메뉴 건너뛰기




Volumn 2, Issue 3, 2010, Pages 1576-1596

The emerging role of the phosphatidylinositol 3-Kinase/ AKt/Mammalian target of rapamycin signaling network in cancer stem cell biology

Author keywords

Cancer stem cells; Differentiation; Leukemic stem cells; PI3K Akt mTOR; Proliferation; Targeted therapy

Indexed keywords

CYCLOPAMINE; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; GEMCITABINE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN;

EID: 79952262412     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers2031576     Document Type: Review
Times cited : (44)

References (129)
  • 1
    • 33644826473 scopus 로고    scopus 로고
    • Roots and stems: Stem cells in cancer
    • Polyak, K.; Hahn, W.C. Roots and stems: stem cells in cancer. Nat. Med. 2006, 12, 296-300.
    • (2006) Nat. Med. , vol.12 , pp. 296-300
    • Polyak, K.1    Hahn, W.C.2
  • 2
    • 53849096994 scopus 로고    scopus 로고
    • An overview of cancer multidrug resistance: A still unsolved problem
    • Lage, H. An overview of cancer multidrug resistance: A still unsolved problem. Cell. Mol. Life Sci. 2008, 65, 3145-3167.
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 3145-3167
    • Lage, H.1
  • 3
    • 34948837444 scopus 로고    scopus 로고
    • Selective targeting of cancer stem cells: A new concept in cancer therapeutics
    • Korkaya, H.; Wicha, M.S. Selective targeting of cancer stem cells: A new concept in cancer therapeutics. BioDrugs 2007, 21, 299-310.
    • (2007) BioDrugs , vol.21 , pp. 299-310
    • Korkaya, H.1    Wicha, M.S.2
  • 6
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: Variations on a theme
    • Yuan, T.L.; Cantley, L.C. PI3K pathway alterations in cancer: Variations on a theme. Oncogene 2008, 27, 5497-5510.
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 7
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman, J.A. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat. Rev. Cancer 2009, 9, 550-562.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 8
    • 68249093818 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase pathway in cancer
    • Liu, P.; Cheng, H.; Roberts, T.M.; Zhao, J.J. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat. Rev. Cancer 2009, 8, 627-644.
    • (2009) Nat. Rev. Cancer , vol.8 , pp. 627-644
    • Liu, P.1    Cheng, H.2    Roberts, T.M.3    Zhao, J.J.4
  • 9
    • 54949109808 scopus 로고    scopus 로고
    • PI3K/Akt: Getting it right matters
    • Franke, T.F. PI3K/Akt: getting it right matters. Oncogene 2008, 27, 6473-6488.
    • (2008) Oncogene , vol.27 , pp. 6473-6488
    • Franke, T.F.1
  • 10
    • 63749106157 scopus 로고    scopus 로고
    • Should individual PI3 kinase isoforms be targeted in cancer?
    • Jia, S.; Roberts, T.M.; Zhao, J.J. Should individual PI3 kinase isoforms be targeted in cancer? Curr. Opin.Cell Biol. 2009, 21, 199-208.
    • (2009) Curr. Opin.Cell Biol. , vol.21 , pp. 199-208
    • Jia, S.1    Roberts, T.M.2    Zhao, J.J.3
  • 11
    • 61849126233 scopus 로고    scopus 로고
    • Fine tuning the immune response with PI3K
    • Fruman, D.A.; Bismuth, G. Fine tuning the immune response with PI3K. Immunol. Rev. 2009, 228, 253-272.
    • (2009) Immunol. Rev. , vol.228 , pp. 253-272
    • Fruman, D.A.1    Bismuth, G.2
  • 12
    • 62849114529 scopus 로고    scopus 로고
    • Regulation of phosphoinositide 3-kinase expression in health and disease
    • Kok, K.; Geering, B. Vanhaesebroeck, B. Regulation of phosphoinositide 3-kinase expression in health and disease. Trends Biochem. Sci. 2009, 34, 115-127.
    • (2009) Trends Biochem. Sci. , vol.34 , pp. 115-127
    • Kok, K.1    Geering, B.2    Vanhaesebroeck, B.3
  • 13
    • 72049110528 scopus 로고    scopus 로고
    • Rethinking phosphatidylinositol 3-monophosphate
    • Falasca, M.; Maffucci, T. Rethinking phosphatidylinositol 3-monophosphate. Biochim. Biophys. Acta 2009, 1793, 1795-1803.
    • (2009) Biochim. Biophys. Acta , vol.1793 , pp. 1795-1803
    • Falasca, M.1    Maffucci, T.2
  • 14
    • 39749141485 scopus 로고    scopus 로고
    • The regulation and function of Class III PI3Ks: Novel roles for Vps34
    • Backer, J.M. The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem. J. 2008, 410, 1-17.
    • (2008) Biochem. J. , vol.410 , pp. 1-17
    • Backer, J.M.1
  • 16
    • 2342565881 scopus 로고    scopus 로고
    • Advances in protein kinase B signalling: AKTion on multiple fronts
    • Brazil, D.P.; Yang, Z.Z.; Hemmings, B.A. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem. Sci. 2004, 29, 233-242.
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 233-242
    • Brazil, D.P.1    Yang, Z.Z.2    Hemmings, B.A.3
  • 17
    • 59749095009 scopus 로고    scopus 로고
    • Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer
    • Chin, Y.R.; Toker, A. Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. Cell. Signal. 2009, 21, 470-476.
    • (2009) Cell. Signal. , vol.21 , pp. 470-476
    • Chin, Y.R.1    Toker, A.2
  • 18
    • 33744457653 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia
    • Martelli, A.M.; Nyakern, M.; Tabellini, G.; Bortul, R.; Tazzari, P.L.; Evangelisti, C.; Cocco, L. Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. Leukemia 2006, 20, 911-928.
    • (2006) Leukemia , vol.20 , pp. 911-928
    • Martelli, A.M.1    Nyakern, M.2    Tabellini, G.3    Bortul, R.4    Tazzari, P.L.5    Evangelisti, C.6    Cocco, L.7
  • 19
    • 1342321750 scopus 로고    scopus 로고
    • PI 3-kinase, Akt and cell survival
    • Downward, J. PI 3-kinase, Akt and cell survival. Semin. Cell Dev. Biol. 2004, 15, 177-182.
    • (2004) Semin. Cell Dev. Biol. , vol.15 , pp. 177-182
    • Downward, J.1
  • 21
    • 60549096247 scopus 로고    scopus 로고
    • Akt-dependent and -independent mechanisms of mTOR regulation in cancer
    • Memmott, R.M.; Dennis, P.A. Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell Signal. 2009, 21, 656-664.
    • (2009) Cell Signal. , vol.21 , pp. 656-664
    • Memmott, R.M.1    Dennis, P.A.2
  • 23
    • 46149092748 scopus 로고    scopus 로고
    • Role of mTOR in anticancer drug resistance: Perspectives for improved drug treatment
    • Jiang, B.H.; Liu, L.Z., Role of mTOR in anticancer drug resistance: Perspectives for improved drug treatment. Drug Resist. Updat. 2008, 11, 63-76.
    • (2008) Drug Resist. Updat. , vol.11 , pp. 63-76
    • Jiang, B.H.1    Liu, L.Z.2
  • 26
    • 74849131091 scopus 로고    scopus 로고
    • Targeting mTOR globally in cancer: Thinking beyond rapamycin
    • Shor, B.; Gibbons, J.J.; Abraham, R.T.; Yu, K. Targeting mTOR globally in cancer: Thinking beyond rapamycin. Cell Cycle 2009, 8, 3831-3837.
    • (2009) Cell Cycle , vol.8 , pp. 3831-3837
    • Shor, B.1    Gibbons, J.J.2    Abraham, R.T.3    Yu, K.4
  • 27
    • 77955430762 scopus 로고    scopus 로고
    • Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment
    • Garcia-Echeverria, C. Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment. Bioorg. Med. Chem. Lett. 2010, 20, 4308-4312.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 4308-4312
    • Garcia-Echeverria, C.1
  • 28
    • 62749096589 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms
    • Dunlop, E.A.; Tee, A.R. Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms. Cell. Signal. 2009, 21, 827-835.
    • (2009) Cell. Signal. , vol.21 , pp. 827-835
    • Dunlop, E.A.1    Tee, A.R.2
  • 29
    • 52949137425 scopus 로고    scopus 로고
    • Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: Rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1
    • Rosner, M.; Hengstschlager, M. Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1. Hum. Mol. Genet. 2008, 17, 2934-2948.
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 2934-2948
    • Rosner, M.1    Hengstschlager, M.2
  • 31
    • 0028034233 scopus 로고
    • Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
    • Pause, A.; Belsham, G.J.; Gingras, A.C.; Donze, O.; Lin, T.A.; Lawrence, J.C., Jr.; Sonenberg, N. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature 1994, 371, 762-767.
    • (1994) Nature , vol.371 , pp. 762-767
    • Pause, A.1    Belsham, G.J.2    Gingras, A.C.3    Donze, O.4    Lin, T.A.5    Lawrence Jr., J.C.6    Sonenberg, N.7
  • 32
    • 2342489456 scopus 로고    scopus 로고
    • eIF-4E expression and its role in malignancies and metastases
    • De Benedetti, A.; Graff, J.R. eIF-4E expression and its role in malignancies and metastases. Oncogene 2004, 23, 3189-3199.
    • (2004) Oncogene , vol.23 , pp. 3189-3199
    • de Benedetti, A.1    Graff, J.R.2
  • 33
    • 21244504900 scopus 로고    scopus 로고
    • Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis
    • Yuan, X.; Zhou, Y.; Casanova, E.; Chai, M.; Kiss, E.; Grone, H.J.; Schutz, G.; Grummt, I. Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol. Cell 2005, 19, 77-87.
    • (2005) Mol. Cell , vol.19 , pp. 77-87
    • Yuan, X.1    Zhou, Y.2    Casanova, E.3    Chai, M.4    Kiss, E.5    Grone, H.J.6    Schutz, G.7    Grummt, I.8
  • 34
    • 1542343973 scopus 로고    scopus 로고
    • mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability
    • Mayer, C.; Zhao, J.; Yuan, X.; Grummt, I. mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev. 2004, 18, 423-434.
    • (2004) Genes Dev. , vol.18 , pp. 423-434
    • Mayer, C.1    Zhao, J.2    Yuan, X.3    Grummt, I.4
  • 35
    • 34547784053 scopus 로고    scopus 로고
    • Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate
    • Renner, O.; Fominaya, J.; Alonso, S.; Blanco-Aparicio, C.; Leal, J.F.; Carnero, A. Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate. Carcinogenesis 2007, 28, 1418-1425.
    • (2007) Carcinogenesis , vol.28 , pp. 1418-1425
    • Renner, O.1    Fominaya, J.2    Alonso, S.3    Blanco-Aparicio, C.4    Leal, J.F.5    Carnero, A.6
  • 36
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • Ma, X.M.; Blenis, J. Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell Biol. 2009, 10, 307-318.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 37
    • 70350418625 scopus 로고    scopus 로고
    • mTOR signaling at a glance
    • Laplante, M.; Sabatini, D.M. mTOR signaling at a glance. J. Cell Sci. 2009, 122, 3589-3594.
    • (2009) J. Cell Sci. , vol.122 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 39
    • 62949091373 scopus 로고    scopus 로고
    • Autophagy: A lysosomal degradation pathway with a central role in health and disease
    • Eskelinen, E.L.; Saftig, P. Autophagy: A lysosomal degradation pathway with a central role in health and disease. Biochim. Biophys. Acta 2009, 1793, 664-673.
    • (2009) Biochim. Biophys. Acta , vol.1793 , pp. 664-673
    • Eskelinen, E.L.1    Saftig, P.2
  • 40
    • 66449083078 scopus 로고    scopus 로고
    • ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
    • Ganley, I.G.; Lam du, H.; Wang, J.; Ding, X.; Chen, S.; Jiang, X. ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J. Biol. Chem. 2009, 284, 12297-12305.
    • (2009) J. Biol. Chem. , vol.284 , pp. 12297-12305
    • Ganley, I.G.1    du Lam, H.2    Wang, J.3    Ding, X.4    Chen, S.5    Jiang, X.6
  • 44
    • 47049127002 scopus 로고    scopus 로고
    • Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation
    • Wang, L.; Harris, T.E.; Lawrence, J.C., Jr. Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation. J. Biol. Chem. 2008, 283, 15619-15627.
    • (2008) J. Biol. Chem. , vol.283 , pp. 15619-15627
    • Wang, L.1    Harris, T.E.2    Lawrence Jr., J.C.3
  • 45
    • 34548359244 scopus 로고    scopus 로고
    • PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
    • Fonseca, B.D.; Smith, E.M.; Lee, V.H.; MacKintosh, C.; Proud, C.G. PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J. Biol. Chem. 2007, 282, 24514-24524.
    • (2007) J. Biol. Chem. , vol.282 , pp. 24514-24524
    • Fonseca, B.D.1    Smith, E.M.2    Lee, V.H.3    Mackintosh, C.4    Proud, C.G.5
  • 46
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
    • Ma, L.; Chen, Z.; Erdjument-Bromage, H.; Tempst, P.; Pandolfi, P.P. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005, 121, 179-193.
    • (2005) Cell , vol.121 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 47
    • 49549108896 scopus 로고    scopus 로고
    • Wnt and beyond Wnt: Multiple mechanisms control the transcriptional property of β-catenin
    • Jin, T.; George Fantus, I.; Sun, J. Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of β-catenin. Cell. Signal. 2008, 20, 1697-1704.
    • (2008) Cell. Signal. , vol.20 , pp. 1697-1704
    • Jin, T.1    George, F.I.2    Sun, J.3
  • 52
    • 10044276784 scopus 로고    scopus 로고
    • The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
    • Reiling, J.H.; Hafen, E. The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev. 2004, 18, 2879-2892.
    • (2004) Genes Dev. , vol.18 , pp. 2879-2892
    • Reiling, J.H.1    Hafen, E.2
  • 53
    • 21744459535 scopus 로고    scopus 로고
    • Regulation of mTOR and cell growth in response to energy stress by REDD1
    • Sofer, A.; Lei, K.; Johannessen, C.M.; Ellisen, L.W. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol. Cell. Biol. 2005, 25, 5834-5845.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 5834-5845
    • Sofer, A.1    Lei, K.2    Johannessen, C.M.3    Ellisen, L.W.4
  • 54
    • 38349056675 scopus 로고    scopus 로고
    • Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
    • DeYoung, M.P.; Horak, P.; Sofer, A.; Sgroi, D.; Ellisen, L.W. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev. 2008, 22, 239-251.
    • (2008) Genes Dev. , vol.22 , pp. 239-251
    • Deyoung, M.P.1    Horak, P.2    Sofer, A.3    Sgroi, D.4    Ellisen, L.W.5
  • 57
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov, D.D.; Guertin, D.A.; Ali, S.M.; Sabatini, D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005, 307, 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 59
    • 58649092475 scopus 로고    scopus 로고
    • mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
    • Garcia-Martinez, J.M.; Alessi, D.R. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem. J. 2008, 416, 375-385.
    • (2008) Biochem. J. , vol.416 , pp. 375-385
    • Garcia-Martinez, J.M.1    Alessi, D.R.2
  • 60
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • Jacinto, E.; Loewith, R.; Schmidt, A.; Lin, S.; Ruegg, M.A.; Hall, A.; Hall, M.N. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 2004, 6, 1122-1128.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3    Lin, S.4    Ruegg, M.A.5    Hall, A.6    Hall, M.N.7
  • 63
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • Huang, J.; Manning, B.D. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem. Soc. Trans. 2009, 37, 217-222.
    • (2009) Biochem. Soc. Trans. , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.D.2
  • 64
    • 4544343980 scopus 로고    scopus 로고
    • Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
    • Shah, O.J.; Wang, Z.; Hunter, T. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 2004, 14, 1650-1656.
    • (2004) Curr. Biol. , vol.14 , pp. 1650-1656
    • Shah, O.J.1    Wang, Z.2    Hunter, T.3
  • 65
    • 34047095297 scopus 로고    scopus 로고
    • The two TORCs and Akt
    • Bhaskar, P.T.; Hay, N. The two TORCs and Akt. Dev. Cell 2007, 12, 487-502.
    • (2007) Dev. Cell , vol.12 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 66
    • 77950371095 scopus 로고    scopus 로고
    • Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells
    • Lang, S.A.; Hackl, C.; Moser, C.; Fichtner-Feigl, S.; Koehl, G.E.; Schlitt, H.J.; Geissler, E.K.; Stoeltzing, O. Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells. Biochim. Biophys. Acta 2010, 1803, 435-442.
    • (2010) Biochim. Biophys. Acta , vol.1803 , pp. 435-442
    • Lang, S.A.1    Hackl, C.2    Moser, C.3    Fichtner-Feigl, S.4    Koehl, G.E.5    Schlitt, H.J.6    Geissler, E.K.7    Stoeltzing, O.8
  • 69
    • 5444222234 scopus 로고    scopus 로고
    • XBP1: A link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum
    • Sriburi, R.; Jackowski, S.; Mori, K.; Brewer, J.W. XBP1: A link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J. Cell Biol. 2004, 167, 35-41.
    • (2004) J. Cell Biol. , vol.167 , pp. 35-41
    • Sriburi, R.1    Jackowski, S.2    Mori, K.3    Brewer, J.W.4
  • 70
    • 70350545722 scopus 로고    scopus 로고
    • Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
    • Dibble, C.C.; Asara, J.M.; Manning, B.D., Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol. Cell. Biol. 2009, 29, 5657-5670.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 5657-5670
    • Dibble, C.C.1    Asara, J.M.2    Manning, B.D.3
  • 72
    • 38049187096 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: Rationale for therapeutic inhibition of both pathways
    • Tamburini, J.; Chapuis, N.; Bardet, V.; Park, S.; Sujobert, P.; Willems, L.; Ifrah, N.; Dreyfus, F.; Mayeux, P.; Lacombe, C.; Bouscary, D. Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways. Blood 2008, 111, 379-382.
    • (2008) Blood , vol.111 , pp. 379-382
    • Tamburini, J.1    Chapuis, N.2    Bardet, V.3    Park, S.4    Sujobert, P.5    Willems, L.6    Ifrah, N.7    Dreyfus, F.8    Mayeux, P.9    Lacombe, C.10    Bouscary, D.11
  • 73
    • 51849097348 scopus 로고    scopus 로고
    • The role of PTEN signaling perturbations in cancer and in targeted therapy
    • Keniry, M.; Parsons, R. The role of PTEN signaling perturbations in cancer and in targeted therapy. Oncogene 2008, 27, 5477-5485.
    • (2008) Oncogene , vol.27 , pp. 5477-5485
    • Keniry, M.1    Parsons, R.2
  • 74
    • 59649130242 scopus 로고    scopus 로고
    • Phosphatase and tensin homologue deleted on chromosome 10: Extending its PTENtacles
    • Stiles, B.L. Phosphatase and tensin homologue deleted on chromosome 10: Extending its PTENtacles. Int. J. Biochem. Cell Biol. 2009, 41, 757-761.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 757-761
    • Stiles, B.L.1
  • 76
    • 77951568703 scopus 로고    scopus 로고
    • Phosphoinositide signalling in cancer: Beyond PI3K and PTEN
    • Bunney, T.D.; Katan, M. Phosphoinositide signalling in cancer: Beyond PI3K and PTEN. Nat. Cancer Rev. 2010, 10, 342-352.
    • (2010) Nat. Cancer Rev. , vol.10 , pp. 342-352
    • Bunney, T.D.1    Katan, M.2
  • 78
    • 47249105677 scopus 로고    scopus 로고
    • PHLiPPing the switch on Akt and protein kinase C signaling
    • Brognard, J.; Newton, A.C. PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol. Metab. 2008, 19, 223-230.
    • (2008) Trends Endocrinol. Metab. , vol.19 , pp. 223-230
    • Brognard, J.1    Newton, A.C.2
  • 79
    • 69249144030 scopus 로고    scopus 로고
    • Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms
    • Hirano, I.; Nakamura, S.; Yokota, D.; Ono, T.; Shigeno, K.; Fujisawa, S.; Shinjo, K.; Ohnishi, K. Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms. J. Biol. Chem. 2009, 284, 22155-22165.
    • (2009) J. Biol. Chem. , vol.284 , pp. 22155-22165
    • Hirano, I.1    Nakamura, S.2    Yokota, D.3    Ono, T.4    Shigeno, K.5    Fujisawa, S.6    Shinjo, K.7    Ohnishi, K.8
  • 80
    • 69849104865 scopus 로고    scopus 로고
    • The leukemic stem cell niche: Current concepts and therapeutic opportunities
    • Lane, S.W.; Scadden, D.T.; Gilliland, D.G. The leukemic stem cell niche: Current concepts and therapeutic opportunities. Blood 2009, 114, 1150-1157.
    • (2009) Blood , vol.114 , pp. 1150-1157
    • Lane, S.W.1    Scadden, D.T.2    Gilliland, D.G.3
  • 82
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • Yilmaz, O.H.; Valdez, R.; Theisen, B.K.; Guo, W.; Ferguson, D.O.; Wu, H.; Morrison, S.J. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 2006, 441, 475-482.
    • (2006) Nature , vol.441 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3    Guo, W.4    Ferguson, D.O.5    Wu, H.6    Morrison, S.J.7
  • 83
    • 77952423161 scopus 로고    scopus 로고
    • Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN
    • Yu, H.; Li, Y.; Gao, C.; Fabien, L.; Jia, Y.; Lu, J.; Silberstein, L.E.; Pinkus, G.S.; Ye, K.; Chai, L.; Luo, H.R. Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN. Leukemia 2010, 24, 1077-1080.
    • (2010) Leukemia , vol.24 , pp. 1077-1080
    • Yu, H.1    Li, Y.2    Gao, C.3    Fabien, L.4    Jia, Y.5    Lu, J.6    Silberstein, L.E.7    Pinkus, G.S.8    Ye, K.9    Chai, L.10    Luo, H.R.11
  • 84
    • 77449117864 scopus 로고    scopus 로고
    • PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice
    • Peng, C.; Chen, Y.; Yang, Z.; Zhang, H.; Osterby, L.; Rosmarin, A.G.; Li, S. PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice. Blood 2010, 115, 626-635.
    • (2010) Blood , vol.115 , pp. 626-635
    • Peng, C.1    Chen, Y.2    Yang, Z.3    Zhang, H.4    Osterby, L.5    Rosmarin, A.G.6    Li, S.7
  • 86
    • 34548856481 scopus 로고    scopus 로고
    • Genetic and pharmacologic evidence implicating the p85 α, but not p85 β, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis
    • Munugalavadla, V.; Sims, E.C.; Borneo, J.; Chan, R.J.; Kapur, R. Genetic and pharmacologic evidence implicating the p85 α, but not p85 β, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis. Blood 2007, 110, 1612-1620.
    • (2007) Blood , vol.110 , pp. 1612-1620
    • Munugalavadla, V.1    Sims, E.C.2    Borneo, J.3    Chan, R.J.4    Kapur, R.5
  • 89
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • Chen, C.; Liu, Y.; Liu, R.; Ikenoue, T.; Guan, K.L.; Liu, Y.; Zheng, P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 2008, 205, 2397-2408.
    • (2008) J. Exp. Med. , vol.205 , pp. 2397-2408
    • Chen, C.1    Liu, Y.2    Liu, R.3    Ikenoue, T.4    Guan, K.L.5    Liu, Y.6    Zheng, P.7
  • 90
    • 65949104286 scopus 로고    scopus 로고
    • mTORC1 signaling governs hematopoietic stem cell quiescence
    • Gan, B.; DePinho, R.A. mTORC1 signaling governs hematopoietic stem cell quiescence. Cell Cycle 2009, 8, 1003-1006.
    • (2009) Cell Cycle , vol.8 , pp. 1003-1006
    • Gan, B.1    Depinho, R.A.2
  • 91
    • 28844480101 scopus 로고    scopus 로고
    • mTOR regulates cell survival after etoposide treatment in primary AML cells
    • Xu, Q.; Thompson, J.E.; Carroll, M. mTOR regulates cell survival after etoposide treatment in primary AML cells. Blood 2005, 106, 4261-4268.
    • (2005) Blood , vol.106 , pp. 4261-4268
    • Xu, Q.1    Thompson, J.E.2    Carroll, M.3
  • 95
    • 62549136153 scopus 로고    scopus 로고
    • Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice
    • Rountree, C.B.; Ding, W.; He, L.; Stiles, B., Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice. Stem Cells 2009, 27, 290-299.
    • (2009) Stem Cells , vol.27 , pp. 290-299
    • Rountree, C.B.1    Ding, W.2    He, L.3    Stiles, B.4
  • 96
    • 66249140268 scopus 로고    scopus 로고
    • Accumulating progenitor cells in the luminal epithelial cell layer are candidate tumor initiating cells in a Pten knockout mouse prostate cancer model
    • Korsten, H.; Ziel-vander Made, A.; Ma, X.; van der Kwast, T.; Trapman, J. Accumulating progenitor cells in the luminal epithelial cell layer are candidate tumor initiating cells in a Pten knockout mouse prostate cancer model. PLoS One 2009, 4, e5662.
    • (2009) PLoS One , vol.4
    • Korsten, H.1    Ziel-vander, M.A.2    Ma, X.3    van der Kwast, T.4    Trapman, J.5
  • 100
    • 18744377702 scopus 로고    scopus 로고
    • The Sca-1 cell surface marker enriches for a prostateregenerating cell subpopulation that can initiate prostate tumorigenesis
    • Xin, L.; Lawson, D.A.; Witte, O.N. The Sca-1 cell surface marker enriches for a prostateregenerating cell subpopulation that can initiate prostate tumorigenesis. Proc. Natl. Acad. Sci. USA 2005, 102, 6942-6947.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 6942-6947
    • Xin, L.1    Lawson, D.A.2    Witte, O.N.3
  • 104
    • 43049131769 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations
    • LoPiccolo, J.; Blumenthal, G.M.; Bernstein, W.B.; Dennis, P.A. Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations. Drug Resist. Updat. 2008, 11, 32-50.
    • (2008) Drug Resist. Updat. , vol.11 , pp. 32-50
    • Lopiccolo, J.1    Blumenthal, G.M.2    Bernstein, W.B.3    Dennis, P.A.4
  • 106
    • 40749150740 scopus 로고    scopus 로고
    • CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
    • Ma, S.; Lee, T.K.; Zheng, B.J.; Chan, K.W.; Guan, X.Y. CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene 2008, 27, 1749-1758.
    • (2008) Oncogene , vol.27 , pp. 1749-1758
    • Ma, S.1    Lee, T.K.2    Zheng, B.J.3    Chan, K.W.4    Guan, X.Y.5
  • 108
    • 71049156626 scopus 로고    scopus 로고
    • ABCG2: The key to chemoresistance in cancer stem cells?
    • An, Y.; Ongkeko, W.M. ABCG2: the key to chemoresistance in cancer stem cells? Expert Opin. Drug Metab. Toxicol. 2009, 5, 1529-1542.
    • (2009) Expert Opin. Drug Metab Toxicol. , vol.5 , pp. 1529-1542
    • An, Y.1    Ongkeko, W.M.2
  • 110
    • 0029958876 scopus 로고    scopus 로고
    • Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
    • Goodell, M.A.; Brose, K.; Paradis, G.; Conner, A.S.; Mulligan, R.C. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J. Exp. Med. 1996, 183, 1797-1806.
    • (1996) J. Exp. Med. , vol.183 , pp. 1797-1806
    • Goodell, M.A.1    Brose, K.2    Paradis, G.3    Conner, A.S.4    Mulligan, R.C.5
  • 114
    • 77952885076 scopus 로고    scopus 로고
    • Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer
    • Salcido, C.D.; Larochelle, A.; Taylor, B.J.; Dunbar, C.E.; Varticovski, L. Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer. Br. J. Cancer 2010, 102, 1636-1644.
    • (2010) Br. J. Cancer , vol.102 , pp. 1636-1644
    • Salcido, C.D.1    Larochelle, A.2    Taylor, B.J.3    Dunbar, C.E.4    Varticovski, L.5
  • 115
    • 77949674648 scopus 로고    scopus 로고
    • Cytotoxic effects induced by docetaxel, gefitinib, and cyclopamine on side population and nonside population cell fractions from human invasive prostate cancer cells
    • Mimeault, M.; Johansson, S.L.; Henichart, J.P.; Depreux, P.; Batra, S.K. Cytotoxic effects induced by docetaxel, gefitinib, and cyclopamine on side population and nonside population cell fractions from human invasive prostate cancer cells. Mol. Cancer Ther. 2010, 9, 617-630.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 617-630
    • Mimeault, M.1    Johansson, S.L.2    Henichart, J.P.3    Depreux, P.4    Batra, S.K.5
  • 116
    • 77649270350 scopus 로고    scopus 로고
    • Side-population cells in luminal-type breast cancer have tumourinitiating cell properties, and are regulated by HER2 expression and signalling
    • Nakanishi, T.; Chumsri, S.; Khakpour, N.; Brodie, A.H.; Leyland-Jones, B.; Hamburger, A.W.; Ross, D.D.; Burger, A.M. Side-population cells in luminal-type breast cancer have tumourinitiating cell properties, and are regulated by HER2 expression and signalling. Br. J. Cancer 2010, 102, 815-826.
    • (2010) Br. J. Cancer , vol.102 , pp. 815-826
    • Nakanishi, T.1    Chumsri, S.2    Khakpour, N.3    Brodie, A.H.4    Leyland-Jones, B.5    Hamburger, A.W.6    Ross, D.D.7    Burger, A.M.8
  • 119
    • 60849117508 scopus 로고    scopus 로고
    • PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    • Bleau, A.M.; Hambardzumyan, D.; Ozawa, T.; Fomchenko, E.I.; Huse, J.T.; Brennan, C.W.; Holland, E.C. PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 2009, 4, 226-235.
    • (2009) Cell Stem Cell , vol.4 , pp. 226-235
    • Bleau, A.M.1    Hambardzumyan, D.2    Ozawa, T.3    Fomchenko, E.I.4    Huse, J.T.5    Brennan, C.W.6    Holland, E.C.7
  • 120
    • 57349094741 scopus 로고    scopus 로고
    • Analysis of ABCG2 expression and side population identifies intrinsic drug efflux in the HCC cell line MHCC-97L and its modulation by Akt signaling
    • Hu, C.; Li, H.; Li, J.; Zhu, Z.; Yin, S.; Hao, X.; Yao, M.; Zheng, S.; Gu, J. Analysis of ABCG2 expression and side population identifies intrinsic drug efflux in the HCC cell line MHCC-97L and its modulation by Akt signaling. Carcinogenesis 2008, 29, 2289-2297.
    • (2008) Carcinogenesis , vol.29 , pp. 2289-2297
    • Hu, C.1    Li, H.2    Li, J.3    Zhu, Z.4    Yin, S.5    Hao, X.6    Yao, M.7    Zheng, S.8    Gu, J.9
  • 122
    • 39449135834 scopus 로고    scopus 로고
    • PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
    • Hambardzumyan, D.; Becher, O.J.; Rosenblum, M.K.; Pandolfi, P.P.; Manova-Todorova, K.; Holland, E.C. PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev. 2008, 22, 436-448.
    • (2008) Genes Dev. , vol.22 , pp. 436-448
    • Hambardzumyan, D.1    Becher, O.J.2    Rosenblum, M.K.3    Pandolfi, P.P.4    Manova-Todorova, K.5    Holland, E.C.6
  • 123
    • 77954955537 scopus 로고    scopus 로고
    • The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis
    • Martelli, A.M.; Evangelisti, C.; Chiarini, F.; Grimaldi, C.; Cappellini, A.; Ognibene, A.; McCubrey, J.A. The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis. Biochim. Biophys. Acta 2010, 1803, 991-1002.
    • (2010) Biochim. Biophys. Acta , vol.1803 , pp. 991-1002
    • Martelli, A.M.1    Evangelisti, C.2    Chiarini, F.3    Grimaldi, C.4    Cappellini, A.5    Ognibene, A.6    McCubrey, J.A.7
  • 127
    • 77953693899 scopus 로고    scopus 로고
    • Targeting Hedgehog -- a Cancer Stem Cell Pathway
    • Merchant, A.A.; Matsui, W. Targeting Hedgehog -- a Cancer Stem Cell Pathway. Clin. Cancer Res. 2010, 16, 3130-3140.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3130-3140
    • Merchant, A.A.1    Matsui, W.2
  • 128
    • 77953696850 scopus 로고    scopus 로고
    • Controversies in Cancer Stem Cells: Targeting Embryonic Signaling Pathways
    • Takebe, N.; Ivy, S.P. Controversies in Cancer Stem Cells: Targeting Embryonic Signaling Pathways. Clin. Cancer Res. 2010, 16, 3106-3112.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3106-3112
    • Takebe, N.1    Ivy, S.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.