Natural inhibitors of PI3K/AKT signaling in breast cancer: Emphasis on newly-discovered molecular mechanisms of action

Pharmacological Research

Volumn 93, Issue , 2015, Pages 314-318

  Safdari, Yaghoub ^a,c   Khalili, Masoumeh ^b,e   Ebrahimzadeh, Mohammad Ali ^b   Yazdani, Yaghoub ^c   Farajnia, Safar ^d  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c GOLESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

AKT; Breast cancer; Natural inhibitors; PI3K

Indexed keywords

2 (2 DIFLUOROMETHYLBENZIMIDAZOL 1 YL) 4,6 DIMORPHOLINO 1,3,5 TRIAZINE; 2 BENZOYL 3 PHENYL 6,7 DICHLOROQUINOXALINE 1,4 DIOXIDE; 2 [4 (2 PIPERIDINOETHOXY)PHENYL] 3 PHENYL 2H 1 BENZOPYRAN; ALPELISIB; ANTINEOPLASTIC AGENT; ASCOFURANONE; BOSWELLIA OVALIFOLIOLATA EXTRACT; DRUG THERAPY; EPIDERMAL GROWTH FACTOR RECEPTOR; EVEROLIMUS; EXCISANIN A; FENRETINIDE; FLAVOPIRIDOL; GRAPE SEED EXTRACT; ISOLIQUIRITIGENIN; LL 202; MELITTIN; NAPHTHO[1,2 B]FURAN 4,5 DIONE; NATURAL PRODUCT; ORIDONIN; PHARMACOLOGY; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLANT EXTRACT; PLATYCODIN; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; QUERCETIN; RPF 101; RY 10 4; SILIBININ; TEHRANOLIDE; THYMOQUINONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; WOGONIN;

ANGIOGENESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARACHIDONIC ACID METABOLISM; ARTICLE; BOSWELLIA; BOSWELLIA OVALIFOLIOLATA; BREAST CANCER; BREAST CANCER CELL LINE; BREAST METASTASIS; BREAST NEOPLASMS; CANCER GROWTH; CELL CYCLE ARREST; CELL HYPOXIA; DOWN REGULATION; DRUG THERAPY; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; MCF 7 CELL LINE; METABOLISM; MITOCHONDRION; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR INVASION;

ANIMALS; ANTAGONISTS AND INHIBITORS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; DRUG THERAPY; FEMALE; HUMANS; METABOLISM; PHARMACOLOGY; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; THERAPEUTIC USE;

EID: 84920177908     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2014.12.004     Document Type: Review

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