Mechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin - An in vitro and in silico approach

Chemico-Biological Interactions

Volumn 210, Issue 1, 2014, Pages 51-63

  Mohankumar, Kumaravel ^a   Pajaniradje, Sankar ^a   Sridharan, Subhashree ^a   Singh, Vivek Kumar ^a   Ronsard, Larance ^b   Banerjea, Akhil C ^b   Benson, Chellakkan Selvanesan ^c   Coumar, Mohane Selvaraj ^a   Rajagopalan, Rukkumani ^a  

^a PONDICHERRY UNIVERSITY   (India)

^b NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^c UNIVERSITY OF MADRAS   (India)

Author keywords

Apoptosis; BDMC A; Curcumin; MCF 7; Molecular docking; Western blotting

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 8; CASPASE 9; CURCUMIN; CYTOCHROME C; DICHLORODIHYDROFLUORESCEIN DIACETATE; FAS LIGAND; FLUORESCENT DYE; HYDROXYL GROUP; LIPOCORTIN 5; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PHOSPHATIDYLSERINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER SURVIVAL; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL;

APOPTOSIS; BDMC-A; CURCUMIN; MCF-7; MOLECULAR DOCKING; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MCF-7 CELLS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84893091135     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.12.006     Document Type: Article

References (44)

1. C.P. Prasad, G. Rath, S. Mathur, D. Bhatnagar, and R. Ralhan Potent growth suppressive activity of curcumin in human breast cancer cells: modulation of Wnt/beta-catenin signaling Chem. Biol. Interact. 181 2009 263 271
2. G. Sa, and T. Das Anti cancer effects of curcumin: cycle of life and death Cell. Div. 3 2008 14
3. B.B. Aggarwal, C. Sundaram, N. Malani, and H. Ichikawa Curcumin: the Indian solid gold Adv. Exp. Med. Biol. 595 2007 1 75
4. W.D. Lu, Y. Qin, C. Yang, and L. Li Effect of curcumin on human colon cancer multidrug resistance in vitro and in vivo Clinics 68 2013 5 10.6061/clinics/2013(05)18
5. P. Anand, C. Sundaram, S. Jhurani, A.B. Kunnumakkara, and B.B. Aggarwal Curcumin and cancer: an "old-age" disease with an "age-old" solution Cancer Lett. 267 2008 133 164
6. J. Ravindran, S. Prasad, and B.B. Aggarwal Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J. 11 2009 495 510
7. N.A. Abdullah Thani, B. Sallis, R. Nuttall, F.R. Schubert, M. Ahsan, D. Davies, S. Purewal, A. Cooper, and H.K. Rooprai Induction of apoptosis and reduction of MMP gene expression in the U373 cell line by polyphenolics in Aronia melanocarpa and by curcumin Oncol. Rep. 28 2012 1435 1442
8. J.M. Brown, and B.G. Wouters Apoptosis, p53, and tumor cell sensitivity to anticancer agents Cancer Res. 59 1999 1391 1399 (Pubitemid 29160097)
9. S. Elmore Apoptosis: a review of programmed cell death Toxicol. Pathol. 35 2007 495 516 (Pubitemid 46911891)
10. P. Anand, S.G. Thomas, A.B. Kunnumakkara, C. Sundaram, K.B. Harikumar, B. Sung, S.T. Tharakan, K. Misra, I.K. Priyadarsini, K.N. Rajasekharan, and B.B. Aggarwal Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature Biochem. Pharmacol. 76 2008 1590 1611
11. Y.L. Liu, H.P. Yang, L. Gong, C.L. Tang, and H.J. Wang Hypomethylation effects of curcumin, demethoxycurcumin and bisdemethoxycurcumin on WIF-1 promoter in non-small cell lung cancer cell lines Mol. Med. Rep. 4 2011 675 679
12. B. Yadav, S. Taurin, L. Larsen, and R.J. Rosengren RL71, a second-generation curcumin analog, induces apoptosis and downregulates Akt in ER-negative breast cancer cells Int. J. Oncol. 41 2012 1119 1127
13. F. Faião-Flores, J.A. Suarez, P.C. Pardi, and D.A. Maria DM-1, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy- phenolate: a curcumin analog with a synergic effect in combination with paclitaxel in breast cancer treatment Tumour Biol. 33 2012 775 785
14. R.J. Anto, J. George, K.V. Babu, K.N. Rajasekharan, and R. Kuttan Antimutagenic and anticarcino-genic activity of natural and synthetic curcuminoid Mutat. Res. 370 1996 127 131 (Pubitemid 26343824)
15. R.J. Anto, G. Kuttan, K.V.D. Babu, K.V. Rajasekharan, and R. Kuttan Anti-tumour and free radical scavenging activity of synthetic curcuminoids Inter. J. Pharm. 131 1996 1 7 (Pubitemid 26144947)
16. R. Rukkumani, K. Aruna, P.S. Varma, K.N. Rajasekaran, and V.P. Menon Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress J. Pharm. Pharm. Sci. 7 2004 274 283 (Pubitemid 41528902)
17. R. Rukkumani, K. Aruna, P.S. Varma, K.N. Rajasekaran, and V.P. Menon Comparative effects of curcumin and its analog on alcohol and polyunsaturated fatty acid-induced alterations in circulatory lipid profiles J. Med. Food 8 2005 256 260 (Pubitemid 41008992)
18. R. Rukkumani, K. Aruna, P.S. Varma, P. Viswanathan, K.N. Rajasekaran, and V.P. Menon Protective role of a novel curcuminoid on alcohol and PUFA-induced hyperlipidemia Toxicol. Mech. Methods 15 2005 227 234 (Pubitemid 40896651)
19. R. Rajagopalan, S. Sridharan, and V.P. Menon Hepatoprotective role of bis-demethoxy curcumin analog on the expression of matrix metalloproteinase induced by alcohol and polyunsaturated fatty acid in rats Toxicol. Mech. Methods 20 2010 252 259
20. T. Devasena, K.N. Rajasekaran, and V.P. Menon Bis-1,7-(2-hydroxyphenyl)- hepta-1,6-diene-3,5-dione (a curcumin analog) ameliorates DMH-induced hepatic oxidative stress during colon carcinogenesis Pharmacol. Res. 46 2002 39 45 (Pubitemid 35300791)
21. M.M. Hill, C. Adrain, P.J. Duriez, E.M. Creagh, and S.J. Martin Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes EMBO J. 23 2004 2134 2145 (Pubitemid 38737740)
22. M. Li, Z. Zhang, D.L. Hill, H. Wang, and R. Zhang Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway Cancer Res. 67 2007 1988 1996 (Pubitemid 46424215)
23. M.S. Squires, E.A. Hudson, L. Howells, S. Sale, C.E. Houghton, J.L. Jones, L.H. Fox, M. Dickens, S.A. Prigent, and M.M. Manson Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells Biochem. Pharmacol. 65 2003 361 376 (Pubitemid 36084553)
24. L.R. Chaudhary, and K.A. Hruska Inhibition of cell survival signal protein kinase B/Akt by curcumin in human prostate cancer cells J. Cell. Biochem. 89 2003 1 5 (Pubitemid 36459092)
25. K.V. Dinesh Babu, and K.N. Rajasekharan Simplified conditions for the synthesis of curcumin I and other curcuminoids Org. Prep. Proc. Int. 24 1994 674 677
26. R.J. Fido, A.S. Tatham, P.R. Shewry, Western blotting analysis, in: H. Jones (Ed.), Methods in Molecular Biology: Plant Gene Transfer and Expression Protocols, vol. 49, 1995, pp. 423-437.
27. P. Chomczynski, and N. Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal. Biochem. 162 1987 156 159 (Pubitemid 17064313)
28. M. Kumaravel, P. Sankar, and R. Rukkumani Antiproliferative effect of an analog of curcumin bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione in human breast cancer cells Eur. Rev. Med. Pharmacol. Sci. 16 2012 1900 1907
29. C. Brana, and C. Benham A method for characterising cell death in vitro by combining propidium iodide staining with immunoistochemistry Brain Res. Protoc. 10 2002 109 114 (Pubitemid 35335977)
30. C.A. Castaneda, H. Cortes-Funes, H.L. Gomez, and E.M. Ciruelos The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer Cancer Metastasis Rev. 29 2010 751 759
31. X.L. Xu, S.Z. Chen, W. Chen, W.H. Zheng, X.H. Xia, H.J. Yang, B. Li, and W.M. Mao The impact of cyclin D1 overexpression on the prognosis of ER-positive breast cancers: a meta-analysis Breast Cancer Res. Treat. 139 2013 329 339
32. R. Arunkumar, G. Sharmila, P. Elumalai, K. Senthilkumar, S. Banudevi, D.N. Gunadharini, C.S. Benson, P. Daisy, and J. Arunakaran Effect of diallyl disulfide on insulin like growth factor signaling molecules involved in cell survival and proliferation of human prostate cancer cells in vitro and in silico approach through docking analysis Phytomedicine 19 2012 912 923
33. N. Singh, D. Zaidi, H. Shyam, R. Sharma, and A.K. Balapure Polyphenols sensitization potentiates susceptibility of MCF-7 and MDA MB-231 cells to Centchroman PLoS One 7 2012 e37736 10.1371/journal.pone.0037736
34. S. Haupt, M. Berger, Z. Goldberg, and Y. Haupt Apoptosis - the p53 network J. Cell Sci. 116 2003 4077 4085 (Pubitemid 37337082)
35. T. Miyashita, and J.C. Reed Tumor suppressor p53 is a direct transcriptional activator of the human bax gene Cell 80 1995 293 299
36. K. Polyak, T. Waldman, T.C. He, K.W. Kinzler, and B. Vogelstein Genetic determinants of p53-induced apoptosis and growth arrest Genes Dev. 10 1996 1945 1952 (Pubitemid 26281688)
37. S. Kondo, Y. Tamura, J.W. Bawden, and S. Tanase The immunohistochemical localization of Bax and Bcl-2 and their relation to apoptosis during amelogenesis in developing rat molars Arch. Oral Biol. 46 2001 557 568 (Pubitemid 32476086)
38. J.J. Reiners Jr., J.A. Caruso, P. Mathieu, B. Chelladurai, X.M. Yin, and D. Kessel Release of cytochrome c and activation of pro-caspase-9 following lysosomal photodamage involves Bid cleavage Cell Death Differ. 9 2002 934 944 (Pubitemid 35033432)
39. S. Uddin, A.R. Hussain, P.S. Manogaran, K. Al-Hussein, L.C. Platanias, M.I. Gutierrez, and K.G. Bhatia Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma Oncogene 24 2005 7022 7030 (Pubitemid 41573631)
40. K.W. Sun, Y.Y. Ma, T.P. Guan, Y.J. Xia, C.M. Shao, L.G. Chen, Y.J. Ren, H.B. Yao, Q. Yang, and X.J. He Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway World J. Gastroenterol. 18 2012 7166 7174
41. H.F. Lu, K.C. Lai, S.C. Hsu, H.J. Lin, M.D. Yang, Y.L. Chen, M.J. Fan, J.S. Yang, P.Y. Cheng, C.L. Kuo, and J.G. Chung Curcumin induces apoptosis through FAS and FADD, in caspase-3-dependent and -independent pathways in theN18 mouse-rat hybrid retina ganglion cells Oncol. Rep. 22 2009 97 104
42. T. Ozben Oxidative stress and apoptosis: impact on cancer therapy J. Pharm. Sci. 96 2007 2181 2196 (Pubitemid 47477879)
43. E.H. Walker, M.E. Pacold, O. Perisic, L. Stephens, P.T. Hawkins, M.P. Whymann, and R.L. Williams Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine Mol. Cell 6 2000 909 919
44. M. Addie, P. Ballard, D. Buttar, C. Crafter, G. Currie, B.R. Davies, J. Debreczeni, H. Dry, P. Dudley, R. Greenwood, P.D. Johnson, J.G. Kettle, C. Lane, G. Lamont, A. Leach, R.W. Luke, J. Morris, D. Ogilvie, K. Page, M. Pass, S. Pearson, and L. Ruston Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3- hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases J. Med. Chem. 56 2013 2059 2073