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Volumn 23, Issue 4, 2012, Pages 395-401

Autophagy and cancer cell metabolism

Author keywords

Autophagy; Cancer cell metabolism; Glycolysis; Oxidative phosphorylation; Warburg effect

Indexed keywords

AMINO ACID; AMMONIA; CARBOHYDRATE; KETONE; LACTIC ACID; LIPID; NUCLEIC ACID; REACTIVE OXYGEN METABOLITE;

EID: 84861972253     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2012.01.005     Document Type: Review
Times cited : (161)

References (83)
  • 1
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: process and function
    • Mizushima N. Autophagy: process and function. Genes & Development 2007, 21(22):2861-2873.
    • (2007) Genes & Development , vol.21 , Issue.22 , pp. 2861-2873
    • Mizushima, N.1
  • 2
    • 77956404377 scopus 로고    scopus 로고
    • Eaten alive: a history of macroautophagy
    • Yang Z., Klionsky D.J. Eaten alive: a history of macroautophagy. Nature Cell Biology 2010, 12(9):814-822.
    • (2010) Nature Cell Biology , vol.12 , Issue.9 , pp. 814-822
    • Yang, Z.1    Klionsky, D.J.2
  • 3
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima N., Levine B., Cuervo A.M., Klionsky D.J. Autophagy fights disease through cellular self-digestion. Nature 2008, 451(7182):1069-1075.
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 4
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy and metabolism
    • Rabinowitz J.D., White E. Autophagy and metabolism. Science 2010, 330(6009):1344-1348.
    • (2010) Science , vol.330 , Issue.6009 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 6
    • 77956416339 scopus 로고    scopus 로고
    • Autophagy in mammalian development and differentiation
    • Mizushima N., Levine B. Autophagy in mammalian development and differentiation. Nature Cell Biology 2010, 12(9):823-830.
    • (2010) Nature Cell Biology , vol.12 , Issue.9 , pp. 823-830
    • Mizushima, N.1    Levine, B.2
  • 7
    • 58149083189 scopus 로고    scopus 로고
    • The role of autophagy during the oocyte-to-embryo transition
    • Tsukamoto S., Kuma A., Mizushima N. The role of autophagy during the oocyte-to-embryo transition. Autophagy 2008, 4(8):1076-1078.
    • (2008) Autophagy , vol.4 , Issue.8 , pp. 1076-1078
    • Tsukamoto, S.1    Kuma, A.2    Mizushima, N.3
  • 8
    • 46849115787 scopus 로고    scopus 로고
    • Autophagy is essential for preimplantation development of mouse embryos
    • Tsukamoto S., Kuma A., Mizushima N. Autophagy is essential for preimplantation development of mouse embryos. Science 2008, 321(5885):117-120.
    • (2008) Science , vol.321 , Issue.5885 , pp. 117-120
    • Tsukamoto, S.1    Kuma, A.2    Mizushima, N.3
  • 11
    • 77951227871 scopus 로고    scopus 로고
    • TOR-dependent control of autophagy: biting the hand that feeds
    • Neufeld T.P. TOR-dependent control of autophagy: biting the hand that feeds. Current Opinion in Cell Biology 2010, 22(2):157-168.
    • (2010) Current Opinion in Cell Biology , vol.22 , Issue.2 , pp. 157-168
    • Neufeld, T.P.1
  • 12
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He C., Klionsky D.J. Regulation mechanisms and signaling pathways of autophagy. Annual Review of Genetics 2009, 43:67-93.
    • (2009) Annual Review of Genetics , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 13
    • 67650228579 scopus 로고    scopus 로고
    • Rapamycin inhibits mTORC1: but not completely
    • Thoreen C.C., Sabatini D.M. Rapamycin inhibits mTORC1: but not completely. Autophagy 2009, 5(5):725-726.
    • (2009) Autophagy , vol.5 , Issue.5 , pp. 725-726
    • Thoreen, C.C.1    Sabatini, D.M.2
  • 14
    • 80052511813 scopus 로고    scopus 로고
    • The AMPK signalling pathway coordinates cell growth: autophagy and metabolism
    • Mihaylova M.M., Shaw R.J. The AMPK signalling pathway coordinates cell growth: autophagy and metabolism. Nature Cell Biology 2011, 13(9):1016-1023.
    • (2011) Nature Cell Biology , vol.13 , Issue.9 , pp. 1016-1023
    • Mihaylova, M.M.1    Shaw, R.J.2
  • 16
    • 79251587803 scopus 로고    scopus 로고
    • Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    • Egan D.F., Shackelford D.B., Mihaylova M.M., Gelino S., Kohnz R.A., Mair W., et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011, 331(6016):456-461.
    • (2011) Science , vol.331 , Issue.6016 , pp. 456-461
    • Egan, D.F.1    Shackelford, D.B.2    Mihaylova, M.M.3    Gelino, S.4    Kohnz, R.A.5    Mair, W.6
  • 19
    • 80051752834 scopus 로고    scopus 로고
    • Essential amino acids and glutamine regulate induction of mitochondrial elongation during autophagy
    • Gomes L.C., Di Benedetto G., Scorrano L. Essential amino acids and glutamine regulate induction of mitochondrial elongation during autophagy. Cell Cycle 2011, 10(16):2635-2639.
    • (2011) Cell Cycle , vol.10 , Issue.16 , pp. 2635-2639
    • Gomes, L.C.1    Di Benedetto, G.2    Scorrano, L.3
  • 20
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak Y., Bar-Peled L., Zoncu R., Markhard A.L., Nada S., Sabatini D.M., et al. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010, 141(2):290-303.
    • (2010) Cell , vol.141 , Issue.2 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 23
    • 77957666080 scopus 로고    scopus 로고
    • Glutaminolysis yields a metabolic by-product that stimulates autophagy
    • Eng C.H., Abraham R.T. Glutaminolysis yields a metabolic by-product that stimulates autophagy. Autophagy 2010, 6(7):968-970.
    • (2010) Autophagy , vol.6 , Issue.7 , pp. 968-970
    • Eng, C.H.1    Abraham, R.T.2
  • 24
    • 77953861522 scopus 로고    scopus 로고
    • Ammonia derived from glutaminolysis is a diffusible regulator of autophagy
    • Eng C.H., Yu K., Lucas J., White E., Abraham R.T. Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Science Signaling 2010, 3(119):ra31.
    • (2010) Science Signaling , vol.3 , Issue.119
    • Eng, C.H.1    Yu, K.2    Lucas, J.3    White, E.4    Abraham, R.T.5
  • 27
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • Qu X. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. Journal of Clinical Investigation 2003, 112(12):1809-1820.
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.12 , pp. 1809-1820
    • Qu, X.1
  • 29
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis: inflammation, and tumorigenesis
    • Degenhardt K., Mathew R., Beaudoin B., Bray K., Anderson D., Chen G., et al. Autophagy promotes tumor cell survival and restricts necrosis: inflammation, and tumorigenesis. Cancer Cell 2006, 10(1):51-64.
    • (2006) Cancer Cell , vol.10 , Issue.1 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3    Bray, K.4    Anderson, D.5    Chen, G.6
  • 30
  • 32
    • 80052380331 scopus 로고    scopus 로고
    • Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1alpha-mediated signaling
    • Wang K., Liu R., Li J., Mao J., Lei Y., Wu J., et al. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1alpha-mediated signaling. Autophagy 2011, 7(9):966-978.
    • (2011) Autophagy , vol.7 , Issue.9 , pp. 966-978
    • Wang, K.1    Liu, R.2    Li, J.3    Mao, J.4    Lei, Y.5    Wu, J.6
  • 33
    • 67650885510 scopus 로고    scopus 로고
    • Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab
    • Vazquez-Martin A., Oliveras-Ferraros C., Menendez J.A. Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PLoS One 2009, 4(7):e6251.
    • (2009) PLoS One , vol.4 , Issue.7
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Menendez, J.A.3
  • 34
    • 78751556979 scopus 로고    scopus 로고
    • Autophagy as a therapeutic target in cancer
    • Chen N., Karantza V. Autophagy as a therapeutic target in cancer. Cancer Biology & Therapy 2011, 11(2):157-168.
    • (2011) Cancer Biology & Therapy , vol.11 , Issue.2 , pp. 157-168
    • Chen, N.1    Karantza, V.2
  • 35
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • Hara T., Nakamura K., Matsui M., Yamamoto A., Nakahara Y., Suzuki-Migishima R., et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006, 441(7095):885-889.
    • (2006) Nature , vol.441 , Issue.7095 , pp. 885-889
    • Hara, T.1    Nakamura, K.2    Matsui, M.3    Yamamoto, A.4    Nakahara, Y.5    Suzuki-Migishima, R.6
  • 36
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neurodegeneration in mice
    • Komatsu M., Waguri S., Chiba T., Murata S., Iwata J., Tanida I., et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006, 441(7095):880-884.
    • (2006) Nature , vol.441 , Issue.7095 , pp. 880-884
    • Komatsu, M.1    Waguri, S.2    Chiba, T.3    Murata, S.4    Iwata, J.5    Tanida, I.6
  • 37
    • 36849089101 scopus 로고    scopus 로고
    • Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
    • Komatsu M., Waguri S., Koike M., Sou Y.S., Ueno T., Hara T., et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007, 131(6):1149-1163.
    • (2007) Cell , vol.131 , Issue.6 , pp. 1149-1163
    • Komatsu, M.1    Waguri, S.2    Koike, M.3    Sou, Y.S.4    Ueno, T.5    Hara, T.6
  • 40
    • 0344142468 scopus 로고    scopus 로고
    • Cloning and genomic organization of beclin 1: a candidate tumor suppressor gene on chromosome 17q21
    • Aita V.M., Liang X.H., Murty V.V., Pincus D.L., Yu W., Cayanis E., et al. Cloning and genomic organization of beclin 1: a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999, 59(1):59-65.
    • (1999) Genomics , vol.59 , Issue.1 , pp. 59-65
    • Aita, V.M.1    Liang, X.H.2    Murty, V.V.3    Pincus, D.L.4    Yu, W.5    Cayanis, E.6
  • 41
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • Liang X.H., Jackson S., Seaman M., Brown K., Kempkes B., Hibshoosh H., et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999, 402(6762):672-676.
    • (1999) Nature , vol.402 , Issue.6762 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3    Brown, K.4    Kempkes, B.5    Hibshoosh, H.6
  • 43
    • 34848899280 scopus 로고    scopus 로고
    • Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
    • Takahashi Y., Coppola D., Matsushita N., Cualing H.D., Sun M., Sato Y., et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nature Cell Biology 2007, 9(10):1142-1151.
    • (2007) Nature Cell Biology , vol.9 , Issue.10 , pp. 1142-1151
    • Takahashi, Y.1    Coppola, D.2    Matsushita, N.3    Cualing, H.D.4    Sun, M.5    Sato, Y.6
  • 44
  • 46
    • 77953952646 scopus 로고    scopus 로고
    • BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair
    • O'Donovan P.J., Livingston D.M. BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis 2010, 31(6):961-967.
    • (2010) Carcinogenesis , vol.31 , Issue.6 , pp. 961-967
    • O'Donovan, P.J.1    Livingston, D.M.2
  • 47
    • 34848920863 scopus 로고    scopus 로고
    • ROS: mitochondria and the regulation of autophagy
    • Scherz-Shouval R., Elazar Z. ROS: mitochondria and the regulation of autophagy. Trends in Cell Biology 2007, 17(9):422-427.
    • (2007) Trends in Cell Biology , vol.17 , Issue.9 , pp. 422-427
    • Scherz-Shouval, R.1    Elazar, Z.2
  • 48
    • 66449099090 scopus 로고    scopus 로고
    • Autophagy suppresses tumorigenesis through elimination of p62
    • Mathew R., Karp C.M., Beaudoin B., Vuong N., Chen G., Chen H.Y., et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009, 137(6):1062-1075.
    • (2009) Cell , vol.137 , Issue.6 , pp. 1062-1075
    • Mathew, R.1    Karp, C.M.2    Beaudoin, B.3    Vuong, N.4    Chen, G.5    Chen, H.Y.6
  • 51
    • 77954754620 scopus 로고    scopus 로고
    • Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer
    • Brest P., Corcelle E.A., Cesaro A., Chargui A., Belaid A., Klionsky D.J., et al. Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer. Current Molecular Medicine 2010, 10(5):486-502.
    • (2010) Current Molecular Medicine , vol.10 , Issue.5 , pp. 486-502
    • Brest, P.1    Corcelle, E.A.2    Cesaro, A.3    Chargui, A.4    Belaid, A.5    Klionsky, D.J.6
  • 53
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell K., Liu J.Y., Brown S.L., Miyoshi H., Loh J., Lennerz J.K., et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008, 456(7219):259-263.
    • (2008) Nature , vol.456 , Issue.7219 , pp. 259-263
    • Cadwell, K.1    Liu, J.Y.2    Brown, S.L.3    Miyoshi, H.4    Loh, J.5    Lennerz, J.K.6
  • 54
    • 61649114427 scopus 로고    scopus 로고
    • A common role for Atg16L1: Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease
    • Cadwell K., Patel K.K., Komatsu M., Virgin H.W., Stappenbeck T.S. A common role for Atg16L1: Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease. Autophagy 2009, 5(2):250-252.
    • (2009) Autophagy , vol.5 , Issue.2 , pp. 250-252
    • Cadwell, K.1    Patel, K.K.2    Komatsu, M.3    Virgin, H.W.4    Stappenbeck, T.S.5
  • 55
    • 52049102433 scopus 로고    scopus 로고
    • Efficient cross-presentation depends on autophagy in tumor cells
    • Li Y., Wang L.X., Yang G., Hao F., Urba W.J., Hu H.M., et al. Efficient cross-presentation depends on autophagy in tumor cells. Cancer Research 2008, 68(17):6889-6895.
    • (2008) Cancer Research , vol.68 , Issue.17 , pp. 6889-6895
    • Li, Y.1    Wang, L.X.2    Yang, G.3    Hao, F.4    Urba, W.J.5    Hu, H.M.6
  • 57
    • 34248583745 scopus 로고    scopus 로고
    • Maintaining T lymphocyte homeostasis: another duty of autophagy
    • Pua H.H., He Y.W., Dzhagalov I., Chuck M., Mizushima N., He Y.W., et al. Maintaining T lymphocyte homeostasis: another duty of autophagy. Autophagy 2007, 3(3):266-267.
    • (2007) Autophagy , vol.3 , Issue.3 , pp. 266-267
    • Pua, H.H.1    He, Y.W.2    Dzhagalov, I.3    Chuck, M.4    Mizushima, N.5    He, Y.W.6
  • 58
    • 52149099867 scopus 로고    scopus 로고
    • Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
    • Nedjic J., Aichinger M., Emmerich J., Mizushima N., Klein L. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature 2008, 455(7211):396-400.
    • (2008) Nature , vol.455 , Issue.7211 , pp. 396-400
    • Nedjic, J.1    Aichinger, M.2    Emmerich, J.3    Mizushima, N.4    Klein, L.5
  • 60
    • 79960401862 scopus 로고    scopus 로고
    • Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
    • Wei H., Wei S., Gan B., Peng X., Zou W., Guan J.L., et al. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes & Development 2011, 25(14):1510-1527.
    • (2011) Genes & Development , vol.25 , Issue.14 , pp. 1510-1527
    • Wei, H.1    Wei, S.2    Gan, B.3    Peng, X.4    Zou, W.5    Guan, J.L.6
  • 61
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis R.J., Lum J.J., Hatzivassiliou G., Thompson C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metabolism 2008, 7(1):11-20.
    • (2008) Cell Metabolism , vol.7 , Issue.1 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 62
    • 0023158728 scopus 로고
    • Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes
    • Flier J.S., Mueckler M.M., Usher P., Lodish H.F. Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 1987, 235(4795):1492-1495.
    • (1987) Science , vol.235 , Issue.4795 , pp. 1492-1495
    • Flier, J.S.1    Mueckler, M.M.2    Usher, P.3    Lodish, H.F.4
  • 67
    • 79953856887 scopus 로고    scopus 로고
    • Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation
    • Kim M.J., Woo S.J., Yoon C.H., Lee J.S., An S., Choi Y.H., et al. Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation. Journal of Biological Chemistry 2011, 286(15):12924-12932.
    • (2011) Journal of Biological Chemistry , vol.286 , Issue.15 , pp. 12924-12932
    • Kim, M.J.1    Woo, S.J.2    Yoon, C.H.3    Lee, J.S.4    An, S.5    Choi, Y.H.6
  • 68
    • 70350575440 scopus 로고    scopus 로고
    • Modulation of intracellular ROS levels by TIGAR controls autophagy
    • Bensaad K., Cheung E.C., Vousden K.H. Modulation of intracellular ROS levels by TIGAR controls autophagy. The EMBO Journal 2009, 28(19):3015-3026.
    • (2009) The EMBO Journal , vol.28 , Issue.19 , pp. 3015-3026
    • Bensaad, K.1    Cheung, E.C.2    Vousden, K.H.3
  • 70
    • 60449083715 scopus 로고    scopus 로고
    • Glutamine increases autophagy under Basal and stressed conditions in intestinal epithelial cells
    • Sakiyama T., Musch M.W., Ropeleski M.J., Tsubouchi H., Chang E.B. Glutamine increases autophagy under Basal and stressed conditions in intestinal epithelial cells. Gastroenterology 2009, 136(3):924-932.
    • (2009) Gastroenterology , vol.136 , Issue.3 , pp. 924-932
    • Sakiyama, T.1    Musch, M.W.2    Ropeleski, M.J.3    Tsubouchi, H.4    Chang, E.B.5
  • 71
    • 60749108379 scopus 로고    scopus 로고
    • Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment
    • Azad M.B., Chen Y., Gibson S.B. Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment. Antioxidants & Redox Signaling 2009, 11(4):777-790.
    • (2009) Antioxidants & Redox Signaling , vol.11 , Issue.4 , pp. 777-790
    • Azad, M.B.1    Chen, Y.2    Gibson, S.B.3
  • 72
    • 77951228508 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy: cell death or cell survival?
    • Mazure N.M., Pouyssegur J. Hypoxia-induced autophagy: cell death or cell survival?. Current Opinion in Cell Biology 2010, 22(2):177-180.
    • (2010) Current Opinion in Cell Biology , vol.22 , Issue.2 , pp. 177-180
    • Mazure, N.M.1    Pouyssegur, J.2
  • 73
    • 10044276783 scopus 로고    scopus 로고
    • Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
    • Brugarolas J., Lei K., Hurley R.L., Manning B.D., Reiling J.H., Hafen E., et al. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes & Development 2004, 18(23):2893-2904.
    • (2004) Genes & Development , vol.18 , Issue.23 , pp. 2893-2904
    • Brugarolas, J.1    Lei, K.2    Hurley, R.L.3    Manning, B.D.4    Reiling, J.H.5    Hafen, E.6
  • 74
    • 74949118681 scopus 로고    scopus 로고
    • The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
    • Rouschop K.M., van den Beucken T., Dubois L., Niessen H., Bussink J., Savelkouls K., et al. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. The Journal of Clinical Investigation 2010, 120(1):127-141.
    • (2010) The Journal of Clinical Investigation , vol.120 , Issue.1 , pp. 127-141
    • Rouschop, K.M.1    van den Beucken, T.2    Dubois, L.3    Niessen, H.4    Bussink, J.5    Savelkouls, K.6
  • 75
    • 58849131828 scopus 로고    scopus 로고
    • Cancer and the tumor microenvironment: a review of an essential relationship
    • Mbeunkui F., Johann D.J. Cancer and the tumor microenvironment: a review of an essential relationship. Cancer Chemotherapy and Pharmacology 2009, 63(4):571-582.
    • (2009) Cancer Chemotherapy and Pharmacology , vol.63 , Issue.4 , pp. 571-582
    • Mbeunkui, F.1    Johann, D.J.2
  • 76
    • 77954162846 scopus 로고    scopus 로고
    • Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: a new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
    • Martinez-Outschoorn U.E., Balliet R.M., Rivadeneira D.B., Chiavarina B., Pavlides S., Wang C., et al. Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: a new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle 2010, 9(16):3256-3276.
    • (2010) Cell Cycle , vol.9 , Issue.16 , pp. 3256-3276
    • Martinez-Outschoorn, U.E.1    Balliet, R.M.2    Rivadeneira, D.B.3    Chiavarina, B.4    Pavlides, S.5    Wang, C.6
  • 77
    • 79961101955 scopus 로고    scopus 로고
    • Cancer cells metabolically fertilize the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors
    • Martinez-Outschoorn U.E., Lin Z., Trimmer C., Flomenberg N., Wang C., Pavlides S., et al. Cancer cells metabolically fertilize the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors. Cell Cycle 2011, 10(15):2504-2520.
    • (2011) Cell Cycle , vol.10 , Issue.15 , pp. 2504-2520
    • Martinez-Outschoorn, U.E.1    Lin, Z.2    Trimmer, C.3    Flomenberg, N.4    Wang, C.5    Pavlides, S.6
  • 79
    • 61649116590 scopus 로고    scopus 로고
    • Macroautophagy: the key ingredient to a healthy diet?
    • Hannigan A.M., Gorski S.M. Macroautophagy: the key ingredient to a healthy diet?. Autophagy 2009, 5(2):140-151.
    • (2009) Autophagy , vol.5 , Issue.2 , pp. 140-151
    • Hannigan, A.M.1    Gorski, S.M.2
  • 80
    • 50349098812 scopus 로고    scopus 로고
    • Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells
    • Han J., Hou W., Goldstein L.A., Lu C., Stolz D.B., Yin X.M., et al. Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells. The Journal of Biological Chemistry 2008, 283(28):19665-19677.
    • (2008) The Journal of Biological Chemistry , vol.283 , Issue.28 , pp. 19665-19677
    • Han, J.1    Hou, W.2    Goldstein, L.A.3    Lu, C.4    Stolz, D.B.5    Yin, X.M.6
  • 82
    • 77953289524 scopus 로고    scopus 로고
    • Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model
    • Li J., Hou N., Faried A., Tsutsumi S., Kuwano H. Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. European Journal of Cancer 2010, 46(10):1900-1909.
    • (2010) European Journal of Cancer , vol.46 , Issue.10 , pp. 1900-1909
    • Li, J.1    Hou, N.2    Faried, A.3    Tsutsumi, S.4    Kuwano, H.5
  • 83
    • 77956627000 scopus 로고    scopus 로고
    • Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies
    • Stein M., Lin H., Jeyamohan C., Dvorzhinski D., Gounder M., Bray K., et al. Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies. The Prostate 2010, 70(13):1388-1394.
    • (2010) The Prostate , vol.70 , Issue.13 , pp. 1388-1394
    • Stein, M.1    Lin, H.2    Jeyamohan, C.3    Dvorzhinski, D.4    Gounder, M.5    Bray, K.6


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