Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma

Cellular and Molecular Life Sciences

Volumn 67, Issue 5, 2010, Pages 807-816

  Cuperus, Roos ^a   Leen, René ^a   Tytgat, Godelieve A M ^a   Caron, Huib N ^a   Van Kuilenburg, André B P ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Fenretinide; Mitochondrial respiratory chain; Mitoq; Neuroblastoma; Reactive oxygen species; Trolox

Indexed keywords

ADENOSINE TRIPHOSPHATE; FENRETINIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); 10 (6' UBIQUINONYL)DECYLTRIPHENYLPHOSPHONIUM BROMIDE; 10-(6'-UBIQUINONYL)DECYLTRIPHENYLPHOSPHONIUM BROMIDE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; DRUG DERIVATIVE; ORGANOPHOSPHORUS COMPOUND; UBIQUINONE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NEUROBLASTOMA CELL; OXIDATIVE STRESS; BIOLOGICAL MODEL; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; DRUG SCREENING; ELECTRON TRANSPORT; METABOLISM; MITOCHONDRION; NEUROBLASTOMA; PATHOLOGY; TUMOR CELL CULTURE;

VASCONCELLEA CANDICANS;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; ELECTRON TRANSPORT; FENRETINIDE; HUMANS; MITOCHONDRIA; MODELS, BIOLOGICAL; NEUROBLASTOMA; ORGANOPHOSPHORUS COMPOUNDS; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED; UBIQUINONE;

EID: 77949899141     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-0212-2     Document Type: Article

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