D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells

Biochemical Pharmacology

Volumn 89, Issue 1, 2014, Pages 31-42

  Neophytou, Christiana M ^a   Constantinou, Constantina ^b   Papageorgis, Panagiotis ^a   Constantinou, Andreas I ^a  

^a UNIVERSITY OF CYPRUS   (Cyprus)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

AKT pathway; Apoptosis; Breast cancer; Cell cycle; Survivin; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; CASPASE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DELTA ALPHA TOCOPHERYL POLYETHYLENE GLYCOL SUCCINATE; DRUG CARRIER; GLYCOL; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P21; SEPANTRONIUM BROMIDE; SURVIVIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CELL; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SELECTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; G1 PHASE CELL CYCLE CHECKPOINT; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MCF 10A CELL; MCF 12F CELL; PRIORITY JOURNAL; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

AKT PATHWAY; APOPTOSIS; BREAST CANCER; CELL CYCLE; SURVIVIN; VITAMIN E;

APOPTOSIS; BASE SEQUENCE; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; POLYETHYLENE GLYCOLS; REAL-TIME POLYMERASE CHAIN REACTION; VITAMIN E;

EID: 84897987761     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.02.003     Document Type: Article

References (44)

1. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA Cancer J Clin 61 2011 69 90
2. R. Suter, and J.A. Marcum The molecular genetics of breast cancer and targeted therapy Biologics 1 2007 241 258
3. W. Yu, M. Simmons-Menchaca, A. Gapor, B.G. Sanders, and K. Kline Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols Nutr Cancer 33 1999 26 32 (Pubitemid 29196119)
4. R. Tiwary, W. Yu, B.G. Sanders, and K. Kline alpha-TEA cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant, triple-negative human breast cancer cells via activating p73 Breast Cancer Res 13 2011 R1
5. K. Nesaretnam, P. Meganathan, S.D. Veerasenan, and K.R. Selvaduray Tocotrienols and breast cancer: the evidence to date Genes Nutr 7 2012 3 9
6. C. Constantinou, A. Papas, and A.I. Constantinou Vitamin E and cancer: an insight into the anticancer activities of vitamin E isomers and analogs Int J Cancer 123 2008 739 752 (Pubitemid 352032398)
7. Y. Li, T. Hahn, K. Garrison, Z.H. Cui, A. Thorburn, and J. Thorburn et al. The vitamin E analogue alpha-TEA stimulates tumor autophagy and enhances antigen cross-presentation Cancer Res 72 2012 3535 3545
8. K.A. Lawson, K. Anderson, M. Menchaca, J. Atkinson, L. Sun, and V. Knight et al. Novel vitamin E analogue decreases syngeneic mouse mammary tumor burden and reduces lung metastasis Mol Cancer Ther 2 2003 437 444
9. K. Anderson, M. Simmons-Menchaca, K.A. Lawson, J. Atkinson, B.G. Sanders, and K. Kline Differential response of human ovarian cancer cells to induction of apoptosis by vitamin E Succinate and vitamin E analogue, alpha-TEA Cancer Res 64 2004 4263 4269 (Pubitemid 38802432)
10. Z. Zhang, S. Tan, and S.S. Feng Vitamin E TPGS as a molecular biomaterial for drug delivery Biomaterials 33 2012 4889 4906
11. P.P. Constantinides, J. Han, and S.S. Davis Advances in the use of tocols as drug delivery vehicles Pharm Res 23 2006 243 255 (Pubitemid 43237855)
12. M.V. Varma, and R. Panchagnula Enhanced oral paclitaxel absorption with vitamin E-TPGS: effect on solubility and permeability in vitro, in situ and in vivo Eur J Pharm Sci 25 2005 445 453 (Pubitemid 40853872)
13. C. Constantinou, C.M. Neophytou, P. Vraka, J.A. Hyatt, K.A. Papas, and A.I. Constantinou Induction of DNA damage and caspase-independent programmed cell death by vitamin E Nutr Cancer 64 2012 136 152
14. C. Charalambous, C.A. Pitta, and A.I. Constantinou Equol enhances tamoxifen's anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells BMC Cancer 13 2013 238
15. P. Papageorgis, A.W. Lambert, S. Ozturk, F. Gao, H. Pan, and U. Manne et al. Smad signaling is required to maintain epigenetic silencing during breast cancer progression Cancer Res 70 2010 968 978
16. D.D. Sarbassov, D.A. Guertin, S.M. Ali, and D.M. Sabatini Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Science 307 2005 1098 1101 (Pubitemid 40262113)
17. C. Constantinou, K.A. Papas, and A.I. Constantinou Caspase-independent pathways of programmed cell death: the unraveling of new targets of cancer therapy? Curr Cancer Drug Targets 9 2009 717 728
18. S. Elmore Apoptosis: a review of programmed cell death Toxicol Pathol 35 2007 495 516 (Pubitemid 46911891)
19. R.U. Janicke, M.L. Sprengart, M.R. Wati, and A.G. Porter Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis J Biol Chem 273 1998 9357 9360 (Pubitemid 28183012)
20. D.C. Altieri Survivin, cancer networks and pathway-directed drug discovery Nat Rev Cancer 8 2008 61 70
21. M. Pennati, M. Folini, and N. Zaffaroni Targeting survivin in cancer therapy Expert Opin Ther Targets 12 2008 463 476 (Pubitemid 351551639)
22. V. Vaira, C.W. Lee, H.L. Goel, S. Bosari, L.R. Languino, and D.C. Altieri Regulation of survivin expression by IGF-1/mTOR signaling Oncogene 26 2007 2678 2684 (Pubitemid 46663841)
23. D.R. Alessi, M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, and P. Cohen et al. Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J 15 1996 6541 6551 (Pubitemid 26413787)
24. S.M. Kennedy, L. O'Driscoll, R. Purcell, N. Fitz-Simons, E.W. McDermott, and A.D. Hill et al. Prognostic importance of survivin in breast cancer Br J Cancer 88 2003 1077 1083 (Pubitemid 36560779)
25. S. Wang, X. Huang, C.K. Lee, and B. Liu Elevated expression of erbB3 confers paclitaxel resistance in erbB2-overexpressing breast cancer cells via upregulation of Survivin Oncogene 29 2010 4225 4236
26. T. Nakahara, M. Takeuchi, I. Kinoyama, T. Minematsu, K. Shirasuna, and A. Matsuhisa et al. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts Cancer Res 67 2007 8014 8021 (Pubitemid 47395135)
27. C.C. Hu, C.H. Tang, and J.J. Wang Caspase activation in response to cytotoxic Rana catesbeiana ribonuclease in MCF-7 cells FEBS Lett 503 2001 65 68
28. C. Constantinou, J.A. Hyatt, P.S. Vraka, A. Papas, K.A. Papas, and C. Neophytou et al. Induction of caspase-independent programmed cell death by vitamin E natural homologs and synthetic derivatives Nutr Cancer 61 2009 864 874
29. N. Bidere, H.K. Lorenzo, S. Carmona, M. Laforge, F. Harper, and C. Dumont et al. Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis J Biol Chem 278 2003 31401 31411 (Pubitemid 36994661)
30. T. Cirman, K. Oresic, G.D. Mazovec, V. Turk, J.C. Reed, and R.M. Myers et al. Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins J Biol Chem 279 2004 3578 3587 (Pubitemid 38140598)
31. M. Osaki, M. Oshimura, and H. Ito PI3K-Akt pathway: its functions and alterations in human cancer Apoptosis 9 2004 667 676 (Pubitemid 40941196)
32. H. Asanuma, T. Torigoe, K. Kamiguchi, Y. Hirohashi, T. Ohmura, and K. Hirata et al. Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells Cancer Res 65 2005 11018 11025 (Pubitemid 41713372)
33. A. Crawford, and R. Nahta Targeting Bcl-2 in herceptin-resistant breast cancer cell lines Curr Pharmacogenomics Person Med 9 2011 184 190
34. F. Gesbert, W.R. Sellers, S. Signoretti, M. Loda, and J.D. Griffin BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway J Biol Chem 275 2000 39223 39230 (Pubitemid 32058940)
35. B.P. Zhou, Y. Liao, W. Xia, B. Spohn, M.H. Lee, and M.C. Hung Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells Nat Cell Biol 3 2001 245 252 (Pubitemid 32201319)
36. X. Zhang, N. Tang, T.J. Hadden, and A.K. Rishi Akt, FoxO and regulation of apoptosis Biochim Biophys Acta 1813 2011 1978 1986
37. T. Abbas, and A. Dutta p21 in cancer: intricate networks and multiple activities Nat Rev Cancer 9 2009 400 414
38. J. Lee, and S.S. Kim The function of p27 KIP1 during tumor development Exp Mol Med 41 2009 765 771
39. G. Ambrosini, C. Adida, and D.C. Altieri A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma Nat Med 3 1997 917 921 (Pubitemid 27353455)
40. A. Giodini, M.J. Kallio, N.R. Wall, G.J. Gorbsky, S. Tognin, and P.C. Marchisio et al. Regulation of microtubule stability and mitotic progression by survivin Cancer Res 62 2002 2462 2467 (Pubitemid 34462718)
41. T. Dohi, K. Okada, F. Xia, C.E. Wilford, T. Samuel, and K. Welsh et al. An IAP-IAP complex inhibits apoptosis J Biol Chem 279 2004 34087 34090 (Pubitemid 39318028)
42. Z. Song, X. Yao, and M. Wu Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis J Biol Chem 278 2003 23130 23140 (Pubitemid 36830379)
43. G. Ceballos-Cancino, M. Espinosa, V. Maldonado, and J. Melendez-Zajgla Regulation of mitochondrial Smac/DIABLO-selective release by survivin Oncogene 26 2007 7569 7575 (Pubitemid 350207708)
44. T. Liu, B. Brouha, and D. Grossman Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells Oncogene 23 2004 39 48 (Pubitemid 38142238)