LL-202, a newly synthesized flavonoid, inhibits tumor growth via inducing G2/M phase arrest and cell apoptosis in MCF-7 human breast cancer cells in vitro and in vivo

Toxicology Letters

Volumn 228, Issue 1, 2014, Pages 1-12

  Tao, Lei ^a   Fu, Rong ^b   Wang, Xiaoping ^b   Yao, Jing ^b   Zhou, Yuxin ^b   Dai, Qinsheng ^b   Li, Zhiyu ^b   Lu, Na ^b   Wang, Weiyun ^a  

^a ANHUI AGRICULTURAL UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle arrest; LL 202; MCF 7 cells; Mitochondria; ROS

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; CYCLIN A; CYCLIN B1; CYTOCHROME C; FLAVONOID; LL 202; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BID; PROTEIN P21; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CYTOSOL; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; M PHASE CELL CYCLE CHECKPOINT; MCF 7 CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; TUMOR XENOGRAFT;

APOPTOSIS; CELL CYCLE ARREST; LL-202; MCF-7 CELLS; MITOCHONDRIA; ROS;

ANIMALS; ANNEXIN A5; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; COLORING AGENTS; FLAVONOIDS; FREE RADICAL SCAVENGERS; G2 PHASE; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE, INBRED BALB C; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS; TETRAZOLIUM SALTS; THIAZOLES;

EID: 84899870846     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.04.002     Document Type: Article

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