RPF101, A new capsaicin-like analogue, Disrupts the microtubule network accompanied by arrest in the G2/M phase, Inducing apoptosis and mitotic catastrophe in the MCF-7 breast cancer cells

Toxicology and Applied Pharmacology

Volumn 266, Issue 3, 2013, Pages 385-398

  De Sá Júnior, Paulo Luiz ^a   Pasqualoto, Kerly Fernanda Mesquita ^a   Ferreira, Adilson Kleber ^a   Tavares, Maurício Temotheo ^b   Damião, Mariana Celestina Frojuello Costa Bernstorff ^b   De Azevedo, Ricardo Alexandre ^a   Câmara, Diana Aparecida Dias ^a   Pereira, Alexandre ^a   De Souza, Dener Madeiro ^a   Parise Filho, Roberto ^b  

^a INSTITUTO BUTANTAN   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Antitumoral; Apoptosis; Capsaicin like analogue; Cell cycle; Molecular modeling; RPF101

Indexed keywords

ANTINEOPLASTIC AGENT; CAPSAICIN DERIVATIVE; RPF 101; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN MCF 7; CYTOTOXICITY; DNA FRAGMENTATION; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MICROTUBULE ASSEMBLY; MITOSIS INHIBITION; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE;

ADENOCARCINOMA; APOPTOSIS; BREAST NEOPLASMS; CAPSAICIN; CELL SURVIVAL; DNA FRAGMENTATION; FEMALE; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MCF-7 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, CONFOCAL; MICROTUBULES; MODELS, MOLECULAR;

CAPSICUM ANNUUM VAR. ANNUUM;

EID: 84871898027     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.11.029     Document Type: Article

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