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Volumn 43, Issue 4, 2014, Pages 1115-1136

The role of endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer's disease

Author keywords

2 AG; Alzheimer's disease; amyloid ; anandamide; cannabinoids; CB1; CB2; FAAH; MAGL; tau

Indexed keywords

AMYLOID BETA PROTEIN; CANNABINOID; ENDOCANNABINOID;

EID: 84919948769     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-141635     Document Type: Review
Times cited : (81)

References (194)
  • 1
    • 84866290209 scopus 로고    scopus 로고
    • Dementia: A global health priority-highlights from an ADI and World Health Organization report
    • Wortmann M (2012) Dementia: A global health priority-highlights from an ADI and World Health Organization report. Alzheimers Res Ther 4, 40.
    • (2012) Alzheimers Res Ther , vol.4 , pp. 40
    • Wortmann, M.1
  • 2
    • 84886600387 scopus 로고    scopus 로고
    • Therapeutics of Alzheimer's disease: Past, present and future
    • Anand R, Gill KD, Mahdi AA (2014) Therapeutics of Alzheimer's disease: Past, present and future. Neuropharmacology 76 Part A, 27-50.
    • (2014) Neuropharmacology , vol.76 , pp. 27-50
    • Anand, R.1    Gill, K.D.2    Mahdi, A.A.3
  • 4
    • 33645453054 scopus 로고    scopus 로고
    • Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia
    • Walther S, Mahlberg R, Eichmann U, Kunz D (2006) Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia. Psychopharmacology (Berl) 185, 524-528.
    • (2006) Psychopharmacology (Berl) , vol.185 , pp. 524-528
    • Walther, S.1    Mahlberg, R.2    Eichmann, U.3    Kunz, D.4
  • 5
    • 84887907214 scopus 로고    scopus 로고
    • Endocannabinoid signalling in Alzheimer's disease
    • Maroof N, Pardon MC, Kendall DA (2013) Endocannabinoid signalling in Alzheimer's disease. Biochem Soc Trans 41, 1583-1587.
    • (2013) Biochem Soc Trans , vol.41 , pp. 1583-1587
    • Maroof, N.1    Pardon, M.C.2    Kendall, D.A.3
  • 6
    • 84859614049 scopus 로고    scopus 로고
    • The therapeutic potential of the endocannabinoid system for Alzheimer's disease
    • Karl T, Cheng D, Garner B, Arnold JC (2012) The therapeutic potential of the endocannabinoid system for Alzheimer's disease. Expert Opin Ther Targets 16, 407-420.
    • (2012) Expert Opin Ther Targets , vol.16 , pp. 407-420
    • Karl, T.1    Cheng, D.2    Garner, B.3    Arnold, J.C.4
  • 7
    • 52949112654 scopus 로고    scopus 로고
    • The role of the endocannabinoid system in Alzheimer's disease: Facts and hypotheses
    • Bisogno T, Di Marzo V (2008) The role of the endocannabinoid system in Alzheimer's disease: Facts and hypotheses. Curr Pharm Des 14, 2299-3305.
    • (2008) Curr Pharm des , vol.14 , pp. 2299-3305
    • Bisogno, T.1    Di Marzo, V.2
  • 8
    • 84897952453 scopus 로고    scopus 로고
    • Cannabinoids for treatment of Alzheimer's disease: Moving toward the clinic
    • Aso E, Ferrer I (2014) Cannabinoids for treatment of Alzheimer's disease: Moving toward the clinic. Front Pharmacol 5, 37.
    • (2014) Front Pharmacol , vol.5 , pp. 37
    • Aso, E.1    Ferrer, I.2
  • 10
    • 84895759461 scopus 로고    scopus 로고
    • The influence of cannabinoids on generic traits of neurodegeneration
    • Fagan SG, Campbell VA (2014) The influence of cannabinoids on generic traits of neurodegeneration. Br J Pharmacol 171, 1347-1360.
    • (2014) Br J Pharmacol , vol.171 , pp. 1347-1360
    • Fagan, S.G.1    Campbell, V.A.2
  • 12
    • 0025269152 scopus 로고
    • Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
    • DeKosky ST, Scheff SW (1990) Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity. Ann Neurol 27, 457-464.
    • (1990) Ann Neurol , vol.27 , pp. 457-464
    • Dekosky, S.T.1    Scheff, S.W.2
  • 13
    • 0024314702 scopus 로고
    • Amyloid beta protein precursor and the pathogenesis of Alzheimer's disease
    • Selkoe DJ (1989) Amyloid beta protein precursor and the pathogenesis of Alzheimer's disease. Cell 58, 611-612.
    • (1989) Cell , vol.58 , pp. 611-612
    • Selkoe, D.J.1
  • 14
    • 0036592537 scopus 로고    scopus 로고
    • Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease
    • Iqbal K, Grundke-Iqbal I (2002) Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease. J Alzheimers Dis 4, 235-238.
    • (2002) J Alzheimers Dis , vol.4 , pp. 235-238
    • Iqbal, K.1    Grundke-Iqbal, I.2
  • 15
    • 0024824922 scopus 로고
    • Patterns of gliosis in Alzheimer's disease and aging cerebrum
    • Beach TG, Walker R, McGeer EG (1989) Patterns of gliosis in Alzheimer's disease and aging cerebrum. Glia 2, 420-436.
    • (1989) Glia , vol.2 , pp. 420-436
    • Beach, T.G.1    Walker, R.2    McGeer, E.G.3
  • 16
    • 0024157709 scopus 로고
    • Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease
    • Rogers J, Luber-Narod J, Styren SD, Civin WH (1988) Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease. Neurobiol Aging 9, 339-349.
    • (1988) Neurobiol Aging , vol.9 , pp. 339-349
    • Rogers, J.1    Luber-Narod, J.2    Styren, S.D.3    Civin, W.H.4
  • 17
    • 77955979357 scopus 로고    scopus 로고
    • Pathways linking Abeta and tau pathologies
    • LaFerlaFM(2010) Pathways linking Abeta and tau pathologies. Biochem Soc Trans 38, 993-995.
    • (2010) Biochem Soc Trans , vol.38 , pp. 993-995
    • Laferla, F.M.1
  • 18
    • 0032408458 scopus 로고    scopus 로고
    • Molecular genetics of Alzheimer's disease
    • Cruts M, Van Broeckhoven C (1998) Molecular genetics of Alzheimer's disease. Ann Med 30, 560-565.
    • (1998) Ann Med , vol.30 , pp. 560-565
    • Cruts, M.1    Van Broeckhoven, C.2
  • 19
    • 77953892400 scopus 로고    scopus 로고
    • Molecular mechanisms of neurodegeneration in Alzheimer's disease
    • Crews L, Masliah E (2010) Molecular mechanisms of neurodegeneration in Alzheimer's disease. Hum Mol Genet 19, R12-R20.
    • (2010) Hum Mol Genet , vol.19 , pp. R12-R20
    • Crews, L.1    Masliah, E.2
  • 20
    • 84872552899 scopus 로고    scopus 로고
    • Synaptotoxic amyloid-beta oligomers: A molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease?
    • Klein WL (2013) Synaptotoxic amyloid-beta oligomers: A molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease? J Alzheimers Dis 33 Suppl 1, S49-S65.
    • (2013) J Alzheimers Dis , vol.33 , pp. S49-S65
    • Klein, W.L.1
  • 21
    • 0035297712 scopus 로고    scopus 로고
    • Targeting small Abeta oligomers: The solution to an Alzheimer's disease conundrum?
    • Klein WL, Krafft GA, Finch CE (2001) Targeting small Abeta oligomers: The solution to an Alzheimer's disease conundrum? Trends Neurosci 24, 219-224.
    • (2001) Trends Neurosci , vol.24 , pp. 219-224
    • Klein, W.L.1    Krafft, G.A.2    Finch, C.E.3
  • 22
    • 2542427690 scopus 로고    scopus 로고
    • Oligomers on the brain: The emerging role of soluble protein aggregates in neurodegeneration
    • Walsh DM, Selkoe DJ (2004) Oligomers on the brain: The emerging role of soluble protein aggregates in neurodegeneration. Protein Pept Lett 11, 213-228.
    • (2004) Protein Pept Lett , vol.11 , pp. 213-228
    • Walsh, D.M.1    Selkoe, D.J.2
  • 23
    • 84880153942 scopus 로고    scopus 로고
    • The influence of beta-amyloid peptide on the functions of excitable tissues: Physiological and pathological aspects
    • Mukhamedyarov MA, Zefirov AL (2013) The influence of beta-amyloid peptide on the functions of excitable tissues: Physiological and pathological aspects. Usp Fiziol Nauk 44, 55-71.
    • (2013) Usp Fiziol Nauk , vol.44 , pp. 55-71
    • Mukhamedyarov, M.A.1    Zefirov, A.L.2
  • 24
    • 5344277556 scopus 로고    scopus 로고
    • Deciphering the molecular basis of memory failure in Alzheimer's disease
    • Walsh DM, Selkoe DJ (2004) Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 44, 181-193.
    • (2004) Neuron , vol.44 , pp. 181-193
    • Walsh, D.M.1    Selkoe, D.J.2
  • 26
    • 3042845492 scopus 로고    scopus 로고
    • Microglia and Alzheimer's disease pathogenesis
    • Streit WJ (2004) Microglia and Alzheimer's disease pathogenesis. J Neurosci Res 77, 1-8.
    • (2004) J Neurosci Res , vol.77 , pp. 1-8
    • Streit, W.J.1
  • 27
    • 73449131129 scopus 로고    scopus 로고
    • Targeting p38 MAPK pathway for the treatment of Alzheimer's disease
    • Munoz L, Ammit AJ (2010) Targeting p38 MAPK pathway for the treatment of Alzheimer's disease. Neuropharmacology 58, 561-568.
    • (2010) Neuropharmacology , vol.58 , pp. 561-568
    • Munoz, L.1    Ammit, A.J.2
  • 28
    • 0026643708 scopus 로고
    • Reactive microglia/macrophages phagocytose amyloid precursor protein produced by neurons following neural damage
    • Shigematsu K, McGeer PL,Walker DG, Ishii T, McGeer EG (1992) Reactive microglia/macrophages phagocytose amyloid precursor protein produced by neurons following neural damage. J Neurosci Res 31, 443-453.
    • (1992) J Neurosci Res , vol.31 , pp. 443-453
    • Shigematsu, K.1    McGeer, P.L.2    Walker, D.G.3    Ishii, T.4    McGeer, E.G.5
  • 29
    • 0033080919 scopus 로고    scopus 로고
    • Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins
    • Combs CK, Johnson DE, Cannady SB, Lehman TM, Landreth GE (1999) Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins. J Neurosci 19, 928-939.
    • (1999) J Neurosci , vol.19 , pp. 928-939
    • Combs, C.K.1    Johnson, D.E.2    Cannady, S.B.3    Lehman, T.M.4    Landreth, G.E.5
  • 30
    • 61349164312 scopus 로고    scopus 로고
    • Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia
    • Sondag CM, Dhawan G, Combs CK (2009) Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia. J Neuroinflammation 6, 1.
    • (2009) J Neuroinflammation , vol.6 , pp. 1
    • Sondag, C.M.1    Dhawan, G.2    Combs, C.K.3
  • 31
    • 33644516288 scopus 로고    scopus 로고
    • Contribution of inflammatory processes to Alzheimer's disease: Molecular mechanisms
    • SastreM,KlockgetherT, HenekaMT(2006) Contribution of inflammatory processes to Alzheimer's disease: Molecular mechanisms. Int J Dev Neurosci 24, 167-176.
    • (2006) Int J Dev Neurosci , vol.24 , pp. 167-176
    • Sastre, M.1    Klockgether, T.2    Heneka, M.T.3
  • 32
    • 14744283139 scopus 로고    scopus 로고
    • Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation
    • White JA, Manelli AM, Holmberg KH, Van Eldik LJ, Ladu MJ (2005) Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation. Neurobiol Dis 18, 459-465.
    • (2005) Neurobiol Dis , vol.18 , pp. 459-465
    • White, J.A.1    Manelli, A.M.2    Holmberg, K.H.3    Van Eldik, L.J.4    Ladu, M.J.5
  • 34
    • 70349323417 scopus 로고    scopus 로고
    • CD14 and toll-like receptors 2 and 4 are required for fibrillaA{beta}-stimulated microglial activation
    • Reed-Geaghan EG, Savage JC, Hise AG, Landreth GE (2009) CD14 and toll-like receptors 2 and 4 are required for fibrillarA{beta}-stimulated microglial activation. J Neurosci 29, 11982-11992.
    • (2009) J Neurosci , vol.29 , pp. 11982-11992
    • Reed-Geaghan, E.G.1    Savage, J.C.2    Hise, A.G.3    Landreth, G.E.4
  • 35
    • 40849139482 scopus 로고    scopus 로고
    • Long-term potentiation inhibition by low-level N-methyl-D-aspartate receptor activation involves calcineurin, nitric oxide, and p38 mitogen-activated protein kinase
    • Izumi Y, Tokuda K, Zorumski CF (2008) Long-term potentiation inhibition by low-level N-methyl-D-aspartate receptor activation involves calcineurin, nitric oxide, and p38 mitogen-activated protein kinase. Hippocampus 18, 258-265.
    • (2008) Hippocampus , vol.18 , pp. 258-265
    • Izumi, Y.1    Tokuda, K.2    Zorumski, C.F.3
  • 36
    • 43749094768 scopus 로고    scopus 로고
    • Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase underlies metabotropic glutamate receptor-dependent long-term depression
    • Moult PR, Correa SA, Collingridge GL, Fitzjohn SM, Bashir ZI (2008) Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase underlies metabotropic glutamate receptor-dependent long-term depression. J Physiol 586, 2499-2510.
    • (2008) J Physiol , vol.586 , pp. 2499-2510
    • Moult, P.R.1    Correa, S.A.2    Collingridge, G.L.3    Fitzjohn, S.M.4    Bashir, Z.I.5
  • 37
    • 0242268553 scopus 로고    scopus 로고
    • The molecular logic of endocannabinoid signalling
    • Piomelli D (2003) The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 4, 873-884.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 873-884
    • Piomelli, D.1
  • 38
    • 0037661996 scopus 로고    scopus 로고
    • Role of endogenous cannabinoids in synaptic signaling
    • Freund TF, Katona I, Piomelli D (2003) Role of endogenous cannabinoids in synaptic signaling. Physiol Rev 83, 1017-1066.
    • (2003) Physiol Rev , vol.83 , pp. 1017-1066
    • Freund, T.F.1    Katona, I.2    Piomelli, D.3
  • 43
    • 0030066244 scopus 로고    scopus 로고
    • Enzymatic synthesis of anandamide, an endogenous cannabinoid receptor ligand, through N-acylphosphatidylethanolamine pathway in testis: Involvement of Ca(2+)-dependent transacylase and phosphodiesterase activities
    • Sugiura T, Kondo S, Sukagawa A, Tonegawa T, Nakane S, Yamashita A, Waku K (1996) Enzymatic synthesis of anandamide, an endogenous cannabinoid receptor ligand, through N-acylphosphatidylethanolamine pathway in testis: Involvement of Ca(2+)-dependent transacylase and phosphodiesterase activities. Biochem Biophys Res Commun 218, 113-117.
    • (1996) Biochem Biophys Res Commun , vol.218 , pp. 113-117
    • Sugiura, T.1    Kondo, S.2    Sukagawa, A.3    Tonegawa, T.4    Nakane, S.5    Yamashita, A.6    Waku, K.7
  • 44
    • 0033567190 scopus 로고    scopus 로고
    • Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages
    • Di Marzo V, Bisogno T, De Petrocellis L, Melck D, Orlando P, Wagner JA, Kunos G (1999) Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages. Eur J Biochem 264, 258-267.
    • (1999) Eur J Biochem , vol.264 , pp. 258-267
    • Di Marzo, V.1    Bisogno, T.2    De Petrocellis, L.3    Melck, D.4    Orlando, P.5    Wagner, J.A.6    Kunos, G.7
  • 48
    • 0034614374 scopus 로고    scopus 로고
    • Evidence that 2-arachidonoylglycerol but not Npalmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells
    • Sugiura T, Kondo S, Kishimoto S, Miyashita T, Nakane S, Kodaka T, Suhara Y, Takayama H, Waku K (2000) Evidence that 2-arachidonoylglycerol but not Npalmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. J Biol Chem 275, 605-612.
    • (2000) J Biol Chem , vol.275 , pp. 605-612
    • Sugiura, T.1    Kondo, S.2    Kishimoto, S.3    Miyashita, T.4    Nakane, S.5    Kodaka, T.6    Suhara, Y.7    Takayama, H.8    Waku, K.9
  • 49
    • 78049232267 scopus 로고    scopus 로고
    • Intracellular trafficking of anandamide: New concepts for signaling
    • Maccarrone M, Dainese E, Oddi S (2010) Intracellular trafficking of anandamide: New concepts for signaling. Trends Biochem Sci 35, 601-608.
    • (2010) Trends Biochem Sci , vol.35 , pp. 601-608
    • Maccarrone, M.1    Dainese, E.2    Oddi, S.3
  • 50
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346, 561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 52
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro S, Thomas KL, Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature 365, 61-65.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 55
    • 33244493807 scopus 로고    scopus 로고
    • Expression of the cannabinoid CB2 receptor in the rat cerebellum: An immunohistochemical study
    • Ashton JC, Friberg D, Darlington CL, Smith PF (2006) Expression of the cannabinoid CB2 receptor in the rat cerebellum: An immunohistochemical study. Neurosci Lett 396, 113-116.
    • (2006) Neurosci Lett , vol.396 , pp. 113-116
    • Ashton, J.C.1    Friberg, D.2    Darlington, C.L.3    Smith, P.F.4
  • 57
    • 77952623444 scopus 로고    scopus 로고
    • CB2:Acannabinoid receptor with an identity crisis
    • Atwood BK, MackieK(2010) CB2:Acannabinoid receptor with an identity crisis. Br J Pharmacol 160, 467-479.
    • (2010) Br J Pharmacol , vol.160 , pp. 467-479
    • Atwood, B.K.1    Mackie, K.2
  • 58
    • 81955164773 scopus 로고    scopus 로고
    • Targeting CB(2) receptor as a neuroinflammatory modulator in experimental autoimmune encephalomyelitis
    • Lou ZY, Chen C, He Q, Zhao CB, Xiao BG (2011) Targeting CB(2) receptor as a neuroinflammatory modulator in experimental autoimmune encephalomyelitis. Mol Immunol 49, 453-461.
    • (2011) Mol Immunol , vol.49 , pp. 453-461
    • Lou, Z.Y.1    Chen, C.2    He, Q.3    Zhao, C.B.4    Xiao, B.G.5
  • 59
    • 58049170379 scopus 로고    scopus 로고
    • Endocannabinoid signaling in microglial cells
    • Stella N (2009) Endocannabinoid signaling in microglial cells. Neuropharmacology 56 (Suppl 1), 244-253.
    • (2009) Neuropharmacology , vol.56 , pp. 244-253
    • Stella, N.1
  • 60
    • 63049105150 scopus 로고    scopus 로고
    • Emerging role of the cannabinoid receptor CB2 in immune regulation: Therapeutic prospects for neuroinflammation
    • Cabral GA, Griffin-Thomas L (2009) Emerging role of the cannabinoid receptor CB2 in immune regulation: Therapeutic prospects for neuroinflammation. Expert Rev Mol Med 11, e3.
    • (2009) Expert Rev Mol Med , vol.11 , pp. e3
    • Cabral, G.A.1    Griffin-Thomas, L.2
  • 62
    • 36448995830 scopus 로고    scopus 로고
    • GPR55: A new member of the cannabinoid receptor clan?
    • Pertwee RG (2007) GPR55: A new member of the cannabinoid receptor clan? Br J Pharmacol 152, 984-986.
    • (2007) Br J Pharmacol , vol.152 , pp. 984-986
    • Pertwee, R.G.1
  • 64
  • 65
    • 77950692040 scopus 로고    scopus 로고
    • Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: A neuroprotective therapeutic modality
    • Hwang J, Adamson C, Butler D, Janero DR, Makriyannis A, BahrBA(2010) Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: A neuroprotective therapeutic modality. Life Sci 86, 615-623.
    • (2010) Life Sci , vol.86 , pp. 615-623
    • Hwang, J.1    Adamson, C.2    Butler, D.3    Janero, D.R.4    Makriyannis, A.5    Bahr, B.A.6
  • 66
    • 0032898720 scopus 로고    scopus 로고
    • Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors
    • Goparaju SK, Ueda N, Taniguchi K, Yamamoto S (1999) Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors. Biochem Pharmacol 57, 417-423.
    • (1999) Biochem Pharmacol , vol.57 , pp. 417-423
    • Goparaju, S.K.1    Ueda, N.2    Taniguchi, K.3    Yamamoto, S.4
  • 68
    • 78649374688 scopus 로고    scopus 로고
    • TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus
    • Chavez AE, Chiu CQ, Castillo PE (2010) TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus. Nat Neurosci 13, 1511-1518.
    • (2010) Nat Neurosci , vol.13 , pp. 1511-1518
    • Chavez, A.E.1    Chiu, C.Q.2    Castillo, P.E.3
  • 69
    • 80051686884 scopus 로고    scopus 로고
    • Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide
    • Brailoiu GC, Oprea TI, Zhao P, Abood ME, Brailoiu E (2011) Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. J Biol Chem 286, 29166-29174.
    • (2011) J Biol Chem , vol.286 , pp. 29166-29174
    • Brailoiu, G.C.1    Oprea, T.I.2    Zhao, P.3    Abood, M.E.4    Brailoiu, E.5
  • 70
    • 46749113793 scopus 로고    scopus 로고
    • Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3
    • Rozenfeld R, Devi LA (2008) Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3.FASEB J 22, 2311-2322.
    • (2008) FASEB J , vol.22 , pp. 2311-2322
    • Rozenfeld, R.1    Devi, L.A.2
  • 72
    • 0017139133 scopus 로고
    • The limbic system in Alzheimer's disease. A neuropathologic investigation
    • Hopper MW, Vogel FS (1976) The limbic system in Alzheimer's disease. A neuropathologic investigation. Am J Pathol 85, 1-20.
    • (1976) Am J Pathol , vol.85 , pp. 1-20
    • Hopper, M.W.1    Vogel, F.S.2
  • 73
    • 33645774927 scopus 로고    scopus 로고
    • Distribution of cannabinoid receptors in the central and peripheral nervous system
    • Mackie K (2005) Distribution of cannabinoid receptors in the central and peripheral nervous system. Handb Exp Pharmacol, 299-325.
    • (2005) Handb Exp Pharmacol , pp. 299-325
    • Mackie, K.1
  • 74
    • 4143121265 scopus 로고    scopus 로고
    • Role of the endocannabinoid system in Alzheimer's disease: New perspectives
    • Pazos MR, Nunez E, Benito C, Tolon RM, Romero J (2004) Role of the endocannabinoid system in Alzheimer's disease: New perspectives. Life Sci 75, 1907-1915.
    • (2004) Life Sci , vol.75 , pp. 1907-1915
    • Pazos, M.R.1    Nunez, E.2    Benito, C.3    Tolon, R.M.4    Romero, J.5
  • 75
    • 57349123576 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system in Alzheimer's disease
    • Koppel J, Davies P (2008) Targeting the endocannabinoid system in Alzheimer's disease. J Alzheimers Dis 15, 495-504.
    • (2008) J Alzheimers Dis , vol.15 , pp. 495-504
    • Koppel, J.1    Davies, P.2
  • 77
    • 35648944275 scopus 로고    scopus 로고
    • Alzheimer's disease; Taking the edge off with cannabinoids?
    • CampbellVA,GowranA(2007) Alzheimer's disease; taking the edge off with cannabinoids? Br J Pharmacol 152, 655-662.
    • (2007) Br J Pharmacol , vol.152 , pp. 655-662
    • Campbell, V.A.1    Gowran, A.2
  • 78
    • 0027948317 scopus 로고
    • Cannabinoid receptor binding and messenger RNA expression in human brain: A in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brains
    • Westlake TM, Howlett AC, Bonner TI, Matsuda LA, Herkenham M (1994) Cannabinoid receptor binding and messenger RNA expression in human brain: An in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brains. Neuroscience 63, 637-652.
    • (1994) Neuroscience , vol.63 , pp. 637-652
    • Westlake, T.M.1    Howlett, A.C.2    Bonner, T.I.3    Matsuda, L.A.4    Herkenham, M.5
  • 79
    • 0348010292 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains
    • Benito C, Nunez E,TolonRM,Carrier EJ, Rabano A, Hillard CJ, Romero J (2003) Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. J Neurosci 23, 11136-11141.
    • (2003) J Neurosci , vol.23 , pp. 11136-11141
    • Benito, C.1    Nunez, E.2    Tolon, R.M.3    Carrier, E.J.4    Rabano, A.5    Hillard, C.J.6    Romero, J.7
  • 82
    • 14244264502 scopus 로고    scopus 로고
    • Prevention of Alzheimer's disease pathology by cannabinoids: Neuroprotection mediated by blockade of microglial activation
    • Ramirez BG, Blazquez C, Gomez del Pulgar T, Guzman M, de Ceballos ML (2005) Prevention of Alzheimer's disease pathology by cannabinoids: Neuroprotection mediated by blockade of microglial activation. J Neurosci 25, 1904-1913.
    • (2005) J Neurosci , vol.25 , pp. 1904-1913
    • Ramirez, B.G.1    Blazquez, C.2    Gomez Del Pulgar, T.3    Guzman, M.4    De Ceballos, M.L.5
  • 83
    • 84870574017 scopus 로고    scopus 로고
    • CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients
    • Solas M, Francis PT, Franco R, Ramirez MJ (2013) CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients. Neurobiol Aging 34, 805-808.
    • (2013) Neurobiol Aging , vol.34 , pp. 805-808
    • Solas, M.1    Francis, P.T.2    Franco, R.3    Ramirez, M.J.4
  • 86
    • 79851509826 scopus 로고    scopus 로고
    • Distribution patterns of cannabinoid CB1 receptors in the hippocampus of APPswe/PS1DeltaE9 double transgenic mice
    • Kalifa S, Polston EK, Allard JS, Manaye KF (2011) Distribution patterns of cannabinoid CB1 receptors in the hippocampus of APPswe/PS1DeltaE9 double transgenic mice. Brain Res 1376, 94-100.
    • (2011) Brain Res , vol.1376 , pp. 94-100
    • Kalifa, S.1    Polston, E.K.2    Allard, J.S.3    Manaye, K.F.4
  • 89
    • 0037417989 scopus 로고    scopus 로고
    • Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its agedependent decline in mice
    • Wang L, Liu J, Harvey-White J, Zimmer A, Kunos G (2003) Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its agedependent decline in mice. Proc Natl Acad Sci U S A 100, 1393-1398.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 1393-1398
    • Wang, L.1    Liu, J.2    Harvey-White, J.3    Zimmer, A.4    Kunos, G.5
  • 93
    • 84861859231 scopus 로고    scopus 로고
    • An amyloid beta42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease
    • Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, CotmanCW, PiomelliD(2012) An amyloid beta42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiol Aging 33, 1522-1532.
    • (2012) Neurobiol Aging , vol.33 , pp. 1522-1532
    • Jung, K.M.1    Astarita, G.2    Yasar, S.3    Vasilevko, V.4    Cribbs, D.H.5    Head, E.6    Cotman, C.W.7    Piomelli, D.8
  • 94
    • 3843066799 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: An immunohistochemical study
    • Nunez E, Benito C, Pazos MR, Barbachano A, Fajardo O, Gonzalez S, Tolon RM, Romero J (2004) Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: An immunohistochemical study. Synapse 53, 208-213.
    • (2004) Synapse , vol.53 , pp. 208-213
    • Nunez, E.1    Benito, C.2    Pazos, M.R.3    Barbachano, A.4    Fajardo, O.5    Gonzalez, S.6    Tolon, R.M.7    Romero, J.8
  • 95
    • 37849049077 scopus 로고    scopus 로고
    • Glial expression of cannabinoid CB(2) receptors and fatty acid amide hydrolase are beta amyloidlinked events in Down's syndrome
    • Nunez E, Benito C, Tolon RM, Hillard CJ, Griffin WS, Romero J (2008) Glial expression of cannabinoid CB(2) receptors and fatty acid amide hydrolase are beta amyloidlinked events in Down's syndrome. Neuroscience 151, 104-110.
    • (2008) Neuroscience , vol.151 , pp. 104-110
    • Nunez, E.1    Benito, C.2    Tolon, R.M.3    Hillard, C.J.4    Griffin, W.S.5    Romero, J.6
  • 100
    • 0023824378 scopus 로고
    • Neurochemical aspects of Alzheimer's disease: Involvement of membrane phospholipids
    • Farooqui AA, Liss L, Horrocks LA (1988) Neurochemical aspects of Alzheimer's disease: Involvement of membrane phospholipids. Metab Brain Dis 3, 19-35.
    • (1988) Metab Brain Dis , vol.3 , pp. 19-35
    • Farooqui, A.A.1    Liss, L.2    Horrocks, L.A.3
  • 102
    • 67649881952 scopus 로고    scopus 로고
    • Cannabinoid system in neurodegeneration: New perspectives in Alzheimer's disease
    • Campillo NE, Paez JA (2009) Cannabinoid system in neurodegeneration: New perspectives in Alzheimer's disease. Mini Rev Med Chem 9, 539-559.
    • (2009) Mini Rev Med Chem , vol.9 , pp. 539-559
    • Campillo, N.E.1    Paez, J.A.2
  • 103
    • 35648993493 scopus 로고    scopus 로고
    • Endocannabinoids and neurodegenerative diseases
    • Micale V, Mazzola C, Drago F (2007) Endocannabinoids and neurodegenerative diseases. Pharmacol Res 56, 382-392.
    • (2007) Pharmacol Res , vol.56 , pp. 382-392
    • Micale, V.1    Mazzola, C.2    Drago, F.3
  • 105
    • 84868131884 scopus 로고    scopus 로고
    • The endocannabinoid system in normal and pathological brain ageing
    • Bilkei-Gorzo A (2012) The endocannabinoid system in normal and pathological brain ageing. Philos Trans R Soc Lond B Biol Sci 367, 3326-3341.
    • (2012) Philos Trans R Soc Lond B Biol Sci , vol.367 , pp. 3326-3341
    • Bilkei-Gorzo, A.1
  • 106
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    • Hickman SE, Allison EK, El Khoury J (2008) Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci 28, 8354-8360.
    • (2008) J Neurosci , vol.28 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 109
    • 84893798834 scopus 로고    scopus 로고
    • Cannabinoid effects on beta amyloid fibril and aggregate formation, neuronal and microglial-activated neurotoxicit
    • Janefjord E, Maag JL, Harvey BS, SmidSD(2014) Cannabinoid effects on beta amyloid fibril and aggregate formation, neuronal and microglial-activated neurotoxicity in vitro. Cell Mol Neurobiol 34, 31-42.
    • (2014) Vitro. Cell Mol Neurobiol , vol.34 , pp. 31-42
    • Janefjord, E.1    Maag, J.L.2    Harvey, B.S.3    Smid, S.D.4
  • 110
    • 84888151723 scopus 로고    scopus 로고
    • CB(2) receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease
    • Koppel J,VingtdeuxV, Marambaud P, d'Abramo C, Jimenez H, Stauber M, Friedman R, Davies P (2013) CB(2) receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease. Mol Med 19, 357-364.
    • (2013) Mol Med , vol.19 , pp. 357-364
    • Koppel, J.1    Vingtdeux, V.2    Marambaud, P.3    D'abramo, C.4    Jimenez, H.5    Stauber, M.6    Friedman, R.7    Davies, P.8
  • 111
    • 84881542568 scopus 로고    scopus 로고
    • Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition
    • Stumm C, Hiebel C, Hanstein R, Purrio M, Nagel H, Conrad A, Lutz B, Behl C, Clement AB (2013) Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition. Neurobiol Aging 34, 2574-2584.
    • (2013) Neurobiol Aging , vol.34 , pp. 2574-2584
    • Stumm, C.1    Hiebel, C.2    Hanstein, R.3    Purrio, M.4    Nagel, H.5    Conrad, A.6    Lutz, B.7    Behl, C.8    Clement, A.B.9
  • 112
    • 84880934071 scopus 로고    scopus 로고
    • Role of the cannabinoid system in the transit of betaamyloid across the blood-brain barrier
    • Bachmeier C, Beaulieu-Abdelahad D, Mullan M, Paris D (2013) Role of the cannabinoid system in the transit of betaamyloid across the blood-brain barrier. Mol Cell Neurosci 56, 255-262.
    • (2013) Mol Cell Neurosci , vol.56 , pp. 255-262
    • Bachmeier, C.1    Beaulieu-Abdelahad, D.2    Mullan, M.3    Paris, D.4
  • 113
    • 0038823590 scopus 로고    scopus 로고
    • Adipocyte low density lipoprotein receptor-related protein gene expression and function is regulated by peroxisome proliferator-activated receptor gamma
    • Gauthier A, Vassiliou G, Benoist F, McPherson R (2003) Adipocyte low density lipoprotein receptor-related protein gene expression and function is regulated by peroxisome proliferator-activated receptor gamma. J Biol Chem 278, 11945-11953.
    • (2003) J Biol Chem , vol.278 , pp. 11945-11953
    • Gauthier, A.1    Vassiliou, G.2    Benoist, F.3    McPherson, R.4
  • 115
  • 116
    • 84881128469 scopus 로고    scopus 로고
    • Advances in the pathogenesis of Alzheimer's disease: Focusing on taumediated neurodegeneration
    • Duan Y, Dong S, Gu F, Hu Y, Zhao Z (2012) Advances in the pathogenesis of Alzheimer's disease: Focusing on taumediated neurodegeneration. Transl Neurodegener 1, 24.
    • (2012) Transl Neurodegener , vol.1 , pp. 24
    • Duan, Y.1    Dong, S.2    Gu, F.3    Hu, Y.4    Zhao, Z.5
  • 117
    • 33646198145 scopus 로고    scopus 로고
    • Tau therapeutic strategies for the treatment of Alzheimer's disease
    • Churcher I (2006) Tau therapeutic strategies for the treatment of Alzheimer's disease. Curr Top Med Chem 6, 579-595.
    • (2006) Curr Top Med Chem , vol.6 , pp. 579-595
    • Churcher, I.1
  • 118
    • 78649997930 scopus 로고    scopus 로고
    • The role of caspases in Alzheimer's disease; Potential novel therapeutic opportunities
    • Rohn TT (2010) The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities. Apoptosis 15, 1403-1409.
    • (2010) Apoptosis , vol.15 , pp. 1403-1409
    • Rohn, T.T.1
  • 120
    • 4043058045 scopus 로고    scopus 로고
    • Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons
    • Saez TE, Pehar M, Vargas M, Barbeito L, Maccioni RB (2004) Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons. In Vivo 18, 275-280.
    • (2004) Vivo , vol.18 , pp. 275-280
    • Saez, T.E.1    Pehar, M.2    Vargas, M.3    Barbeito, L.4    Maccioni, R.B.5
  • 121
    • 33746296471 scopus 로고    scopus 로고
    • CB1 receptor selective activa tion inhibits amyloid-induced iNOS protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons
    • Esposito G, De Filippis D, Steardo L, Scuderi C, Savani C, Cuomo V, Iuvone T (2006) CB1 receptor selective activa tion inhibits amyloid-induced iNOS protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons. Neurosci Lett 404, 342-346.
    • (2006) Neurosci Lett , vol.404 , pp. 342-346
    • Esposito, G.1    De Filippis, D.2    Steardo, L.3    Scuderi, C.4    Savani, C.5    Cuomo, V.6    Iuvone, T.7
  • 122
    • 33344456093 scopus 로고    scopus 로고
    • The marijuana component cannabidiol inhibits betaamyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells
    • Esposito G, De Filippis D, Carnuccio R, Izzo AA, Iuvone T (2006) The marijuana component cannabidiol inhibits betaamyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells. J Mol Med (Berl) 84, 253-258.
    • (2006) J Mol Med (Berl) , vol.84 , pp. 253-258
    • Esposito, G.1    De Filippis, D.2    Carnuccio, R.3    Izzo, A.A.4    Iuvone, T.5
  • 123
    • 0028981873 scopus 로고
    • Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells
    • Sperber BR, Leight S, Goedert M, Lee VM (1995) Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells. Neurosci Lett 197, 149-153.
    • (1995) Neurosci Lett , vol.197 , pp. 149-153
    • Sperber, B.R.1    Leight, S.2    Goedert, M.3    Lee, V.M.4
  • 125
    • 84876210341 scopus 로고    scopus 로고
    • BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and beta-amyloid production in Alzheimer's disease
    • Chami L, Checler F (2012) BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and beta-amyloid production in Alzheimer's disease. Mol Neurodegener 7, 52.
    • (2012) Mol Neurodegener , vol.7 , pp. 52
    • Chami, L.1    Checler, F.2
  • 126
    • 33747333885 scopus 로고    scopus 로고
    • Endocannabinoids and reactive nitrogen and oxygen species in neuropathologies
    • Howlett AC, Mukhopadhyay S, Norford DC (2006) Endocannabinoids and reactive nitrogen and oxygen species in neuropathologies. J Neuroimmune Pharmacol 1, 305-316.
    • (2006) J Neuroimmune Pharmacol , vol.1 , pp. 305-316
    • Howlett, A.C.1    Mukhopadhyay, S.2    Norford, D.C.3
  • 128
    • 33646142292 scopus 로고    scopus 로고
    • The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
    • Panikashvili D, Shein NA, Mechoulam R, Trembovler V, Kohen R, Alexandrovich A, Shohami E (2006) The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines. Neurobiol Dis 22, 257-264.
    • (2006) Neurobiol Dis , vol.22 , pp. 257-264
    • Panikashvili, D.1    Shein, N.A.2    Mechoulam, R.3    Trembovler, V.4    Kohen, R.5    Alexandrovich, A.6    Shohami, E.7
  • 129
    • 84870489074 scopus 로고    scopus 로고
    • Activation of the CB2 receptor system reverses amyloidinduced memory deficiency
    • Wu J, Bie B, Yang H, Xu JJ, Brown DL, Naguib M (2013) Activation of the CB2 receptor system reverses amyloidinduced memory deficiency. Neurobiol Aging 34, 791-804.
    • (2013) Neurobiol Aging , vol.34 , pp. 791-804
    • Wu, J.1    Bie, B.2    Yang, H.3    Xu, J.J.4    Brown, D.L.5    Naguib, M.6
  • 134
    • 13244283049 scopus 로고    scopus 로고
    • Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1betastimulated human astrocytes
    • Sheng WS, Hu S, Min X, Cabral GA, Lokensgard JR, Peterson PK (2005) Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1betastimulated human astrocytes. Glia 49, 211-219.
    • (2005) Glia , vol.49 , pp. 211-219
    • Sheng, W.S.1    Hu, S.2    Min, X.3    Cabral, G.A.4    Lokensgard, J.R.5    Peterson, P.K.6
  • 135
    • 33646078800 scopus 로고    scopus 로고
    • Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in amyloid stimulated PC12 neurons through p38 MAP kinase and NF-B involvement
    • Esposito G, De Filippis D, Maiuri MC, De Stefano D, Carnuccio R, Iuvone T (2006) Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in amyloid stimulated PC12 neurons through p38 MAP kinase and NF-B involvement. Neurosci Lett 399, 91-95.
    • (2006) Neurosci Lett , vol.399 , pp. 91-95
    • Esposito, G.1    De Filippis, D.2    Maiuri, M.C.3    De Stefano, D.4    Carnuccio, R.5    Iuvone, T.6
  • 136
    • 84924933470 scopus 로고    scopus 로고
    • Endocannabinoids in synaptic plasticity and neuroprotection
    • Xu JY, Chen C (2014) Endocannabinoids in synaptic plasticity and neuroprotection. Neuroscientist. doi: 10.1177/1073858414524632
    • (2014) Neuroscientist.
    • Xu, J.Y.1    Chen, C.2
  • 137
    • 84861302815 scopus 로고    scopus 로고
    • Beta-Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-alpha, PPAR-gamma and TRPV1, but not CB(1) or CB(2) receptors
    • Benito C, Tolon RM, Castillo AI, Ruiz-Valdepenas L, Martinez-Orgado JA, Fernandez-Sanchez FJ, Vazquez C, Cravatt BF, Romero J (2012) beta-Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-alpha, PPAR-gamma and TRPV1, but not CB(1) or CB(2) receptors. Br J Pharmacol 166, 1474-1489.
    • (2012) Br J Pharmacol , vol.166 , pp. 1474-1489
    • Benito, C.1    Tolon, R.M.2    Castillo, A.I.3    Ruiz-Valdepenas, L.4    Martinez-Orgado, J.A.5    Fernandez-Sanchez, F.J.6    Vazquez, C.7    Cravatt, B.F.8    Romero, J.9
  • 138
    • 84867519027 scopus 로고    scopus 로고
    • PPARalpha as a therapeutic target in inflammation-associated diseases
    • Gervois P, Mansouri RM (2012) PPARalpha as a therapeutic target in inflammation-associated diseases. Expert Opin Ther Targets 16, 1113-1125.
    • (2012) Expert Opin Ther Targets , vol.16 , pp. 1113-1125
    • Gervois, P.1    Mansouri, R.M.2
  • 139
    • 84893718412 scopus 로고    scopus 로고
    • Peripheral gating of pain signals by endogenous lipid mediators
    • Piomelli D, Sasso O (2014) Peripheral gating of pain signals by endogenous lipid mediators. Nat Neurosci 17, 164-174.
    • (2014) Nat Neurosci , vol.17 , pp. 164-174
    • Piomelli, D.1    Sasso, O.2
  • 140
    • 84863612316 scopus 로고    scopus 로고
    • WIN55212-2 attenuates amyloid-betainduced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-gamma pathway
    • Fakhfouri G, Ahmadiani A, Rahimian R, Grolla AA, Moradi F, Haeri A (2012) WIN55212-2 attenuates amyloid-betainduced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-gamma pathway. Neuropharmacology 63, 653-666.
    • (2012) Neuropharmacology , vol.63 , pp. 653-666
    • Fakhfouri, G.1    Ahmadiani, A.2    Rahimian, R.3    Grolla, A.A.4    Moradi, F.5    Haeri, A.6
  • 142
    • 84901791811 scopus 로고    scopus 로고
    • COX-2-derived endocannabinoid metabolites as novel inflammatory mediators
    • Alhouayek M, Muccioli GG (2014) COX-2-derived endocannabinoid metabolites as novel inflammatory mediators. Trends Pharmacol Sci 35, 284-292.
    • (2014) Trends Pharmacol Sci , vol.35 , pp. 284-292
    • Alhouayek, M.1    Muccioli, G.G.2
  • 144
    • 53049105828 scopus 로고    scopus 로고
    • Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation
    • Zhang J, Chen C (2008) Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation. J Biol Chem 283, 22601-22611.
    • (2008) J Biol Chem , vol.283 , pp. 22601-22611
    • Zhang, J.1    Chen, C.2
  • 145
    • 79952004102 scopus 로고    scopus 로고
    • Endocannabinoid 2-arachidonoylglycerol protects neurons against beta-amyloid insults
    • Chen X, Zhang J, Chen C (2011) Endocannabinoid 2-arachidonoylglycerol protects neurons against beta-amyloid insults. Neuroscience 178, 159-168.
    • (2011) Neuroscience , vol.178 , pp. 159-168
    • Chen, X.1    Zhang, J.2    Chen, C.3
  • 146
    • 79960310251 scopus 로고    scopus 로고
    • Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-gamma
    • Du H, Chen X, Zhang J, Chen C (2011) Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-gamma. Br J Pharmacol 163, 1533-1549.
    • (2011) Br J Pharmacol , vol.163 , pp. 1533-1549
    • Du, H.1    Chen, X.2    Zhang, J.3    Chen, C.4
  • 147
    • 84862776580 scopus 로고    scopus 로고
    • Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor
    • Hoshino T, Namba T, Takehara M, Murao N, Matsushima T, Sugimoto Y, Narumiya S, Suzuki T, Mizushima T (2012) Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor. J Neurochem 120, 795-805.
    • (2012) J Neurochem , vol.120 , pp. 795-805
    • Hoshino, T.1    Namba, T.2    Takehara, M.3    Murao, N.4    Matsushima, T.5    Sugimoto, Y.6    Narumiya, S.7    Suzuki, T.8    Mizushima, T.9
  • 148
    • 78649638441 scopus 로고    scopus 로고
    • Endocannabinoids prevent beta-amyloid-mediated lysosomal destabilization in cultured neurons
    • Noonan J, Tanveer R, Klompas A, Gowran A, McKiernan J, Campbell VA (2010) Endocannabinoids prevent beta-amyloid-mediated lysosomal destabilization in cultured neurons. J Biol Chem 285, 38543-38554.
    • (2010) J Biol Chem , vol.285 , pp. 38543-38554
    • Noonan, J.1    Tanveer, R.2    Klompas, A.3    Gowran, A.4    McKiernan, J.5    Campbell, V.A.6
  • 149
    • 0037206662 scopus 로고    scopus 로고
    • Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide
    • Milton NG (2002) Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide. Neurosci Lett 332, 127-130.
    • (2002) Neurosci Lett , vol.332 , pp. 127-130
    • Milton, N.G.1
  • 150
    • 84855998880 scopus 로고    scopus 로고
    • Contrasting protective effects of cannabinoids against oxidative stress and amyloid evoked neurotoxicity in vitro
    • Harvey BS, Ohlsson KS, Maag JLV, Musgrave IF, Smid SD (2012) Contrasting protective effects of cannabinoids against oxidative stress and amyloid evoked neurotoxicity in vitro. Neurotoxicology 33, 138-146.
    • (2012) Neurotoxicology , vol.33 , pp. 138-146
    • Harvey, B.S.1    Ohlsson, K.S.2    Maag, J.L.V.3    Musgrave, I.F.4    Smid, S.D.5
  • 151
    • 84859912791 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor activation rescues amyloid beta-induced alterations in behaviour and intrinsic electrophysiological properties of rat hippocampal CA1 pyramidal neurones
    • Haghani M, Shabani M, Javan M, Motamedi F, JanahmadiM( 2012) CB1 cannabinoid receptor activation rescues amyloid beta-induced alterations in behaviour and intrinsic electrophysiological properties of rat hippocampal CA1 pyramidal neurones. Cell Physiol Biochem 29, 391-406.
    • (2012) Cell Physiol Biochem , vol.29 , pp. 391-406
    • Haghani, M.1    Shabani, M.2    Javan, M.3    Motamedi, F.4    Janahmadi, M.5
  • 152
    • 21744455710 scopus 로고    scopus 로고
    • Cannabinoid-receptor 1 null mice are susceptible to neurofilament damage and caspase 3 activation
    • Jackson SJ, Pryce G, Diemel LT, Cuzner ML, Baker D (2005) Cannabinoid-receptor 1 null mice are susceptible to neurofilament damage and caspase 3 activation. Neuroscience 134, 261-268.
    • (2005) Neuroscience , vol.134 , pp. 261-268
    • Jackson, S.J.1    Pryce, G.2    Diemel, L.T.3    Cuzner, M.L.4    Baker, D.5
  • 154
    • 84861470082 scopus 로고    scopus 로고
    • Methionine-35 of abeta(1-42): Importance for oxidative stress in Alzheimer disease
    • Butterfield DA, Sultana R (2011) Methionine-35 of abeta(1-42): Importance for oxidative stress in Alzheimer disease. J Amino Acid 2011, 198430.
    • (2011) J Amino Acid , vol.2011 , pp. 198430
    • Butterfield, D.A.1    Sultana, R.2
  • 155
    • 0026068870 scopus 로고
    • Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo
    • Moncada S, Rees DD, Schulz R, Palmer RM (1991) Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc Natl Acad Sci U S A 88, 2166-2170.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 2166-2170
    • Moncada, S.1    Rees, D.D.2    Schulz, R.3    Palmer, R.M.4
  • 156
    • 1842510018 scopus 로고    scopus 로고
    • Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on betaamyloid-induced toxicity in PC12 cells
    • Iuvone T, Esposito G, Esposito R, Santamaria R, Di Rosa M, Izzo AA (2004) Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on betaamyloid-induced toxicity in PC12 cells. J Neurochem 89, 134-141.
    • (2004) J Neurochem , vol.89 , pp. 134-141
    • Iuvone, T.1    Esposito, G.2    Esposito, R.3    Santamaria, R.4    Di Rosa, M.5    Izzo, A.A.6
  • 157
    • 0037023277 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase and argininosuccinate synthetase: Co-induction in brain tissue of patients with Alzheimer's dementia and following stimulation with beta-amyloid 1-42 in vitro
    • Haas J, Storch-Hagenlocher B, Biessmann A, Wildemann B (2002) Inducible nitric oxide synthase and argininosuccinate synthetase: Co-induction in brain tissue of patients with Alzheimer's dementia and following stimulation with beta-amyloid 1-42 in vitro. Neurosci Lett 322, 121-125.
    • (2002) Neurosci Lett , vol.322 , pp. 121-125
    • Haas, J.1    Storch-Hagenlocher, B.2    Biessmann, A.3    Wildemann, B.4
  • 158
    • 0032493197 scopus 로고    scopus 로고
    • Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants
    • Hampson AJ, Grimaldi M, Axelrod J, Wink D (1998) Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci U S A 95, 8268-8273.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8268-8273
    • Hampson, A.J.1    Grimaldi, M.2    Axelrod, J.3    Wink, D.4
  • 160
    • 0016590028 scopus 로고
    • The influence of delta9-tetrahydrocannabinol, cannabinol and cannabidiol on tissue oxygen consumption
    • Chiu P, Karler R, Craven C, Olsen DM, Turkanis SA (1975) The influence of delta9-tetrahydrocannabinol, cannabinol and cannabidiol on tissue oxygen consumption. Res Commun Chem Pathol Pharmacol 12, 267-286.
    • (1975) Res Commun Chem Pathol Pharmacol , vol.12 , pp. 267-286
    • Chiu, P.1    Karler, R.2    Craven, C.3    Olsen, D.M.4    Turkanis, S.A.5
  • 161
    • 78651356681 scopus 로고    scopus 로고
    • Anandamide inhibits oxidative phosphorylation in isolated liver mitochondria
    • Zaccagnino P, Corcelli A, Baronio M, Lorusso M (2011) Anandamide inhibits oxidative phosphorylation in isolated liver mitochondria. FEBS Lett 585, 429-434.
    • (2011) FEBS Lett , vol.585 , pp. 429-434
    • Zaccagnino, P.1    Corcelli, A.2    Baronio, M.3    Lorusso, M.4
  • 162
    • 77957845422 scopus 로고    scopus 로고
    • Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure
    • Velez-Pardo C, Jimenez-Del-Rio M, Lores-Arnaiz S, Bustamante J (2010) Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure. Neurochem Res 35, 1323-1332.
    • (2010) Neurochem Res , vol.35 , pp. 1323-1332
    • Velez-Pardo, C.1    Jimenez-Del-Rio, M.2    Lores-Arnaiz, S.3    Bustamante, J.4
  • 163
    • 84863863361 scopus 로고    scopus 로고
    • The endocannabinoid 2-arachidonoylglicerol decreases calcium induced cytochrome c release from liver mitochondria
    • Zaccagnino P, D'Oria S, Romano LL, Di Venere A, Sardanelli AM, Lorusso M (2012) The endocannabinoid 2-arachidonoylglicerol decreases calcium induced cytochrome c release from liver mitochondria. J Bioenerg Biomembr 44, 273-280.
    • (2012) J Bioenerg Biomembr , vol.44 , pp. 273-280
    • Zaccagnino, P.1    D'oria, S.2    Romano, L.L.3    Di Venere, A.4    Sardanelli, A.M.5    Lorusso, M.6
  • 164
    • 69249213381 scopus 로고    scopus 로고
    • Anandamide increases swelling and reduces calcium sensitivity of mitochondria
    • Catanzaro G, Rapino C, Oddi S, Maccarrone M (2009) Anandamide increases swelling and reduces calcium sensitivity of mitochondria. Biochem Biophys Res Commun 388, 439-442.
    • (2009) Biochem Biophys Res Commun , vol.388 , pp. 439-442
    • Catanzaro, G.1    Rapino, C.2    Oddi, S.3    Maccarrone, M.4
  • 165
    • 79952111552 scopus 로고    scopus 로고
    • Roles of the endocannabinoid system in learning and memory
    • Marsicano G, Lafenetre P (2009) Roles of the endocannabinoid system in learning and memory. Curr Top Behav Neurosci 1, 201-230.
    • (2009) Curr Top Behav Neurosci , vol.1 , pp. 201-230
    • Marsicano, G.1    Lafenetre, P.2
  • 166
    • 51349141952 scopus 로고    scopus 로고
    • Endocannabinoid signaling as a synaptic circuit breaker in neurological disease
    • Katona I, Freund TF (2008) Endocannabinoid signaling as a synaptic circuit breaker in neurological disease. Nat Med 14, 923-930.
    • (2008) Nat Med , vol.14 , pp. 923-930
    • Katona, I.1    Freund, T.F.2
  • 167
    • 0034069795 scopus 로고    scopus 로고
    • Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides
    • Chen QS, Kagan BL, Hirakura Y, Xie CW (2000) Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides. J Neurosci Res 60, 65-72.
    • (2000) J Neurosci Res , vol.60 , pp. 65-72
    • Chen, Q.S.1    Kagan, B.L.2    Hirakura, Y.3    Xie, C.W.4
  • 168
    • 84902477504 scopus 로고    scopus 로고
    • Beta-Amyloid inhibits E-S potentiation through suppression of cannabinoid receptor 1-dependent synaptic disinhibition
    • Orr AL, Hanson JE, Li D, Klotz A, Wright S, Schenk D, Seubert P, Madison DV (2014) beta-Amyloid inhibits E-S potentiation through suppression of cannabinoid receptor 1-dependent synaptic disinhibition. Neuron 82, 1334-1345.
    • (2014) Neuron , vol.82 , pp. 1334-1345
    • Orr, A.L.1    Hanson, J.E.2    Li, D.3    Klotz, A.4    Wright, S.5    Schenk, D.6    Seubert, P.7    Madison, D.V.8
  • 170
    • 84907972104 scopus 로고    scopus 로고
    • Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer's disease transgenic mice
    • Cheng D, Spiro AS, Jenner AM, Garner B, Karl T (2014) Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer's disease transgenic mice. J Alzheimers Dis 42, 1383-1396.
    • (2014) J Alzheimers Dis , vol.42 , pp. 1383-1396
    • Cheng, D.1    Spiro, A.S.2    Jenner, A.M.3    Garner, B.4    Karl, T.5
  • 172
    • 77952476532 scopus 로고    scopus 로고
    • Effect of synthetic cannabinoid HU210 on memory deficits and neuropathology in Alzheimer's disease mouse model
    • Chen B, Bromley-Brits K, He G, Cai F, Zhang X, Song W (2010) Effect of synthetic cannabinoid HU210 on memory deficits and neuropathology in Alzheimer's disease mouse model. Curr Alzheimer Res 7, 255-261.
    • (2010) Curr Alzheimer Res , vol.7 , pp. 255-261
    • Chen, B.1    Bromley-Brits, K.2    He, G.3    Cai, F.4    Zhang, X.5    Song, W.6
  • 173
    • 1642320366 scopus 로고    scopus 로고
    • Amnesia induced by beta-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade
    • Mazzola C, Micale V, Drago F (2003) Amnesia induced by beta-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade. Eur J Pharmacol 477, 219-225.
    • (2003) Eur J Pharmacol , vol.477 , pp. 219-225
    • Mazzola, C.1    Micale, V.2    Drago, F.3
  • 177
    • 0027329873 scopus 로고
    • Blockade of 45Ca2+ influx through the N-methyl-D-aspartate receptor ion channel by the non-psychoactive cannabinoid HU-211
    • Nadler V, Mechoulam R, SokolovskyM(1993) Blockade of 45Ca2+ influx through the N-methyl-D-aspartate receptor ion channel by the non-psychoactive cannabinoid HU-211. Brain Res 622, 79-85.
    • (1993) Brain Res , vol.622 , pp. 79-85
    • Nadler, V.1    Mechoulam, R.2    Sokolovsky, M.3
  • 178
    • 0027788085 scopus 로고
    • HU-211, a nonpsychotropic cannabinoid, rescues cortical neurones from excitatory amino acid toxicity in culture
    • Eshhar N, Striem S, Biegon A (1993) HU-211, a nonpsychotropic cannabinoid, rescues cortical neurones from excitatory amino acid toxicity in culture. Neuroreport 5, 237-240.
    • (1993) Neuroreport , vol.5 , pp. 237-240
    • Eshhar, N.1    Striem, S.2    Biegon, A.3
  • 179
    • 0029165097 scopus 로고
    • Neuroprotective and antioxidant activities of HU-211, a novel NMDA receptor antagonist
    • Eshhar N, Striem S, Kohen R, Tirosh O, Biegon A (1995) Neuroprotective and antioxidant activities of HU-211, a novel NMDA receptor antagonist. Eur J Pharmacol 283, 19-29.
    • (1995) Eur J Pharmacol , vol.283 , pp. 19-29
    • Eshhar, N.1    Striem, S.2    Kohen, R.3    Tirosh, O.4    Biegon, A.5
  • 181
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: A simple pathway becomes complex
    • Bray SJ (2006) Notch signalling: A simple pathway becomes complex. Nat Rev Mol Cell Biol 7, 678-689.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 678-689
    • Bray, S.J.1
  • 182
    • 0041700113 scopus 로고    scopus 로고
    • Learning and memory deficits in Notch mutant mice
    • Costa RM, Honjo T, Silva AJ (2003) Learning and memory deficits in Notch mutant mice. Curr Biol 13, 1348-1354.
    • (2003) Curr Biol , vol.13 , pp. 1348-1354
    • Costa, R.M.1    Honjo, T.2    Silva, A.J.3
  • 183
    • 84867257671 scopus 로고    scopus 로고
    • The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-beta and in the cortex of aged rats
    • Tanveer R, Gowran A, Noonan J, Keating SE, Bowie AG, Campbell VA (2012) The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-beta and in the cortex of aged rats. J Biol Chem 287, 34709-34721.
    • (2012) J Biol Chem , vol.287 , pp. 34709-34721
    • Tanveer, R.1    Gowran, A.2    Noonan, J.3    Keating, S.E.4    Bowie, A.G.5    Campbell, V.A.6
  • 184
    • 0035816432 scopus 로고    scopus 로고
    • Hemodynamic effects of cannabinoids: Coronary and cerebral vasodilation mediated by cannabinoid CB1 receptors
    • Wagner JA, Járai Z, Bátkai S, Kunos G (2001) Hemodynamic effects of cannabinoids: Coronary and cerebral vasodilation mediated by cannabinoid CB1 receptors. Eur J Pharmacol 423, 203-210.
    • (2001) Eur J Pharmacol , vol.423 , pp. 203-210
    • Wagner, J.A.1    Járai, Z.2    Bátkai, S.3    Kunos, G.4
  • 186
    • 44849141696 scopus 로고    scopus 로고
    • Enzymatic pathways that regulate endocannabinoid signaling in the nervous system
    • Ahn K, McKinney MK, Cravatt BF (2008) Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chem Rev 108, 1687-1707.
    • (2008) Chem Rev , vol.108 , pp. 1687-1707
    • Ahn, K.1    McKinney, M.K.2    Cravatt, B.F.3
  • 189
    • 20444379218 scopus 로고    scopus 로고
    • Endocannabinoid system and stress and anxiety responses
    • Viveros MP, Marco EM, File SE (2005) Endocannabinoid system and stress and anxiety responses. Pharmacol Biochem Behav 81, 331-342.
    • (2005) Pharmacol Biochem Behav , vol.81 , pp. 331-342
    • Viveros, M.P.1    Marco, E.M.2    File, S.E.3
  • 190
    • 61649089261 scopus 로고    scopus 로고
    • Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: Focus on anxiety and depression
    • Moreira FA, Grieb M, Lutz B (2009) Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: Focus on anxiety and depression. Best Pract Res Clin Endocrinol Metab 23, 133-144.
    • (2009) Best Pract Res Clin Endocrinol Metab , vol.23 , pp. 133-144
    • Moreira, F.A.1    Grieb, M.2    Lutz, B.3
  • 191
    • 84875046157 scopus 로고    scopus 로고
    • Functional autoradiography shows unaltered cannabinoid CB1 receptor signalling in hippocampus and cortex of APP/PS1 transgenic mice
    • Karkkaine E, Tanila H, Laitinen JT (2012) Functional autoradiography shows unaltered cannabinoid CB1 receptor signalling in hippocampus and cortex of APP/PS1 transgenic mice. CNS Neurol Disord Drug Targets 11, 1038-1044.
    • (2012) CNS Neurol Disord Drug Targets , vol.11 , pp. 1038-1044
    • Karkkaine, E.1    Tanila, H.2    Laitinen, J.T.3
  • 193
    • 84929049319 scopus 로고    scopus 로고
    • Reductions in endocannabinoid levels and enhanced coupling of cannabinoid receptors in the striatum are accompanied by cognitive impairments in the APPswe/PS1E9 mouse model of Alzheimer's disease
    • in press
    • Maroof N, Ravipati S, Pardon MC, Barrett DA, Kendall DA (2014) Reductions in endocannabinoid levels and enhanced coupling of cannabinoid receptors in the striatum are accompanied by cognitive impairments in the APPswe/PS1E9 mouse model of Alzheimer's disease. J Alzheimers Dis. doi: 10.3233/JAD-131961, in press.
    • (2014) J Alzheimers Dis.
    • Maroof, N.1    Ravipati, S.2    Pardon, M.C.3    Barrett, D.A.4    Kendall, D.A.5
  • 194
    • 0033771946 scopus 로고    scopus 로고
    • Cannabinoid receptor-mediated inhibition of acetylcholine release from hippocampal and cortical synaptosomes
    • Gifford AN, Bruneus M, Gatley SJ, Volkow ND (2000) Cannabinoid receptor-mediated inhibition of acetylcholine release from hippocampal and cortical synaptosomes. Br J Pharmacol 131, 645-650.
    • (2000) Br J Pharmacol , vol.131 , pp. 645-650
    • Gifford, A.N.1    Bruneus, M.2    Gatley, S.J.3    Volkow, N.D.4


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