3,5,4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition

Toxicology and Applied Pharmacology

Volumn 272, Issue 3, 2013, Pages 746-756

  Tsai, Jie Heng ^a   Hsu, Li Sung ^a,b   Lin, Chih Li ^a,b   Hong, Hui Mei ^a,b   Pan, Min Hsiung ^c   Way, Tzong Der ^d   Chen, Wei Jen ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL KAOHSIUNG UNIVERSITY OF APPLIED SCIENCES   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Catenin; 3,5,4' Trimethoxystilbene (MR 3); E cadherin; Epithelial mesenchymal transition (EMT); Glycogen synthase kinase (GSK) 3

Indexed keywords

3,5,4' TRIMETHOXYSTILBENE; BETA CATENIN; ESTROGEN RECEPTOR ALPHA; GLYCOGEN SYNTHASE KINASE 3; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RESVERATROL; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; WNT PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CELL ADHESION; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL STRAIN MCF 7; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; DOWN REGULATION; DRUG CYTOTOXICITY; E BOX ELEMENT; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; GENE TARGETING; HUMAN; HUMAN CELL; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UBIQUITINATION; WNT SIGNALING PATHWAY;

Β-CATENIN; 3,5,4′-TRIMETHOXYSTILBENE (MR-3); E-CADHERIN; EPITHELIAL-MESENCHYMAL TRANSITION (EMT); GLYCOGEN SYNTHASE KINASE (GSK)-3Β;

ANTICARCINOGENIC AGENTS; BETA CATENIN; BREAST NEOPLASMS; CELL LINE, TUMOR; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; MCF-7 CELLS; NEOPLASM INVASIVENESS; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; STILBENES; WNT SIGNALING PATHWAY;

EID: 84884723023     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.07.019     Document Type: Article

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