-
1
-
-
33847328747
-
FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity
-
Abida W.M., Nikolaev A., Zhao W., Zhang W., and Gu W. FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J. Biol. Chem. 282 (2007) 1797-1804
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 1797-1804
-
-
Abida, W.M.1
Nikolaev, A.2
Zhao, W.3
Zhang, W.4
Gu, W.5
-
2
-
-
65549154109
-
Oncogenic viral protein HPV E7 upregulates the SIRT1 longivity protein in human cervical cancer cells
-
Allison S.J., Jiang M., and Milner J. Oncogenic viral protein HPV E7 upregulates the SIRT1 longivity protein in human cervical cancer cells. Aging 1 (2009) 316-327
-
(2009)
Aging
, vol.1
, pp. 316-327
-
-
Allison, S.J.1
Jiang, M.2
Milner, J.3
-
3
-
-
2942612843
-
Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53
-
An W., Kim J., and Roeder R.G. Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell 117 (2004) 735-748
-
(2004)
Cell
, vol.117
, pp. 735-748
-
-
An, W.1
Kim, J.2
Roeder, R.G.3
-
4
-
-
0034818446
-
Post-translational modifications and activation of p53 by genotoxic stresses
-
Appella E., and Anderson C.W. Post-translational modifications and activation of p53 by genotoxic stresses. Eur. J. Biochem. 268 (2001) 2764-2772
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 2764-2772
-
-
Appella, E.1
Anderson, C.W.2
-
5
-
-
0033020147
-
Regulation of p53 function and stability by phosphorylation
-
Ashcroft M., Kubbutat M.H., and Vousden K.H. Regulation of p53 function and stability by phosphorylation. Mol. Cell. Biol. 19 (1999) 1751-1758
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1751-1758
-
-
Ashcroft, M.1
Kubbutat, M.H.2
Vousden, K.H.3
-
6
-
-
0034003005
-
Stress signals utilize multiple pathways to stabilize p53
-
Ashcroft M., Taya Y., and Vousden K.H. Stress signals utilize multiple pathways to stabilize p53. Mol. Cell. Biol. 20 (2000) 3224-3233
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 3224-3233
-
-
Ashcroft, M.1
Taya, Y.2
Vousden, K.H.3
-
7
-
-
0034869859
-
Latent and active p53 are identical in conformation
-
Ayed A., Mulder F.A., Yi G.S., Lu Y., Kay L.E., and Arrowsmith C.H. Latent and active p53 are identical in conformation. Nat. Struct. Biol. 8 (2001) 756-760
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 756-760
-
-
Ayed, A.1
Mulder, F.A.2
Yi, G.S.3
Lu, Y.4
Kay, L.E.5
Arrowsmith, C.H.6
-
8
-
-
0024536654
-
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
-
Baker S.J., Fearon E.R., Nigro J.M., Hamilton S.R., Preisinger A.C., Jessup J.M., vanTuinen P., Ledbetter D.H., Barker D.F., Nakamura Y., et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 244 (1989) 217-221
-
(1989)
Science
, vol.244
, pp. 217-221
-
-
Baker, S.J.1
Fearon, E.R.2
Nigro, J.M.3
Hamilton, S.R.4
Preisinger, A.C.5
Jessup, J.M.6
vanTuinen, P.7
Ledbetter, D.H.8
Barker, D.F.9
Nakamura, Y.10
-
9
-
-
50349088876
-
Mdm2 and Mdm4 loss regulates distinct p53 activities
-
Barboza J.A., Iwakuma T., Terzian T., El-Naggar A.K., and Lozano G. Mdm2 and Mdm4 loss regulates distinct p53 activities. Mol. Cancer Res. 6 (2008) 947-954
-
(2008)
Mol. Cancer Res.
, vol.6
, pp. 947-954
-
-
Barboza, J.A.1
Iwakuma, T.2
Terzian, T.3
El-Naggar, A.K.4
Lozano, G.5
-
10
-
-
0025858631
-
Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication
-
Bargonetti J., Friedman P.N., Kern S.E., Vogelstein B., and Prives C. Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Cell 65 (1991) 1083-1091
-
(1991)
Cell
, vol.65
, pp. 1083-1091
-
-
Bargonetti, J.1
Friedman, P.N.2
Kern, S.E.3
Vogelstein, B.4
Prives, C.5
-
11
-
-
0037312920
-
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
-
Bergamaschi D., Samuels Y., O'Neil N.J., Trigiante G., Crook T., Hsieh J.K., O'Connor D.J., Zhong S., Campargue I., Tomlinson M.L., et al. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat. Genet. 33 (2003) 162-167
-
(2003)
Nat. Genet.
, vol.33
, pp. 162-167
-
-
Bergamaschi, D.1
Samuels, Y.2
O'Neil, N.J.3
Trigiante, G.4
Crook, T.5
Hsieh, J.K.6
O'Connor, D.J.7
Zhong, S.8
Campargue, I.9
Tomlinson, M.L.10
-
12
-
-
12144289681
-
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
-
Berns K., Hijmans E.M., Mullenders J., Brummelkamp T.R., Velds A., Heimerikx M., Kerkhoven R.M., Madiredjo M., Nijkamp W., Weigelt B., et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428 (2004) 431-437
-
(2004)
Nature
, vol.428
, pp. 431-437
-
-
Berns, K.1
Hijmans, E.M.2
Mullenders, J.3
Brummelkamp, T.R.4
Velds, A.5
Heimerikx, M.6
Kerkhoven, R.M.7
Madiredjo, M.8
Nijkamp, W.9
Weigelt, B.10
-
13
-
-
0033522143
-
DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation
-
Blattner C., Tobiasch E., Litfen M., Rahmsdorf H.J., and Herrlich P. DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation. Oncogene 18 (1999) 1723-1732
-
(1999)
Oncogene
, vol.18
, pp. 1723-1732
-
-
Blattner, C.1
Tobiasch, E.2
Litfen, M.3
Rahmsdorf, H.J.4
Herrlich, P.5
-
14
-
-
0037377060
-
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation
-
Brooks C.L., and Gu W. Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr. Opin. Cell Biol. 15 (2003) 164-171
-
(2003)
Curr. Opin. Cell Biol.
, vol.15
, pp. 164-171
-
-
Brooks, C.L.1
Gu, W.2
-
15
-
-
31544457877
-
p53 ubiquitination: Mdm2 and beyond
-
Brooks C.L., and Gu W. p53 ubiquitination: Mdm2 and beyond. Mol. Cell 21 (2006) 307-315
-
(2006)
Mol. Cell
, vol.21
, pp. 307-315
-
-
Brooks, C.L.1
Gu, W.2
-
16
-
-
33646343474
-
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors
-
Brummelkamp T.R., Fabius A.W., Mullenders J., Madiredjo M., Velds A., Kerkhoven R.M., Bernards R., and Beijersbergen R.L. An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors. Nat. Chem. Biol. 2 (2006) 202-206
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 202-206
-
-
Brummelkamp, T.R.1
Fabius, A.W.2
Mullenders, J.3
Madiredjo, M.4
Velds, A.5
Kerkhoven, R.M.6
Bernards, R.7
Beijersbergen, R.L.8
-
17
-
-
0034704175
-
The N terminus of p53 regulates its dissociation from DNA
-
Cain C., Miller S., Ahn J., and Prives C. The N terminus of p53 regulates its dissociation from DNA. J. Biol. Chem. 275 (2000) 39944-39953
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 39944-39953
-
-
Cain, C.1
Miller, S.2
Ahn, J.3
Prives, C.4
-
18
-
-
34047103990
-
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53
-
Carter S., Bischof O., Dejean A., and Vousden K.H. C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. Nat. Cell Biol. 9 (2007) 428-435
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 428-435
-
-
Carter, S.1
Bischof, O.2
Dejean, A.3
Vousden, K.H.4
-
19
-
-
10744226888
-
Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs
-
Cawley S., Bekiranov S., Ng H.H., Kapranov P., Sekinger E.A., Kampa D., Piccolboni A., Sementchenko V., Cheng J., Williams A.J., et al. Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell 116 (2004) 499-509
-
(2004)
Cell
, vol.116
, pp. 499-509
-
-
Cawley, S.1
Bekiranov, S.2
Ng, H.H.3
Kapranov, P.4
Sekinger, E.A.5
Kampa, D.6
Piccolboni, A.7
Sementchenko, V.8
Cheng, J.9
Williams, A.J.10
-
20
-
-
32944458404
-
Ubiquitination of p53 at multiple sites in the DNA-binding domain
-
Chan W.M., Mak M.C., Fung T.K., Lau A., Siu W.Y., and Poon R.Y. Ubiquitination of p53 at multiple sites in the DNA-binding domain. Mol. Cancer Res. 4 (2006) 15-25
-
(2006)
Mol. Cancer Res.
, vol.4
, pp. 15-25
-
-
Chan, W.M.1
Mak, M.C.2
Fung, T.K.3
Lau, A.4
Siu, W.Y.5
Poon, R.Y.6
-
21
-
-
0142039901
-
Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses
-
Chao C., Hergenhahn M., Kaeser M.D., Wu Z., Saito S., Iggo R., Hollstein M., Appella E., and Xu Y. Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses. J. Biol. Chem. 278 (2003) 41028-41033
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 41028-41033
-
-
Chao, C.1
Hergenhahn, M.2
Kaeser, M.D.3
Wu, Z.4
Saito, S.5
Iggo, R.6
Hollstein, M.7
Appella, E.8
Xu, Y.9
-
22
-
-
33745752959
-
Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression
-
Chao C., Herr D., Chun J., and Xu Y. Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J. 25 (2006) 2615-2622
-
(2006)
EMBO J.
, vol.25
, pp. 2615-2622
-
-
Chao, C.1
Herr, D.2
Chun, J.3
Xu, Y.4
-
23
-
-
33748667324
-
Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage
-
Chao C., Wu Z., Mazur S.J., Borges H., Rossi M., Lin T., Wang J.Y., Anderson C.W., Appella E., and Xu Y. Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol. Cell. Biol. 26 (2006) 6859-6869
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 6859-6869
-
-
Chao, C.1
Wu, Z.2
Mazur, S.J.3
Borges, H.4
Rossi, M.5
Lin, T.6
Wang, J.Y.7
Anderson, C.W.8
Appella, E.9
Xu, Y.10
-
24
-
-
21244451434
-
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
-
Chen D., Kon N., Li M., Zhang W., Qin J., and Gu W. ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell 121 (2005) 1071-1083
-
(2005)
Cell
, vol.121
, pp. 1071-1083
-
-
Chen, D.1
Kon, N.2
Li, M.3
Zhang, W.4
Qin, J.5
Gu, W.6
-
25
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
Cheng H.L., Mostoslavsky R., Saito S., Manis J.P., Gu Y., Patel P., Bronson R., Appella E., Alt F.W., and Chua K.F. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl. Acad. Sci. USA 100 (2003) 10794-10799
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 10794-10799
-
-
Cheng, H.L.1
Mostoslavsky, R.2
Saito, S.3
Manis, J.P.4
Gu, Y.5
Patel, P.6
Bronson, R.7
Appella, E.8
Alt, F.W.9
Chua, K.F.10
-
26
-
-
0027983669
-
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations
-
Cho Y., Gorina S., Jeffrey P.D., and Pavletich N.P. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 265 (1994) 346-355
-
(1994)
Science
, vol.265
, pp. 346-355
-
-
Cho, Y.1
Gorina, S.2
Jeffrey, P.D.3
Pavletich, N.P.4
-
27
-
-
0842278331
-
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
-
Chipuk J.E., Kuwana T., Bouchier-Hayes L., Droin N.M., Newmeyer D.D., Schuler M., and Green D.R. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303 (2004) 1010-1014
-
(2004)
Science
, vol.303
, pp. 1010-1014
-
-
Chipuk, J.E.1
Kuwana, T.2
Bouchier-Hayes, L.3
Droin, N.M.4
Newmeyer, D.D.5
Schuler, M.6
Green, D.R.7
-
28
-
-
9244247669
-
Regulation of p53 activity through lysine methylation
-
Chuikov S., Kurash J.K., Wilson J.R., Xiao B., Justin N., Ivanov G.S., McKinney K., Tempst P., Prives C., Gamblin S.J., et al. Regulation of p53 activity through lysine methylation. Nature 432 (2004) 353-360
-
(2004)
Nature
, vol.432
, pp. 353-360
-
-
Chuikov, S.1
Kurash, J.K.2
Wilson, J.R.3
Xiao, B.4
Justin, N.5
Ivanov, G.S.6
McKinney, K.7
Tempst, P.8
Prives, C.9
Gamblin, S.J.10
-
29
-
-
1842431904
-
Tumour suppression: disruption of HAUSP gene stabilizes p53
-
1 p following 486
-
Cummins J.M., Rago C., Kohli M., Kinzler K.W., Lengauer C., and Vogelstein B. Tumour suppression: disruption of HAUSP gene stabilizes p53. Nature 428 (2004) 1 p following 486
-
(2004)
Nature
, vol.428
-
-
Cummins, J.M.1
Rago, C.2
Kohli, M.3
Kinzler, K.W.4
Lengauer, C.5
Vogelstein, B.6
-
30
-
-
4344685939
-
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
-
Dai M.S., Zeng S.X., Jin Y., Sun X.X., David L., and Lu H. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol. Cell. Biol. 24 (2004) 7654-7668
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 7654-7668
-
-
Dai, M.S.1
Zeng, S.X.2
Jin, Y.3
Sun, X.X.4
David, L.5
Lu, H.6
-
31
-
-
34548049032
-
Hzf, a key modulator of p53 mediated transcription, functions as a critical determinant of cell survival and death upon genotoxic stress
-
Das S., Raj L., Zhao B., Bernstein A., Aaronson S.A., and Lee S.W. Hzf, a key modulator of p53 mediated transcription, functions as a critical determinant of cell survival and death upon genotoxic stress. Cell 130 (2007) 624-637
-
(2007)
Cell
, vol.130
, pp. 624-637
-
-
Das, S.1
Raj, L.2
Zhao, B.3
Bernstein, A.4
Aaronson, S.A.5
Lee, S.W.6
-
32
-
-
0018743916
-
Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse
-
DeLeo A.B., Jay G., Appella E., Dubois G.C., Law L.W., and Old L.J. Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc. Natl. Acad. Sci. USA 76 (1979) 2420-2424
-
(1979)
Proc. Natl. Acad. Sci. USA
, vol.76
, pp. 2420-2424
-
-
DeLeo, A.B.1
Jay, G.2
Appella, E.3
Dubois, G.C.4
Law, L.W.5
Old, L.J.6
-
33
-
-
2342447397
-
The ubiquitin ligase COP1 is a critical negative regulator of p53
-
Dornan D., Wertz I., Shimizu H., Arnott D., Frantz G.D., Dowd P., O'Rourke K., Koeppen H., and Dixit V.M. The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature 429 (2004) 86-92
-
(2004)
Nature
, vol.429
, pp. 86-92
-
-
Dornan, D.1
Wertz, I.2
Shimizu, H.3
Arnott, D.4
Frantz, G.D.5
Dowd, P.6
O'Rourke, K.7
Koeppen, H.8
Dixit, V.M.9
-
34
-
-
0026849821
-
Definition of a consensus binding site for p53
-
El-Deiry W.S., Kern S.E., Pietenpol J.A., Kinzler K.W., and Vogelstein B. Definition of a consensus binding site for p53. Nat. Genet. 1 (1992) 45-49
-
(1992)
Nat. Genet.
, vol.1
, pp. 45-49
-
-
El-Deiry, W.S.1
Kern, S.E.2
Pietenpol, J.A.3
Kinzler, K.W.4
Vogelstein, B.5
-
35
-
-
0034881964
-
Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
-
Espinosa J.M., and Emerson B.M. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol. Cell 8 (2001) 57-69
-
(2001)
Mol. Cell
, vol.8
, pp. 57-69
-
-
Espinosa, J.M.1
Emerson, B.M.2
-
36
-
-
0034708458
-
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
-
Fang S., Jensen J.P., Ludwig R.L., Vousden K.H., and Weissman A.M. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J. Biol. Chem. 275 (2000) 8945-8951
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8945-8951
-
-
Fang, S.1
Jensen, J.P.2
Ludwig, R.L.3
Vousden, K.H.4
Weissman, A.M.5
-
37
-
-
20744448187
-
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity
-
Feng L., Lin T., Uranishi H., Gu W., and Xu Y. Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol. Cell. Biol. 25 (2005) 5389-5395
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 5389-5395
-
-
Feng, L.1
Lin, T.2
Uranishi, H.3
Gu, W.4
Xu, Y.5
-
38
-
-
0024382760
-
The p53 proto-oncogene can act as a suppressor of transformation
-
Finlay C.A., Hinds P.W., and Levine A.J. The p53 proto-oncogene can act as a suppressor of transformation. Cell 57 (1989) 1083-1093
-
(1989)
Cell
, vol.57
, pp. 1083-1093
-
-
Finlay, C.A.1
Hinds, P.W.2
Levine, A.J.3
-
39
-
-
0034234237
-
CBP/p300 in cell growth, transformation, and development
-
Goodman R.H., and Smolik S. CBP/p300 in cell growth, transformation, and development. Genes Dev. 14 (2000) 1553-1577
-
(2000)
Genes Dev.
, vol.14
, pp. 1553-1577
-
-
Goodman, R.H.1
Smolik, S.2
-
40
-
-
0030797585
-
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
-
Gu W., and Roeder R.G. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90 (1997) 595-606
-
(1997)
Cell
, vol.90
, pp. 595-606
-
-
Gu, W.1
Roeder, R.G.2
-
41
-
-
0033010438
-
A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation
-
Gu W., Malik S., Ito M., Yuan C.X., Fondell J.D., Zhang X., Martinez E., Qin J., and Roeder R.G. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol. Cell 3 (1999) 97-108
-
(1999)
Mol. Cell
, vol.3
, pp. 97-108
-
-
Gu, W.1
Malik, S.2
Ito, M.3
Yuan, C.X.4
Fondell, J.D.5
Zhang, X.6
Martinez, E.7
Qin, J.8
Roeder, R.G.9
-
42
-
-
0033992478
-
p53 and human cancer: the first ten thousand mutations
-
Hainaut P., and Hollstein M. p53 and human cancer: the first ten thousand mutations. Adv. Cancer Res. 77 (2000) 81-137
-
(2000)
Adv. Cancer Res.
, vol.77
, pp. 81-137
-
-
Hainaut, P.1
Hollstein, M.2
-
43
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y., Maya R., Kazaz A., and Oren M. Mdm2 promotes the rapid degradation of p53. Nature 387 (1997) 296-299
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
44
-
-
0033521621
-
Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
-
Honda R., and Yasuda H. Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J. 18 (1999) 22-27
-
(1999)
EMBO J.
, vol.18
, pp. 22-27
-
-
Honda, R.1
Yasuda, H.2
-
45
-
-
0031583962
-
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
-
Honda R., Tanaka H., and Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420 (1997) 25-27
-
(1997)
FEBS Lett.
, vol.420
, pp. 25-27
-
-
Honda, R.1
Tanaka, H.2
Yasuda, H.3
-
46
-
-
33845204856
-
Repression of p53 activity by Smyd2-mediated methylation
-
Huang J., Perez-Burgos L., Placek B.J., Sengupta R., Richter M., Dorsey J.A., Kubicek S., Opravil S., Jenuwein T., and Berger S.L. Repression of p53 activity by Smyd2-mediated methylation. Nature 444 (2006) 629-632
-
(2006)
Nature
, vol.444
, pp. 629-632
-
-
Huang, J.1
Perez-Burgos, L.2
Placek, B.J.3
Sengupta, R.4
Richter, M.5
Dorsey, J.A.6
Kubicek, S.7
Opravil, S.8
Jenuwein, T.9
Berger, S.L.10
-
47
-
-
34548513035
-
p53 is regulated by the lysine demethylase LSD1
-
Huang J., Sengupta R., Espejo A.B., Lee M.G., Dorsey J.A., Richter M., Opravil S., Shiekhattar R., Bedford M.T., Jenuwein T., et al. p53 is regulated by the lysine demethylase LSD1. Nature 449 (2007) 105-108
-
(2007)
Nature
, vol.449
, pp. 105-108
-
-
Huang, J.1
Sengupta, R.2
Espejo, A.B.3
Lee, M.G.4
Dorsey, J.A.5
Richter, M.6
Opravil, S.7
Shiekhattar, R.8
Bedford, M.T.9
Jenuwein, T.10
-
48
-
-
0026448672
-
Regulation of the specific DNA binding function of p53
-
Hupp T.R., Meek D.W., Midgley C.A., and Lane D.P. Regulation of the specific DNA binding function of p53. Cell 71 (1992) 875-886
-
(1992)
Cell
, vol.71
, pp. 875-886
-
-
Hupp, T.R.1
Meek, D.W.2
Midgley, C.A.3
Lane, D.P.4
-
49
-
-
35148847384
-
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
-
Itahana K., Mao H., Jin A., Itahana Y., Clegg H.V., Lindstrom M.S., Bhat K.P., Godfrey V.L., Evan G.I., and Zhang Y. Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell 12 (2007) 355-366
-
(2007)
Cancer Cell
, vol.12
, pp. 355-366
-
-
Itahana, K.1
Mao, H.2
Jin, A.3
Itahana, Y.4
Clegg, H.V.5
Lindstrom, M.S.6
Bhat, K.P.7
Godfrey, V.L.8
Evan, G.I.9
Zhang, Y.10
-
50
-
-
0035868964
-
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
-
Ito A., Lai C.H., Zhao X., Saito S., Hamilton M.H., Appella E., and Yao T.P. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J. 20 (2001) 1331-1340
-
(2001)
EMBO J.
, vol.20
, pp. 1331-1340
-
-
Ito, A.1
Lai, C.H.2
Zhao, X.3
Saito, S.4
Hamilton, M.H.5
Appella, E.6
Yao, T.P.7
-
51
-
-
0028242909
-
Two cellular proteins that bind to wild-type but not mutant p53
-
Iwabuchi K., Bartel P.L., Li B., Marraccino R., and Fields S. Two cellular proteins that bind to wild-type but not mutant p53. Proc. Natl. Acad. Sci. USA 91 (1994) 6098-6102
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 6098-6102
-
-
Iwabuchi, K.1
Bartel, P.L.2
Li, B.3
Marraccino, R.4
Fields, S.5
-
52
-
-
34047194383
-
Crippling p53 activities via knock-in mutations in mouse models
-
Iwakuma T., and Lozano G. Crippling p53 activities via knock-in mutations in mouse models. Oncogene 26 (2007) 2177-2184
-
(2007)
Oncogene
, vol.26
, pp. 2177-2184
-
-
Iwakuma, T.1
Lozano, G.2
-
54
-
-
57049087451
-
Arginine methylation regulates the p53 response
-
Jansson M., Durant S.T., Cho E.C., Sheahan S., Edelmann M., Kessler B., and La Thangue N.B. Arginine methylation regulates the p53 response. Nat. Cell Biol. 10 (2008) 1431-1439
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 1431-1439
-
-
Jansson, M.1
Durant, S.T.2
Cho, E.C.3
Sheahan, S.4
Edelmann, M.5
Kessler, B.6
La Thangue, N.B.7
-
55
-
-
0035839136
-
Translating the histone code
-
Jenuwein T., and Allis C.D. Translating the histone code. Science 293 (2001) 1074-1080
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
56
-
-
13944278507
-
The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality
-
Johnson T.M., Hammond E.M., Giaccia A., and Attardi L.D. The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Nat. Genet. 37 (2005) 145-152
-
(2005)
Nat. Genet.
, vol.37
, pp. 145-152
-
-
Johnson, T.M.1
Hammond, E.M.2
Giaccia, A.3
Attardi, L.D.4
-
57
-
-
0028834902
-
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
-
Jones S.N., Roe A.E., Donehower L.A., and Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378 (1995) 206-208
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
Bradley, A.4
-
58
-
-
0037039319
-
Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
-
Kaeser M.D., and Iggo R.D. Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proc. Natl. Acad. Sci. USA 99 (2002) 95-100
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 95-100
-
-
Kaeser, M.D.1
Iggo, R.D.2
-
59
-
-
0025815451
-
Identification of p53 as a sequence-specific DNA-binding protein
-
Kern S.E., Kinzler K.W., Bruskin A., Jarosz D., Friedman P., Prives C., and Vogelstein B. Identification of p53 as a sequence-specific DNA-binding protein. Science 252 (1991) 1708-1711
-
(1991)
Science
, vol.252
, pp. 1708-1711
-
-
Kern, S.E.1
Kinzler, K.W.2
Bruskin, A.3
Jarosz, D.4
Friedman, P.5
Prives, C.6
Vogelstein, B.7
-
60
-
-
0033518119
-
Influence of promoter DNA topology on sequence-specific DNA binding and transactivation by tumor suppressor p53
-
Kim E., Rohaly G., Heinrichs S., Gimnopoulos D., Meissner H., and Deppert W. Influence of promoter DNA topology on sequence-specific DNA binding and transactivation by tumor suppressor p53. Oncogene 18 (1999) 7310-7318
-
(1999)
Oncogene
, vol.18
, pp. 7310-7318
-
-
Kim, E.1
Rohaly, G.2
Heinrichs, S.3
Gimnopoulos, D.4
Meissner, H.5
Deppert, W.6
-
61
-
-
38749088678
-
DBC1 is a negative regulator of SIRT1
-
Kim J.E., Chen J., and Lou Z. DBC1 is a negative regulator of SIRT1. Nature 451 (2008) 583-586
-
(2008)
Nature
, vol.451
, pp. 583-586
-
-
Kim, J.E.1
Chen, J.2
Lou, Z.3
-
62
-
-
33646817028
-
Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate
-
Knights C.D., Catania J., Di Giovanni S., Muratoglu S., Perez R., Swartzbeck A., Quong A.A., Zhang X., Beerman T., Pestell R.G., et al. Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate. J. Cell Biol. 173 (2006) 533-544
-
(2006)
J. Cell Biol.
, vol.173
, pp. 533-544
-
-
Knights, C.D.1
Catania, J.2
Di Giovanni, S.3
Muratoglu, S.4
Perez, R.5
Swartzbeck, A.6
Quong, A.A.7
Zhang, X.8
Beerman, T.9
Pestell, R.G.10
-
63
-
-
22544484456
-
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
-
Krummel K.A., Lee C.J., Toledo F., and Wahl G.M. The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc. Natl. Acad. Sci. USA 102 (2005) 10188-10193
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 10188-10193
-
-
Krummel, K.A.1
Lee, C.J.2
Toledo, F.3
Wahl, G.M.4
-
64
-
-
59149085299
-
MSL2 promotes MDM2 independent cytoplasmic localization of p53
-
Kruse J.P., and Gu W. MSL2 promotes MDM2 independent cytoplasmic localization of p53. J. Biol. Chem. 284 (2008) 3250-3263
-
(2008)
J. Biol. Chem.
, vol.284
, pp. 3250-3263
-
-
Kruse, J.P.1
Gu, W.2
-
65
-
-
43949107925
-
SnapShot: p53 posttranslational modifications
-
Kruse J.P., and Gu W. SnapShot: p53 posttranslational modifications. Cell 133 (2008) 930
-
(2008)
Cell
, vol.133
, pp. 930
-
-
Kruse, J.P.1
Gu, W.2
-
66
-
-
0030965946
-
Regulation of p53 stability by Mdm2
-
Kubbutat M.H., Jones S.N., and Vousden K.H. Regulation of p53 stability by Mdm2. Nature 387 (1997) 299-303
-
(1997)
Nature
, vol.387
, pp. 299-303
-
-
Kubbutat, M.H.1
Jones, S.N.2
Vousden, K.H.3
-
67
-
-
33749013398
-
Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation
-
Kulikov R., Winter M., and Blattner C. Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation. J. Biol. Chem. 281 (2006) 28575-28583
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 28575-28583
-
-
Kulikov, R.1
Winter, M.2
Blattner, C.3
-
68
-
-
42949114938
-
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator
-
Lain S., Hollick J.J., Campbell J., Staples O.D., Higgins M., Aoubala M., McCarthy A., Appleyard V., Murray K.E., Baker L., et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13 (2008) 454-463
-
(2008)
Cancer Cell
, vol.13
, pp. 454-463
-
-
Lain, S.1
Hollick, J.J.2
Campbell, J.3
Staples, O.D.4
Higgins, M.5
Aoubala, M.6
McCarthy, A.7
Appleyard, V.8
Murray, K.E.9
Baker, L.10
-
69
-
-
0027109075
-
Cancer. p53, guardian of the genome
-
Lane D.P. Cancer. p53, guardian of the genome. Nature 358 (1992) 15-16
-
(1992)
Nature
, vol.358
, pp. 15-16
-
-
Lane, D.P.1
-
70
-
-
0018348655
-
T antigen is bound to a host protein in SV40-transformed cells
-
Lane D.P., and Crawford L.V. T antigen is bound to a host protein in SV40-transformed cells. Nature 278 (1979) 261-263
-
(1979)
Nature
, vol.278
, pp. 261-263
-
-
Lane, D.P.1
Crawford, L.V.2
-
71
-
-
33646807491
-
Transcriptional regulation by p53: one protein, many possibilities
-
Laptenko O., and Prives C. Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ. 13 (2006) 951-961
-
(2006)
Cell Death Differ.
, vol.13
, pp. 951-961
-
-
Laptenko, O.1
Prives, C.2
-
72
-
-
0037459377
-
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation
-
Leng R.P., Lin Y., Ma W., Wu H., Lemmers B., Chung S., Parant J.M., Lozano G., Hakem R., and Benchimol S. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell 112 (2003) 779-791
-
(2003)
Cell
, vol.112
, pp. 779-791
-
-
Leng, R.P.1
Lin, Y.2
Ma, W.3
Wu, H.4
Lemmers, B.5
Chung, S.6
Parant, J.M.7
Lozano, G.8
Hakem, R.9
Benchimol, S.10
-
73
-
-
2342553892
-
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
-
Leu J.I., Dumont P., Hafey M., Murphy M.E., and George D.L. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat. Cell Biol. 6 (2004) 443-450
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 443-450
-
-
Leu, J.I.1
Dumont, P.2
Hafey, M.3
Murphy, M.E.4
George, D.L.5
-
74
-
-
0030941458
-
p53, the cellular gatekeeper for growth and division
-
Levine A.J. p53, the cellular gatekeeper for growth and division. Cell 88 (1997) 323-331
-
(1997)
Cell
, vol.88
, pp. 323-331
-
-
Levine, A.J.1
-
75
-
-
0037061508
-
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
-
Li M., Chen D., Shiloh A., Luo J., Nikolaev A.Y., Qin J., and Gu W. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 416 (2002) 648-653
-
(2002)
Nature
, vol.416
, pp. 648-653
-
-
Li, M.1
Chen, D.2
Shiloh, A.3
Luo, J.4
Nikolaev, A.Y.5
Qin, J.6
Gu, W.7
-
76
-
-
0037184969
-
Acetylation of p53 inhibits its ubiquitination by Mdm2
-
Li M., Luo J., Brooks C.L., and Gu W. Acetylation of p53 inhibits its ubiquitination by Mdm2. J. Biol. Chem. 277 (2002) 50607-50611
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50607-50611
-
-
Li, M.1
Luo, J.2
Brooks, C.L.3
Gu, W.4
-
77
-
-
0348134742
-
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2
-
Li M., Brooks C.L., Wu-Baer F., Chen D., Baer R., and Gu W. Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science 302 (2003) 1972-1975
-
(2003)
Science
, vol.302
, pp. 1972-1975
-
-
Li, M.1
Brooks, C.L.2
Wu-Baer, F.3
Chen, D.4
Baer, R.5
Gu, W.6
-
78
-
-
1842421376
-
A dynamic role of HAUSP in the p53-Mdm2 pathway
-
Li M., Brooks C.L., Kon N., and Gu W. A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol. Cell 13 (2004) 879-886
-
(2004)
Mol. Cell
, vol.13
, pp. 879-886
-
-
Li, M.1
Brooks, C.L.2
Kon, N.3
Gu, W.4
-
79
-
-
0142123127
-
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
-
Linares L.K., Hengstermann A., Ciechanover A., Muller S., and Scheffner M. HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Proc. Natl. Acad. Sci. USA 100 (2003) 12009-12014
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 12009-12014
-
-
Linares, L.K.1
Hengstermann, A.2
Ciechanover, A.3
Muller, S.4
Scheffner, M.5
-
80
-
-
0018760324
-
Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
-
Linzer D.I., and Levine A.J. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17 (1979) 43-52
-
(1979)
Cell
, vol.17
, pp. 43-52
-
-
Linzer, D.I.1
Levine, A.J.2
-
81
-
-
0032906633
-
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
-
Liu L., Scolnick D.M., Trievel R.C., Zhang H.B., Marmorstein R., Halazonetis T.D., and Berger S.L. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol. Cell. Biol. 19 (1999) 1202-1209
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1202-1209
-
-
Liu, L.1
Scolnick, D.M.2
Trievel, R.C.3
Zhang, H.B.4
Marmorstein, R.5
Halazonetis, T.D.6
Berger, S.L.7
-
82
-
-
22144452221
-
Facilitated search for specific genomic targets by p53 C-terminal basic DNA binding domain
-
Liu Y., Lagowski J.P., Vanderbeek G.E., and Kulesz-Martin M.F. Facilitated search for specific genomic targets by p53 C-terminal basic DNA binding domain. Cancer Biol. Ther. 3 (2004) 1102-1108
-
(2004)
Cancer Biol. Ther.
, vol.3
, pp. 1102-1108
-
-
Liu, Y.1
Lagowski, J.P.2
Vanderbeek, G.E.3
Kulesz-Martin, M.F.4
-
83
-
-
0034744224
-
Stabilization of p53 by p14(ARF) without relocation of MDM2 to the nucleolus
-
Llanos S., Clark P.A., Rowe J., and Peters G. Stabilization of p53 by p14(ARF) without relocation of MDM2 to the nucleolus. Nat. Cell Biol. 3 (2001) 445-452
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 445-452
-
-
Llanos, S.1
Clark, P.A.2
Rowe, J.3
Peters, G.4
-
84
-
-
0035201820
-
C-terminal ubiquitination of p53 contributes to nuclear export
-
Lohrum M.A., Woods D.B., Ludwig R.L., Balint E., and Vousden K.H. C-terminal ubiquitination of p53 contributes to nuclear export. Mol. Cell. Biol. 21 (2001) 8521-8532
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 8521-8532
-
-
Lohrum, M.A.1
Woods, D.B.2
Ludwig, R.L.3
Balint, E.4
Vousden, K.H.5
-
85
-
-
0038724615
-
Regulation of HDM2 activity by the ribosomal protein L11
-
Lohrum M.A., Ludwig R.L., Kubbutat M.H., Hanlon M., and Vousden K.H. Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell 3 (2003) 577-587
-
(2003)
Cancer Cell
, vol.3
, pp. 577-587
-
-
Lohrum, M.A.1
Ludwig, R.L.2
Kubbutat, M.H.3
Hanlon, M.4
Vousden, K.H.5
-
86
-
-
0037309326
-
Tumor suppression by Ink4a-Arf: progress and puzzles
-
Lowe S.W., and Sherr C.J. Tumor suppression by Ink4a-Arf: progress and puzzles. Curr. Opin. Genet. Dev. 13 (2003) 77-83
-
(2003)
Curr. Opin. Genet. Dev.
, vol.13
, pp. 77-83
-
-
Lowe, S.W.1
Sherr, C.J.2
-
87
-
-
35148893194
-
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop
-
Lu X., Ma O., Nguyen T.A., Jones S.N., Oren M., and Donehower L.A. The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell 12 (2007) 342-354
-
(2007)
Cancer Cell
, vol.12
, pp. 342-354
-
-
Lu, X.1
Ma, O.2
Nguyen, T.A.3
Jones, S.N.4
Oren, M.5
Donehower, L.A.6
-
88
-
-
0034676439
-
Deacetylation of p53 modulates its effect on cell growth and apoptosis
-
Luo J., Su F., Chen D., Shiloh A., and Gu W. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408 (2000) 377-381
-
(2000)
Nature
, vol.408
, pp. 377-381
-
-
Luo, J.1
Su, F.2
Chen, D.3
Shiloh, A.4
Gu, W.5
-
89
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo J., Nikolaev A.Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., and Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 (2001) 137-148
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.3
Chen, D.4
Su, F.5
Shiloh, A.6
Guarente, L.7
Gu, W.8
-
90
-
-
20844451888
-
Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23
-
MacPherson D., Kim J., Kim T., Rhee B.K., Van Oostrom C.T., DiTullio R.A., Venere M., Halazonetis T.D., Bronson R., De Vries A., et al. Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. EMBO J. 23 (2004) 3689-3699
-
(2004)
EMBO J.
, vol.23
, pp. 3689-3699
-
-
MacPherson, D.1
Kim, J.2
Kim, T.3
Rhee, B.K.4
Van Oostrom, C.T.5
DiTullio, R.A.6
Venere, M.7
Halazonetis, T.D.8
Bronson, R.9
De Vries, A.10
-
91
-
-
34548256424
-
The role of ubiquitination in the direct mitochondrial death program of p53
-
Marchenko N.D., and Moll U.M. The role of ubiquitination in the direct mitochondrial death program of p53. Cell Cycle 6 (2007) 1718-1723
-
(2007)
Cell Cycle
, vol.6
, pp. 1718-1723
-
-
Marchenko, N.D.1
Moll, U.M.2
-
92
-
-
33847276654
-
Monoubiquitylation promotes mitochondrial p53 translocation
-
Marchenko N.D., Wolff S., Erster S., Becker K., and Moll U.M. Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J. 26 (2007) 923-934
-
(2007)
EMBO J.
, vol.26
, pp. 923-934
-
-
Marchenko, N.D.1
Wolff, S.2
Erster, S.3
Becker, K.4
Moll, U.M.5
-
94
-
-
33646794425
-
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4
-
Marine J.C., Francoz S., Maetens M., Wahl G., Toledo F., and Lozano G. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ. 13 (2006) 927-934
-
(2006)
Cell Death Differ.
, vol.13
, pp. 927-934
-
-
Marine, J.C.1
Francoz, S.2
Maetens, M.3
Wahl, G.4
Toledo, F.5
Lozano, G.6
-
95
-
-
0036710512
-
The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network
-
Mayo L.D., and Donner D.B. The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Trends Biochem. Sci. 27 (2002) 462-467
-
(2002)
Trends Biochem. Sci.
, vol.27
, pp. 462-467
-
-
Mayo, L.D.1
Donner, D.B.2
-
96
-
-
3242883729
-
The p53 response to DNA damage
-
Meek D.W. The p53 response to DNA damage. DNA Repair (Amst.) 3 (2004) 1049-1056
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 1049-1056
-
-
Meek, D.W.1
-
98
-
-
34547669249
-
The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain
-
Mellert H., Sykes S.M., Murphy M.E., and McMahon S.B. The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain. Cell Cycle 6 (2007) 1304-1306
-
(2007)
Cell Cycle
, vol.6
, pp. 1304-1306
-
-
Mellert, H.1
Sykes, S.M.2
Murphy, M.E.3
McMahon, S.B.4
-
99
-
-
25444478027
-
ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation
-
Meulmeester E., Pereg Y., Shiloh Y., and Jochemsen A.G. ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation. Cell Cycle 4 (2005) 1166-1170
-
(2005)
Cell Cycle
, vol.4
, pp. 1166-1170
-
-
Meulmeester, E.1
Pereg, Y.2
Shiloh, Y.3
Jochemsen, A.G.4
-
100
-
-
0037329056
-
The p53-Mdm2 module and the ubiquitin system
-
Michael D., and Oren M. The p53-Mdm2 module and the ubiquitin system. Semin. Cancer Biol. 13 (2003) 49-58
-
(2003)
Semin. Cancer Biol.
, vol.13
, pp. 49-58
-
-
Michael, D.1
Oren, M.2
-
101
-
-
0036311067
-
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
-
Migliorini D., Denchi E.L., Danovi D., Jochemsen A., Capillo M., Gobbi A., Helin K., Pelicci P.G., and Marine J.C. Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol. Cell. Biol. 22 (2002) 5527-5538
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 5527-5538
-
-
Migliorini, D.1
Denchi, E.L.2
Danovi, D.3
Jochemsen, A.4
Capillo, M.5
Gobbi, A.6
Helin, K.7
Pelicci, P.G.8
Marine, J.C.9
-
102
-
-
0037349289
-
p53 has a direct apoptogenic role at the mitochondria
-
Mihara M., Erster S., Zaika A., Petrenko O., Chittenden T., Pancoska P., and Moll U.M. p53 has a direct apoptogenic role at the mitochondria. Mol. Cell 11 (2003) 577-590
-
(2003)
Mol. Cell
, vol.11
, pp. 577-590
-
-
Mihara, M.1
Erster, S.2
Zaika, A.3
Petrenko, O.4
Chittenden, T.5
Pancoska, P.6
Moll, U.M.7
-
103
-
-
8844232663
-
The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression
-
Minsky N., and Oren M. The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. Mol. Cell 16 (2004) 631-639
-
(2004)
Mol. Cell
, vol.16
, pp. 631-639
-
-
Minsky, N.1
Oren, M.2
-
104
-
-
0028823020
-
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
-
Montes de Oca Luna R., Wagner D.S., and Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378 (1995) 203-206
-
(1995)
Nature
, vol.378
, pp. 203-206
-
-
Montes de Oca Luna, R.1
Wagner, D.S.2
Lozano, G.3
-
105
-
-
33745194153
-
Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription
-
Ohkubo S., Tanaka T., Taya Y., Kitazato K., and Prives C. Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription. J. Biol. Chem. 281 (2006) 16943-16950
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 16943-16950
-
-
Ohkubo, S.1
Tanaka, T.2
Taya, Y.3
Kitazato, K.4
Prives, C.5
-
106
-
-
0034863683
-
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
-
Parant J., Chavez-Reyes A., Little N.A., Yan W., Reinke V., Jochemsen A.G., and Lozano G. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat. Genet. 29 (2001) 92-95
-
(2001)
Nat. Genet.
, vol.29
, pp. 92-95
-
-
Parant, J.1
Chavez-Reyes, A.2
Little, N.A.3
Yan, W.4
Reinke, V.5
Jochemsen, A.G.6
Lozano, G.7
-
107
-
-
0034644274
-
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
-
Pearson M., Carbone R., Sebastiani C., Cioce M., Fagioli M., Saito S., Higashimoto Y., Appella E., Minucci S., Pandolfi P.P., et al. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406 (2000) 207-210
-
(2000)
Nature
, vol.406
, pp. 207-210
-
-
Pearson, M.1
Carbone, R.2
Sebastiani, C.3
Cioce, M.4
Fagioli, M.5
Saito, S.6
Higashimoto, Y.7
Appella, E.8
Minucci, S.9
Pandolfi, P.P.10
-
108
-
-
33846239416
-
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity
-
Poyurovsky M.V., Priest C., Kentsis A., Borden K.L., Pan Z.Q., Pavletich N., and Prives C. The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J. 26 (2007) 90-101
-
(2007)
EMBO J.
, vol.26
, pp. 90-101
-
-
Poyurovsky, M.V.1
Priest, C.2
Kentsis, A.3
Borden, K.L.4
Pan, Z.Q.5
Pavletich, N.6
Prives, C.7
-
109
-
-
33845185824
-
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo
-
Ringshausen I., O'Shea C.C., Finch A.J., Swigart L.B., and Evan G.I. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell 10 (2006) 501-514
-
(2006)
Cancer Cell
, vol.10
, pp. 501-514
-
-
Ringshausen, I.1
O'Shea, C.C.2
Finch, A.J.3
Swigart, L.B.4
Evan, G.I.5
-
110
-
-
0032530486
-
DNA damage activates p53 through a phosphorylation-acetylation cascade
-
Sakaguchi K., Herrera J.E., Saito S., Miki T., Bustin M., Vassilev A., Anderson C.W., and Appella E. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 12 (1998) 2831-2841
-
(1998)
Genes Dev.
, vol.12
, pp. 2831-2841
-
-
Sakaguchi, K.1
Herrera, J.E.2
Saito, S.3
Miki, T.4
Bustin, M.5
Vassilev, A.6
Anderson, C.W.7
Appella, E.8
-
111
-
-
17944379798
-
ASPP proteins specifically stimulate the apoptotic function of p53
-
Samuels-Lev Y., O'Connor D.J., Bergamaschi D., Trigiante G., Hsieh J.K., Zhong S., Campargue I., Naumovski L., Crook T., and Lu X. ASPP proteins specifically stimulate the apoptotic function of p53. Mol. Cell 8 (2001) 781-794
-
(2001)
Mol. Cell
, vol.8
, pp. 781-794
-
-
Samuels-Lev, Y.1
O'Connor, D.J.2
Bergamaschi, D.3
Trigiante, G.4
Hsieh, J.K.5
Zhong, S.6
Campargue, I.7
Naumovski, L.8
Crook, T.9
Lu, X.10
-
112
-
-
41649102468
-
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
-
Shangary S., Qin D., McEachern D., Liu M., Miller R.S., Qiu S., Nikolovska-Coleska Z., Ding K., Wang G., Chen J., et al. Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc. Natl. Acad. Sci. USA 105 (2008) 3933-3938
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 3933-3938
-
-
Shangary, S.1
Qin, D.2
McEachern, D.3
Liu, M.4
Miller, R.S.5
Qiu, S.6
Nikolovska-Coleska, Z.7
Ding, K.8
Wang, G.9
Chen, J.10
-
113
-
-
65249100143
-
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy
-
Shangary S., and Wang S. Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Annu. Rev. Pharmacol. Toxicol. 49 (2009) 223-241
-
(2009)
Annu. Rev. Pharmacol. Toxicol.
, vol.49
, pp. 223-241
-
-
Shangary, S.1
Wang, S.2
-
114
-
-
33747819484
-
Divorcing ARF and p53: an unsettled case
-
Sherr C.J. Divorcing ARF and p53: an unsettled case. Nat. Rev. Cancer 6 (2006) 663-673
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 663-673
-
-
Sherr, C.J.1
-
115
-
-
34547809957
-
Modulation of p53 function by SET8-mediated methylation at lysine 382
-
Shi X., Kachirskaia I., Yamaguchi H., West L.E., Wen H., Wang E.W., Dutta S., Appella E., and Gozani O. Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol. Cell 27 (2007) 636-646
-
(2007)
Mol. Cell
, vol.27
, pp. 636-646
-
-
Shi, X.1
Kachirskaia, I.2
Yamaguchi, H.3
West, L.E.4
Wen, H.5
Wang, E.W.6
Dutta, S.7
Appella, E.8
Gozani, O.9
-
116
-
-
0030667702
-
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
-
Shieh S.Y., Ikeda M., Taya Y., and Prives C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91 (1997) 325-334
-
(1997)
Cell
, vol.91
, pp. 325-334
-
-
Shieh, S.Y.1
Ikeda, M.2
Taya, Y.3
Prives, C.4
-
117
-
-
0034142034
-
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
-
Shieh S.Y., Ahn J., Tamai K., Taya Y., and Prives C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 14 (2000) 289-300
-
(2000)
Genes Dev.
, vol.14
, pp. 289-300
-
-
Shieh, S.Y.1
Ahn, J.2
Tamai, K.3
Taya, Y.4
Prives, C.5
-
118
-
-
1642458412
-
Phosphorylation of serine 18 regulates distinct p53 functions in mice
-
Sluss H.K., Armata H., Gallant J., and Jones S.N. Phosphorylation of serine 18 regulates distinct p53 functions in mice. Mol. Cell. Biol. 24 (2004) 976-984
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 976-984
-
-
Sluss, H.K.1
Armata, H.2
Gallant, J.3
Jones, S.N.4
-
119
-
-
46949093338
-
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex
-
Song M.S., Song S.J., Kim S.Y., Oh H.J., and Lim D.S. The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. EMBO J. 27 (2008) 1863-1874
-
(2008)
EMBO J.
, vol.27
, pp. 1863-1874
-
-
Song, M.S.1
Song, S.J.2
Kim, S.Y.3
Oh, H.J.4
Lim, D.S.5
-
120
-
-
2342567852
-
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
-
Stommel J.M., and Wahl G.M. Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J. 23 (2004) 1547-1556
-
(2004)
EMBO J.
, vol.23
, pp. 1547-1556
-
-
Stommel, J.M.1
Wahl, G.M.2
-
121
-
-
2942702012
-
Yin Yang 1 is a negative regulator of p53
-
Sui G., Affar E.B., Shi Y., Brignone C., Wall N.R., Yin P., Donohoe M., Luke M.P., Calvo D., and Grossman S.R. Yin Yang 1 is a negative regulator of p53. Cell 117 (2004) 859-872
-
(2004)
Cell
, vol.117
, pp. 859-872
-
-
Sui, G.1
Affar, E.B.2
Shi, Y.3
Brignone, C.4
Wall, N.R.5
Yin, P.6
Donohoe, M.7
Luke, M.P.8
Calvo, D.9
Grossman, S.R.10
-
122
-
-
33845656738
-
Acetylation of the p53 DNA-binding domain regulates apoptosis induction
-
Sykes S.M., Mellert H.S., Holbert M.A., Li K., Marmorstein R., Lane W.S., and McMahon S.B. Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol. Cell 24 (2006) 841-851
-
(2006)
Mol. Cell
, vol.24
, pp. 841-851
-
-
Sykes, S.M.1
Mellert, H.S.2
Holbert, M.A.3
Li, K.4
Marmorstein, R.5
Lane, W.S.6
McMahon, S.B.7
-
123
-
-
0035028599
-
Kinetics of p53 binding to promoter sites in vivo
-
Szak S.T., Mays D., and Pietenpol J.A. Kinetics of p53 binding to promoter sites in vivo. Mol. Cell. Biol. 21 (2001) 3375-3386
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3375-3386
-
-
Szak, S.T.1
Mays, D.2
Pietenpol, J.A.3
-
124
-
-
33746648187
-
Critical role for Daxx in regulating Mdm2
-
Tang J., Qu L.K., Zhang J., Wang W., Michaelson J.S., Degenhardt Y.Y., El-Deiry W.S., and Yang X. Critical role for Daxx in regulating Mdm2. Nat. Cell Biol. 8 (2006) 855-862
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 855-862
-
-
Tang, J.1
Qu, L.K.2
Zhang, J.3
Wang, W.4
Michaelson, J.S.5
Degenhardt, Y.Y.6
El-Deiry, W.S.7
Yang, X.8
-
125
-
-
33845668241
-
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
-
Tang Y., Luo J., Zhang W., and Gu W. Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol. Cell 24 (2006) 827-839
-
(2006)
Mol. Cell
, vol.24
, pp. 827-839
-
-
Tang, Y.1
Luo, J.2
Zhang, W.3
Gu, W.4
-
126
-
-
43049163953
-
Acetylation is indispensable for p53 activation
-
Tang Y., Zhao W., Chen Y., Zhao Y., and Gu W. Acetylation is indispensable for p53 activation. Cell 133 (2008) 612-626
-
(2008)
Cell
, vol.133
, pp. 612-626
-
-
Tang, Y.1
Zhao, W.2
Chen, Y.3
Zhao, Y.4
Gu, W.5
-
127
-
-
34547956843
-
hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes
-
Tanaka T., Ohkubo S., Tatsuno I., and Prives C. hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell 130 (2007) 638-650
-
(2007)
Cell
, vol.130
, pp. 638-650
-
-
Tanaka, T.1
Ohkubo, S.2
Tatsuno, I.3
Prives, C.4
-
128
-
-
44649141966
-
Regulation of autophagy by cytoplasmic p53
-
Tasdemir E., Maiuri M.C., Galluzzi L., Vitale I., Djavaheri-Mergny M., D'Amelio M., Criollo A., Morselli E., Zhu C., Harper F., et al. Regulation of autophagy by cytoplasmic p53. Nat. Cell Biol. 10 (2008) 676-687
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 676-687
-
-
Tasdemir, E.1
Maiuri, M.C.2
Galluzzi, L.3
Vitale, I.4
Djavaheri-Mergny, M.5
D'Amelio, M.6
Criollo, A.7
Morselli, E.8
Zhu, C.9
Harper, F.10
-
129
-
-
0028922929
-
p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60
-
Thut C.J., Chen J.L., Klemm R., and Tjian R. p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. Science 267 (1995) 100-104
-
(1995)
Science
, vol.267
, pp. 100-104
-
-
Thut, C.J.1
Chen, J.L.2
Klemm, R.3
Tjian, R.4
-
130
-
-
67349221185
-
KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis
-
10.1038/ncb1864 in press Published online April 19, 2009
-
Tian C., Xing G., Xie P., Lu K., Nie J., Wang J., Li L., Gao M., Zhang L., and He F. KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat. Cell Biol. (2009) 10.1038/ncb1864 in press Published online April 19, 2009
-
(2009)
Nat. Cell Biol.
-
-
Tian, C.1
Xing, G.2
Xie, P.3
Lu, K.4
Nie, J.5
Wang, J.6
Li, L.7
Gao, M.8
Zhang, L.9
He, F.10
-
131
-
-
33845270990
-
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
-
Toledo F., and Wahl G.M. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat. Rev. Cancer 6 (2006) 909-923
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 909-923
-
-
Toledo, F.1
Wahl, G.M.2
-
132
-
-
33646826684
-
WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization
-
Tomita Y., Marchenko N., Erster S., Nemajerova A., Dehner A., Klein C., Pan H., Kessler H., Pancoska P., and Moll U.M. WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization. J. Biol. Chem. 281 (2006) 8600-8606
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 8600-8606
-
-
Tomita, Y.1
Marchenko, N.2
Erster, S.3
Nemajerova, A.4
Dehner, A.5
Klein, C.6
Pan, H.7
Kessler, H.8
Pancoska, P.9
Moll, U.M.10
-
133
-
-
32444449180
-
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy
-
Tovar C., Rosinski J., Filipovic Z., Higgins B., Kolinsky K., Hilton H., Zhao X., Vu B.T., Qing W., Packman K., et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc. Natl. Acad. Sci. USA 103 (2006) 1888-1893
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 1888-1893
-
-
Tovar, C.1
Rosinski, J.2
Filipovic, Z.3
Higgins, B.4
Kolinsky, K.5
Hilton, H.6
Zhao, X.7
Vu, B.T.8
Qing, W.9
Packman, K.10
-
134
-
-
33644555840
-
ASPP [corrected] and cancer
-
Trigiante G., and Lu X. ASPP [corrected] and cancer. Nat. Rev. Cancer 6 (2006) 217-226
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 217-226
-
-
Trigiante, G.1
Lu, X.2
-
135
-
-
33846193699
-
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
-
Uldrijan S., Pannekoek W.J., and Vousden K.H. An essential function of the extreme C-terminus of MDM2 can be provided by MDMX. EMBO J. 26 (2007) 102-112
-
(2007)
EMBO J.
, vol.26
, pp. 102-112
-
-
Uldrijan, S.1
Pannekoek, W.J.2
Vousden, K.H.3
-
136
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev L.T., Vu B.T., Graves B., Carvajal D., Podlaski F., Filipovic Z., Kong N., Kammlott U., Lukacs C., Klein C., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 (2004) 844-848
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
-
137
-
-
0035913903
-
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., and Weinberg R.A. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107 (2001) 149-159
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Ng Eaton, E.3
Imai, S.I.4
Frye, R.A.5
Pandita, T.K.6
Guarente, L.7
Weinberg, R.A.8
-
140
-
-
33646787483
-
Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo
-
Wahl G.M. Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo. Cell Death Differ. 13 (2006) 973-983
-
(2006)
Cell Death Differ.
, vol.13
, pp. 973-983
-
-
Wahl, G.M.1
-
141
-
-
33745949757
-
Dual-site regulation of MDM2 E3-ubiquitin ligase activity
-
Wallace M., Worrall E., Pettersson S., Hupp T.R., and Ball K.L. Dual-site regulation of MDM2 E3-ubiquitin ligase activity. Mol. Cell 23 (2006) 251-263
-
(2006)
Mol. Cell
, vol.23
, pp. 251-263
-
-
Wallace, M.1
Worrall, E.2
Pettersson, S.3
Hupp, T.R.4
Ball, K.L.5
-
142
-
-
1542358136
-
Inhibition of p53 degradation by Mdm2 acetylation
-
Wang X., Taplick J., Geva N., and Oren M. Inhibition of p53 degradation by Mdm2 acetylation. FEBS Lett. 56 (2004) 195-201
-
(2004)
FEBS Lett.
, vol.56
, pp. 195-201
-
-
Wang, X.1
Taplick, J.2
Geva, N.3
Oren, M.4
-
143
-
-
0033130010
-
Nucleolar Arf sequesters Mdm2 and activates p53
-
Weber J.D., Taylor L.J., Roussel M.F., Sherr C.J., and Bar-Sagi D. Nucleolar Arf sequesters Mdm2 and activates p53. Nat. Cell Biol. 1 (1999) 20-26
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 20-26
-
-
Weber, J.D.1
Taylor, L.J.2
Roussel, M.F.3
Sherr, C.J.4
Bar-Sagi, D.5
-
144
-
-
30344478870
-
A global map of p53 transcription-factor binding sites in the human genome
-
Wei C.L., Wu Q., Vega V.B., Chiu K.P., Ng P., Zhang T., Shahab A., Yong H.C., Fu Y., Weng Z., et al. A global map of p53 transcription-factor binding sites in the human genome. Cell 124 (2006) 207-219
-
(2006)
Cell
, vol.124
, pp. 207-219
-
-
Wei, C.L.1
Wu, Q.2
Vega, V.B.3
Chiu, K.P.4
Ng, P.5
Zhang, T.6
Shahab, A.7
Yong, H.C.8
Fu, Y.9
Weng, Z.10
-
145
-
-
0036205321
-
Mutation of mouse p53 Ser23 and the response to DNA damage
-
Wu Z., Earle J., Saito S., Anderson C.W., Appella E., and Xu Y. Mutation of mouse p53 Ser23 and the response to DNA damage. Mol. Cell. Biol. 22 (2002) 2441-2449
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 2441-2449
-
-
Wu, Z.1
Earle, J.2
Saito, S.3
Anderson, C.W.4
Appella, E.5
Xu, Y.6
-
146
-
-
3142570737
-
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
-
Xirodimas D.P., Saville M.K., Bourdon J.C., Hay R.T., and Lane D.P. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 118 (2004) 83-97
-
(2004)
Cell
, vol.118
, pp. 83-97
-
-
Xirodimas, D.P.1
Saville, M.K.2
Bourdon, J.C.3
Hay, R.T.4
Lane, D.P.5
-
147
-
-
20444369867
-
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
-
Yang Y., Ludwig R.L., Jensen J.P., Pierre S.A., Medaglia M.V., Davydov I.V., Safiran Y.J., Oberoi P., Kenten J.H., Phillips A.C., et al. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell 7 (2005) 547-559
-
(2005)
Cancer Cell
, vol.7
, pp. 547-559
-
-
Yang, Y.1
Ludwig, R.L.2
Jensen, J.P.3
Pierre, S.A.4
Medaglia, M.V.5
Davydov, I.V.6
Safiran, Y.J.7
Oberoi, P.8
Kenten, J.H.9
Phillips, A.C.10
-
148
-
-
31944433282
-
The central region of HDM2 provides a second binding site for p53
-
Yu G.W., Rudiger S., Veprintsev D., Freund S., Fernandez-Fernandez M.R., and Fersht A.R. The central region of HDM2 provides a second binding site for p53. Proc. Natl. Acad. Sci. USA 103 (2006) 1227-1232
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 1227-1232
-
-
Yu, G.W.1
Rudiger, S.2
Veprintsev, D.3
Freund, S.4
Fernandez-Fernandez, M.R.5
Fersht, A.R.6
-
149
-
-
0242721592
-
Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway
-
Zhang Y., Wolf G.W., Bhat K., Jin A., Allio T., Burkhart W.A., and Xiong Y. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol. Cell. Biol. 23 (2003) 8902-8912
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 8902-8912
-
-
Zhang, Y.1
Wolf, G.W.2
Bhat, K.3
Jin, A.4
Allio, T.5
Burkhart, W.A.6
Xiong, Y.7
-
150
-
-
38749132992
-
Negative regulation of the deacetylase SIRT1 by DBC1
-
Zhao W., Kruse J.P., Tang Y., Jung S.Y., Qin J., and Gu W. Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451 (2008) 587-590
-
(2008)
Nature
, vol.451
, pp. 587-590
-
-
Zhao, W.1
Kruse, J.P.2
Tang, Y.3
Jung, S.Y.4
Qin, J.5
Gu, W.6
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