Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells

Environmental Toxicology and Pharmacology

Volumn 38, Issue 1, 2014, Pages 58-70

  Thummuri, Dinesh ^a   Jeengar, Manish Kumar ^a   Shrivastava, Shweta ^a   Areti, Aparna ^a   Yerra, Veera Ganesh ^a   Yamjala, Samyuktha ^a   Komirishetty, Prashanth ^a   Naidu, V G M ^a   Kumar, Ashutosh ^a   Sistla, Ramakrishna ^b  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Boswellia ovalifoliolata; Chemoresistance; NF B; ROS; S phase; TNBC

Indexed keywords

ACRIDINE ORANGE; ANTINEOPLASTIC AGENT; BOSWELLIA OVALIFOLIOLATA EXTRACT; CASPASE 3; CISPLATIN; DOXORUBICIN; ETHIDIUM BROMIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; BAX PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; BOSWELLIA; BOSWELLIA OVALIFOLIOLATA; CANCER CELL CULTURE; CANCER MORPHOLOGY; CANCER RESISTANCE; CHEMOSENSITIZATION; COLON CANCER; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVITY; FLUORESCENCE MICROSCOPY; IC 50; LUNG CANCER; PLANT LEAF; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT; TRIPLE NEGATIVE BREAST CANCER; UPREGULATION; UTERINE CERVIX CANCER; WESTERN BLOTTING; CELL CYCLE; CELL SURVIVAL; DRUG EFFECTS; DRUG RESISTANCE; FEMALE; HUMAN; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BOSWELLIA; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; DNA FRAGMENTATION; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; NF-KAPPA B; PLANT EXTRACTS; PLANT LEAVES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84901981420     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2014.05.002     Document Type: Article

References (35)

1. Anders C., Carey L.A. Understanding and treating triple-negative breast cancer. Oncology 2008, 22(11):1233-1239.
2. Anitha G., Sudarsanam G. Studies on antimicrobial activity of Boswellia ovalifoliolata against Xanthomonas - citri and Salmonella thyphynurium. Int. J. Appl. Biol. Pharm. Technol. 2011, 4(1):243-247.
3. Athar M., Back J.H., Tang X., Kim K.H., Kopelovich L., Bickers D.R., Kim A.L. Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol. Appl. Pharmacol. 2007, 224(3):274-283.
4. Bansal P., Gupta V.V., Bansal R., Sapra R. Dietary phytochemicals in cell cycle arrest and apoptosis - an insight. J. Drug Deliv. Ther. 2012, 2(2):8-17.
5. Biswas R., Mandal S.K., Dutta S., Bhattacharyya S.S., Boujedaini N., Khuda A.R., Bukhsh Thujone-rich fraction of Thuja occidentalis demonstrates major anti-cancer potentials: evidences from in vitro studies on A375 cells. Evid. Based Complement Altern. Med. 2011, 1-16. 2011.
6. 1 expression in oral carcinogenic models. J. Nutr. Biochem. 2007, 18(10):667-675.
7. Chou T.-C., Talalay P. Analysis of combined drug effects: a new look at a very old problem. Trends Pharmacol. Sci. 1983, 4:450-454.
8. DeSantis C., Siegel R., Bandi P., Jemal A. Breast cancer statistics, 2011. CA Cancer J. Clin. 2011, 61(6):408-418.
9. Devi P.S., Adilaxmamma K., Rao G.S., Srilatha C. Evaluation of anti-inflammatory activity of stem bark of Boswellia ovalifoliolata in rats. Toxicol. Int. 2012, 19(2):115-120.
10. Estrov Z., Shishodia S., Faderl S., Harris D., Van Q., Kantarjian H.M., Talpaz M., Aggarwal B.B. Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood 2003, 102(3):987-995.
11. Giri K., Ghosh U., Bhattacharyya N.P., Basak S. Caspase 8 mediated apoptotic cell death induced by beta-sheet forming polyalanine peptides. FEBS Lett. 2003, 555(2):380-384.
12. Gu J.-W., Makey K.L., Tucker K.B., Chinchar E., Mao X., Pei I., Thomas E.Y., Miele L. EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression. Vasc. Cell 2013, 5(1):9.
13. Joe A.K., Liu H., Suzui M., Vural M.E., Xiao D., Weinstein I.B. Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin. Cancer Res. 2002, 8(3):893-903.
14. Jónsson ZaO, Hübscher U. Proliferating cell nuclear antigen: more than a clamp for DNA polymerases. Bioessays 1997, 19(11):967-975.
15. Kloesch B., Becker T., Dietersdorfer E., Kiener H., Steiner G. Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes. Int. Immunopharmacol. 2013, 15(2):400-405.
16. Kumar B.D. In vivo analgesic activity of petroleum ether extract of Boswellia ovalifoliolata Linn. leaves. Int. J. Res. Pharmacol. Pharmacother. 2012, 1(1).
17. Lee M.-H., Choi B.Y., Kundu J.K., Shin Y.K., Na H.-K., Surh Y.-J. Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. Cancer Res. 2009, 69(18):7449-7458.
18. Lee S.T., Li Z., Wu Z., Aau M., Guan P., Karuturi R.K., Liou Y.C., Yu Q. Context-specific regulation of NF-kappaB target gene expression by EZH2 in breast cancers. Mol. Cell 2011, 43(5):798-810.
19. Lee E.-J., Oh S.-Y., Sung M.-K. Luteolin exerts anti-tumor activity through the suppression of epidermal growth factor receptor-mediated pathway in MDA-MB-231 ER-negative breast cancer cells. Food Chem. Toxicol. 2012, 50(11):4136-4143.
20. Liu D., Chen Z. The effect of curcumin on breast cancer cells. J. Breast Cancer 2013, 16(2):133-137.
21. Manda G., Nechifor M.T., Neagu T.-M. Reactive oxygen species, cancer and anti-cancer therapies. Curr. Chem. Biol. 2009, 3(1):22-46.
22. Metzger-Filho O., Tutt A., de Azambuja E., Saini K.S., Viale G., Loi S., Bradbury I., Bliss J.M., Azim H.A., Ellis P. Dissecting the heterogeneity of triple-negative breast cancer. J. Clin. Oncol. 2012, 30(15):1879-1887.
23. Nabekura T. Overcoming multidrug resistance in human cancer cells by natural compounds. Toxins 2010, 2(6):1207-1224.
24. Naidu V., Bandari U.M., Giddam A.K., Babu K.R.D., Ding J., Babu K.S., Ramesh B., Pragada R.R., Gopalakrishnakone P. Apoptogenic activity of ethyl acetate extract of leaves of Memecylon edule on human gastric carcinoma cells via mitochondrial dependent pathway. Asian Pac. J. Trop. Med. 2013, 6(5):337-345.
25. Nakshatri H., Bhat-Nakshatri P., Martin D.A., Goulet R., Sledge G. Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth. Mol. Cell. Biol. 1997, 17(7):3629-3639.
26. Oeckinghaus A., Ghosh S. The NF-kB family of transcription factors and its regulation. Cold Spring Harb. Perspect. Biol. 2009, 1:a000034.
27. Perou C.M., SÃ̧rlie T., Eisen M.B., van de Rijn M., Jeffrey S.S., Rees C.A., Pollack J.R., Ross D.T., Johnsen H., Akslen L.A. Molecular portraits of human breast tumours. Nature 2000, 406(6797):747-752.
28. Porter A.G., JÃnicke R.U. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 1999, 6(2).
29. Ravichandran N., Suresh G., Ramesh B., Vijaiyan Siva G. Fisetin, a novel flavonol attenuates benzo (a) pyrene-induced lung carcinogenesis in Swiss albino mice. Food Chem. Toxicol. 2011, 49(5):1141-1147.
30. Rebecca D., Maureen T., Kathleen I.P., Wedad M.H., Harriet K.K., Carol A.S. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin. Cancer Res. 2007, 13(15):4429-4434.
31. Ribble D., Goldstein N.B., Norris D.A., Shellman Y.G. A simple technique for quantifying apoptosis in 96-well plates. BMC Biotechnol. 2005, 5(1):5-12.
32. Savithramma N., Venkateswarlu P., Suhrulatha D., Basha S., Devi C. Studies of Boswellia ovalifoliolata Bal. and Henry - an endemic and endangered medicinal plant. Bioscan 2010, 5(3):359-362.
33. Uma Mahesh B., Shrivastava S., Kuncha M., Sahu B.D., Swamy C.V., Pragada R.R., Naidu V.G.M., Sistla R. Ethanolic extract of Boswellia ovalifoliolata bark and leaf attenuates Doxorubicin-induced cardiotoxicity in mice. Environ. Toxicol. Pharmacol. 2013, 36(3):840-849.
34. Wang Z., Li Y., Sarkar F.H. Signaling mechanism (s) of reactive oxygen species in epithelial-mesenchymal transition reminiscent of cancer stem cells in tumor progression. Curr. Stem Cell Res. Ther. 2010, 5(1):74.
35. Wu J.T., Kral J.G. The NF-κB/IκB signaling system: a molecular target in breast cancer therapy. J. Surg. Res. 2005, 123(1):158-169.