Human De-Etiolated-Regulates c-Jun by Assembling a CUL4A Ubiquitin Ligase

Science

Volumn 303, Issue 5662, 2004, Pages 1371-1374

  Wertz, Ingrid E ^a,b   O'Rourke, Karen M ^a   Zhang, Zemin ^a   Dornan, David ^a   Arnott, David ^a   Deshaies, Raymond J ^c   Dixit, Vishva M ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIODEGRADATION; CELLS; MICROORGANISMS;

MAMMALIAN CELLS;

ENZYMES;

CULLIN 4A; DE ETIOLATED 1 PROTEIN; DNA DAMAGE BINDING PROTEIN 1; PHOTOMORPHOGENIC 1 PROTEIN; PROTEIN; PROTEIN ROC1; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

BIOLOGY; PROTEIN;

ARABIDOPSIS; ARTICLE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MAMMAL CELL; NUCLEOTIDE SEQUENCE; PHOTOMORPHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RNA INTERFERENCE; UBIQUITINATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CARRIER PROTEINS; CELL LINE; CLONING, MOLECULAR; CULLIN PROTEINS; DNA-BINDING PROTEINS; GENES, JUN; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEOMICS; PROTO-ONCOGENE PROTEINS C-JUN; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

ARABIDOPSIS; ARABIDOPSIS THALIANA; INVERTEBRATA; MAMMALIA; VERTEBRATA;

EID: 1342275414     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1093549     Document Type: Article

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28. We thank J. Stinson, C. Grimaldi, and S. Schilbach for assistance with hCOP1 cloning; C. Reed and N. Chiang for generating hCOP1 and hDET1 antibodies; H. Maecker for fluorescence-activated cell sorting analysis assistance; J. Lee for cDNA libraries; S. Palmieri for confocal microscopy expertise, A. Waugh for bioinformatics analysis, K. Newton for editorial assistance; and G. Cope and members of the Dixit Lab for discussions. R.J.D. was supported in part by NIH grant GM065997 and is an assistant investigator of the Howard Hughes Medical Institute. I.E.W. was supported in part by a Physician Scientist Training Program fellowship from the University of California at Davis.