Furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo

Cellular Physiology and Biochemistry

Volumn 30, Issue 3, 2012, Pages 778-790

  Zhong, Zhangfeng ^a,b   Dang, Yuanye ^a,b   Yuan, Xia ^c   Guo, Wei ^c   Li, Yingbo ^a,b   Tan, Wen ^a,b   Cui, Jingrong ^c   Lu, Jinjian ^a,b   Zhang, Qingwen ^a,b   Chen, Xiuping ^a,b   Wang, Yitao ^a,b  

^a UNIVERSITY OF MACAU   (Macao)

^b University of Macau   (Macao)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Apoptosis; Breast cancer; Cell cycle; Furanodiene; Proliferation

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 7; CASPASE 9; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLOPHOSPHAMIDE; DNA; FURANODIENE; LACTATE DEHYDROGENASE; NATURAL PRODUCT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE ARREST; CELL CYCLE DISTRIBUTION; CELL MEMBRANE DEPOLARIZATION; CELL PROLIFERATION; CELLULAR PARAMETERS; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG INHIBITION; DRUG STRUCTURE; HORMONE RELEASE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; WESTERN BLOTTING;

CURCUMA WENYUJIN; MUS MUSCULUS;

EID: 84864402186     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000341457     Document Type: Article

References (34)

1. Efferth T, Li PC, Konkimalla VS, Kaina B: From traditional chinese medicine to rational cancer therapy. Trends Mol Med 2007;13:353-361.
2. Tan W, Lu J, Huang M, Li Y, Chen M, Wu G, Gong J, Zhong Z, Xu Z, Dang Y, Guo J, Chen X, Wang Y: Anti-cancer natural products isolated from chinese medicinal herbs. Chin Med 2011;6:27.
3. Parekh HS, Liu G, Wei MQ: A new dawn for the use of traditional chinese medicine in cancer therapy. Mol Cancer 2009;8:21.
4. Tian G, Guo L, Gao W: Use of compound chinese medicine in the treatment of lung cancer. Curr Drug Discov Technol 2010;7:32-36.
5. Wang S, Penchala S, Prabhu S, Wang J, Huang Y: Molecular basis of traditional chinese medicine in cancer chemoprevention. Curr Drug Discov Technol 2010;7:67-75.
6. Sun Y, Xun K, Wang Y, Chen X: A systematic review of the anticancer properties of berberine, a natural product from chinese herbs. Anticancer Drugs 2009;20:757-769.
7. Epstein J, Sanderson IR, Macdonald TT: Curcumin as a therapeutic agent: The evidence from in vitro, animal and human studies. Br J Nutr 2010;103:1545-1557.
8. Murakami A, Ashida H, Terao J: Multitargeted cancer prevention by quercetin. Cancer Lett 2008;269:315-325.
9. Yao CS: Natural drug: Curcuma wenyujin y.H.Chen et c.Ling. Beijing, Peoples Health Publishing House, 2008, pp 326.
10. Rui D, Xiaoyan C, Taixiang W, Guanjian L: Elemene for the treatment of lung cancer. Cochrane Database Syst Rev 2007:CD006054.
11. Yang FQ, Li SP, Chen Y, Lao SC, Wang YT, Dong TTX, Tsim KWK: Identification and quantitation of eleven sesquiterpenes in three species of curcuma rhizomes by pressurized liquid extraction and gas chromatography-mass spectrometry. J Pharmaceut Biom Anal 2005;39:552-558.
12. Morikawa T, Matsuda H, Ninomiya K, Yoshikawa M: Medicinal foodstuffs. XXIX. Potent protective effects of sesquiterpenes and curcumin from zedoariae rhizoma on liver injury induced by d-galactosamine/lipopolysaccharide or tumor necrosis factor-alpha. Biol Pharm Bull 2002;25:627-631.
13. Matsuda H, Ninomiya K, Morikawa T, Yoshikawa M: Inhibitory effect and action mechanism of sesquiterpenes from zedoariae rhizoma on d-galactosamine/lipopolysaccharide-induced liver injury. Bioorg Med Chem Lett 1998;8:339-344.
14. Makabe H, Maru N, Kuwabara A, Kamo T, Hirota M: Anti-inflammatory sesquiterpenes from curcuma zedoaria. Nat Prod Res 2006;20:680-685.
15. Sun XY, Zheng YP, Lin DH, Zhang H, Zhao F, Yuan CS: Potential anti-cancer activities of furanodiene, a sesquiterpene from curcuma wenyujin. Am J Chinese Med 2009;37:589-596.
16. Ma E, Wang X, Li Y, Sun X, Tai W, Li T, Guo T: Induction of apoptosis by furanodiene in hl60 leukemia cells through activation of tnfr1 signaling pathway. Cancer Lett 2008;271:158-166.
17. Xiao Y, Yang FQ, Li SP, Gao JL, Hu G, Lao SC, Conceicao EL, Fung KP, Wang YT, Lee SMY: Furanodiene induces g(2)/m cell cycle arrest and apoptosis through mapk signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells. Cancer Biol Ther 2007;6:1044-1050.
18. Zhong ZF, Hoi PM, Wu GS, Xu ZT, Tan W, Chen XP, Cui L, Wu T, Wang YT: Anti-angiogenic effect of furanodiene on huvecs in vitro and on zebrafish in vivo. J Ethnopharmacol 2012;141:721-729.
19. Wang Y, Liu X, Wang X, Li F, Li J, Cao W: Furanodiene blocks nf-kb-dependent mmp-9 and vegf activation and inhibits cellular invasiveness and angiogenesis of breast cancer cells in vitro and in vivo. Biomedical Research 2012;23:SI 231-237.
20. Chen X, Pei L, Zhong Z, Guo J, Zhang Q, Wang Y: Anti-tumor potential of ethanol extract of curcuma phaeocaulis valeton against breast cancer cells. Phytomedicine 2011;18:1238-1243.
21. Xiao Y, Yang FQ, Li SP, Gao JL, Hu G, Lao SC, Conceicao EL, Fung KP, Wangl YT, Lee SM: Furanodiene induces g2/m cell cycle arrest and apoptosis through mapk signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells. Cancer Biol Ther 2007;6:1044-1050.
22. Zhong ZF, Li YB, Wang SP, Tan W, Chen XP, Chen MW, Wang YT: Furanodiene enhances tamoxifen-induced growth inhibitory activity of era-positive breast cancer cells in a ppargamma independent manner. J Cell Biochem 2012;113:2643-2651.
23. Zhong Z, Chen X, Tan W, Xu Z, Zhou K, Wu T, Cui L, Wang Y: Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis. Eur J Pharmacol 2011;667:50-55.
24. Yang FQ, Wang YT, Li SP: Simultaneous determination of 11 characteristic components in three species of curcuma rhizomes using pressurized liquid extraction and high-performance liquid chromatography. J Chromatogr A 2006;1134:226-231.
25. Zhang ZY, Pan LJ, Zhang ZM: Functional interactions among stim1, orai1 and trpc1 on the activation of socs in hl-7702 cells. Amino Acids 2010;39:195-204.
26. Armstrong JS: Mitochondria: A target for cancer therapy. Br J Pharmacol 2006;147:239-248.
27. Fulda S: Exploiting mitochondrial apoptosis for the treatment of cancer. Mitochondrion 2010;10:598-603.
28. Ola MS, Nawaz M, Ahsan H: Role of bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem 2011;351:41-58.
29. Shi Y: Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell 2002;9:459-470.
30. Chen CJ, Makino S: Murine coronavirus replication induces cell cycle arrest in g0/g1 phase. J Virol 2004;78:5658-5669.
31. Abbas T, Dutta A: P21 in cancer: Intricate networks and multiple activities. Nat Rev Cancer 2009;9:400-414.
32. Kannaiyan R, Manu KA, Chen L, Li F, Rajendran P, Subramaniam A, Lam P, Kumar AP, Sethi G: Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-jun n-terminal kinase and suppression of pi3 k/akt signaling pathways. Apoptosis 2011;16:1028-1041.
33. Yuan J, He Z, Wu J, Lin Y, Zhu X: A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking akt activation in human breast cancer cells. Mol Med Report 2011;4:261-265.
34. Chang HL, Sugimoto Y, Liu S, Wang LS, Huang YW, Ye W, Lin YC: Keratinocyte growth factor (kgf) regulates estrogen receptor-alpha (er-alpha) expression and cell apoptosis via phosphatidylinositol 3-kinase (pi3k)/akt pathway in human breast cancer cells. Anticancer Res 2009;29:3195-3205.