.6
  • 17
    • 3442878125 scopus 로고    scopus 로고
    • Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas
    • Broderick, D. K., Di, C., Parrett, T. J., Samuels, Y. R., Cummins, J. M., McLendon, R. E. et al.(2004). Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. Cancer Res 64: 5048-5050.
    • (2004) Cancer Res , vol.64 , pp. 5048
    • Broderick, D.K.1    Di, C.2    Parrett, T.J.3    Samuels, Y.R.4    Cummins, J.M.5    McLendon, R.E.6
  • 19
    • 84882958819 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours. Nature
    • Cancer Genome Atlas, N. (2012). Comprehensive molecular portraits of human breast tumours. Nature 490: 61-70.
    • (2012) , vol.490 , pp. 61-70
    • Cancer Genome Atlas, N.1
  • 20
    • 43749120732 scopus 로고    scopus 로고
    • The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets
    • Carnero, A., Blanco-Aparicio, C., Renner, O., Link, W., Leal, J. F. (2008). The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 8: 187-198.
    • (2008) , vol.8 , pp. 187-198
    • Carnero, A.1    Blanco-Aparicio, C.2    Renner, O.3    Link, W.4    Leal, J.F.5
  • 21
    • 77949513542 scopus 로고    scopus 로고
    • The PKB/AKT Pathway in Cancer. Current Pharmacological Design
    • Carnero, A. (2009). The PKB/AKT Pathway in Cancer. Current Pharmacological Design 17: 1435-1449.
    • (2009) , vol.17 , pp. 1435-1449
    • Carnero, A.1
  • 22
    • 34547172596 scopus 로고    scopus 로고
    • A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
    • Carpten, J. D., Faber, A. L., Horn, C., Donoho, G. P., Briggs, S. L., Robbins, C. M. et al.(2007). A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448: 439-444.
    • (2007) Nature , vol.448 , pp. 439-444
    • Carpten, J.D.1    Faber, A.L.2    Horn, C.3    Donoho, G.P.4    Briggs, S.L.5    Robbins, C.M.6
  • 23
    • 51849084360 scopus 로고    scopus 로고
    • The PTEN-PI3K pathway: of feedbacks and crosstalks. Oncogene
    • Carracedo, A., Pandolfi, P. P. (2008). The PTEN-PI3K pathway: of feedbacks and crosstalks. Oncogene 27: 5527-5541.
    • (2008) , vol.27 , pp. 5527-5541
    • Carracedo, A.1    Pandolfi, P.P.2
  • 24
    • 33749363890 scopus 로고    scopus 로고
    • Mouse modeling in oncologic preclinical and translational research. Clin Cancer Res
    • Carver, B. S., Pandolfi, P. P. (2006). Mouse modeling in oncologic preclinical and translational research. Clin Cancer Res 12: 5305-5311.
    • (2006) , vol.12 , pp. 5305-5311
    • Carver, B.S.1    Pandolfi, P.P.2
  • 26
    • 3142679581 scopus 로고    scopus 로고
    • PTEN regulates Mdm2 expression through the P1 promoter. J Biol Chem
    • Chang, C. J., Freeman, D. J., Wu, H. (2004). PTEN regulates Mdm2 expression through the P1 promoter. J Biol Chem 279: 29841-29848.
    • (2004) , vol.279 , pp. 29841-29848
    • Chang, C.J.1    Freeman, D.J.2    Wu, H.3
  • 27
    • 23244460597 scopus 로고    scopus 로고
    • Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature
    • Chen, Z., Trotman, L. C., Shaffer, D., Lin, H. K., Dotan, Z. A., Niki, M. et al. (2005). Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436: 725-730.
    • (2005) , vol.436 , pp. 725-730
    • Chen, Z.1    Trotman, L.C.2    Shaffer, D.3    Lin, H.K.4    Dotan, Z.A.5    Niki, M.6
  • 28
    • 0033856110 scopus 로고    scopus 로고
    • PTEN, a unique tumor suppressor gene. Endocr Relat Cancer
    • Dahia, P. L. (2000). PTEN, a unique tumor suppressor gene. Endocr Relat Cancer 7: 115-129.
    • (2000) , vol.7 , pp. 115-129
    • Dahia, P.L.1
  • 29
    • 48649088412 scopus 로고    scopus 로고
    • Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res
    • Daikoku, T., Hirota, Y., Tranguch, S., Joshi, A. R., DeMayo, F. J., Lydon, J. P. et al. (2008).Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res 68: 5619-5627.
    • (2008) , vol.68 , pp. 5619-5627
    • Daikoku, T.1    Hirota, Y.2    Tranguch, S.3    Joshi, A.R.4    DeMayo, F.J.5    Lydon, J.P.6
  • 30
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: a play in three Akts. Genes Dev
    • Datta, S. R., Brunet, A., Greenberg, M. E. (1999). Cellular survival: a play in three Akts. Genes Dev 13: 2905-2927.
    • (1999) , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 31
    • 0034748550 scopus 로고    scopus 로고
    • Knockout mouse models and mammary tumorigenesis. Semin Cancer Biol
    • Deng, C. X., Brodie, S. G. (2001). Knockout mouse models and mammary tumorigenesis. Semin Cancer Biol 11: 387-394.
    • (2001) , vol.11 , pp. 387-394
    • Deng, C.X.1    Brodie, S.G.2
  • 32
    • 0031870959 scopus 로고    scopus 로고
    • Pten is essential for embryonic development and tumour suppression. Nat Genet
    • Di Cristofano, A., Pesce, B., Cordon-Cardo, C., Pandolfi, P. P. (1998). Pten is essential for embryonic development and tumour suppression. Nat Genet 19: 348-355.
    • (1998) , vol.19 , pp. 348-355
    • Di Cristofano, A.1    Pesce, B.2    Cordon-Cardo, C.3    Pandolfi, P.P.4
  • 34
    • 79951512852 scopus 로고    scopus 로고
    • barrier constrains prostate cancer growth and metastatic progression. Nature
    • barrier constrains prostate cancer growth and metastatic progression. Nature 470: 269-273.
    • , vol.470 , pp. 269-273
  • 35
    • 84862776643 scopus 로고    scopus 로고
    • Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases
    • Ding, Z., Wu, C. J., Jaskelioff, M., Ivanova, E., Kost-Alimova, M., Protopopov, A. et al.(2012). Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell 148: 896-907.
    • (2012) Cell , vol.148 , pp. 896
    • Ding, Z.1    Wu, C.J.2    Jaskelioff, M.3    Ivanova, E.4    Kost-Alimova, M.5    Protopopov, A.6
  • 36
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer
    • Downward, J. (2003). Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 3: 11-22.
    • (2003) , vol.3 , pp. 11-22
    • Downward, J.1
  • 37
    • 1342321750 scopus 로고    scopus 로고
    • PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol
    • Downward, J. (2004). PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 15: 177-182.
    • (2004) , vol.15 , pp. 177-182
    • Downward, J.1
  • 39
    • 33750380920 scopus 로고    scopus 로고
    • Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol
    • Dummler, B., Tschopp, O., Hynx, D., Yang, Z. Z., Dirnhofer, S., Hemmings, B. A. (2006). Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol 26: 8042-8051.
    • (2006) , vol.26 , pp. 8042-8051
    • Dummler, B.1    Tschopp, O.2    Hynx, D.3    Yang, Z.Z.4    Dirnhofer, S.5    Hemmings, B.A.6
  • 40
    • 34247116441 scopus 로고    scopus 로고
    • Physiological roles of PKB/Akt isoforms in development and disease. Biochem Soc Trans
    • Dummler, B., Hemmings, B. A. (2007). Physiological roles of PKB/Akt isoforms in development and disease. Biochem Soc Trans 35: 231-235.
    • (2007) , vol.35 , pp. 231-235
    • Dummler, B.1    Hemmings, B.A.2
  • 41
    • 0035863108 scopus 로고    scopus 로고
    • Mammary ductal and alveolar development:lesson learned from genetically manipulated mice. Microsc Res Tech
    • Dunbar, M. E., Wysolmerski, J. J. (2001). Mammary ductal and alveolar development:lesson learned from genetically manipulated mice. Microsc Res Tech 52: 163-170.
    • (2001) , vol.52 , pp. 163-170
    • Dunbar, M.E.1    Wysolmerski, J.J.2
  • 42
    • 57349194139 scopus 로고    scopus 로고
    • Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
    • Engelman, J. A., Chen, L., Tan, X., Crosby, K., Guimaraes, A. R., Upadhyay, R. et al.(2008). Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 14: 1351-1356.
    • (2008) Nat Med , vol.14 , pp. 1351
    • Engelman, J.A.1    Chen, L.2    Tan, X.3    Crosby, K.4    Guimaraes, A.R.5    Upadhyay, R.6
  • 43
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer
    • Engelman, J. A. (2009). Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 9: 550-562.
    • (2009) , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 44
    • 84876437832 scopus 로고    scopus 로고
    • Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer. Cancer Cell
    • Eser, S., Reiff, N., Messer, M., Seidler, B., Gottschalk, K., Dobler, M. et al. (2013). Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer. Cancer Cell 23: 406-420.
    • (2013) , vol.23 , pp. 406-420
    • Eser, S.1    Reiff, N.2    Messer, M.3    Seidler, B.4    Gottschalk, K.5    Dobler, M.6
  • 45
    • 33746154235 scopus 로고    scopus 로고
    • Genetic background controls tumor development in PTEN-deficient mice. Cancer Res
    • Freeman, D., Lesche, R., Kertesz, N., Wang, S., Li, G., Gao, J. et al. (2006). Genetic background controls tumor development in PTEN-deficient mice. Cancer Res 66: 6492-6496.
    • (2006) , vol.66 , pp. 6492-6496
    • Freeman, D.1    Lesche, R.2    Kertesz, N.3    Wang, S.4    Li, G.5    Gao J.et, al.6
  • 46
    • 0041450058 scopus 로고    scopus 로고
    • PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell
    • Freeman, D. J., Li, A. G., Wei, G., Li, H. H., Kertesz, N., Lesche, R. et al. (2003). PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell 3: 117-130.
    • (2003) , vol.3 , pp. 117-130
    • Freeman, D.J.1    Li, A.G.2    Wei, G.3    Li, H.H.4    Kertesz, N.5    Lesche, R.6
  • 47
    • 33748038440 scopus 로고    scopus 로고
    • Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice. Cancer Res
    • Gao, H., Ouyang, X., Banach-Petrosky, W. A., Shen, M. M., Abate-Shen, C. (2006).Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice. Cancer Res 66: 7929-7933.
    • (2006) , vol.66 , pp. 7929-7933
    • Gao, H.1    Ouyang, X.2    Banach-Petrosky, W.A.3    Shen, M.M.4    Abate-Shen, C.5
  • 49
    • 33847062378 scopus 로고    scopus 로고
    • Nuclear PTEN: a tale of many tails. Cell Death Differ
    • Gil, A., Andres-Pons, A., Pulido, R. (2007). Nuclear PTEN: a tale of many tails. Cell Death Differ 14: 395-399.
    • (2007) , vol.14 , pp. 395-399
    • Gil, A.1    Andres-Pons, A.2    Pulido, R.3
  • 50
    • 85047699328 scopus 로고    scopus 로고
    • Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene
    • Gottlieb, T. M., Leal, J. F., Seger, R., Taya, Y., Oren, M. (2002). Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene 21:1299-1303.
    • (2002) , vol.21 , pp. 1299-1303
    • Gottlieb, T.M.1    Leal, J.F.2    Seger, R.3    Taya, Y.4    Oren, M.5
  • 51
    • 44349119736 scopus 로고    scopus 로고
    • Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature
    • Graupera, M., Guillermet-Guibert, J., Foukas, L. C., Phng, L. K., Cain, R. J., Salpekar, A. et al. (2008). Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature 453: 662-666.
    • (2008) , vol.453 , pp. 662-666
    • Graupera, M.1    Guillermet-Guibert, J.2    Foukas, L.C.3    Phng, L.K.4    Cain, R.J.5    Salpekar, A.6
  • 52
    • 34249026448 scopus 로고    scopus 로고
    • Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell
    • Gupta, S., Ramjaun, A. R., Haiko, P., Wang, Y., Warne, P. H., Nicke, B. et al. (2007).Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell 129: 957-968.
    • (2007) , vol.129 , pp. 957-968
    • Gupta, S.1    Ramjaun, A.R.2    Haiko, P.3    Wang, Y.4    Warne, P.H.5    Nicke, B.6
  • 54
    • 0034020459 scopus 로고    scopus 로고
    • Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet
    • Holland, E. C., Celestino, J., Dai, C., Schaefer, L., Sawaya, R. E., Fuller, G. N. (2000).Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet 25: 55-57.
    • (2000) , vol.25 , pp. 55-57
    • Holland, E.C.1    Celestino, J.2    Dai, C.3    Schaefer, L.4    Sawaya, R.E.5    Fuller, G.N.6
  • 55
    • 33947230755 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines. Molecular cancer research: MCR
    • Hollestelle, A., Elstrodt, F., Nagel, J. H., Kallemeijn, W. W., Schutte, M. (2007).Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines. Molecular cancer research: MCR 5: 195-201.
    • (2007) , vol.5 , pp. 195-201
    • Hollestelle, A.1    Elstrodt, F.2    Nagel, J.H.3    Kallemeijn, W.W.4    Schutte, M.5
  • 56
    • 0035008874 scopus 로고    scopus 로고
    • Activation of Akt(protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol
    • Hutchinson, J., Jin, J., Cardiff, R. D., Woodgett, J. R., Muller, W. J. (2001). Activation of Akt(protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol 21: 2203-2212.
    • (2001) , vol.21 , pp. 2203-2212
    • Hutchinson, J.1    Jin, J.2    Cardiff, R.D.3    Woodgett, J.R.4    Muller, W.J.5
  • 57
    • 2342527930 scopus 로고    scopus 로고
    • Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion. Cancer Res
    • Hutchinson, J. N., Jin, J., Cardiff, R. D., Woodgett, J. R., Muller, W. J. (2004). Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion. Cancer Res 64: 3171-3178.
    • (2004) , vol.64 , pp. 3171-3178
    • Hutchinson, J.N.1    Jin, J.2    Cardiff, R.D.3    Woodgett, J.R.4    Muller, W.J.5
  • 58
    • 84878747814 scopus 로고    scopus 로고
    • Recent progress in mouse models for tumor suppressor genes and its implications in human cancer. Clin Med Insights Oncol
    • Inoue, K., Fry, E. A., Taneja, P. (2013). Recent progress in mouse models for tumor suppressor genes and its implications in human cancer. Clin Med Insights Oncol 7: 103-122.
    • (2013) , vol.7 , pp. 103-122
    • Inoue, K.1    Fry, E.A.2    Taneja, P.3
  • 59
    • 39449134253 scopus 로고    scopus 로고
    • Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. Cancer Res
    • Iwanaga, K., Yang, Y., Raso, M. G., Ma, L., Hanna, A. E., Thilaganathan, N. et al. (2008).Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. Cancer Res 68: 1119-1127.
    • (2008) , vol.68 , pp. 1119-1127
    • Iwanaga, K.1    Yang, Y.2    Raso, M.G.3    Ma, L.4    Hanna, A.E.5    Thilaganathan, N.6
  • 60
    • 84864945212 scopus 로고    scopus 로고
    • PIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab. Annals of oncology: official journal of the European Society for Medical Oncology/ESMO
    • Jensen, J. D., Knoop, A., Laenkholm, A. V., Grauslund, M., Jensen, M. B., Santoni-Rugiu, E. et al. (2012). PIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab. Annals of oncology: official journal of the European Society for Medical Oncology/ESMO 23: 2034-2042.
    • (2012) , vol.23 , pp. 2034-2042
    • Jensen, J.D.1    Knoop, A.2    Laenkholm, A.V.3    Grauslund, M.4    Jensen, M.B.5    Santoni-Rugiu, E.6
  • 61
    • 49649087385 scopus 로고    scopus 로고
    • Essential roles of PI(3)Kp110beta in cell growth, metabolism and tumorigenesis. Nature
    • Jia, S., Liu, Z., Zhang, S., Liu, P., Zhang, L., Lee, S. H. et al. (2008). Essential roles of PI(3)Kp110beta in cell growth, metabolism and tumorigenesis. Nature 454: 776-779.
    • (2008) , vol.454 , pp. 776-779
    • Jia, S.1    Liu, Z.2    Zhang, S.3    Liu, P.4    Zhang, L.5    Lee, S.H.6
  • 62
    • 0032472913 scopus 로고    scopus 로고
    • Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase. Embo J
    • Jimenez, C., Jones, D. R., Rodriguez-Viciana, P., Gonzalez-Garcia, A., Leonardo, E., Wennstrom, S. et al. (1998). Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase. Embo J 17: 743-753.
    • (1998) , vol.17 , pp. 743-753
    • Jimenez, C.1    Jones, D.R.2    Rodriguez-Viciana, P.3    Gonzalez-Garcia, A.4    Leonardo, E.5    Wennstrom, S.6
  • 63
    • 34249301918 scopus 로고    scopus 로고
    • Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A
    • Ju, X., Katiyar, S., Wang, C., Liu, M., Jiao, X., Li, S. et al. (2007). Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A 104: 7438-7443.
    • (2007) , vol.104 , pp. 7438-7443
    • Ju, X.1    Katiyar, S.2    Wang, C.3    Liu, M.4    Jiao, X.5    Li, S.6
  • 64
    • 0033604585 scopus 로고    scopus 로고
    • The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res
    • Kandel, E. S., Hay, N. (1999). The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 253: 210-229.
    • (1999) , vol.253 , pp. 210-229
    • Kandel, E.S.1    Hay, N.2
  • 65
    • 14144252004 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci U S A
    • Kang, S., Bader, A. G., Vogt, P. K. (2005). Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci U S A 102: 802-807.
    • (2005) , vol.102 , pp. 802-807
    • Kang, S.1    Bader, A.G.2    Vogt, P.K.3
  • 66
    • 79953315567 scopus 로고    scopus 로고
    • Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol Cell
    • Kennedy, A. L., Morton, J. P., Manoharan, I., Nelson, D. M., Jamieson, N. B., Pawlikowski, J. S. et al. (2011). Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol Cell 42: 36-49.
    • (2011) , vol.42 , pp. 36-49
    • Kennedy, A.L.1    Morton, J.P.2    Manoharan, I.3    Nelson, D.M.4    Jamieson, N.B.5    Pawlikowski, J.S.6
  • 67
    • 68249096687 scopus 로고    scopus 로고
    • Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer
    • e1000542
    • Kim, J., Eltoum, I. E., Roh, M., Wang, J., Abdulkadir, S. A. (2009). Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer. PLoS Genet 5:e1000542.
    • (2009) PLoS Genet , vol.5
    • Kim, J.1    Eltoum, I.E.2    Roh, M.3    Wang, J.4    Abdulkadir, S.A.5
  • 68
    • 26044443105 scopus 로고    scopus 로고
    • AKT activation predicts outcome in breast cancer patients treated with tamoxifen
    • Kirkegaard, T., Witton, C. J., McGlynn, L. M., Tovey, S. M., Dunne, B., Lyon, A. et al.(2005). AKT activation predicts outcome in breast cancer patients treated with tamoxifen. J Pathol 207: 139-146.
    • (2005) J Pathol , vol.207 , pp. 139
    • Kirkegaard, T.1    Witton, C.J.2    McGlynn, L.M.3    Tovey, S.M.4    Dunne, B.5    Lyon, A.6
  • 69
    • 0037310664 scopus 로고    scopus 로고
    • Physiological functions of Pten in mouse tissues. Cell Struct Funct
    • Kishimoto, H., Hamada, K., Saunders, M., Backman, S., Sasaki, T., Nakano, T. et al. (2003).Physiological functions of Pten in mouse tissues. Cell Struct Funct 28: 11-21.
    • (2003) , vol.28 , pp. 11-21
    • Kishimoto, H.1    Hamada, K.2    Saunders, M.3    Backman, S.4    Sasaki, T.5    Nakano, T.6
  • 70
    • 84875812144 scopus 로고    scopus 로고
    • Genetically engineered mouse models of PI3K signaling in breast cancer. Mol Oncol
    • Klarenbeek, S., van Miltenburg, M. H., Jonkers, J. (2013). Genetically engineered mouse models of PI3K signaling in breast cancer. Mol Oncol 7: 146-164.
    • (2013) , vol.7 , pp. 146-164
    • Klarenbeek, S.1    van Miltenburg, M.H.2    Jonkers, J.3
  • 71
    • 44849089702 scopus 로고    scopus 로고
    • Pten haploinsufficiency accelerates formation of high-grade astrocytomas
    • Kwon, C. H., Zhao, D., Chen, J., Alcantara, S., Li, Y., Burns, D. K. et al. (2008). Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res 68:3286-3294.
    • (2008) Cancer Res , vol.68 , pp. 3286-3294
    • Kwon, C.H.1    Zhao, D.2    Chen, J.3    Alcantara, S.4    Li, Y.5    Burns, D.K.6
  • 72
    • 33746990186 scopus 로고    scopus 로고
    • Mechanistic insights into maintenance of high p53 acetylation by PTEN. Mol Cell
    • Li, A. G., Piluso, L. G., Cai, X., Wei, G., Sellers, W. R., Liu, X. (2006). Mechanistic insights into maintenance of high p53 acetylation by PTEN. Mol Cell 23: 575-587.
    • (2006) , vol.23 , pp. 575-587
    • Li, A.G.1    Piluso, L.G.2    Cai, X.3    Wei, G.4    Sellers, W.R.5    Liu, X.6
  • 73
    • 0036714806 scopus 로고    scopus 로고
    • Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development
    • Li, G., Robinson, G. W., Lesche, R., Martinez-Diaz, H., Jiang, Z., Rozengurt, N. et al. (2002).Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development 129: 4159-4170.
    • (2002) , vol.129 , pp. 4159-4170
    • Li, G.1    Robinson, G.W.2    Lesche, R.3    Martinez-Diaz, H.4    Jiang, Z.5    Rozengurt N.et, al.6
  • 74
    • 74749101634 scopus 로고    scopus 로고
    • PIK3CA mutations mostly begin to develop in ductal carcinoma of the breast. Experimental and molecular pathology
    • Li, H., Zhu, R., Wang, L., Zhu, T., Li, Q., Chen, Q. et al. (2010). PIK3CA mutations mostly begin to develop in ductal carcinoma of the breast. Experimental and molecular pathology 88: 150-155.
    • (2010) , vol.88 , pp. 150-155
    • Li, H.1    Zhu, R.2    Wang, L.3    Zhu, T.4    Li, Q.5    Chen, Q.6
  • 75
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science
    • Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I. et al. (1997). PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943-1947.
    • (1997) , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3    Podsypanina, K.4    Bose, S.5    Wang, S.I.6
  • 76
    • 2542451142 scopus 로고    scopus 로고
    • Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice
    • Li, Y., Podsypanina, K., Liu, X., Crane, A., Tan, L. K., Parsons, R. et al. (2001). Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice. BMC Mol Biol 2: 2.
    • (2001) BMC Mol Biol , vol.2 , pp. 2
    • Li, Y.1    Podsypanina, K.2    Liu, X.3    Crane, A.4    Tan, L.K.5    Parsons, R.6
  • 77
    • 27844535741 scopus 로고    scopus 로고
    • Class reunion: PTEN joins the nuclear crew. Oncogene
    • Lian, Z., Di Cristofano, A. (2005). Class reunion: PTEN joins the nuclear crew. Oncogene 24: 7394-7400.
    • (2005) , vol.24 , pp. 7394-7400
    • Lian, Z.1    Di Cristofano, A.2
  • 78
    • 0031004088 scopus 로고    scopus 로고
    • Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet
    • Liaw, D., Marsh, D. J., Li, J., Dahia, P. L., Wang, S. I., Zheng, Z. et al. (1997). Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 16: 64-67.
    • (1997) , vol.16 , pp. 64-67
    • Liaw, D.1    Marsh, D.J.2    Li, J.3    Dahia, P.L.4    Wang, S.I.5    Zheng, Z.6
  • 79
    • 33845972919 scopus 로고    scopus 로고
    • Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression. J Cell Sci
    • Lindsay, Y., McCoull, D., Davidson, L., Leslie, N. R., Fairservice, A., Gray, A. et al. (2006).Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression. J Cell Sci 119: 5160-5168.
    • (2006) , vol.119 , pp. 5160-5168
    • Lindsay, Y.1    McCoull, D.2    Davidson, L.3    Leslie, N.R.4    Fairservice, A.5    Gray A.et, al.6
  • 80
    • 26244445559 scopus 로고    scopus 로고
    • Membrane localization of all class I PI 3-kinase isoforms suppresses c-Myc-induced apoptosis in Rat1 fibroblasts via Akt. J Cell Biochem
    • Link, W., Rosado, A., Fominaya, J., Thomas, J. E., Carnero, A. (2005). Membrane localization of all class I PI 3-kinase isoforms suppresses c-Myc-induced apoptosis in Rat1 fibroblasts via Akt. J Cell Biochem 95: 979-989.
    • (2005) , vol.95 , pp. 979-989
    • Link, W.1    Rosado, A.2    Fominaya, J.3    Thomas, J.E.4    Carnero, A.5
  • 81
    • 80052490834 scopus 로고    scopus 로고
    • Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathwaydependent and PI3K pathway-independent mechanisms. Nat Med
    • Liu, P., Cheng, H., Santiago, S., Raeder, M., Zhang, F., Isabella, A. et al. (2011). Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathwaydependent and PI3K pathway-independent mechanisms. Nat Med 17: 1116-1120.
    • (2011) , vol.17 , pp. 1116-1120
    • Liu, P.1    Cheng, H.2    Santiago, S.3    Raeder, M.4    Zhang, F.5    Isabella, A.6
  • 83
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem
    • Maehama, T., Dixon, J. E. (1998). The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:13375-13378.
    • (1998) , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 84
    • 0038271762 scopus 로고    scopus 로고
    • Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci U S A
    • Majumder, P. K., Yeh, J. J., George, D. J., Febbo, P. G., Kum, J., Xue, Q. et al. (2003).Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci U S A 100: 7841-7846.
    • (2003) , vol.100 , pp. 7841-7846
    • Majumder, P.K.1    Yeh, J.J.2    George, D.J.3    Febbo, P.G.4    Kum, J.5    Xue, Q.6
  • 85
    • 48449092237 scopus 로고    scopus 로고
    • A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression. Cancer Cell
    • Majumder, P. K., Grisanzio, C., O'Connell, F., Barry, M., Brito, J. M., Xu, Q. et al. (2008). A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression. Cancer Cell 14: 146-155.
    • (2008) , vol.14 , pp. 146-155
    • Majumder, P.K.1    Grisanzio, C.2    O'Connell, F.3    Barry, M.4    Brito, J.M.5    Xu, Q.6
  • 86
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: navigating downstream. Cell
    • Manning, B. D., Cantley, L. C. (2007). AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274.
    • (2007) , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 87
    • 0032853452 scopus 로고    scopus 로고
    • PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome
    • Marsh, D. J., Kum, J. B., Lunetta, K. L., Bennett, M. J., Gorlin, R. J., Ahmed, S. F. et al.(1999). PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome. Hum Mol Genet 8: 1461-1472.
    • (1999) Hum Mol Genet , vol.8 , pp. 1461
    • Marsh, D.J.1    Kum, J.B.2    Lunetta, K.L.3    Bennett, M.J.4    Gorlin, R.J.5    Ahmed, S.F.6
  • 88
    • 38849167565 scopus 로고    scopus 로고
    • Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors. Cancer Res
    • Martinez-Cruz, A. B., Santos, M., Lara, M. F., Segrelles, C., Ruiz, S., Moral, M. et al. (2008).Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors. Cancer Res 68: 683-692.
    • (2008) , vol.68 , pp. 683-692
    • Martinez-Cruz, A.B.1    Santos, M.2    Lara, M.F.3    Segrelles, C.4    Ruiz, S.5    Moral, M.6
  • 89
    • 68549096090 scopus 로고    scopus 로고
    • Spontaneous tumor formation in Trp53-deficient epidermis mediated by chromosomal instability and inflammation. Anticancer Res
    • Martinez-Cruz, A. B., Santos, M., Garcia-Escudero, R., Moral, M., Segrelles, C., Lorz, C. et al. (2009). Spontaneous tumor formation in Trp53-deficient epidermis mediated by chromosomal instability and inflammation. Anticancer Res 29: 3035-3042.
    • (2009) , vol.29 , pp. 3035-3042
    • Martinez-Cruz, A.B.1    Santos, M.2    Garcia-Escudero, R.3    Moral, M.4    Segrelles, C.5    Lorz, C.6
  • 90
    • 0035949588 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci U S A
    • Mayo, L. D., Donner, D. B. (2001). A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci U S A 98:11598-11603.
    • (2001) , vol.98 , pp. 11598-11603
    • Mayo, L.D.1    Donner, D.B.2
  • 91
    • 79959860167 scopus 로고    scopus 로고
    • Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors. Cancer Res
    • Meyer, D. S., Brinkhaus, H., Muller, U., Muller, M., Cardiff, R. D., Bentires-Alj, M. (2011).Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors. Cancer Res 71: 4344-4351.
    • (2011) , vol.71 , pp. 4344-4351
    • Meyer, D.S.1    Brinkhaus, H.2    Muller, U.3    Muller, M.4    Cardiff, R.D.5    Bentires-Alj, M.6
  • 92
    • 84885435958 scopus 로고    scopus 로고
    • Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R
    • Meyer, D. S., Koren, S., Leroy, C., Brinkhaus, H., Muller, U., Klebba, I. et al. (2013).Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R. Oncogenesis 2: e74.
    • (2013) Oncogenesis , vol.2 , pp. 74
    • Meyer, D.S.1    Koren, S.2    Leroy, C.3    Brinkhaus, H.4    Muller, U.5    Klebba, I.6
  • 93
    • 59149092491 scopus 로고    scopus 로고
    • Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma. Cancer Res
    • Moral, M., Segrelles, C., Lara, M. F., Martinez-Cruz, A. B., Lorz, C., Santos, M. et al. (2009).Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma. Cancer Res 69: 1099-1108.
    • (2009) , vol.69 , pp. 1099-1108
    • Moral, M.1    Segrelles, C.2    Lara, M.F.3    Martinez-Cruz, A.B.4    Lorz, C.5    Santos, M.6
  • 94
    • 79958764107 scopus 로고    scopus 로고
    • Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell
    • Mulholland, D. J., Tran, L. M., Li, Y., Cai, H., Morim, A., Wang, S. et al. (2011). Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell 19: 792-804.
    • (2011) , vol.19 , pp. 792-804
    • Mulholland, D.J.1    Tran, L.M.2    Li, Y.3    Cai, H.4    Morim, A.5    Wang, S.6
  • 95
    • 0030837555 scopus 로고    scopus 로고
    • P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A
    • Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H. et al. (1997). P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A 94: 9052-9057.
    • (1997) , vol.94 , pp. 9052-9057
    • Myers, M.P.1    Stolarov, J.P.2    Eng, C.3    Li, J.4    Wang, S.I.5    Wigler, M.H.6
  • 97
    • 33751190974 scopus 로고    scopus 로고
    • Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms. Cancer Biol Ther
    • Nakayama, K., Nakayama, N., Kurman, R. J., Cope, L., Pohl, G., Samuels, Y. et al. (2006).Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms. Cancer Biol Ther 5: 779-785.
    • (2006) , vol.5 , pp. 779-785
    • Nakayama, K.1    Nakayama, N.2    Kurman, R.J.3    Cope, L.4    Pohl, G.5    Samuels, Y.6
  • 99
    • 84875681472 scopus 로고    scopus 로고
    • Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia
    • e60277
    • Narlik-Grassow, M., Blanco-Aparicio, C., Cecilia, Y., Perez, M., Munoz-Galvan, S., Canamero, M. et al. (2013). Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia. PLoS ONE 8: e60277.
    • (2013) PLoS ONE , vol.8
    • Narlik-Grassow, M.1    Blanco-Aparicio, C.2    Cecilia, Y.3    Perez, M.4    Munoz-Galvan S. Canamero, M.5
  • 100
    • 84907057686 scopus 로고    scopus 로고
    • Pim1 Kinase Cooperates with Hormone Treatment to Promote Bladder and Ureteral Urothelial Hyperplasia. J Carcinog Mutagen 5: 2-6.Nelen, M. R., van Staveren, W. C., Peeters, E. A., Hassel, M. B., Gorlin, R. J., Hamm, H. et al. (1997). Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. Hum Mol Genet
    • Narlik-Grassow, M., Blanco-Aparicio, C., Cecilia, Y., Perez, M., Munoz-Galvan, S., Canamero, M. et al. (2014). Pim1 Kinase Cooperates with Hormone Treatment to Promote Bladder and Ureteral Urothelial Hyperplasia. J Carcinog Mutagen 5: 2-6.Nelen, M. R., van Staveren, W. C., Peeters, E. A., Hassel, M. B., Gorlin, R. J., Hamm, H. et al. (1997). Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. Hum Mol Genet 6: 1383-1387.
    • (2014) , vol.6 , pp. 1383-1387
    • Narlik-Grassow, M.1    Blanco-Aparicio, C.2    Cecilia, Y.3    Perez, M.4    Munoz-Galvan S. Canamero, M.5
  • 101
    • 0037714004 scopus 로고    scopus 로고
    • Genetic alterations in esophageal cancer. Methods Mol Biol
    • Okano, J., Snyder, L., Rustgi, A. K. (2003). Genetic alterations in esophageal cancer. Methods Mol Biol 222: 131-145.
    • (2003) , vol.222 , pp. 131-145
    • Okano, J.1    Snyder, L.2    Rustgi, A.K.3
  • 103
    • 0036710675 scopus 로고    scopus 로고
    • Regulation of p53: intricate loops and delicate balances. Biochem Pharmacol
    • Oren, M., Damalas, A., Gottlieb, T., Michael, D., Taplick, J., Leal, J. F. et al. (2002).Regulation of p53: intricate loops and delicate balances. Biochem Pharmacol 64: 865-871.
    • (2002) , vol.64 , pp. 865-871
    • Oren, M.1    Damalas, A.2    Gottlieb, T.3    Michael, D.4    Taplick, J.5    Leal, J.F.6
  • 104
    • 0033539945 scopus 로고    scopus 로고
    • PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein. Oncogene
    • Paramio, J. M., Navarro, M., Segrelles, C., Gomez-Casero, E., Jorcano, J. L. (1999). PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein. Oncogene 18: 7462-7468.
    • (1999) , vol.18 , pp. 7462-7468
    • Paramio, J.M.1    Navarro, M.2    Segrelles, C.3    Gomez-Casero, E.4    Jorcano, J.L.5
  • 106
    • 27844526600 scopus 로고    scopus 로고
    • Akt-dependent transformation: there is more to growth than just surviving. Oncogene
    • Plas, D. R., Thompson, C. B. (2005). Akt-dependent transformation: there is more to growth than just surviving. Oncogene 24: 7435-7442.
    • (2005) , vol.24 , pp. 7435-7442
    • Plas, D.R.1    Thompson, C.B.2
  • 108
    • 0042971700 scopus 로고    scopus 로고
    • PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1. Mol Cell Biol
    • Radu, A., Neubauer, V., Akagi, T., Hanafusa, H., Georgescu, M. M. (2003). PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1. Mol Cell Biol 23: 6139-6149.
    • (2003) , vol.23 , pp. 6139-6149
    • Radu, A.1    Neubauer, V.2    Akagi, T.3    Hanafusa, H.4    Georgescu, M.M.5
  • 109
    • 34547784053 scopus 로고    scopus 로고
    • Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate. Carcinogenesis
    • Renner, O., Fominaya, J., Alonso, S., Blanco-Aparicio, C., Leal, J. F., Carnero, A. (2007).Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate. Carcinogenesis 28: 1418-1425.
    • (2007) , vol.28 , pp. 1418-1425
    • Renner, O.1    Fominaya, J.2    Alonso, S.3    Blanco-Aparicio, C.4    Leal, J.F.5    Carnero, A.6
  • 110
    • 58149382112 scopus 로고    scopus 로고
    • Genetic modelling of the PTEN/AKT pathway in cancer research
    • Renner, O., Blanco-Aparicio, C., Carnero, A. (2008a). Genetic modelling of the PTEN/AKT pathway in cancer research. Clin Transl Oncol 10: 618-627.
    • (2008) Clin Transl Oncol , vol.10 , pp. 618-627
    • Renner, O.1    Blanco-Aparicio, C.2    Carnero, A.3
  • 111
    • 57149098047 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation
    • Renner, O., Blanco-Aparicio, C., Grassow, M., Canamero, M., Leal, J. F., Carnero, A.(2008b). Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation. Cancer Res 68:9643-9653.
    • (2008) Cancer Res , vol.68 , pp. 9643-9653
    • Renner, O.1    Blanco-Aparicio, C.2    Grassow, M.3    Canamero, M.4    Leal, J.F.5    Carnero, A.6
  • 112
    • 70449715939 scopus 로고    scopus 로고
    • Mouse models to decipher the PI3K signaling network in human cancer. Curr Mol Med
    • Renner, O., Carnero, A. (2009). Mouse models to decipher the PI3K signaling network in human cancer. Curr Mol Med 9: 612-625.
    • (2009) , vol.9 , pp. 612-625
    • Renner, O.1    Carnero, A.2
  • 113
    • 20144387695 scopus 로고    scopus 로고
    • PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res
    • Saal, L. H., Holm, K., Maurer, M., Memeo, L., Su, T., Wang, X. et al. (2005). PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 65: 2554-2559.
    • (2005) , vol.65 , pp. 2554-2559
    • Saal, L.H.1    Holm, K.2    Maurer, M.3    Memeo, L.4    Su, T.5    Wang, X.6
  • 115
    • 37549020704 scopus 로고    scopus 로고
    • Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet
    • Saal, L. H., Gruvberger-Saal, S. K., Persson, C., Lovgren, K., Jumppanen, M., Staaf, J. et al. (2008). Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet 40: 102-107.
    • (2008) , vol.40 , pp. 102-107
    • Saal, L.H.1    Gruvberger-Saal, S.K.2    Persson, C.3    Lovgren, K.4    Jumppanen, M.5    Staaf, J.6
  • 116
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S. et al. (2004). High frequency of mutations of the PIK3CA gene in human cancers. Science 304: 554.
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3    Silliman, N.4    Ptak, J.5    Szabo, S.6
  • 117
    • 67650553421 scopus 로고    scopus 로고
    • PTEN deficiency in a luminal ErbB-2 mouse model results in dramatic acceleration of mammary tumorigenesis and metastasis. J Biol Chem
    • Schade, B., Rao, T., Dourdin, N., Lesurf, R., Hallett, M., Cardiff, R. D. et al. (2009). PTEN deficiency in a luminal ErbB-2 mouse model results in dramatic acceleration of mammary tumorigenesis and metastasis. J Biol Chem 284: 19018-19026.
    • (2009) , vol.284 , pp. 19018-19026
    • Schade, B.1    Rao, T.2    Dourdin, N.3    Lesurf, R.4    Hallett, M.5    Cardiff, R.D.6
  • 118
    • 0031975070 scopus 로고    scopus 로고
    • Clinical and pathological features of breast disease in Cowden's syndrome: an underrecognized syndrome with an increased risk of breast cancer. Hum Pathol
    • Schrager, C. A., Schneider, D., Gruener, A. C., Tsou, H. C., Peacocke, M. (1998). Clinical and pathological features of breast disease in Cowden's syndrome: an underrecognized syndrome with an increased risk of breast cancer. Hum Pathol 29: 47-53.
    • (1998) , vol.29 , pp. 47-53
    • Schrager, C.A.1    Schneider, D.2    Gruener, A.C.3    Tsou, H.C.4    Peacocke, M.5
  • 119
    • 0034987031 scopus 로고    scopus 로고
    • Mammary gland involution is delayed by activated Akt in transgenic mice. Mol Endocrinol
    • Schwertfeger, K. L., Richert, M. M., Anderson, S. M. (2001). Mammary gland involution is delayed by activated Akt in transgenic mice. Mol Endocrinol 15: 867-881.
    • (2001) , vol.15 , pp. 867-881
    • Schwertfeger, K.L.1    Richert, M.M.2    Anderson, S.M.3
  • 120
    • 0037012011 scopus 로고    scopus 로고
    • Functional roles of Akt signaling in mouse skin tumorigenesis. Oncogene
    • Segrelles, C., Ruiz, S., Perez, P., Murga, C., Santos, M., Budunova, I. V. et al. (2002).Functional roles of Akt signaling in mouse skin tumorigenesis. Oncogene 21: 53-64.
    • (2002) , vol.21 , pp. 53-64
    • Segrelles, C.1    Ruiz, S.2    Perez, P.3    Murga, C.4    Santos, M.5    Budunova, I.V.6
  • 121
    • 33644554236 scopus 로고    scopus 로고
    • Molecular determinants of Akt-induced keratinocyte transformation. Oncogene
    • Segrelles, C., Moral, M., Lara, M. F., Ruiz, S., Santos, M., Leis, H. et al. (2006). Molecular determinants of Akt-induced keratinocyte transformation. Oncogene 25: 1174-1185.
    • (2006) , vol.25 , pp. 1174-1185
    • Segrelles, C.1    Moral, M.2    Lara, M.F.3    Ruiz, S.4    Santos, M.5    Leis, H.6
  • 123
    • 36348947025 scopus 로고    scopus 로고
    • Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis
    • Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis. Cancer Res 67: 10879-10888.
    • Cancer Res , vol.67 , pp. 10879-10888
  • 124
    • 84902593659 scopus 로고    scopus 로고
    • Akt signalling leads to stem cell activation and promotes tumour development in epidermis. Stem Cells.
    • Segrelles, C., Garcia-Escudero, R., Garin, M. I., Aranda, J. F., Hernandez, P., Ariza, J. M. et al. (2014). Akt signalling leads to stem cell activation and promotes tumour development in epidermis. Stem Cells.
    • (2014)
    • Segrelles, C.1    Garcia-Escudero, R.2    Garin, M.I.3    Aranda, J.F.4    Hernandez, P.5    Ariza, J.M.6
  • 125
    • 0034213075 scopus 로고    scopus 로고
    • The conserved phosphoinositide 3-kinase pathway determines heart size in mice. Embo J
    • Shioi, T., Kang, P. M., Douglas, P. S., Hampe, J., Yballe, C. M., Lawitts, J. et al. (2000). The conserved phosphoinositide 3-kinase pathway determines heart size in mice. Embo J 19: 2537-2548.
    • (2000) , vol.19 , pp. 2537-2548
    • Shioi, T.1    Kang, P.M.2    Douglas, P.S.3    Hampe, J.4    Yballe, C.M.5    Lawitts, J.6
  • 126
    • 0034234268 scopus 로고    scopus 로고
    • High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice
    • Stambolic, V., Tsao, M. S., Macpherson, D., Suzuki, A., Chapman, W. B., Mak, T. W.(2000). High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice. Cancer Res 60: 3605-3611.
    • (2000) Cancer Res , vol.60 , pp. 3605
    • Stambolic, V.1    Tsao, M.S.2    Macpherson, D.3    Suzuki, A.4    Chapman, W.B.5    Mak, T.W.6
  • 128
    • 24944572259 scopus 로고    scopus 로고
    • Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell
    • Stanger, B. Z., Stiles, B., Lauwers, G. Y., Bardeesy, N., Mendoza, M., Wang, Y. et al. (2005).Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 8: 185-195.
    • (2005) , vol.8 , pp. 185-195
    • Stanger, B.Z.1    Stiles, B.2    Lauwers, G.Y.3    Bardeesy, N.4    Mendoza, M.5    Wang Y.et, al.6
  • 129
    • 51049118140 scopus 로고    scopus 로고
    • An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer research
    • Stemke-Hale, K., Gonzalez-Angulo, A. M., Lluch, A., Neve, R. M., Kuo, W. L., Davies, M. et al. (2008). An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer research 68: 6084-6091.
    • (2008) , vol.68 , pp. 6084-6091
    • Stemke-Hale, K.1    Gonzalez-Angulo, A.M.2    Lluch, A.3    Neve, R.M.4    Kuo, W.L.5    Davies, M.6
  • 130
    • 4344698040 scopus 로고    scopus 로고
    • PTENless means more. Dev Biol 273: 175-184.Stokoe, D. (2001)
    • Stiles, B., Groszer, M., Wang, S., Jiao, J., Wu, H. (2004). PTENless means more. Dev Biol 273: 175-184.Stokoe, D. (2001). Pten. Curr Biol 11: R502.
    • (2004) Pten. Curr Biol , vol.11 , pp. 502
    • Stiles, B.1    Groszer, M.2    Wang, S.3    Jiao, J.4    Wu, H.5
  • 131
    • 13144249184 scopus 로고    scopus 로고
    • High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol
    • Suzuki, A., de la Pompa, J. L., Stambolic, V., Elia, A. J., Sasaki, T., del Barco Barrantes, I. et al. (1998). High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 8: 1169-1178.
    • (1998) , vol.8 , pp. 1169-1178
    • Suzuki, A.1    De la Pompa, J.L.2    Stambolic, V.3    Elia, A.J.4    Sasaki, T.5    Del Barco Barrantes, I.6
  • 132
    • 0034995242 scopus 로고    scopus 로고
    • T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity
    • Suzuki, A., Yamaguchi, M. T., Ohteki, T., Sasaki, T., Kaisho, T., Kimura, Y. et al. (2001). T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity 14: 523-534.
    • (2001) , vol.14 , pp. 523-534
    • Suzuki, A.1    Yamaguchi, M.T.2    Ohteki, T.3    Sasaki, T.4    Kaisho, T.5    Kimura, Y.6
  • 133
    • 84861634733 scopus 로고    scopus 로고
    • Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERalpha-positive tumors, e36924
    • Tikoo, A., Roh, V., Montgomery, K. G., Ivetac, I., Waring, P., Pelzer, R. et al. (2012).Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERalpha-positive tumors. PLoS ONE 7: e36924.
    • (2012) PLoS ONE , vol.7
    • Tikoo, A.1    Roh, V.2    Montgomery, K.G.3    Ivetac, I.4    Waring, P.5    Pelzer, R.6
  • 134
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer
    • Vivanco, I., Sawyers, C. L. (2002). The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501.
    • (2002) , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 135
    • 10744222860 scopus 로고    scopus 로고
    • Prostatespecific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell
    • Wang, S., Gao, J., Lei, Q., Rozengurt, N., Pritchard, C., Jiao, J. et al. (2003). Prostatespecific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 4: 209-221.
    • (2003) , vol.4 , pp. 209-221
    • Wang, S.1    Gao, J.2    Lei, Q.3    Rozengurt, N.4    Pritchard, C.5    Jiao J.et, al.6
  • 136
    • 0031948388 scopus 로고    scopus 로고
    • Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol Cell Biol
    • Webster, M. A., Hutchinson, J. N., Rauh, M. J., Muthuswamy, S. K., Anton, M., Tortorice, C.G. et al. (1998). Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol Cell Biol 18:2344-2359.
    • (1998) , vol.18 , pp. 2344-2359
    • Webster, M.A.1    Hutchinson, J.N.2    Rauh, M.J.3    Muthuswamy, S.K.4    Anton, M.5    Tortorice C.G.et, al.6
  • 137
    • 0035253607 scopus 로고    scopus 로고
    • PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways. Hum Mol Genet
    • Weng, L., Brown, J., Eng, C. (2001). PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways. Hum Mol Genet 10: 237-242.
    • (2001) , vol.10 , pp. 237-242
    • Weng, L.1    Brown, J.2    Eng, C.3
  • 138
    • 0036490954 scopus 로고    scopus 로고
    • Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell
    • Xiao, A., Wu, H., Pandolfi, P. P., Louis, D. N., Van Dyke, T. (2002). Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell 1: 157-168.
    • (2002) , vol.1 , pp. 157-168
    • Xiao, A.1    Wu, H.2    Pandolfi, P.P.3    Louis, D.N.4    Van Dyke, T.5
  • 139
    • 20444484560 scopus 로고    scopus 로고
    • Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation. Cancer Res
    • Xiao, A., Yin, C., Yang, C., Di Cristofano, A., Pandolfi, P. P., Van Dyke, T. (2005). Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation. Cancer Res 65: 5172-5180.
    • (2005) , vol.65 , pp. 5172-5180
    • Xiao, A.1    Yin, C.2    Yang, C.3    Di Cristofano, A.4    Pandolfi, P.P.5    Van Dyke, T.6
  • 140
    • 18744407590 scopus 로고    scopus 로고
    • A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance. Proc Natl Acad Sci U S A
    • Xing, D., Orsulic, S. (2005). A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance. Proc Natl Acad Sci U S A 102: 6936-6941.
    • (2005) , vol.102 , pp. 6936-6941
    • Xing, D.1    Orsulic, S.2
  • 141
    • 32944469320 scopus 로고    scopus 로고
    • PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTENassociated pathways. Cancer Res
    • Yao, D., Alexander, C. L., Quinn, J. A., Porter, M. J., Wu, H., Greenhalgh, D. A. (2006).PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTENassociated pathways. Cancer Res 66: 1302-1312.
    • (2006) , vol.66 , pp. 1302-1312
    • Yao, D.1    Alexander, C.L.2    Quinn, J.A.3    Porter, M.J.4    Wu, H.5    Greenhalgh, D.A.6
  • 142
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: variations on a theme. Oncogene
    • Yuan, T. L., Cantley, L. C. (2008). PI3K pathway alterations in cancer: variations on a theme. Oncogene 27: 5497-5510.
    • (2008) , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 143
    • 84872613150 scopus 로고    scopus 로고
    • Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations. Oncogene
    • Yuan, W., Stawiski, E., Janakiraman, V., Chan, E., Durinck, S., Edgar, K. A. et al. (2013).Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations. Oncogene 32: 318-326.
    • (2013) , vol.32 , pp. 318-326
    • Yuan, W.1    Stawiski, E.2    Janakiraman, V.3    Chan, E.4    Durinck, S.5    Edgar K.A.et, al.6
  • 144
    • 23044480599 scopus 로고    scopus 로고
    • Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis
    • Zhao, H., Cui, Y., Dupont, J., Sun, H., Hennighausen, L., Yakar, S. (2005a). Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis. Cancer Res 65: 6864-6873.
    • (2005) Cancer Res , vol.65 , pp. 6864-6873
    • Zhao, H.1    Cui, Y.2    Dupont, J.3    Sun, H.4    Hennighausen, L.5    Yakar, S.6
  • 145
    • 29444449785 scopus 로고    scopus 로고
    • The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
    • Zhao, J. J., Liu, Z., Wang, L., Shin, E., Loda, M. F., Roberts, T. M. (2005b). The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci U S A 102: 18443-18448.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18443-18448
    • Zhao, J.J.1    Liu, Z.2    Wang, L.3    Shin, E.4    Loda, M.F.5    Roberts, T.M.6
  • 146
    • 51849128358 scopus 로고    scopus 로고
    • Class I PI3K in oncogenic cellular transformation. Oncogene
    • Zhao, L., Vogt, P. K. (2008). Class I PI3K in oncogenic cellular transformation. Oncogene 27: 5486-5496.
    • (2008) , vol.27 , pp. 5486-5496
    • Zhao, L.1    Vogt, P.K.2
  • 147
    • 77951884299 scopus 로고    scopus 로고
    • Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS. CellCycle
    • Zhao, L., Vogt, P. K. (2010). Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS. CellCycle 9: 596-600.
    • (2010) , vol.9 , pp. 596-600
    • Zhao, L.1    Vogt, P.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.