-
1
-
-
77949304859
-
Motor control and aging: Links to age-related brain structural, functional, and biochemical effects
-
doi:10.1016/j.neubiorev.2009.10.005
-
Seidler, R. D., Bernard, J. A., Burutolu, T. B., Fling, B. W., Gordon, M. T., Gwin, J. T., Kwak, Y. & Lipps, D. B. 2010 Motor control and aging: links to age-related brain structural, functional, and biochemical effects. Neurosci. Biobehav. Rev. 34, 721-733. (doi:10.1016/j.neubiorev.2009.10.005)
-
(2010)
Neurosci. Biobehav. Rev
, vol.34
, pp. 721-733
-
-
Seidler, R.D.1
Bernard, J.A.2
Burutolu, T.B.3
Fling, B.W.4
Gordon, M.T.5
Gwin, J.T.6
Kwak, Y.7
Lipps, D.B.8
-
2
-
-
0031005504
-
Emergence of a powerful connection between sensory and cognitive functions across the adult life span: A new window to the study of cognitive aging?
-
doi:10.1037/0882-7974.12.1.12
-
Baltes, P. B. & Lindenberger, U. 1997 Emergence of a powerful connection between sensory and cognitive functions across the adult life span: a new window to the study of cognitive aging? Psychol. Aging 12, 12-21. (doi:10.1037/0882-7974.12.1.12)
-
(1997)
Psychol. Aging
, vol.12
, pp. 12-21
-
-
Baltes, P.B.1
Lindenberger, U.2
-
3
-
-
54049149226
-
Changes in cognitive function in human aging
-
(ed. D. R. Riddle). New York, NY: CRC Press
-
Glisky, E. L. 2007 Changes in cognitive function in human aging. In Brain aging models, methods, and mechanisms (ed. D. R. Riddle). New York, NY: CRC Press.
-
(2007)
Brain Aging Models, Methods, and Mechanisms
-
-
Glisky, E.L.1
-
4
-
-
0024439790
-
Evidence for taskdependent memory dysfunction in the aged monkey
-
Rapp, P. R. & Amaral, D. G. 1989 Evidence for taskdependent memory dysfunction in the aged monkey. J. Neurosci. 9, 3568-3576.
-
(1989)
J. Neurosci
, vol.9
, pp. 3568-3576
-
-
Rapp, P.R.1
Amaral, D.G.2
-
5
-
-
81355139614
-
(-/-) mice
-
doi:10.1016/j.neurobiolaging.2010.07.009
-
(-/-) mice. Neurobiol. Aging 33, e11-e22. (doi:10.1016/j.neurobiolaging.2010.07.009)
-
(2012)
Neurobiol. Aging
, vol.33
-
-
Bilkei-Gorzo, A.1
-
6
-
-
33947405380
-
Cognitive aging in zebrafish
-
doi:10.1371/journal.pone.0000014
-
Yu, L., Tucci, V., Kishi, S. & Zhdanova, I. V. 2006 Cognitive aging in zebrafish. PLoS ONE 1, e14. (doi:10.1371/journal.pone.0000014)
-
(2006)
PLoS ONE
, vol.1
-
-
Yu, L.1
Tucci, V.2
Kishi, S.3
Zhdanova, I.V.4
-
7
-
-
79959752652
-
A review of functional brain imaging correlates of successful cognitive aging
-
doi:10.1016/j.biopsych.2010.12.032
-
Eyler, L. T., Sherzai, A., Kaup, A. R. & Jeste, D. V. 2011 A review of functional brain imaging correlates of successful cognitive aging. Biol. Psychiatry 70, 115-122. (doi:10.1016/j.biopsych.2010.12.032)
-
(2011)
Biol. Psychiatry
, vol.70
, pp. 115-122
-
-
Eyler, L.T.1
Sherzai, A.2
Kaup, A.R.3
Jeste, D.V.4
-
8
-
-
77956076600
-
Selective cell death in neurodegeneration: Why are some neurons spared in vulnerable regions?
-
doi:10.1016/j.pneurobio.2010.06.001
-
Double, K. L., Reyes, S., Werry, E. L. & Halliday, G. M. 2010 Selective cell death in neurodegeneration: why are some neurons spared in vulnerable regions? Prog. Neurobiol. 92, 316-329. (doi:10.1016/j.pneurobio.2010.06.001)
-
(2010)
Prog. Neurobiol
, vol.92
, pp. 316-329
-
-
Double, K.L.1
Reyes, S.2
Werry, E.L.3
Halliday, G.M.4
-
9
-
-
80052962821
-
A pathophysiological framework of hippocampal dysfunction in ageing and disease
-
doi:10.1038/nrn3085
-
Small, S. A., Schobel, S. A., Buxton, R. B., Witter, M. P. & Barnes, C. A. 2011 A pathophysiological framework of hippocampal dysfunction in ageing and disease. Nat. Rev. Neurosci. 12, 585-601. (doi:10.1038/nrn3085)
-
(2011)
Nat. Rev. Neurosci
, vol.12
, pp. 585-601
-
-
Small, S.A.1
Schobel, S.A.2
Buxton, R.B.3
Witter, M.P.4
Barnes, C.A.5
-
10
-
-
79958718254
-
Ageing, neuronal connectivity and brain disorders: An unsolved ripple effect
-
doi:10.1007/s12035-011-8164-6
-
Bano, D., Agostini, M., Melino, G. & Nicotera, P. 2011 Ageing, neuronal connectivity and brain disorders: an unsolved ripple effect. Mol. Neurobiol. 43, 124-130. (doi:10.1007/s12035-011-8164-6)
-
(2011)
Mol. Neurobiol
, vol.43
, pp. 124-130
-
-
Bano, D.1
Agostini, M.2
Melino, G.3
Nicotera, P.4
-
11
-
-
34249092704
-
Calcium and neurodegeneration
-
doi:10.1111/j.1474-9726.2007.00275.x
-
Mattson, M. P. 2007 Calcium and neurodegeneration. Aging Cell 6, 337-350. (doi:10.1111/j.1474-9726.2007.00275.x)
-
(2007)
Aging Cell
, vol.6
, pp. 337-350
-
-
Mattson, M.P.1
-
12
-
-
77955915549
-
Structural brain changes in aging: Courses, causes and cognitive consequences
-
doi:10.1515/REVNEURO.2010.21.3.187
-
Fjell, A. M. & Walhovd, K. B. 2010 Structural brain changes in aging: courses, causes and cognitive consequences. Rev. Neurosci. 21, 187-221. (doi:10.1515/REVNEURO.2010.21.3.187)
-
(2010)
Rev. Neurosci
, vol.21
, pp. 187-221
-
-
Fjell, A.M.1
Walhovd, K.B.2
-
13
-
-
25144437066
-
Changes in volume with age-consistency and interpretation of observed effects
-
discussion 1275-8. (doi:10.1016/j.neurobiolaging.2005.05.016)
-
Jernigan, T. L. & Gamst, A. C. 2005 Changes in volume with age-consistency and interpretation of observed effects. Neurobiol. Aging 26, 1271-1274; discussion 1275-8. (doi:10.1016/j.neurobiolaging.2005.05.016)
-
(2005)
Neurobiol. Aging
, vol.26
, pp. 1271-1274
-
-
Jernigan, T.L.1
Gamst, A.C.2
-
14
-
-
3042662696
-
Heterogeneous agerelated breakdown of white matter structural integrity: Implications for cortical 'disconnection' in aging and Alzheimer's disease
-
doi:10.1016/j.neurobiolaging.2003.09.005
-
Bartzokis, G., Sultzer, D., Lu, P. H., Nuechterlein, K. H., Mintz, J. & Cummings, J. L. 2004 Heterogeneous agerelated breakdown of white matter structural integrity: implications for cortical 'disconnection' in aging and Alzheimer's disease. Neurobiol. Aging 25, 843-851. (doi:10.1016/j.neurobiolaging.2003.09.005)
-
(2004)
Neurobiol. Aging
, vol.25
, pp. 843-851
-
-
Bartzokis, G.1
Sultzer, D.2
Lu, P.H.3
Nuechterlein, K.H.4
Mintz, J.5
Cummings, J.L.6
-
15
-
-
0038467307
-
Marked loss of myelinated nerve fibers in the human brain with age
-
doi:10.1002/cne.10714
-
Marner, L., Nyengaard, J. R., Tang, Y. & Pakkenberg, B. 2003 Marked loss of myelinated nerve fibers in the human brain with age. J. Comp. Neurol. 462, 144-152. (doi:10.1002/cne.10714)
-
(2003)
J. Comp. Neurol
, vol.462
, pp. 144-152
-
-
Marner, L.1
Nyengaard, J.R.2
Tang, Y.3
Pakkenberg, B.4
-
16
-
-
80052205595
-
Neuroanatomical substrates of age-related cognitive decline
-
doi:10.1037/a0023262
-
Salthouse, T. A. 2011 Neuroanatomical substrates of age-related cognitive decline. Psychol. Bull. 137, 753-784. (doi:10.1037/a0023262)
-
(2011)
Psychol. Bull
, vol.137
, pp. 753-784
-
-
Salthouse, T.A.1
-
17
-
-
0037242125
-
Aging and the human neocortex
-
doi:10.1016/S0531-5565(02)00151-1
-
Pakkenberg, B., Pelvig, D., Marner, L., Bundgaard, M. J., Gundersen, H. J., Nyengaard, J. R. & Regeur, L. 2003 Aging and the human neocortex. Exp. Gerontol. 38, 95-99. (doi:10.1016/S0531-5565(02)00151-1)
-
(2003)
Exp. Gerontol
, vol.38
, pp. 95-99
-
-
Pakkenberg, B.1
Pelvig, D.2
Marner, L.3
Bundgaard, M.J.4
Gundersen, H.J.5
Nyengaard, J.R.6
Regeur, L.7
-
18
-
-
0030929886
-
Neocortical neuron number in humans: Effect of sex and age
-
(doi:10.1002/(SICI)1096-9861(19970728)384:2,312::AID-CNE10.3.0.CO;2-K)
-
Pakkenberg, B. & Gundersen, H. J. 1997 Neocortical neuron number in humans: effect of sex and age. J. Comp. Neurol. 384, 312-320. (doi:10.1002/(SICI)1096-9861(19970728)384:2,312::AID-CNE10.3.0.CO;2-K)
-
(1997)
J. Comp. Neurol
, vol.384
, pp. 312-320
-
-
Pakkenberg, B.1
Gundersen, H.J.2
-
19
-
-
0027164617
-
Regionally specific loss of neurons in the aging human hippocampus
-
doi:10.1016/0197-4580(93)90113-P
-
West, M. J. 1993 Regionally specific loss of neurons in the aging human hippocampus. Neurobiol. Aging 14, 287-293. (doi:10.1016/0197-4580(93)90113-P)
-
(1993)
Neurobiol. Aging
, vol.14
, pp. 287-293
-
-
West, M.J.1
-
20
-
-
11844283300
-
Hemispheric asymmetry, modular variability and age-related changes in the human entorhinal cortex
-
doi:10.1016/j.neuroscience.2004.09.040
-
Simic, G., Bexheti, S., Kelovic, Z., Kos, M., Grbic, K., Hof, P. R. & Kostovic, I. 2005 Hemispheric asymmetry, modular variability and age-related changes in the human entorhinal cortex. Neuroscience 130, 911-925. (doi:10.1016/j.neuroscience.2004.09.040)
-
(2005)
Neuroscience
, vol.130
, pp. 911-925
-
-
Simic, G.1
Bexheti, S.2
Kelovic, Z.3
Kos, M.4
Grbic, K.5
Hof, P.R.6
Kostovic, I.7
-
21
-
-
0035131830
-
Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment
-
(doi:10.1002/1531-8249(20010201)49:2,202::AID-ANA40.3.0.CO;2-3)
-
Kordower, J. H., Chu, Y., Stebbins, G. T., DeKosky, S. T., Cochran, E. J., Bennett, D. & Mufson, E. J. 2001 Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment. Ann. Neurol. 49, 202-213. (doi:10.1002/1531-8249(20010201)49:2,202::AID-ANA40.3.0.CO;2-3)
-
(2001)
Ann. Neurol
, vol.49
, pp. 202-213
-
-
Kordower, J.H.1
Chu, Y.2
Stebbins, G.T.3
Dekosky, S.T.4
Cochran, E.J.5
Bennett, D.6
Mufson, E.J.7
-
22
-
-
80255127361
-
Neurogenesis, cellular plasticity and cognition: The impact of stem cells in the adult and aging brain: A mini-review
-
doi:10.1159/000323481
-
Couillard-Despres, S., Iglseder, B. & Aigner, L. 2011 Neurogenesis, cellular plasticity and cognition: the impact of stem cells in the adult and aging brain: a mini-review. Gerontology 57, 559-564. (doi:10.1159/000323481)
-
(2011)
Gerontology
, vol.57
, pp. 559-564
-
-
Couillard-Despres, S.1
Iglseder, B.2
Aigner, L.3
-
23
-
-
80053125086
-
Pattern separation in the hippocampus
-
doi:10.1016/j.tins.2011.06.006
-
Yassa, M. A. & Stark, C. E. 2011 Pattern separation in the hippocampus. Trends Neurosci. 34, 515-525. (doi:10.1016/j.tins.2011.06.006)
-
(2011)
Trends Neurosci
, vol.34
, pp. 515-525
-
-
Yassa, M.A.1
Stark, C.E.2
-
24
-
-
29244439038
-
Neural plasticity in the ageing brain
-
doi:10.1038/nrn1809
-
Burke, S. N. & Barnes, C. A. 2006 Neural plasticity in the ageing brain. Nat. Rev. Neurosci. 7, 30-40. (doi:10.1038/nrn1809)
-
(2006)
Nat. Rev. Neurosci
, vol.7
, pp. 30-40
-
-
Burke, S.N.1
Barnes, C.A.2
-
25
-
-
79956365255
-
Morphological changes in nerve cells during normal aging
-
doi:10.1007/s00429-011-0308-y
-
Pannese, E. 2011 Morphological changes in nerve cells during normal aging. Brain Struct. Funct. 216, 85-89. (doi:10.1007/s00429-011-0308-y)
-
(2011)
Brain Struct. Funct
, vol.216
, pp. 85-89
-
-
Pannese, E.1
-
26
-
-
0027490565
-
Critical issues in the analysis of dendritic extent in aging humans, primates, and rodents
-
doi:10.1016/0197-4580(93)90058-J
-
Flood, D. G. 1993 Critical issues in the analysis of dendritic extent in aging humans, primates, and rodents. Neurobiol. Aging 14, 649-654. (doi:10.1016/0197-4580(93)90058-J)
-
(1993)
Neurobiol. Aging
, vol.14
, pp. 649-654
-
-
Flood, D.G.1
-
27
-
-
0037165871
-
Age-related and laminar- specific dendritic changes in the medial frontal cortex of the rat
-
doi:10.1016/S0006-8993(02)02457-5
-
Grill, J. D. & Riddle, D. R. 2002 Age-related and laminar- specific dendritic changes in the medial frontal cortex of the rat. Brain Res. 937, 8-21. (doi:10.1016/S0006-8993(02)02457-5)
-
(2002)
Brain Res
, vol.937
, pp. 8-21
-
-
Grill, J.D.1
Riddle, D.R.2
-
28
-
-
57649121159
-
Expression profile analysis of brain aging
-
(ed. D. R. Riddle, Boca Raton, FL: CRC Press
-
Ginsberg, S. D. 2007 Expression profile analysis of brain aging. In Brain aging models methods, and mechanisms (ed. D. R. Riddle), pp. 159-185. Boca Raton, FL: CRC Press.
-
(2007)
Brain Aging Models Methods, and Mechanisms
, pp. 159-185
-
-
Ginsberg, S.D.1
-
29
-
-
0037101970
-
Function and regulation of CREB family transcription factors in the nervous system
-
doi:10.1016/S0896-6273(02)00828-0
-
Lonze, B. E. & Ginty, D. D. 2002 Function and regulation of CREB family transcription factors in the nervous system. Neuron 35, 605-623. (doi:10.1016/S0896-6273(02)00828-0)
-
(2002)
Neuron
, vol.35
, pp. 605-623
-
-
Lonze, B.E.1
Ginty, D.D.2
-
30
-
-
79954573504
-
The role of CREB signaling in Alzheimer's disease and other cognitive disorders
-
doi:10.1515/rns.2011.018
-
Saura, C. A. & Valero, J. 2011 The role of CREB signaling in Alzheimer's disease and other cognitive disorders. Rev. Neurosci. 22, 153-169. (doi:10.1515/rns.2011.018)
-
(2011)
Rev. Neurosci
, vol.22
, pp. 153-169
-
-
Saura, C.A.1
Valero, J.2
-
31
-
-
77957343182
-
CREB binding protein is required for both short-term and long-term memory formation
-
doi:10.1523/JNEUROSCI.2378-10.2010
-
Chen, G., Zou, X., Watanabe, H., van Deursen, J. M. & Shen, J. 2010 CREB binding protein is required for both short-term and long-term memory formation. J. Neurosci. 30, 13066-13077. (doi:10.1523/JNEUROSCI.2378-10.2010)
-
(2010)
J. Neurosci
, vol.30
, pp. 13066-13077
-
-
Chen, G.1
Zou, X.2
Watanabe, H.3
van Deursen, J.M.4
Shen, J.5
-
32
-
-
84855433975
-
Successful cognitive aging in rats: A role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways
-
doi:10.1371/journal.pone.0028666
-
Menard, C. & Quirion, R. 2012 Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways. PLoS ONE 7, e28666. (doi:10.1371/journal.pone.0028666)
-
(2012)
PLoS ONE
, vol.7
-
-
Menard, C.1
Quirion, R.2
-
33
-
-
84855389519
-
CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, whileNMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy
-
doi:10.1093/hmg/ddr492
-
Ljungberg, M. C., Ali, Y. O., Zhu, J., Wu, C. S., Oka, K., Zhai, R.G. & Lu, H. C. 2012 CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, whileNMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. Hum. Mol. Genet. 21, 251-267. (doi:10.1093/hmg/ddr492)
-
(2012)
Hum. Mol. Genet
, vol.21
, pp. 251-267
-
-
Ljungberg, M.C.1
Ali, Y.O.2
Zhu, J.3
Wu, C.S.4
Oka, K.5
Zhai, R.G.6
Lu, H.C.7
-
34
-
-
35448930622
-
Evidence of Abeta- and transgenedependent defects in ERK-CREB signaling in Alzheimer's models
-
doi:10.1111/j.1471-4159.2007.04869.x
-
Ma, Q. L., Harris-White, M. E., Ubeda, O. J., Simmons, M., Beech, W., Lim, G. P., Teter, B., Frautschy, S. A. & Cole, G. M. 2007 Evidence of Abeta- and transgenedependent defects in ERK-CREB signaling in Alzheimer's models. J. Neurochem. 103, 1594-1607. (doi:10.1111/j.1471-4159.2007.04869.x)
-
(2007)
J. Neurochem
, vol.103
, pp. 1594-1607
-
-
Ma, Q.L.1
Harris-White, M.E.2
Ubeda, O.J.3
Simmons, M.4
Beech, W.5
Lim, G.P.6
Teter, B.7
Frautschy, S.A.8
Cole, G.M.9
-
35
-
-
33847688564
-
Impairment of CREB phosphorylation in the hippocampal CA1 region of the senescence-accelerated mouse (SAM) P8
-
doi:10.1016/j.brainres.2006.08.026
-
Tomobe, K., Okuma, Y. & Nomura, Y. 2007 Impairment of CREB phosphorylation in the hippocampal CA1 region of the senescence-accelerated mouse (SAM) P8. Brain Res. 1141, 214-217. (doi:10.1016/j.brainres.2006.08.026)
-
(2007)
Brain Res
, vol.1141
, pp. 214-217
-
-
Tomobe, K.1
Okuma, Y.2
Nomura, Y.3
-
36
-
-
30344438257
-
Dysregulation of memory-related proteins in the hippocampus of aged rats and their relation with cognitive impairment
-
doi:10.1002/hipo.20099
-
Monti, B., Berteotti, C. & Contestabile, A. 2005 Dysregulation of memory-related proteins in the hippocampus of aged rats and their relation with cognitive impairment. Hippocampus 15, 1041-1049. (doi:10.1002/hipo.20099)
-
(2005)
Hippocampus
, vol.15
, pp. 1041-1049
-
-
Monti, B.1
Berteotti, C.2
Contestabile, A.3
-
37
-
-
49149105430
-
Alteration of CREB phosphorylation and spatial memory deficits in aged 129T2/Sv mice
-
doi:10.1016/j.neurobiolaging.2007.03.023
-
Porte, Y., Buhot, M. C. & Mons, N. 2008 Alteration of CREB phosphorylation and spatial memory deficits in aged 129T2/Sv mice. Neurobiol. Aging 29, 1533-1546. (doi:10.1016/j.neurobiolaging.2007.03.023)
-
(2008)
Neurobiol. Aging
, vol.29
, pp. 1533-1546
-
-
Porte, Y.1
Buhot, M.C.2
Mons, N.3
-
38
-
-
79951787452
-
Lifespan extension induced byAMPKand calcineurin is mediated by CRTC-1 and CREB
-
doi:10.1038/nature09706
-
Mair, W., Morantte, I., Rodrigues, A. P., Manning, G., Montminy, M., Shaw, R. J. & Dillin, A. 2011 Lifespan extension induced byAMPKand calcineurin is mediated by CRTC-1 and CREB. Nature 470, 404-408. (doi:10.1038/nature09706)
-
(2011)
Nature
, vol.470
, pp. 404-408
-
-
Mair, W.1
Morantte, I.2
Rodrigues, A.P.3
Manning, G.4
Montminy, M.5
Shaw, R.J.6
Dillin, A.7
-
39
-
-
72949109772
-
Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling
-
doi:10.1371/journal.pbio.1000245
-
Zhang, M., Poplawski, M., Yen, K., Cheng, H., Bloss, E., Zhu, X., Patel, H. & Mobbs, C. V. 2009 Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. PLoS Biol. 7, e1000245. (doi:10.1371/journal.pbio.1000245)
-
(2009)
PLoS Biol
, vol.7
-
-
Zhang, M.1
Poplawski, M.2
Yen, K.3
Cheng, H.4
Bloss, E.5
Zhu, X.6
Patel, H.7
Mobbs, C.V.8
-
40
-
-
14944356256
-
2+ and mitochondria as substrates for deficits in synaptic plasticity in normal brain ageing
-
doi:10.1111/j.1582-4934.2004.tb00273.x
-
2+ and mitochondria as substrates for deficits in synaptic plasticity in normal brain ageing. J. Cell Mol. Med. 8, 181-190. (doi:10.1111/j.1582-4934.2004.tb00273.x)
-
(2004)
J. Cell Mol. Med
, vol.8
, pp. 181-190
-
-
Toescu, E.C.1
Verkhratsky, A.2
-
41
-
-
0029782113
-
Increase in single L-type calcium channels in hippocampal neurons during aging
-
doi:10.1126/science.272.5264.1017
-
Thibault, O. & Landfield, P. W. 1996 Increase in single L-type calcium channels in hippocampal neurons during aging. Science 272, 1017-1020. (doi:10.1126/science.272.5264.1017)
-
(1996)
Science
, vol.272
, pp. 1017-1020
-
-
Thibault, O.1
Landfield, P.W.2
-
42
-
-
0030567757
-
Decreased plasma membrane calcium transport activity in aging brain
-
doi:10.1016/0024-3205(96)00319-0
-
Michaelis, M. L. et al. 1996 Decreased plasma membrane calcium transport activity in aging brain. Life Sci. 59, 405-412. (doi:10.1016/0024-3205(96)00319-0)
-
(1996)
Life Sci
, vol.59
, pp. 405-412
-
-
Michaelis, M.L.1
-
43
-
-
0032437456
-
2+-ATPase in F344/BNF1 rats
-
doi:10.1016/S0197-4580(98)00078-5
-
Zaidi, A., Gao, J., Squier, T. C. & Michaelis, M. L. 1998 Age-related decrease in brain synaptic membrane Ca2+-ATPase in F344/BNF1 rats. Neurobiol. Aging 19, 487-495. (doi:10.1016/S0197-4580(98)00078-5)
-
(1998)
Neurobiol. Aging
, vol.19
, pp. 487-495
-
-
Zaidi, A.1
Gao, J.2
Squier, T.C.3
Michaelis, M.L.4
-
44
-
-
0038434115
-
Age-related changes in calbindin-D28k, calretinin, and parvalbumin-immunoreactive neurons in the human cerebral cortex
-
doi:10.1016/S0014-4886(03)00094-3
-
Bu, J., Sathyendra, V., Nagykery, N. & Geula, C. 2003 Age-related changes in calbindin-D28k, calretinin, and parvalbumin-immunoreactive neurons in the human cerebral cortex. Exp. Neurol. 182, 220-231. (doi:10.1016/S0014-4886(03)00094-3)
-
(2003)
Exp. Neurol
, vol.182
, pp. 220-231
-
-
Bu, J.1
Sathyendra, V.2
Nagykery, N.3
Geula, C.4
-
45
-
-
4544262624
-
2+ regulation and gene expression in normal brain aging
-
doi:10.1016/j.tins.2004.07.010
-
2+ regulation and gene expression in normal brain aging. Trends Neurosci. 27, 614-620. (doi:10.1016/j.tins.2004.07.010)
-
(2004)
Trends Neurosci
, vol.27
, pp. 614-620
-
-
Toescu, E.C.1
Verkhratsky, A.2
Landfield, P.W.3
-
46
-
-
77950229880
-
Neural mechanisms of ageing and cognitive decline
-
doi:10.1038/nature08983
-
Bishop, N. A., Lu, T. & Yankner, B. A. 2010 Neural mechanisms of ageing and cognitive decline. Nature 464, 529-535. (doi:10.1038/nature08983)
-
(2010)
Nature
, vol.464
, pp. 529-535
-
-
Bishop, N.A.1
Lu, T.2
Yankner, B.A.3
-
47
-
-
3042631024
-
Gene regulation and DNA damage in the ageing human brain
-
doi:10.1038/nature02661
-
Lu, T., Pan, Y., Kao, S. Y., Li, C., Kohane, I., Chan, J. & Yankner, B. A. 2004 Gene regulation and DNA damage in the ageing human brain. Nature 429, 883-891. (doi:10.1038/nature02661)
-
(2004)
Nature
, vol.429
, pp. 883-891
-
-
Lu, T.1
Pan, Y.2
Kao, S.Y.3
Li, C.4
Kohane, I.5
Chan, J.6
Yankner, B.A.7
-
48
-
-
0000847978
-
Gene-expression profile of the ageing brain in mice
-
doi:10.1038/77046
-
Lee, C. K., Weindruch, R. & Prolla, T. A. 2000 Gene-expression profile of the ageing brain in mice. Nat. Genet. 25, 294-297. (doi:10.1038/77046)
-
(2000)
Nat. Genet
, vol.25
, pp. 294-297
-
-
Lee, C.K.1
Weindruch, R.2
Prolla, T.A.3
-
49
-
-
34547631266
-
Temporal and spatial transcriptional profiles of aging in Drosophila melanogaster
-
doi:10.1101/gr.6216607
-
Zhan, M., Yamaza, H., Sun, Y., Sinclair, J., Li, H. & Zou, S. 2007 Temporal and spatial transcriptional profiles of aging in Drosophila melanogaster. Genome Res. 17, 1236-1243. (doi:10.1101/gr.6216607)
-
(2007)
Genome Res
, vol.17
, pp. 1236-1243
-
-
Zhan, M.1
Yamaza, H.2
Sun, Y.3
Sinclair, J.4
Li, H.5
Zou, S.6
-
50
-
-
80054993342
-
Spatio-temporal transcriptome of the human brain
-
doi:10.1038/nature10523
-
Kang, H. J. et al. 2011 Spatio-temporal transcriptome of the human brain. Nature 478, 483-489. (doi:10.1038/nature10523)
-
(2011)
Nature
, vol.478
, pp. 483-489
-
-
Kang, H.J.1
-
51
-
-
0035852759
-
The effects of aging on gene expression in the hypothalamus and cortex of mice
-
doi:10.1073/pnas.98.4.1930
-
Jiang, C. H., Tsien, J. Z., Schultz, P. G. & Hu, Y. 2001 The effects of aging on gene expression in the hypothalamus and cortex of mice. Proc. Natl Acad. Sci. USA 98, 1930-1934. (doi:10.1073/pnas.98.4.1930)
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 1930-1934
-
-
Jiang, C.H.1
Tsien, J.Z.2
Schultz, P.G.3
Hu, Y.4
-
52
-
-
0038206578
-
Gene microarrays in hippocampal aging: Statistical profiling identifies novel processes correlated with cognitive impairment
-
Blalock, E. M., Chen, K. C., Sharrow, K., Herman, J. P., Porter, N. M., Foster, T. C. & Landfield, P. W. 2003 Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. J. Neurosci. 23, 3807-3819.
-
(2003)
J. Neurosci
, vol.23
, pp. 3807-3819
-
-
Blalock, E.M.1
Chen, K.C.2
Sharrow, K.3
Herman, J.P.4
Porter, N.M.5
Foster, T.C.6
Landfield, P.W.7
-
53
-
-
33750522659
-
Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments
-
doi:10.1016/j.nlm.2006.05.003
-
Burger, C., Lopez, M. C., Feller, J. A., Baker, H. V., Muzyczka, N. & Mandel, R. J. 2007 Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments. Neurobiol. Learn. Mem. 87, 21-41. (doi:10.1016/j.nlm.2006.05.003)
-
(2007)
Neurobiol. Learn. Mem
, vol.87
, pp. 21-41
-
-
Burger, C.1
Lopez, M.C.2
Feller, J.A.3
Baker, H.V.4
Muzyczka, N.5
Mandel, R.J.6
-
54
-
-
77956924897
-
Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice
-
doi:10.1016/j.neurobiolaging.2008.10.016
-
Stranahan, A. M., Lee, K., Becker, K. G., Zhang, Y., Maudsley, S., Martin, B., Cutler, R. G. & Mattson, M. P. 2010 Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice. Neurobiol. Aging 31, 1937-1949. (doi:10.1016/j.neurobiolaging.2008.10.016)
-
(2010)
Neurobiol. Aging
, vol.31
, pp. 1937-1949
-
-
Stranahan, A.M.1
Lee, K.2
Becker, K.G.3
Zhang, Y.4
Maudsley, S.5
Martin, B.6
Cutler, R.G.7
Mattson, M.P.8
-
55
-
-
67349158710
-
Implications of age and diet on canine cerebral cortex transcription
-
doi:10.1016/j.neurobiolaging.2007.10.017
-
Swanson, K. S., Vester, B. M., Apanavicius, C. J., Kirby, N. A. & Schook, L. B. 2009 Implications of age and diet on canine cerebral cortex transcription. Neurobiol. Aging 30, 1314-1326. (doi:10.1016/j.neurobiolaging.2007.10.017)
-
(2009)
Neurobiol. Aging
, vol.30
, pp. 1314-1326
-
-
Swanson, K.S.1
Vester, B.M.2
Apanavicius, C.J.3
Kirby, N.A.4
Schook, L.B.5
-
56
-
-
79960137052
-
Prominent hippocampal CA3 gene expression profile in neurocognitive aging
-
doi:10.1016/j.neurobiolaging.2009.10.005
-
Haberman, R. P., Colantuoni, C., Stocker, A. M., Schmidt, A. C., Pedersen, J. T. & Gallagher, M. 2011 Prominent hippocampal CA3 gene expression profile in neurocognitive aging. Neurobiol. Aging 32, 1678-1692. (doi:10.1016/j.neurobiolaging.2009.10.005)
-
(2011)
Neurobiol. Aging
, vol.32
, pp. 1678-1692
-
-
Haberman, R.P.1
Colantuoni, C.2
Stocker, A.M.3
Schmidt, A.C.4
Pedersen, J.T.5
Gallagher, M.6
-
57
-
-
9744278990
-
A mouse model for Finnish variant late infantile neuronal ceroid lipofuscinosis, CLN5, reveals neuropathology associated with early aging
-
doi:10.1093/hmg/ddh312
-
Kopra, O. et al. 2004 A mouse model for Finnish variant late infantile neuronal ceroid lipofuscinosis, CLN5, reveals neuropathology associated with early aging. Hum. Mol. Genet. 13, 2893-2906. (doi:10.1093/hmg/ddh312)
-
(2004)
Hum. Mol. Genet
, vol.13
, pp. 2893-2906
-
-
Kopra, O.1
-
58
-
-
7044231566
-
Microarray analysis in Alzheimer's disease and normal aging
-
doi:10.1080/15216540 412331286002
-
Ricciarelli, R., d'Abramo, C., Massone, S., Marinari, U., Pronzato, M. & Tabaton, M. 2004 Microarray analysis in Alzheimer's disease and normal aging. IUBMB Life 56, 349-354. (doi:10.1080/15216540 412331286002)
-
(2004)
IUBMB Life
, vol.56
, pp. 349-354
-
-
Ricciarelli, R.1
D'abramo, C.2
Massone, S.3
Marinari, U.4
Pronzato, M.5
Tabaton, M.6
-
59
-
-
31844453586
-
Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease
-
doi:10.1016/j.neurobiolaging.2005.02.010
-
Wu, Z. L., Ciallella, J. R., Flood, D. G., O'Kane, T. M., Bozyczko-Coyne, D. & Savage, M. J. 2006 Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease. Neurobiol. Aging 27, 377-386. (doi:10.1016/j.neurobiolaging.2005.02.010)
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 377-386
-
-
Wu, Z.L.1
Ciallella, J.R.2
Flood, D.G.3
O'Kane, T.M.4
Bozyczko-Coyne, D.5
Savage, M.J.6
-
60
-
-
77952715009
-
Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex
-
doi:10.1073/pnas.1001702107
-
Cheung, I., Shulha, H.P., Jiang, Y., Matevossian, A., Wang, J., Weng, Z. & Akbarian, S. 2010 Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex. Proc. Natl Acad. Sci. USA 107, 8824-8829. (doi:10.1073/pnas.1001702107)
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 8824-8829
-
-
Cheung, I.1
Shulha, H.P.2
Jiang, Y.3
Matevossian, A.4
Wang, J.5
Weng, Z.6
Akbarian, S.7
-
61
-
-
84899552792
-
Do different neurons age differently? Direct genome-wide analysis of aging in single identified cholinergic neurons
-
doi:10.3389/neuro.24.006.2010
-
Moroz, L. L. & Kohn, A. B. 2010 Do different neurons age differently? Direct genome-wide analysis of aging in single identified cholinergic neurons. Front. Aging Neurosci. 2, 6. (doi:10.3389/neuro.24.006.2010)
-
(2010)
Front. Aging Neurosci
, vol.2
, pp. 6
-
-
Moroz, L.L.1
Kohn, A.B.2
-
62
-
-
77952168294
-
Altered histone acetylation is associated with age-dependent memory impairment in mice
-
doi:10.1126/science.1186088
-
Peleg, S. et al. 2010 Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 328, 753-756. (doi:10.1126/science.1186088)
-
(2010)
Science
, vol.328
, pp. 753-756
-
-
Peleg, S.1
-
63
-
-
79955100322
-
Oxidative stress and the aging brain: From theory to prevention
-
(ed. D. R. Riddle, Boca Raton, FL: CRC Press
-
Gemma, C., Vila, J., Bachstetter, A. & Bickford, P. C. 2007 Oxidative stress and the aging brain: from theory to prevention. In Brain aging: models, methods, and mechanisms (ed. D. R. Riddle), pp. 353-374. Boca Raton, FL: CRC Press.
-
(2007)
Brain Aging: Models, Methods, and Mechanisms
, pp. 353-374
-
-
Gemma, C.1
Vila, J.2
Bachstetter, A.3
Bickford, P.C.4
-
64
-
-
2342594384
-
The mitochondrial production of reactive oxygen species in relation to aging and pathology
-
doi:10.1196/annals.1293.010
-
Genova, M. L. et al. 2004 The mitochondrial production of reactive oxygen species in relation to aging and pathology. Ann. NY Acad. Sci. 1011, 86-100. (doi:10.1196/annals.1293.010)
-
(2004)
Ann. NY Acad. Sci
, vol.1011
, pp. 86-100
-
-
Genova, M.L.1
-
65
-
-
8444227821
-
Reactive oxygen species and synaptic plasticity in the aging hippocampus
-
doi:10.1016/j.arr.2004.05.002
-
Serrano, F. & Klann, E. 2004 Reactive oxygen species and synaptic plasticity in the aging hippocampus. Ageing Res. Rev. 3, 431-443. (doi:10.1016/j.arr.2004.05.002)
-
(2004)
Ageing Res. Rev
, vol.3
, pp. 431-443
-
-
Serrano, F.1
Klann, E.2
-
66
-
-
79960167259
-
Selective neuronal vulnerability in neurodegenerative diseases: From stressor thresholds to degeneration
-
doi:10.1016/j.neuron.2011.06.031
-
Saxena, S. & Caroni, P. 2011 Selective neuronal vulnerability in neurodegenerative diseases: from stressor thresholds to degeneration. Neuron 71, 35-48. (doi:10.1016/j.neuron.2011.06.031)
-
(2011)
Neuron
, vol.71
, pp. 35-48
-
-
Saxena, S.1
Caroni, P.2
-
67
-
-
33644959683
-
Mitochondrial respiration and reactive oxygen species in mitochondrial aging mutants
-
doi:10.1016/j.exger.2006.01.004
-
Sedensky, M. M. & Morgan, P. G. 2006 Mitochondrial respiration and reactive oxygen species in mitochondrial aging mutants. Exp. Gerontol. 41, 237-245. (doi:10.1016/j.exger.2006.01.004)
-
(2006)
Exp. Gerontol
, vol.41
, pp. 237-245
-
-
Sedensky, M.M.1
Morgan, P.G.2
-
68
-
-
24944457649
-
Aging and gene expression in the primate brain
-
doi:10.1371/journal.pbio.0030274
-
Fraser, H. B., Khaitovich, P., Plotkin, J. B., Paabo, S. & Eisen, M. B. 2005 Aging and gene expression in the primate brain. PLoS Biol. 3, e274. (doi:10.1371/journal.pbio.0030274)
-
(2005)
PLoS Biol
, vol.3
-
-
Fraser, H.B.1
Khaitovich, P.2
Plotkin, J.B.3
Paabo, S.4
Eisen, M.B.5
-
69
-
-
47349098337
-
Age-related increase of superoxide generation in the brains of mammals and birds
-
doi:10.1111/j.1474-9726.2008.00394.x
-
Sasaki, T., Unno, K., Tahara, S., Shimada, A., Chiba, Y., Hoshino, M. & Kaneko, T. 2008 Age-related increase of superoxide generation in the brains of mammals and birds. Aging Cell 7, 459-469. (doi:10.1111/j.1474-9726.2008.00394.x)
-
(2008)
Aging Cell
, vol.7
, pp. 459-469
-
-
Sasaki, T.1
Unno, K.2
Tahara, S.3
Shimada, A.4
Chiba, Y.5
Hoshino, M.6
Kaneko, T.7
-
70
-
-
41749110458
-
The aging brain
-
doi:10.1146/annurev.pathmechdis.2.010506.092044
-
Yankner, B. A., Lu, T. & Loerch, P. 2008 The aging brain. Annu. Rev. Pathol. 3, 41-66. (doi:10.1146/annurev.pathmechdis.2.010506.092044)
-
(2008)
Annu. Rev. Pathol
, vol.3
, pp. 41-66
-
-
Yankner, B.A.1
Lu, T.2
Loerch, P.3
-
71
-
-
33745287476
-
Normal brain ageing: Models and mechanisms
-
doi:10.1098/rstb.2005.1771
-
Toescu, E. C. 2005 Normal brain ageing: models and mechanisms. Phil. Trans. R. Soc. B 360, 2347-2354. (doi:10.1098/rstb.2005.1771)
-
(2005)
Phil. Trans. R. Soc. B
, vol.360
, pp. 2347-2354
-
-
Toescu, E.C.1
-
72
-
-
0036751954
-
Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases
-
doi:10.1016/S0197-4580(02)00019-2
-
Floyd, R. A. & Hensley, K. 2002 Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol. Aging 23, 795-807. (doi:10.1016/S0197-4580(02)00019-2)
-
(2002)
Neurobiol. Aging
, vol.23
, pp. 795-807
-
-
Floyd, R.A.1
Hensley, K.2
-
73
-
-
78650142376
-
Protein oxidative modifications in the ageing brain: Consequence for the onset of neurodegenerative disease
-
doi:10.3109/10715762.2010.512040
-
Grimm, S., Hoehn, A., Davies, K. J. & Grune, T. 2011 Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease. Free Radic. Res. 45, 73-88. (doi:10.3109/10715762.2010.512040)
-
(2011)
Free Radic. Res
, vol.45
, pp. 73-88
-
-
Grimm, S.1
Hoehn, A.2
Davies, K.J.3
Grune, T.4
-
74
-
-
27744576098
-
Oxidative modification of proteins in the frontal cortex of Alzheimer's disease brain
-
doi:10.1016/j.neurobiolaging.2004.11.010
-
Korolainen, M. A., Goldsteins, G., Nyman, T. A., Alafuzoff, I., Koistinaho, J. & Pirttila, T. 2006 Oxidative modification of proteins in the frontal cortex of Alzheimer's disease brain. Neurobiol. Aging 27, 42-53. (doi:10.1016/j.neurobiolaging.2004.11.010)
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 42-53
-
-
Korolainen, M.A.1
Goldsteins, G.2
Nyman, T.A.3
Alafuzoff, I.4
Koistinaho, J.5
Pirttila, T.6
-
75
-
-
57649221161
-
Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: Lights and shadows
-
doi:10.1196/annals.1427.010
-
Pratico, D. 2008 Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows. Ann. NY Acad. Sci. 1147, 70-78. (doi:10.1196/annals.1427.010)
-
(2008)
Ann. NY Acad. Sci
, vol.1147
, pp. 70-78
-
-
Pratico, D.1
-
76
-
-
84863229362
-
The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons
-
doi:10.1097/NEN.0b013e318248e614
-
Nunomura, A. et al. 2012 The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons. J. Neuropathol. Exp. Neurol. 71, 233-241. (doi:10.1097/NEN.0b013e318248e614)
-
(2012)
J. Neuropathol. Exp. Neurol
, vol.71
, pp. 233-241
-
-
Nunomura, A.1
-
77
-
-
78649815388
-
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
-
doi:10.1073/pnas.1006586107
-
Du, H., Guo, L., Yan, S., Sosunov, A. A., McKhann, G. M. & Yan, S. S. 2010 Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc. Natl Acad. Sci. USA 107, 18670-18675. (doi:10.1073/pnas.1006586107)
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 18670-18675
-
-
Du, H.1
Guo, L.2
Yan, S.3
Sosunov, A.A.4
McKhann, G.M.5
Yan, S.S.6
-
78
-
-
84856002072
-
Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity
-
doi:10.1371/journal.pone.0028033
-
Lee, H. P., Pancholi, N., Esposito, L., Previll, L. A., Wang, X., Zhu, X., Smith, M. A. & Lee, H. G. 2012 Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. PLoS ONE 7, e28033. (doi:10.1371/journal.pone.0028033)
-
(2012)
PLoS ONE
, vol.7
-
-
Lee, H.P.1
Pancholi, N.2
Esposito, L.3
Previll, L.A.4
Wang, X.5
Zhu, X.6
Smith, M.A.7
Lee, H.G.8
-
79
-
-
80155148269
-
The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease
-
(doi:10.1523/JNEUROSCI.0552-11.2011)
-
McManus, M. J., Murphy, M. P. & Franklin, J. L. 2011 The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease. J. Neurosci. 31, 15703-15715. (doi:10.1523/JNEUROSCI.0552-11.2011)
-
(2011)
J. Neurosci
, vol.31
, pp. 15703-15715
-
-
McManus, M.J.1
Murphy, M.P.2
Franklin, J.L.3
-
80
-
-
78649866553
-
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
-
doi:10.1038/nature09536
-
Guzman, J. N., Sanchez-Padilla, J., Wokosin, D., Kondapalli, J., Ilijic, E., Schumacker, P. T. & Surmeier, D. J. 2010 Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 468, 696-700. (doi:10.1038/nature09536)
-
(2010)
Nature
, vol.468
, pp. 696-700
-
-
Guzman, J.N.1
Sanchez-Padilla, J.2
Wokosin, D.3
Kondapalli, J.4
Ilijic, E.5
Schumacker, P.T.6
Surmeier, D.J.7
-
81
-
-
84856372105
-
Increased oxidative damage and decreased antioxidant function in aging human substantia nigra compared to striatum: Implications for Parkinson's disease
-
doi:10.1007/s11064-011-0619-7
-
Venkateshappa, C., Harish, G., Mythri, R. B., Mahadevan, A., Bharath, M. M. & Shankar, S. K. 2012 Increased oxidative damage and decreased antioxidant function in aging human substantia nigra compared to striatum: implications for Parkinson's disease. Neurochem. Res. 37, 358-369. (doi:10.1007/s11064-011-0619-7)
-
(2012)
Neurochem. Res
, vol.37
, pp. 358-369
-
-
Venkateshappa, C.1
Harish, G.2
Mythri, R.B.3
Mahadevan, A.4
Bharath, M.M.5
Shankar, S.K.6
-
82
-
-
0026492005
-
Disease-specific patterns of locus coeruleus cell loss
-
doi:10.1002/ana.410320510
-
German, D. C., Manaye, K. F., White 3rd, C. L., Woodward, D. J., McIntire, D. D., Smith, W. K., Kalaria, R. N. & Mann, D. M. 1992 Disease-specific patterns of locus coeruleus cell loss. Ann. Neurol. 32, 667-676. (doi:10.1002/ana.410320510)
-
(1992)
Ann. Neurol
, vol.32
, pp. 667-676
-
-
German, D.C.1
Manaye, K.F.2
White, C.L.3
Woodward, D.J.4
McIntire, D.D.5
Smith, W.K.6
Kalaria, R.N.7
Mann, D.M.8
-
83
-
-
79955679714
-
Oxidation chemistry of catecholamines and neuronal degeneration: An update
-
doi:10.2174/092986711795496863
-
Napolitano, A., Manini, P. & d'Ischia, M. 2011 Oxidation chemistry of catecholamines and neuronal degeneration: an update. Curr. Med. Chem. 18, 1832-1845. (doi:10.2174/092986711795496863)
-
(2011)
Curr. Med. Chem
, vol.18
, pp. 1832-1845
-
-
Napolitano, A.1
Manini, P.2
D'ischia, M.3
-
84
-
-
62349089251
-
Oxidative damage and cognitive dysfunction: Antioxidant treatments to promote healthy brain aging
-
doi:10.1007/s11064-008-9808-4
-
Head, E. 2009 Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging. Neurochem. Res. 34, 670-678. (doi:10.1007/s11064-008-9808-4)
-
(2009)
Neurochem. Res
, vol.34
, pp. 670-678
-
-
Head, E.1
-
85
-
-
28444463999
-
The beneficial effects of fruit polyphenols on brain aging
-
doi:10.1016/j.neurobiolaging.2005.08.007
-
Lau, F. C., Shukitt-Hale, B. & Joseph, J. A. 2005 The beneficial effects of fruit polyphenols on brain aging. Neurobiol. Aging 26(Suppl. 1), 128-132. (doi:10.1016/j.neurobiolaging.2005.08.007)
-
(2005)
Neurobiol. Aging
, vol.26
, Issue.SUPPL. 1
, pp. 128-132
-
-
Lau, F.C.1
Shukitt-Hale, B.2
Joseph, J.A.3
-
86
-
-
0036233805
-
Therapeutics against mitochondrial oxidative stress in animal models of aging
-
doi:10.1111/j.1749-6632.2002.tb02104.x
-
Melov, S. 2002 Therapeutics against mitochondrial oxidative stress in animal models of aging. Ann. NYAcad. Sci. 959, 330-340. (doi:10.1111/j.1749-6632.2002.tb02104.x)
-
(2002)
Ann. NYAcad. Sci
, vol.959
, pp. 330-340
-
-
Melov, S.1
-
87
-
-
84858342905
-
Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting d-serine-dependent NMDA receptor activation
-
doi:10.1111/j.1474-9726.2012.00792.x
-
Haxaire, C., Turpin, F. R., Potier, B., Kervern, M., Sinet, P. M., Barbanel, G., Mothet, J. P., Dutar, P. & Billard, J. M. 2012 Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting d-serine-dependent NMDA receptor activation. Aging Cell 11, 336-344. (doi:10.1111/j.1474-9726.2012.00792.x)
-
(2012)
Aging Cell
, vol.11
, pp. 336-344
-
-
Haxaire, C.1
Turpin, F.R.2
Potier, B.3
Kervern, M.4
Sinet, P.M.5
Barbanel, G.6
Mothet, J.P.7
Dutar, P.8
Billard, J.M.9
-
88
-
-
0038491473
-
Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics
-
doi:10.1073/pnas.1332809100
-
Liu, R., Liu, I. Y., Bi, X., Thompson, R. F., Doctrow, S. R., Malfroy, B. & Baudry, M. 2003 Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics Proc. Natl Acad. Sci. USA 100, 8526-8531. (doi:10.1073/pnas.1332809100)
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 8526-8531
-
-
Liu, R.1
Liu, I.Y.2
Bi, X.3
Thompson, R.F.4
Doctrow, S.R.5
Malfroy, B.6
Baudry, M.7
-
89
-
-
33745998064
-
Long-term antioxidant supplementation attenuates oxidative stress markers and cognitive deficits in senescent-accelerated OXYS rats
-
doi:10.1016/j.neurobiolaging.2005.07.022
-
Kolosova, N. G., Shcheglova, T. V., Sergeeva, S. V. & Loskutova, L. V. 2006 Long-term antioxidant supplementation attenuates oxidative stress markers and cognitive deficits in senescent-accelerated OXYS rats. Neurobiol. Aging 27, 1289-1297. (doi:10.1016/j.neurobiolaging.2005.07.022)
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 1289-1297
-
-
Kolosova, N.G.1
Shcheglova, T.V.2
Sergeeva, S.V.3
Loskutova, L.V.4
-
90
-
-
20744440945
-
Induction of the Nrf2- driven antioxidant response confers neuroprotection during mitochondrial stress in vivo
-
doi:10.1074/jbc.M414635200
-
Shih, A. Y., Imbeault, S., Barakauskas, V., Erb, H., Jiang, L., Li, P. & Murphy, T. H. 2005 Induction of the Nrf2- driven antioxidant response confers neuroprotection during mitochondrial stress in vivo. J. Biol. Chem. 280, 22925-22936. (doi:10.1074/jbc.M414635200)
-
(2005)
J. Biol. Chem
, vol.280
, pp. 22925-22936
-
-
Shih, A.Y.1
Imbeault, S.2
Barakauskas, V.3
Erb, H.4
Jiang, L.5
Li, P.6
Murphy, T.H.7
-
91
-
-
0036751978
-
A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes
-
doi:10.1016/S0197-4580(02)00078-7
-
Esposito, E., Rotilio, D., Di Matteo, V., Di Giulio, C., Cacchio, M. & Algeri, S. 2002 A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. Neurobiol. Aging 23, 719-735. (doi:10.1016/S0197-4580(02)00078-7)
-
(2002)
Neurobiol. Aging
, vol.23
, pp. 719-735
-
-
Esposito, E.1
Rotilio, D.2
Di Matteo, V.3
Di Giulio, C.4
Cacchio, M.5
Algeri, S.6
-
92
-
-
70350272866
-
Effect of carvedilol on behavioral, mitochondrial dysfunction, and oxidative damage against D-galactose induced senescence in mice
-
doi:10.1007/s00210-009-0442-8
-
Kumar, A., Dogra, S. & Prakash, A. 2009 Effect of carvedilol on behavioral, mitochondrial dysfunction, and oxidative damage against D-galactose induced senescence in mice. Naunyn Schmiedebergs Arch. Pharmacol. 380, 431-441. (doi:10.1007/s00210-009-0442-8)
-
(2009)
Naunyn Schmiedebergs Arch. Pharmacol
, vol.380
, pp. 431-441
-
-
Kumar, A.1
Dogra, S.2
Prakash, A.3
-
93
-
-
77953750340
-
L-3-n-butylphthalide improves cognitive impairment and reduces amyloidbeta in a transgenic model of Alzheimer's disease
-
doi:10.1523/JNEUROSCI.0340-10.2010
-
Peng, Y., Sun, J., Hon, S., Nylander, A.N., Xia, W., Feng, Y., Wang, X. & Lemere, C. A. 2010 L-3-n-butylphthalide improves cognitive impairment and reduces amyloidbeta in a transgenic model of Alzheimer's disease. J. Neurosci. 30, 8180-8189. (doi:10.1523/JNEUROSCI.0340-10.2010)
-
(2010)
J. Neurosci
, vol.30
, pp. 8180-8189
-
-
Peng, Y.1
Sun, J.2
Hon, S.3
Nylander, A.N.4
Xia, W.5
Feng, Y.6
Wang, X.7
Lemere, C.A.8
-
94
-
-
0035910076
-
Delayed-onset ataxia in mice lacking alpha-tocopherol transfer protein: Model for neuronal degeneration caused by chronic oxidative stress
-
doi:10.1073/pnas.261456098
-
Yokota, T. et al. 2001 Delayed-onset ataxia in mice lacking alpha-tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stress. Proc. Natl Acad. Sci. USA 98, 15185-15190. (doi:10.1073/pnas.261456098)
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 15185-15190
-
-
Yokota, T.1
-
95
-
-
77956274584
-
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
-
doi:10.1073/pnas.1009485107
-
Lipinski, M. M. et al. 2010 Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc. Natl Acad. Sci. USA 107, 14164-14169. (doi:10.1073/pnas.1009485107)
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 14164-14169
-
-
Lipinski, M.M.1
-
96
-
-
84857275218
-
Oxidative stress and autophagy: Mediators of synapse growth?
-
doi:10.4161/auto.8.2.18981
-
West, R. J. & Sweeney, S. T. 2012 Oxidative stress and autophagy: mediators of synapse growth? Autophagy 8, 284-285. (doi:10.4161/auto.8.2.18981)
-
(2012)
Autophagy
, vol.8
, pp. 284-285
-
-
West, R.J.1
Sweeney, S.T.2
-
97
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
doi:10.1126/science.1072994
-
Hardy, J. & Selkoe, D. J. 2002 The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356. (doi:10.1126/science.1072994)
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
98
-
-
33751118534
-
Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
-
doi:10.1016/j.nbd.2006.08.021
-
Chu, Y. & Kordower, J. H. 2007 Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: is this the target for Parkinson's disease? Neurobiol. Dis. 25, 134-149. (doi:10.1016/j.nbd.2006.08.021)
-
(2007)
Neurobiol. Dis
, vol.25
, pp. 134-149
-
-
Chu, Y.1
Kordower, J.H.2
-
99
-
-
79959923467
-
Protein aggregate spreading in neurodegenerative diseases: Problems and perspectives
-
doi:10.1016/j.neures.2011.05.008
-
Lee, S. J., Lim, H. S., Masliah, E. & Lee, H. J. 2011 Protein aggregate spreading in neurodegenerative diseases: problems and perspectives. Neurosci. Res. 70, 339-348. (doi:10.1016/j.neures.2011.05.008)
-
(2011)
Neurosci. Res
, vol.70
, pp. 339-348
-
-
Lee, S.J.1
Lim, H.S.2
Masliah, E.3
Lee, H.J.4
-
100
-
-
68949208061
-
Parkin deficiency increases the resistance of midbrain neurons and glia to mild proteasome inhibition: The role of autophagy and glutathione homeostasis
-
doi:10.1111/j.1471-4159.2009.06248.x
-
Casarejos, M. J., Solano, R. M., Rodriguez-Navarro, J. A., Gomez, A., Perucho, J., Castano, J. G., Garcia de Yebenes, J. & Mena, M. A. 2009 Parkin deficiency increases the resistance of midbrain neurons and glia to mild proteasome inhibition: the role of autophagy and glutathione homeostasis. J. Neurochem. 110, 1523-1537. (doi:10.1111/j.1471-4159.2009.06248.x)
-
(2009)
J. Neurochem
, vol.110
, pp. 1523-1537
-
-
Casarejos, M.J.1
Solano, R.M.2
Rodriguez-Navarro, J.A.3
Gomez, A.4
Perucho, J.5
Castano, J.G.6
de Garcia, Y.J.7
Mena, M.A.8
-
101
-
-
0141539641
-
Neuronal and microglial cathepsins in aging and age-related diseases
-
doi:10.1016/S1568-1637(03)00027-8
-
Nakanishi, H. 2003 Neuronal and microglial cathepsins in aging and age-related diseases. Ageing Res. Rev. 2, 367-381. (doi:10.1016/S1568-1637(03)00027-8)
-
(2003)
Ageing Res. Rev
, vol.2
, pp. 367-381
-
-
Nakanishi, H.1
-
102
-
-
34250183177
-
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
-
doi:10.1038/nature05853
-
Pandey, U. B. et al. 2007 HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447, 859-863. (doi:10.1038/nature05853)
-
(2007)
Nature
, vol.447
, pp. 859-863
-
-
Pandey, U.B.1
-
103
-
-
84857762064
-
An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain
-
Caballero, B. & Coto-Montes, A. 2012 An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain. Histol. Histopathol. 27, 263-275.
-
(2012)
Histol. Histopathol
, vol.27
, pp. 263-275
-
-
Caballero, B.1
Coto-Montes, A.2
-
104
-
-
79451471809
-
Brain aging and Abeta neurotoxicity converge via deterioration in autophagy-lysosomal system: A conditional Drosophila model linking Alzheimer's neurodegeneration with aging
-
doi:10.1007/s00401-010-0772-0
-
Ling, D. & Salvaterra, P. M. 2011 Brain aging and Abeta neurotoxicity converge via deterioration in autophagy-lysosomal system: a conditional Drosophila model linking Alzheimer's neurodegeneration with aging. Acta Neuropathol. 121, 183-191. (doi:10.1007/s00401-010-0772-0)
-
(2011)
Acta Neuropathol
, vol.121
, pp. 183-191
-
-
Ling, D.1
Salvaterra, P.M.2
-
105
-
-
80052641742
-
A genome-wide association study of aging
-
Walter, S. et al. 2011 A genome-wide association study of aging. Neurobiol. Aging 32, 2109 e15-e28.
-
(2011)
Neurobiol. Aging
, vol.32
, Issue.2109
-
-
Walter, S.1
-
106
-
-
80052303130
-
Autophagy and aging
-
doi:10.1016/j.cell.2011.07.030
-
Rubinsztein, D. C., Marino, G. & Kroemer, G. 2011 Autophagy and aging. Cell 146, 682-695. (doi:10.1016/j.cell.2011.07.030)
-
(2011)
Cell
, vol.146
, pp. 682-695
-
-
Rubinsztein, D.C.1
Marino, G.2
Kroemer, G.3
-
107
-
-
71849109181
-
Activation of proteasome by insulinlike growth factor-I may enhance clearance of oxidized proteins in the brain
-
doi:10.1016/j.mad.2009.10.005
-
Crowe, E., Sell, C., Thomas, J. D., Johannes, G. J. & Torres, C. 2009 Activation of proteasome by insulinlike growth factor-I may enhance clearance of oxidized proteins in the brain. Mech. Ageing Dev. 130, 793-800. (doi:10.1016/j.mad.2009.10.005)
-
(2009)
Mech. Ageing Dev
, vol.130
, pp. 793-800
-
-
Crowe, E.1
Sell, C.2
Thomas, J.D.3
Johannes, G.J.4
Torres, C.5
-
108
-
-
79251555689
-
Methylene blue reduces abeta levels and rescues early cognitive deficit by increasing proteasome activity
-
doi:10.1111/j.1750-3639.2010.00430.x
-
Medina, D. X., Caccamo, A. & Oddo, S. 2011 Methylene blue reduces abeta levels and rescues early cognitive deficit by increasing proteasome activity. Brain Pathol. 21, 140-149. (doi:10.1111/j.1750-3639.2010.00430.x)
-
(2011)
Brain Pathol
, vol.21
, pp. 140-149
-
-
Medina, D.X.1
Caccamo, A.2
Oddo, S.3
-
109
-
-
0033119124
-
Apparent loss and hypertrophy of interneurons in a mouse model of neuronal ceroid lipofuscinosis: Evidence for partial response to insulin-like growth factor-1 treatment
-
Cooper, J. D., Messer, A., Feng, A. K., Chua-Couzens, J. & Mobley, W. C. 1999 Apparent loss and hypertrophy of interneurons in a mouse model of neuronal ceroid lipofuscinosis: evidence for partial response to insulin-like growth factor-1 treatment. J. Neurosci. 19, 2556-2567.
-
(1999)
J. Neurosci
, vol.19
, pp. 2556-2567
-
-
Cooper, J.D.1
Messer, A.2
Feng, A.K.3
Chua-Couzens, J.4
Mobley, W.C.5
-
110
-
-
82955193788
-
Exposure to 16O-particle radiation causes aging-like decrements in rats through increased oxidative stress, inflammation and loss of autophagy
-
doi:10.1667/RR2605.1
-
Poulose, S. M., Bielinski, D. F., Carrihill-Knoll, K., Rabin, B. M. & Shukitt-Hale, B. 2011 Exposure to 16O-particle radiation causes aging-like decrements in rats through increased oxidative stress, inflammation and loss of autophagy. Radiat. Res. 176, 761-769. (doi:10.1667/RR2605.1)
-
(2011)
Radiat. Res
, vol.176
, pp. 761-769
-
-
Poulose, S.M.1
Bielinski, D.F.2
Carrihill-Knoll, K.3
Rabin, B.M.4
Shukitt-Hale, B.5
-
111
-
-
33646800306
-
Loss of autophagy in the central nervous system causes neurodegeneration in mice
-
doi:10.1038/nature04723
-
Komatsu, M. et al. 2006 Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441, 880-884. (doi:10.1038/nature04723)
-
(2006)
Nature
, vol.441
, pp. 880-884
-
-
Komatsu, M.1
-
112
-
-
44349165060
-
Mechanisms of lysosomal proteases participating in cerebral ischemia-induced neuronal death
-
doi:10.1007/s12264-008-0117-3
-
Qin, A. P., Zhang, H. L. & Qin, Z. H. 2008 Mechanisms of lysosomal proteases participating in cerebral ischemia-induced neuronal death. Neurosci. Bull. 24, 117-123. (doi:10.1007/s12264-008-0117-3)
-
(2008)
Neurosci. Bull
, vol.24
, pp. 117-123
-
-
Qin, A.P.1
Zhang, H.L.2
Qin, Z.H.3
-
113
-
-
72949091020
-
P53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms
-
(doi:10.1111/j.1460-9568.2009.07025.x)
-
Wang, Y., Dong, X. X., Cao, Y., Liang, Z. Q., Han, R., Wu, J. C., Gu, Z. L. & Qin, Z. H. 2009 P53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms. Eur. J. Neurosci. 30, 2258-2270. (doi:10.1111/j.1460-9568.2009.07025.x)
-
(2009)
Eur. J. Neurosci
, vol.30
, pp. 2258-2270
-
-
Wang, Y.1
Dong, X.X.2
Cao, Y.3
Liang, Z.Q.4
Han, R.5
Wu, J.C.6
Gu, Z.L.7
Qin, Z.H.8
-
114
-
-
50249189191
-
Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways
-
Wen, Y. D., Sheng, R., Zhang, L. S., Han, R., Zhang, X., Zhang, X. D., Han, F., Fukunaga, K. & Qin, Z. H. 2008 Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy 4, 762-769.
-
(2008)
Autophagy
, vol.4
, pp. 762-769
-
-
Wen, Y.D.1
Sheng, R.2
Zhang, L.S.3
Han, R.4
Zhang, X.5
Zhang, X.D.6
Han, F.7
Fukunaga, K.8
Qin, Z.H.9
-
115
-
-
84857058225
-
Control of autophagy as a therapy for neurodegenerative disease
-
doi:10.1038/nrneurol.2011.200
-
Harris, H. & Rubinsztein, D. C. 2011 Control of autophagy as a therapy for neurodegenerative disease. Nat. Rev. Neurol. 8, 108-117. (doi:10.1038/nrneurol.2011.200)
-
(2011)
Nat Rev. Neurol
, vol.8
, pp. 108-117
-
-
Harris, H.1
Rubinsztein, D.C.2
-
116
-
-
84856949347
-
Accumulation of resident and peripheral dendritic cells in the aging CNS
-
doi:10.1016/j.neurobiolaging.2010.06.007
-
Kaunzner, U. W., Miller, M. M., Gottfried-Blackmore, A., Gal-Toth, J., Felger, J. C., McEwen, B. S. & Bulloch, K. 2012 Accumulation of resident and peripheral dendritic cells in the aging CNS. Neurobiol. Aging 33, 681-693. (doi:10.1016/j.neurobiolaging.2010.06.007)
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 681-693
-
-
Kaunzner, U.W.1
Miller, M.M.2
Gottfried-Blackmore, A.3
Gal-Toth, J.4
Felger, J.C.5
McEwen, B.S.6
Bulloch, K.7
-
117
-
-
84859487634
-
Microglial activation in healthy aging
-
doi:10.1016/j.neurobiolaging.2010.09.016
-
Schuitemaker, A. et al. 2010 Microglial activation in healthy aging. Neurobiol. Aging 33, 1067-1072. (doi:10.1016/j.neurobiolaging.2010.09.016)
-
(2010)
Neurobiol. Aging
, vol.33
, pp. 1067-1072
-
-
Schuitemaker, A.1
-
118
-
-
52049094570
-
What is the role of astrocyte calcium in neurophysiology?
-
doi:10.1016/j.neuron.2008.09.004
-
Agulhon, C., Petravicz, J., McMullen, A. B., Sweger, E. J., Minton, S. K., Taves, S. R., Casper, K. B., Fiacco, T. A. & McCarthy, K. D. 2008 What is the role of astrocyte calcium in neurophysiology? Neuron 59, 932-946. (doi:10.1016/j.neuron.2008.09.004)
-
(2008)
Neuron
, vol.59
, pp. 932-946
-
-
Agulhon, C.1
Petravicz, J.2
McMullen, A.B.3
Sweger, E.J.4
Minton, S.K.5
Taves, S.R.6
Casper, K.B.7
Fiacco, T.A.8
McCarthy, K.D.9
-
119
-
-
17844404517
-
Microglia and neuroprotection: Implications for Alzheimer's disease
-
doi:10.1016/j.brainresrev.2004.12.013
-
Streit, W. J. 2005 Microglia and neuroprotection: implications for Alzheimer's disease. Brain Res. Brain Res. Rev. 48, 234-239. (doi:10.1016/j.brainresrev.2004.12.013)
-
(2005)
Brain Res. Brain Res. Rev
, vol.48
, pp. 234-239
-
-
Streit, W.J.1
-
120
-
-
67649496586
-
A metabolic switch in brain: Glucose and lactate metabolism modulation by ascorbic acid
-
doi:10.1111/j.1471-4159.2009.06151.x
-
Castro, M. A., Beltran, F. A., Brauchi, S. & Concha, I. I. 2009 A metabolic switch in brain: glucose and lactate metabolism modulation by ascorbic acid. J. Neurochem. 110, 423-440. (doi:10.1111/j.1471-4159.2009.06151.x)
-
(2009)
J. Neurochem
, vol.110
, pp. 423-440
-
-
Castro, M.A.1
Beltran, F.A.2
Brauchi, S.3
Concha, I.I.4
-
121
-
-
80052419916
-
Role of astrocytes in neurovascular coupling
-
doi:10.1016/j.neuron.2011.08.009
-
Petzold, G. C. & Murthy, V. N. 2011 Role of astrocytes in neurovascular coupling. Neuron 71, 782-797. (doi:10.1016/j.neuron.2011.08.009)
-
(2011)
Neuron
, vol.71
, pp. 782-797
-
-
Petzold, G.C.1
Murthy, V.N.2
-
122
-
-
0033611668
-
The role of glial cells in synaptic function
-
doi:10.1098/rstb.1999.0393
-
Bacci, A., Verderio, C., Pravettoni, E. & Matteoli, M. 1999 The role of glial cells in synaptic function. Phil. Trans. R. Soc. Lond. B 354, 403-409. (doi:10.1098/rstb.1999.0393)
-
(1999)
Phil. Trans. R. Soc. Lond. B
, vol.354
, pp. 403-409
-
-
Bacci, A.1
Verderio, C.2
Pravettoni, E.3
Matteoli, M.4
-
123
-
-
79960631454
-
Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis
-
doi:10.1038/nature10229
-
Ferron, S. R. et al. 2011 Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis. Nature 475, 381-385. (doi:10.1038/nature10229)
-
(2011)
Nature
, vol.475
, pp. 381-385
-
-
Ferron, S.R.1
-
124
-
-
84857738205
-
Neuron-microglia dialogue and hippocampal neurogenesis in the aged brain
-
Gemma, C., Bachstetter, A. D. & Bickford, P. C. 2010 Neuron-microglia dialogue and hippocampal neurogenesis in the aged brain. Aging Dis. 1, 232-244.
-
(2010)
Aging Dis
, vol.1
, pp. 232-244
-
-
Gemma, C.1
Bachstetter, A.D.2
Bickford, P.C.3
-
125
-
-
35548986304
-
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
-
doi:10.1038/nn1997
-
Hanisch, U. K. & Kettenmann, H. 2007 Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat. Neurosci. 10, 1387-1394. (doi:10.1038/nn1997)
-
(2007)
Nat. Neurosci
, vol.10
, pp. 1387-1394
-
-
Hanisch, U.K.1
Kettenmann, H.2
-
126
-
-
70349807619
-
Immune activation in brain aging and neurodegeneration: Too much or too little?
-
doi:10.1016/j.neuron.2009.08.039
-
Lucin, K. M. & Wyss-Coray, T. 2009 Immune activation in brain aging and neurodegeneration: too much or too little? Neuron 64, 110-122. (doi:10.1016/j.neuron.2009.08.039)
-
(2009)
Neuron
, vol.64
, pp. 110-122
-
-
Lucin, K.M.1
Wyss-Coray, T.2
-
127
-
-
80755168115
-
The role of microglia in the healthy brain
-
doi:10.1523/JNEUROSCI.4158-11.2011
-
Tremblay, M. E., Stevens, B., Sierra, A., Wake, H., Bessis, A. & Nimmerjahn, A. 2011 The role of microglia in the healthy brain. J. Neurosci. 31, 16064-16069. (doi:10.1523/JNEUROSCI.4158-11.2011)
-
(2011)
J. Neurosci
, vol.31
, pp. 16064-16069
-
-
Tremblay, M.E.1
Stevens, B.2
Sierra, A.3
Wake, H.4
Bessis, A.5
Nimmerjahn, A.6
-
128
-
-
76549115951
-
Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutrition
-
doi:10.1073/pnas.0909606106
-
Finch, C. E. 2010 Evolution in health and medicine Sackler colloquium: evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition. Proc. Natl Acad. Sci. USA 107(Suppl. 1), 1718-1724. (doi:10.1073/pnas.0909606106)
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, Issue.SUPPL. 1
, pp. 1718-1724
-
-
Finch, C.E.1
-
129
-
-
80052410357
-
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
-
doi:10.1038/nature10357
-
Villeda, S. A. et al. 2011 The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477, 90-94. (doi:10.1038/nature10357)
-
(2011)
Nature
, vol.477
, pp. 90-94
-
-
Villeda, S.A.1
-
130
-
-
70449565191
-
Gain in brain immunity in the oldest-old differentiates cognitively normal from demented individuals
-
doi:10.1371/journal.pone.0007642
-
Katsel, P., Tan, W. & Haroutunian, V. 2009 Gain in brain immunity in the oldest-old differentiates cognitively normal from demented individuals. PLoS ONE 4, e7642. (doi:10.1371/journal.pone.0007642)
-
(2009)
PLoS ONE
, vol.4
-
-
Katsel, P.1
Tan, W.2
Haroutunian, V.3
-
131
-
-
80055075419
-
The impact of glial activation in the aging brain
-
Lynch, A. M., Murphy, K. J., Deighan, B. F., O'Reilly, J. A., Gun'ko, Y. K., Cowley, T. R., Gonzalez-Reyes, R. E. & Lynch, M. A. 2010 The impact of glial activation in the aging brain. Aging Dis. 1, 262-278.
-
(2010)
Aging Dis
, vol.1
, pp. 262-278
-
-
Lynch, A.M.1
Murphy, K.J.2
Deighan, B.F.3
O'Reilly, J.A.4
Gun'ko, Y.K.5
Cowley, T.R.6
Gonzalez-Reyes, R.E.7
Lynch, M.A.8
-
132
-
-
79955775349
-
CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease
-
doi:10.1523/JNEUROSCI.0299-11.2011
-
Naert, G. & Rivest, S. 2011 CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. J. Neurosci. 31, 6208-6220. (doi:10.1523/JNEUROSCI.0299-11.2011)
-
(2011)
J. Neurosci
, vol.31
, pp. 6208-6220
-
-
Naert, G.1
Rivest, S.2
-
133
-
-
79952751974
-
Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis
-
doi:10.1523/JNEUROSCI.3617-10.2011
-
Moriyama, M. et al. 2011 Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis. J. Neurosci. 31, 3981-3989. (doi:10.1523/JNEUROSCI.3617-10.2011)
-
(2011)
J. Neurosci
, vol.31
, pp. 3981-3989
-
-
Moriyama, M.1
-
134
-
-
79952444584
-
Effects of neuroinflammation on the regenerative capacity of brain stem cells
-
doi:10.1111/j.1471-4159.2010.07168.x
-
Russo, I., Barlati, S. & Bosetti, F. 2011 Effects of neuroinflammation on the regenerative capacity of brain stem cells. J. Neurochem. 116, 947-956. (doi:10.1111/j.1471-4159.2010.07168.x)
-
(2011)
J. Neurochem
, vol.116
, pp. 947-956
-
-
Russo, I.1
Barlati, S.2
Bosetti, F.3
-
135
-
-
77953483260
-
Age-related neuroinflammatory changes negatively impact on neuronal function
-
Lynch, M. A. 2010 Age-related neuroinflammatory changes negatively impact on neuronal function. Front. Aging Neurosci. 1, 1-8.
-
(2010)
Front. Aging Neurosci
, vol.1
, pp. 1-8
-
-
Lynch, M.A.1
-
136
-
-
0034564998
-
Changes in expressions of proinflammatory cytokines IL-1beta, TNF-alpha and IL-6 in the brain of senescence accelerated mouse (SAM) P8
-
doi:10.1016/S0006-8993(00)02883-3
-
Tha, K. K., Okuma, Y., Miyazaki, H., Murayama, T., Uehara, T., Hatakeyama, R., Hayashi, Y. & Nomura, Y. 2000 Changes in expressions of proinflammatory cytokines IL-1beta, TNF-alpha and IL-6 in the brain of senescence accelerated mouse (SAM) P8. Brain Res. 885, 25-31. (doi:10.1016/S0006-8993(00)02883-3)
-
(2000)
Brain Res
, vol.885
, pp. 25-31
-
-
Tha, K.K.1
Okuma, Y.2
Miyazaki, H.3
Murayama, T.4
Uehara, T.5
Hatakeyama, R.6
Hayashi, Y.7
Nomura, Y.8
-
137
-
-
77950858637
-
Microglia in neurodegenerative disease
-
doi:10.1038/nrneurol.2010.17
-
Perry, V. H., Nicoll, J. A. & Holmes, C. 2010 Microglia in neurodegenerative disease. Nat. Rev. Neurol. 6, 193-201. (doi:10.1038/nrneurol.2010.17)
-
(2010)
Nat. Rev. Neurol
, vol.6
, pp. 193-201
-
-
Perry, V.H.1
Nicoll, J.A.2
Holmes, C.3
-
138
-
-
77955091162
-
Microglia activation and anti-inflammatory regulation in Alzheimer's disease
-
doi:10.1007/s12035-010-8106-8
-
Lue, L. F., Kuo, Y. M., Beach, T. & Walker, D. G. 2010 Microglia activation and anti-inflammatory regulation in Alzheimer's disease. Mol. Neurobiol. 41, 115-128. (doi:10.1007/s12035-010-8106-8)
-
(2010)
Mol. Neurobiol
, vol.41
, pp. 115-128
-
-
Lue, L.F.1
Kuo, Y.M.2
Beach, T.3
Walker, D.G.4
-
139
-
-
84861325911
-
Alzheimer's disease, autoimmunity and inflammation. The good, the bad and the ugly
-
doi:10.1016/j.autrev.2011.09.005
-
Sardi, F., Fassina, L., Venturini, L., Inguscio, M., Guerriero, F., Rolfo, E. & Ricevuti, G. 2011 Alzheimer's disease, autoimmunity and inflammation. The good, the bad and the ugly. Autoimmun. Rev. 11, 149-153. (doi:10.1016/j.autrev.2011.09.005)
-
(2011)
Autoimmun. Rev
, vol.11
, pp. 149-153
-
-
Sardi, F.1
Fassina, L.2
Venturini, L.3
Inguscio, M.4
Guerriero, F.5
Rolfo, E.6
Ricevuti, G.7
-
140
-
-
77049085956
-
Astrocyte phenotype in relation to Alzheimer- type pathology in the ageing brain
-
doi:10.1016/j.neurobiolaging.2008.05.015
-
Simpson, J. E., Ince, P. G., Lace, G., Forster, G., Shaw, P. J., Matthews, F., Savva, G., Brayne, C. & Wharton, S. B. 2010 Astrocyte phenotype in relation to Alzheimer- type pathology in the ageing brain. Neurobiol. Aging 31, 578-590. (doi:10.1016/j.neurobiolaging.2008.05.015)
-
(2010)
Neurobiol. Aging
, vol.31
, pp. 578-590
-
-
Simpson, J.E.1
Ince, P.G.2
Lace, G.3
Forster, G.4
Shaw, P.J.5
Matthews, F.6
Savva, G.7
Brayne, C.8
Wharton, S.B.9
-
141
-
-
76049118058
-
Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms
-
doi:10.1073/pnas.0911503106
-
Bradford, J., Shin, J. Y., Roberts, M., Wang, C. E., Li, X. J. & Li, S. 2009 Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc. Natl Acad. Sci. USA 106, 22480-22485. (doi:10.1073/pnas.0911503106)
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 22480-22485
-
-
Bradford, J.1
Shin, J.Y.2
Roberts, M.3
Wang, C.E.4
Li, X.J.5
Li, S.6
-
142
-
-
79959926626
-
Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model
-
doi:10.1371/journal.pone.0021880
-
Katsouri, L. & Georgopoulos, S. 2011 Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model. PLoS ONE 6, e21880. (doi:10.1371/journal.pone.0021880)
-
(2011)
PLoS ONE
, vol.6
-
-
Katsouri, L.1
Georgopoulos, S.2
-
143
-
-
78650177451
-
Pronounced microgliosis and neurodegeneration in aged rats after tau gene transfer
-
doi:10.1016/j.neurobiolaging.2008.12.002
-
Klein, R. L., Dayton, R. D., Diaczynsky, C. G. & Wang, D. B. 2010 Pronounced microgliosis and neurodegeneration in aged rats after tau gene transfer. Neurobiol. Aging 31, 2091-2102. (doi:10.1016/j.neurobiolaging.2008.12.002)
-
(2010)
Neurobiol. Aging
, vol.31
, pp. 2091-2102
-
-
Klein, R.L.1
Dayton, R.D.2
Diaczynsky, C.G.3
Wang, D.B.4
-
144
-
-
79960969591
-
Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans
-
doi:10.1371/journal.pgen.1002146
-
Tress, O. et al. 2011 Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans. PLoS Genet. 7, e1002146. (doi:10.1371/journal.pgen.1002146)
-
(2011)
PLoS Genet
, vol.7
-
-
Tress, O.1
-
145
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
doi:10.1016/j.cell.2005.02.003
-
Campisi, J. 2005 Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120, 513-522. (doi:10.1016/j.cell.2005.02.003)
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
146
-
-
79959953782
-
Astrocytes in the aging brain express characteristics of senescenceassociated secretory phenotype
-
doi:10.1111/j.1460-9568.2011.07738.x
-
Salminen, A., Ojala, J., Kaarniranta, K., Haapasalo, A., Hiltunen, M. & Soininen, H. 2011 Astrocytes in the aging brain express characteristics of senescenceassociated secretory phenotype. Eur. J. Neurosci. 34, 3-11. (doi:10.1111/j.1460-9568.2011.07738.x)
-
(2011)
Eur. J. Neurosci
, vol.34
, pp. 3-11
-
-
Salminen, A.1
Ojala, J.2
Kaarniranta, K.3
Haapasalo, A.4
Hiltunen, M.5
Soininen, H.6
-
147
-
-
52449114203
-
Dysfunction of astrocytes in senescence-accelerated mice SAMP8 reduces their neuroprotective capacity
-
doi:10.1111/j.1474-9726.2008.00410.x
-
Garcia-Matas, S., Gutierrez-Cuesta, J., Coto-Montes, A., Rubio-Acero, R., Diez-Vives, C., Camins, A., Pallas, M., Sanfeliu, C. & Cristofol, R. 2008 Dysfunction of astrocytes in senescence-accelerated mice SAMP8 reduces their neuroprotective capacity. Aging Cell 7, 630-640. (doi:10.1111/j.1474-9726.2008.00410.x)
-
(2008)
Aging Cell
, vol.7
, pp. 630-640
-
-
Garcia-Matas, S.1
Gutierrez-Cuesta, J.2
Coto-Montes, A.3
Rubio-Acero, R.4
Diez-Vives, C.5
Camins, A.6
Pallas, M.7
Sanfeliu, C.8
Cristofol, R.9
-
148
-
-
64849090408
-
Microglia-aging: Roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging
-
doi:10.1016/j.bbr.2009.02.001
-
Nakanishi, H. & Wu, Z. 2009 Microglia-aging: roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging. Behav. Brain Res. 201, 1-7. (doi:10.1016/j.bbr.2009.02.001)
-
(2009)
Behav. Brain Res
, vol.201
, pp. 1-7
-
-
Nakanishi, H.1
Wu, Z.2
-
149
-
-
77950826971
-
Microglia in the aging brain: Relevance to neurodegeneration
-
doi:10.1186/1750-1326-5-12
-
Luo, X. G., Ding, J. Q. & Chen, S. D. 2010 Microglia in the aging brain: relevance to neurodegeneration. Mol. Neurodegener. 5, 12. (doi:10.1186/1750-1326-5-12)
-
(2010)
Mol. Neurodegener
, vol.5
, pp. 12
-
-
Luo, X.G.1
Ding, J.Q.2
Chen, S.D.3
-
150
-
-
75949127404
-
Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders
-
doi:10.1111/j.1471-4159.2009.06537.x
-
von Bernhardi, R., Tichauer, J. E. & Eugenin, J. 2010 Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders. J. Neurochem. 112, 1099-1114. (doi:10.1111/j.1471-4159.2009.06537.x)
-
(2010)
J. Neurochem
, vol.112
, pp. 1099-1114
-
-
von Bernhardi, R.1
Tichauer, J.E.2
Eugenin, J.3
-
151
-
-
67649403327
-
Immune senescence and brain aging: Can rejuvenation of immunity reverse memory loss?
-
doi:10.1016/j.tins.2009.03.003
-
Ron-Harel, N. & Schwartz, M. 2009 Immune senescence and brain aging: can rejuvenation of immunity reverse memory loss? Trends Neurosci. 32, 367-375. (doi:10.1016/j.tins.2009.03.003)
-
(2009)
Trends Neurosci
, vol.32
, pp. 367-375
-
-
Ron-Harel, N.1
Schwartz, M.2
-
152
-
-
0042591496
-
Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons
-
doi:10.1002/hipo.10081
-
Hampson, R. E., Simeral, J. D., Kelly, E. J. & Deadwyler, S. A. 2003 Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons. Hippocampus 13, 543-556. (doi:10.1002/hipo.10081)
-
(2003)
Hippocampus
, vol.13
, pp. 543-556
-
-
Hampson, R.E.1
Simeral, J.D.2
Kelly, E.J.3
Deadwyler, S.A.4
-
153
-
-
0032538527
-
Endocannabinoids
-
doi:10.1016/S0014-2999(98)00649-9
-
Mechoulam, R., Fride, E. & Di Marzo, V. 1998 Endocannabinoids. Eur. J. Pharmacol. 359, 1-18. (doi:10.1016/S0014-2999(98)00649-9)
-
(1998)
Eur. J. Pharmacol
, vol.359
, pp. 1-18
-
-
Mechoulam, R.1
Fride, E.2
Di Marzo, V.3
-
154
-
-
0034613209
-
2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-alpha production in murine macrophages, and in mice
-
doi:10.1016/S0014-2999(00)00653-1
-
Gallily, R., Breuer, A. & Mechoulam, R. 2000 2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-alpha production in murine macrophages, and in mice. Eur. J. Pharmacol. 406, R5-R7. (doi:10.1016/S0014-2999(00)00653-1)
-
(2000)
Eur. J. Pharmacol
, vol.406
-
-
Gallily, R.1
Breuer, A.2
Mechoulam, R.3
-
155
-
-
81055156684
-
Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation
-
doi:10.1126/science.1209200
-
Nomura, D. K. et al. 2011 Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. Science 334, 809-813. (doi:10.1126/science.1209200)
-
(2011)
Science
, vol.334
, pp. 809-813
-
-
Nomura, D.K.1
-
156
-
-
33846299245
-
1 receptor ligands on lipid peroxidation and antioxidant defense systems in the rat brain
-
Kessiova, M., Alexandrova, A., Georgieva, A., Kirkova, M. & Todorov, S. 2006 In vitro effects of CB1 receptor ligands on lipid peroxidation and antioxidant defense systems in the rat brain. Pharmacol. Rep. 58, 870-875.
-
(2006)
Pharmacol. Rep
, vol.58
, pp. 870-875
-
-
Kessiova, M.1
Alexandrova, A.2
Georgieva, A.3
Kirkova, M.4
Todorov, S.5
-
157
-
-
38049021125
-
Antioxidant and neuroprotective properties of N-arachidonoyldopamine
-
doi:10.1016/j.neulet.2007.11.010
-
Bobrov, M. Y., Lizhin, A. A., Andrianova, E. L., Gretskaya, N. M., Frumkina, L. E., Khaspekov, L. G. & Bezuglov, V. V. 2008 Antioxidant and neuroprotective properties of N-arachidonoyldopamine. Neurosci. Lett. 431, 6-11. (doi:10.1016/j.neulet.2007.11.010)
-
(2008)
Neurosci. Lett
, vol.431
, pp. 6-11
-
-
Bobrov, M.Y.1
Lizhin, A.A.2
Andrianova, E.L.3
Gretskaya, N.M.4
Frumkina, L.E.5
Khaspekov, L.G.6
Bezuglov, V.V.7
-
158
-
-
0036488182
-
1
-
doi:10.1046/j.0022-3042.2001.00716.x
-
Marsicano, G., Moosmann, B., Hermann, H., Lutz, B. & Behl, C. 2002 Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1. J. Neurochem. 80, 448-456. (doi:10.1046/j.0022-3042.2001.00716.x)
-
(2002)
J. Neurochem
, vol.80
, pp. 448-456
-
-
Marsicano, G.1
Moosmann, B.2
Hermann, H.3
Lutz, B.4
Behl, C.5
-
159
-
-
2942729530
-
Ceramide sensitizes astrocytes to oxidative stress: Protective role of cannabinoids
-
doi:10.1042/BJ20031714
-
Carracedo, A., Geelen, M. J., Diez, M., Hanada, K., Guzman, M. & Velasco, G. 2004 Ceramide sensitizes astrocytes to oxidative stress: protective role of cannabinoids. Biochem. J. 380, 435-440. (doi:10.1042/BJ20031714)
-
(2004)
Biochem. J
, vol.380
, pp. 435-440
-
-
Carracedo, A.1
Geelen, M.J.2
Diez, M.3
Hanada, K.4
Guzman, M.5
Velasco, G.6
-
160
-
-
79960300079
-
Symptom-relieving and neuroprotective effects of the phytocannabinoid D-THCV in animal models of Parkinson's disease
-
doi:10.1111/j.1476-5381.2011.01278.x
-
Garcia, C., Palomo-Garo, C., Garcia-Arencibia, M., Ramos, J., Pertwee, R. & Fernandez-Ruiz, J. 2011 Symptom-relieving and neuroprotective effects of the phytocannabinoid D-THCV in animal models of Parkinson's disease. Br. J. Pharmacol. 163, 1495-1506. (doi:10.1111/j.1476-5381.2011.01278.x)
-
(2011)
Br. J. Pharmacol
, vol.163
, pp. 1495-1506
-
-
Garcia, C.1
Palomo-Garo, C.2
Garcia-Arencibia, M.3
Ramos, J.4
Pertwee, R.5
Fernandez-Ruiz, J.6
-
161
-
-
33846401540
-
Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: Importance of antioxidant and cannabinoid receptorindependent properties
-
doi:10.1016/j.brainres.2006.11.063
-
Garcia-Arencibia, M., Gonzalez, S., de Lago, E., Ramos, J. A., Mechoulam, R. & Fernandez-Ruiz, J. 2007 Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptorindependent properties. Brain Res. 1134, 162-170. (doi:10.1016/j.brainres.2006.11.063)
-
(2007)
Brain Res
, vol.1134
, pp. 162-170
-
-
Garcia-Arencibia, M.1
Gonzalez, S.2
de Lago, E.3
Ramos, J.A.4
Mechoulam, R.5
Fernandez-Ruiz, J.6
-
162
-
-
44249127950
-
Cannabinoids inhibit network-driven synapse loss between hippocampal neurons in culture
-
doi:10.1124/jpet.107.131607
-
Kim, H. J., Waataja, J. J. & Thayer, S. A. 2008 Cannabinoids inhibit network-driven synapse loss between hippocampal neurons in culture. J. Pharmacol. Exp. Ther. 325, 850-858. (doi:10.1124/jpet.107.131607)
-
(2008)
J. Pharmacol. Exp. Ther
, vol.325
, pp. 850-858
-
-
Kim, H.J.1
Waataja, J.J.2
Thayer, S.A.3
-
163
-
-
23444431657
-
D9-tetrahydrocannabinol increases C6 glioma cell death produced by oxidative stress
-
doi:10.1016/j.neuroscience.2005.04.042
-
Goncharov, I., Weiner, L. & Vogel, Z. 2005 D9-tetrahydrocannabinol increases C6 glioma cell death produced by oxidative stress. Neuroscience 134, 567-574. (doi:10.1016/j.neuroscience.2005.04.042)
-
(2005)
Neuroscience
, vol.134
, pp. 567-574
-
-
Goncharov, I.1
Weiner, L.2
Vogel, Z.3
-
164
-
-
33747592582
-
Cannabidiolinduced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression
-
doi:10.1124/mol.106.023937
-
McKallip, R. J., Jia, W., Schlomer, J., Warren, J. W., Nagarkatti, P. S. & Nagarkatti, M. 2006 Cannabidiolinduced apoptosis in human leukemia cells: a novel role of cannabidiol in the regulation of p22phox and Nox4 expression. Mol. Pharmacol. 70, 897-908. (doi:10.1124/mol.106.023937)
-
(2006)
Mol. Pharmacol
, vol.70
, pp. 897-908
-
-
McKallip, R.J.1
Jia, W.2
Schlomer, J.3
Warren, J.W.4
Nagarkatti, P.S.5
Nagarkatti, M.6
-
165
-
-
33750576759
-
Anandamide-induced apoptosis in Chang liver cells involves ceramide and JNK/AP-1 pathway
-
Giuliano, M., Calvaruso, G., Pellerito, O., Portanova, P., Carlisi, D., Vento, R. & Tesoriere, G. 2006 Anandamide-induced apoptosis in Chang liver cells involves ceramide and JNK/AP-1 pathway. Int. J. Mol. Med. 17, 811-819.
-
(2006)
Int. J. Mol. Med
, vol.17
, pp. 811-819
-
-
Giuliano, M.1
Calvaruso, G.2
Pellerito, O.3
Portanova, P.4
Carlisi, D.5
Vento, R.6
Tesoriere, G.7
-
166
-
-
34548499520
-
The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species
-
doi:10.1096/fj.06-7717com
-
Siegmund, S. V., Qian, T., de Minicis, S., Harvey-White, J., Kunos, G., Vinod, K. Y., Hungund, B. & Schwabe, R. F. 2007 The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species. FASEB J. 21, 2798-2806. (doi:10.1096/fj.06-7717com)
-
(2007)
FASEB J
, vol.21
, pp. 2798-2806
-
-
Siegmund, S.V.1
Qian, T.2
de Minicis, S.3
Harvey-White, J.4
Kunos, G.5
Vinod, K.Y.6
Hungund, B.7
Schwabe, R.F.8
-
167
-
-
80051686884
-
1) receptors are activated by anandamide
-
doi:10.1074/jbc.M110.217463
-
Brailoiu, G. C., Oprea, T. I., Zhao, P., Abood, M. E. & Brailoiu, E. 2011 Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. J. Biol. Chem. 286, 29166-29174. (doi:10.1074/jbc.M110.217463)
-
(2011)
J. Biol. Chem
, vol.286
, pp. 29166-29174
-
-
Brailoiu, G.C.1
Oprea, T.I.2
Zhao, P.3
Abood, M.E.4
Brailoiu, E.5
-
168
-
-
46749113793
-
1 cannabinoid receptor trafficking by the adaptor protein AP-3
-
doi:10.1096/fj.07-102731
-
Rozenfeld, R. & Devi, L. A. 2008 Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3. FASEB J. 22, 2311-2322. (doi:10.1096/fj.07-102731)
-
(2008)
FASEB J
, vol.22
, pp. 2311-2322
-
-
Rozenfeld, R.1
Devi, L.A.2
-
169
-
-
78649638441
-
Endocannabinoids prevent beta-amyloid-mediated lysosomal destabilization in cultured neurons
-
doi:10.1074/jbc.M110.162040
-
Noonan, J., Tanveer, R., Klompas, A., Gowran, A., McKiernan, J. & Campbell, V. A. 2010 Endocannabinoids prevent beta-amyloid-mediated lysosomal destabilization in cultured neurons. J. Biol. Chem. 285, 38543-38554. (doi:10.1074/jbc.M110.162040)
-
(2010)
J. Biol. Chem
, vol.285
, pp. 38543-38554
-
-
Noonan, J.1
Tanveer, R.2
Klompas, A.3
Gowran, A.4
McKiernan, J.5
Campbell, V.A.6
-
170
-
-
42549128696
-
A role for p53 in the regulation of lysosomal permeability by D9-tetrahydrocannabinol in rat cortical neurones: Implications for neurodegeneration
-
doi:10.1111/j.1471-4159.2008.05278.x
-
Gowran, A. & Campbell, V. A. 2008 A role for p53 in the regulation of lysosomal permeability by D9-tetrahydrocannabinol in rat cortical neurones: implications for neurodegeneration. J. Neurochem. 105, 1513-1524. (doi:10.1111/j.1471-4159.2008.05278.x)
-
(2008)
J. Neurochem
, vol.105
, pp. 1513-1524
-
-
Gowran, A.1
Campbell, V.A.2
-
171
-
-
66449115318
-
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
-
doi:10.1172/JCI37948
-
Salazar, M. et al. 2009 Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J. Clin. Invest. 119, 1359-1372. (doi:10.1172/JCI37948)
-
(2009)
J. Clin. Invest
, vol.119
, pp. 1359-1372
-
-
Salazar, M.1
-
172
-
-
79958809001
-
Anti-tumoral action of cannabinoids on hepatocellular carcinoma: Role of AMPK-dependent activation of autophagy
-
doi:10.1038/cdd.2011.32
-
Vara, D., Salazar, M., Olea-Herrero, N., Guzman, M., Velasco, G. & Diaz-Laviada, I. 2011 Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy. Cell Death Differ. 18, 1099-1111. (doi:10.1038/cdd.2011.32)
-
(2011)
Cell Death Differ
, vol.18
, pp. 1099-1111
-
-
Vara, D.1
Salazar, M.2
Olea-Herrero, N.3
Guzman, M.4
Velasco, G.5
Diaz-Laviada, I.6
-
173
-
-
79959956124
-
Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
-
doi:10.1038/cddis.2011.36
-
Donadelli, M. et al. 2011 Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism. Cell Death Dis. 2, e152. (doi:10.1038/cddis.2011.36)
-
(2011)
Cell Death Dis
, vol.2
-
-
Donadelli, M.1
-
174
-
-
84857910035
-
Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 and Streptococcus pneumoniae R6 by microglial cells
-
doi:10.1016/j.jneuroim.2011.12.013
-
Redlich, S., Ribes, S., Schutze, S., Czesnik, D. & Nau, R. 2012 Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 and Streptococcus pneumoniae R6 by microglial cells. J. Neuroimmunol. 244, 32-34. (doi:10.1016/j.jneuroim.2011.12.013)
-
(2012)
J. Neuroimmunol
, vol.244
, pp. 32-34
-
-
Redlich, S.1
Ribes, S.2
Schutze, S.3
Czesnik, D.4
Nau, R.5
-
175
-
-
35348942818
-
Cannabinoid receptor agonists are mitochondrial inhibitors: A unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death
-
doi:10.1016/j.bbrc.2007.09.107
-
Athanasiou, A. et al. 2007 Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochem. Biophys. Res. Commun. 364, 131-137. (doi:10.1016/j.bbrc.2007.09.107)
-
(2007)
Biochem. Biophys. Res. Commun
, vol.364
, pp. 131-137
-
-
Athanasiou, A.1
-
176
-
-
84859208807
-
Mitochondrial CB(1) receptors regulate neuronal energy metabolism
-
doi:10.1038/nn.3053
-
Benard, G. et al. 2012 Mitochondrial CB(1) receptors regulate neuronal energy metabolism. Nat. Neurosci. 15, 558-564. (doi:10.1038/nn.3053)
-
(2012)
Nat. Neurosci
, vol.15
, pp. 558-564
-
-
Benard, G.1
-
177
-
-
0016590028
-
The influence of D9-tetrahydrocannabinol, cannabinol and cannabidiol on tissue oxygen consumption
-
Chiu, P., Karler, R., Craven, C., Olsen, D. M. & Turkanis, S. A. 1975 The influence of D9-tetrahydrocannabinol, cannabinol and cannabidiol on tissue oxygen consumption. Res. Commun. Chem. Pathol. Pharmacol. 12, 267-286.
-
(1975)
Res. Commun. Chem. Pathol. Pharmacol
, vol.12
, pp. 267-286
-
-
Chiu, P.1
Karler, R.2
Craven, C.3
Olsen, D.M.4
Turkanis, S.A.5
-
178
-
-
78651356681
-
Anandamide inhibits oxidative phosphorylation in isolated liver mitochondria
-
doi:10.1016/j.febslet.2010.12.032
-
Zaccagnino, P., Corcelli, A., Baronio, M. & Lorusso, M. 2011 Anandamide inhibits oxidative phosphorylation in isolated liver mitochondria. FEBS Lett. 585, 429-434. (doi:10.1016/j.febslet.2010.12.032)
-
(2011)
FEBS Lett
, vol.585
, pp. 429-434
-
-
Zaccagnino, P.1
Corcelli, A.2
Baronio, M.3
Lorusso, M.4
-
179
-
-
0034696914
-
Changes in rat brain energetic metabolism after exposure to anandamide or D(9)-tetrahydrocannabinol
-
doi:10.1016/S0014-2999(00)00170-9
-
Costa, B. & Colleoni, M. 2000 Changes in rat brain energetic metabolism after exposure to anandamide or D(9)-tetrahydrocannabinol. Eur. J. Pharmacol. 395, 1-7. (doi:10.1016/S0014-2999(00)00170-9)
-
(2000)
Eur. J. Pharmacol
, vol.395
, pp. 1-7
-
-
Costa, B.1
Colleoni, M.2
-
180
-
-
77957845422
-
Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure
-
doi:10.1007/s11064-010-0188-1
-
Velez-Pardo, C., Jimenez-Del-Rio, M., Lores-Arnaiz, S. & Bustamante, J. 2010 Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure. Neurochem. Res. 35, 1323-1332. (doi:10.1007/s11064-010-0188-1)
-
(2010)
Neurochem. Res
, vol.35
, pp. 1323-1332
-
-
Velez-Pardo, C.1
Jimenez-Del-Rio, M.2
Lores-Arnaiz, S.3
Bustamante, J.4
-
181
-
-
84863863361
-
The endocannabinoid 2-arachidonoylglicerol decreases calcium induced cytochrome c release from liver mitochondria
-
doi:10.1007/s10863-012-9431-6
-
Zaccagnino, P., D'Oria, S., Romano, L. L., di Venere A., Sardanelli, A. M. & Lorusso, M. 2012 The endocannabinoid 2-arachidonoylglicerol decreases calcium induced cytochrome c release from liver mitochondria. J. Bioenerg. Biomembr. 44, 273-280. (doi:10.1007/s10863-012-9431-6)
-
(2012)
J. Bioenerg. Biomembr
, vol.44
, pp. 273-280
-
-
Zaccagnino, P.1
D'oria, S.2
Romano, L.L.3
Di Venere, A.4
Sardanelli, A.M.5
Lorusso, M.6
-
182
-
-
0036179292
-
Effect of the cannabinoid receptor ligand, WIN 55,212-2, on superoxide anion and TNF-a production by human mononuclear cells
-
doi:10.1016/S1567-5769(01)00200-4
-
Germain, N., Boichot, E., Advenier, C., Berdyshev, E. V. & Lagente, V. 2002 Effect of the cannabinoid receptor ligand, WIN 55,212-2, on superoxide anion and TNF-a production by human mononuclear cells. Int. Immunopharmacol. 2, 537-543. (doi:10.1016/S1567-5769(01)00200-4)
-
(2002)
Int. Immunopharmacol
, vol.2
, pp. 537-543
-
-
Germain, N.1
Boichot, E.2
Advenier, C.3
Berdyshev, E.V.4
Lagente, V.5
-
183
-
-
77952623444
-
CB2: A cannabinoid receptor with an identity crisis
-
doi:10.1111/j.1476-5381.2010.00729.x
-
Atwood, B. K. & Mackie, K. 2010 CB2: a cannabinoid receptor with an identity crisis. Br. J. Pharmacol. 160, 467-479. (doi:10.1111/j.1476-5381.2010.00729.x)
-
(2010)
Br. J. Pharmacol
, vol.160
, pp. 467-479
-
-
Atwood, B.K.1
Mackie, K.2
-
184
-
-
81955164773
-
Targeting CB(2) receptor as a neuroinflammatory modulator in experimental autoimmune encephalomyelitis
-
doi:10.1016/j.molimm.2011.09.016
-
Lou, Z. Y., Chen, C., He, Q., Zhao, C. B. & Xiao, B. G. 2011 Targeting CB(2) receptor as a neuroinflammatory modulator in experimental autoimmune encephalomyelitis. Mol. Immunol. 49, 453-461. (doi:10.1016/j.molimm.2011.09.016)
-
(2011)
Mol. Immunol
, vol.49
, pp. 453-461
-
-
Lou, Z.Y.1
Chen, C.2
He, Q.3
Zhao, C.B.4
Xiao, B.G.5
-
185
-
-
58049170379
-
Endocannabinoid signaling in microglial cells
-
doi:10.1016/j.neuropharm.2008.07.037
-
Stella, N. 2009 Endocannabinoid signaling in microglial cells. Neuropharmacology 56(Suppl. 1), 244-253. (doi:10.1016/j.neuropharm.2008.07.037)
-
(2009)
Neuropharmacology
, vol.56
, Issue.SUPPL. 1
, pp. 244-253
-
-
Stella, N.1
-
186
-
-
77954406421
-
Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas
-
doi:10.1002/glia.20983
-
Stella, N. 2010 Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas. Glia 58, 1017-1030. (doi:10.1002/glia.20983)
-
(2010)
Glia
, vol.58
, pp. 1017-1030
-
-
Stella, N.1
-
187
-
-
58149339634
-
Crucial role of CB(2) cannabinoid receptor in the regulation of central immune responses during neuropathic pain
-
doi:10.1523/JNEUROSCI.3400-08.2008
-
Racz, I. et al. 2008 Crucial role of CB(2) cannabinoid receptor in the regulation of central immune responses during neuropathic pain. J. Neurosci. 28, 12125-12135. (doi:10.1523/JNEUROSCI.3400-08.2008)
-
(2008)
J. Neurosci
, vol.28
, pp. 12125-12135
-
-
Racz, I.1
-
188
-
-
70350697391
-
2. cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity
-
doi:10.1093/brain/awp239
-
Palazuelos, J. et al. 2009 Microglial CB2. cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity. Brain 132, 3152-3164. (doi:10.1093/brain/awp239)
-
(2009)
Brain
, vol.132
, pp. 3152-3164
-
-
Palazuelos, J.1
-
189
-
-
0037036436
-
Astrocytes in culture produce anandamide and other acylethanolamides
-
doi:10.1074/jbc.M110813200
-
Walter, L., Franklin, A., Witting, A., Moller, T. & Stella, N. 2002 Astrocytes in culture produce anandamide and other acylethanolamides. J. Biol. Chem. 277, 20869-20876. (doi:10.1074/jbc.M110813200)
-
(2002)
J. Biol. Chem
, vol.277
, pp. 20869-20876
-
-
Walter, L.1
Franklin, A.2
Witting, A.3
Moller, T.4
Stella, N.5
-
190
-
-
1542327667
-
P2X7 receptors control 2-arachidonoylglycerol production by microglial cells
-
doi:10.1073/pnas.0306707101
-
Witting, A., Walter, L., Wacker, J., Moller, T. & Stella, N. 2004 P2X7 receptors control 2-arachidonoylglycerol production by microglial cells. Proc. Natl Acad. Sci. USA 101, 3214-3219. (doi:10.1073/pnas.0306707101)
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 3214-3219
-
-
Witting, A.1
Walter, L.2
Wacker, J.3
Moller, T.4
Stella, N.5
-
191
-
-
37349006157
-
Microglia produce and hydrolyze palmitoylethanolamide
-
doi:10.1016/j.neuropharm.2007.05.015
-
Muccioli, G.G. & Stella, N. 2008 Microglia produce and hydrolyze palmitoylethanolamide. Neuropharmacology 54, 16-22. (doi:10.1016/j.neuropharm.2007.05.015)
-
(2008)
Neuropharmacology
, vol.54
, pp. 16-22
-
-
Muccioli, G.G.1
Stella, N.2
-
192
-
-
1842428537
-
Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism
-
doi:10.1124/mol.65.4.999
-
Carrier, E. J., Kearn, C. S., Barkmeier, A. J., Breese, N. M., Yang, W., Nithipatikom, K., Pfister, S. L., Campbell, W. B. & Hillard, C. J. 2004 Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. Mol. Pharmacol. 65, 999-1007. (doi:10.1124/mol.65.4.999)
-
(2004)
Mol. Pharmacol
, vol.65
, pp. 999-1007
-
-
Carrier, E.J.1
Kearn, C.S.2
Barkmeier, A.J.3
Breese, N.M.4
Yang, W.5
Nithipatikom, K.6
Pfister, S.L.7
Campbell, W.B.8
Hillard, C.J.9
-
193
-
-
33947330328
-
Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells
-
doi:10.1523/JNEUROSCI.4830-06.2007
-
Muccioli, G. G., Xu, C., Odah, E., Cudaback, E., Cisneros, J. A., Lambert, D. M., Lopez Rodriguez, M. L., Bajjalieh, S. & Stella, N. 2007 Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells. J. Neurosci. 27, 2883-2889. (doi:10.1523/JNEUROSCI.4830-06.2007)
-
(2007)
J. Neurosci
, vol.27
, pp. 2883-2889
-
-
Muccioli, G.G.1
Xu, C.2
Odah, E.3
Cudaback, E.4
Cisneros, J.A.5
Lambert, D.M.6
Lopez Rodriguez, M.L.7
Bajjalieh, S.8
Stella, N.9
-
194
-
-
4644310682
-
ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase
-
doi:10.1523/JNEUROSCI.2419-04.2004
-
Walter, L., Dinh, T. & Stella, N. 2004 ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase. J. Neurosci. 24, 8068-8074. (doi:10.1523/JNEUROSCI.2419-04.2004)
-
(2004)
J. Neurosci
, vol.24
, pp. 8068-8074
-
-
Walter, L.1
Dinh, T.2
Stella, N.3
-
195
-
-
29544446576
-
The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells
-
doi:10.1016/j.neuron.2005.11.027
-
Eljaschewitsch, E. et al. 2006 The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. Neuron 49, 67-79. (doi:10.1016/j.neuron.2005.11.027)
-
(2006)
Neuron
, vol.49
, pp. 67-79
-
-
Eljaschewitsch, E.1
-
196
-
-
40849100074
-
Endocannabinoids mediate neuron-astrocyte communication
-
doi:10.1016/j.neuron.2008.01.029
-
Navarrete, M. & Araque, A. 2008 Endocannabinoids mediate neuron-astrocyte communication. Neuron 57, 883-893. (doi:10.1016/j.neuron.2008.01.029)
-
(2008)
Neuron
, vol.57
, pp. 883-893
-
-
Navarrete, M.1
Araque, A.2
-
197
-
-
79960572625
-
1 cannabinoid receptors on GABAergic neurons in brain aging
-
doi:10.1073/pnas.1016442108
-
Albayram, O. et al. 2011 Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging. Proc. Natl Acad. Sci. USA 108, 11256-11261. (doi:10.1073/pnas.1016442108)
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 11256-11261
-
-
Albayram, O.1
-
198
-
-
79953672641
-
Molecular reorganization of endocannabinoid signalling in Alzheimer's disease
-
doi:10.1093/brain/awr046
-
Mulder, J. et al. 2011 Molecular reorganization of endocannabinoid signalling in Alzheimer's disease. Brain 134, 1041-1060. (doi:10.1093/brain/awr046)
-
(2011)
Brain
, vol.134
, pp. 1041-1060
-
-
Mulder, J.1
-
199
-
-
79960209990
-
Cannabinoid receptor expression in HIV encephalitis and HIV-associated neuropathologic comorbidities
-
doi:10.1111/j.1365-2990.2011.01177.x
-
Cosenza-Nashat, M. A., Bauman, A., Zhao, M. L., Morgello, S., Suh, H. S. & Lee, S. C. 2011 Cannabinoid receptor expression in HIV encephalitis and HIV-associated neuropathologic comorbidities. Neuropathol. Appl. Neurobiol. 37, 464-483. (doi:10.1111/j.1365-2990.2011.01177.x)
-
(2011)
Neuropathol. Appl. Neurobiol
, vol.37
, pp. 464-483
-
-
Cosenza-Nashat, M.A.1
Bauman, A.2
Zhao, M.L.3
Morgello, S.4
Suh, H.S.5
Lee, S.C.6
-
200
-
-
34250185741
-
Inhibition of microglial fatty acid amide hydrolase modulates LPS stimulated release of inflammatory mediators
-
doi:10.1016/j.febslet.2007.05.037
-
Tham, C. S., Whitaker, J., Luo, L. & Webb, M. 2007 Inhibition of microglial fatty acid amide hydrolase modulates LPS stimulated release of inflammatory mediators. FEBS Lett. 581, 2899-2904. (doi:10.1016/j.febslet.2007.05.037)
-
(2007)
FEBS Lett
, vol.581
, pp. 2899-2904
-
-
Tham, C.S.1
Whitaker, J.2
Luo, L.3
Webb, M.4
-
201
-
-
27844552904
-
Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures
-
doi:10.1002/glia.20229
-
Ortega-Gutierrez, S., Molina-Holgado, E. & Guaza, C. 2005 Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures. Glia 52, 163-168. (doi:10.1002/glia.20229)
-
(2005)
Glia
, vol.52
, pp. 163-168
-
-
Ortega-Gutierrez, S.1
Molina-Holgado, E.2
Guaza, C.3
-
202
-
-
13244283049
-
Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes
-
doi:10.1002/glia.20108
-
Sheng, W. S., Hu, S., Min, X., Cabral, G. A., Lokensgard, J. R. & Peterson, P. K. 2005 Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes. Glia 49, 211-219. (doi:10.1002/glia.20108)
-
(2005)
Glia
, vol.49
, pp. 211-219
-
-
Sheng, W.S.1
Hu, S.2
Min, X.3
Cabral, G.A.4
Lokensgard, J.R.5
Peterson, P.K.6
-
203
-
-
67650249730
-
Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation
-
doi:10.1186/1744-8069-5-25
-
Romero-Sandoval, E. A., Horvath, R., Landry, R. P. & DeLeo, J. A. 2009 Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation. Mol. Pain 5, 25. (doi:10.1186/1744-8069-5-25)
-
(2009)
Mol. Pain
, vol.5
, pp. 25
-
-
Romero-Sandoval, E.A.1
Horvath, R.2
Landry, R.P.3
Deleo, J.A.4
-
204
-
-
0036773310
-
Acute neuronal injury, excitotoxicity, and the endocannabinoid system
-
doi:10.1385/MN:26:2-3:317
-
van der Stelt, M., Veldhuis, W. B., Maccarrone, M., Bar, P. R., Nicolay, K., Veldink, G. A., di Marzo, V. & Vliegenthart, J. F. 2002 Acute neuronal injury, excitotoxicity, and the endocannabinoid system. Mol. Neurobiol. 26, 317-346. (doi:10.1385/MN:26:2-3:317)
-
(2002)
Mol. Neurobiol
, vol.26
, pp. 317-346
-
-
van der Stelt, M.1
Veldhuis, W.B.2
Maccarrone, M.3
Bar, P.R.4
Nicolay, K.5
Veldink, G.A.6
Di Marzo, V.7
Vliegenthart, J.F.8
-
205
-
-
53949111613
-
New insights into brain BDNF function in normal aging and Alzheimer disease
-
doi:10.1016/j.brainresrev.2008.07.007
-
Tapia-Arancibia, L., Aliaga, E., Silhol, M. & Arancibia, S. 2008 New insights into brain BDNF function in normal aging and Alzheimer disease. Brain Res. Rev. 59, 201-220. (doi:10.1016/j.brainresrev.2008.07.007)
-
(2008)
Brain Res. Rev
, vol.59
, pp. 201-220
-
-
Tapia-Arancibia, L.1
Aliaga, E.2
Silhol, M.3
Arancibia, S.4
-
206
-
-
83055185674
-
Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging
-
doi:10.1523/JNEUROSCI.3878-11.2011
-
Zeng, Y., Tan, M., Kohyama, J., Sneddon, M., Watson, J. B., Sun, Y. E. & Xie, C.-W. 2011 Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. J. Neurosci. 31, 17800-17810. (doi:10.1523/JNEUROSCI.3878-11.2011)
-
(2011)
J. Neurosci
, vol.31
, pp. 17800-17810
-
-
Zeng, Y.1
Tan, M.2
Kohyama, J.3
Sneddon, M.4
Watson, J.B.5
Sun, Y.E.6
Xie, C.-W.7
-
207
-
-
0037207075
-
Assessment of cannabinoid induced gene changes: Tolerance and neuroprotection
-
doi:10.1016/S0009-3084(02)00161-5
-
Grigorenko, E. et al. 2002 Assessment of cannabinoid induced gene changes: tolerance and neuroprotection. Chem. Phys. Lipids 121, 257-266. (doi:10.1016/S0009-3084(02)00161-5)
-
(2002)
Chem. Phys. Lipids
, vol.121
, pp. 257-266
-
-
Grigorenko, E.1
-
208
-
-
18844450416
-
In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to D-tetrahydrocannabinol
-
doi:10.1111/j.1471-4159.2005.03074.x
-
Butovsky, E., Juknat, A., Goncharov, I., Elbaz, J., Eilam, R., Zangen, A. & Vogel, Z. 2005 In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to D-tetrahydrocannabinol. J. Neurochem. 93, 802-811. (doi:10.1111/j.1471-4159.2005.03074.x)
-
(2005)
J. Neurochem
, vol.93
, pp. 802-811
-
-
Butovsky, E.1
Juknat, A.2
Goncharov, I.3
Elbaz, J.4
Eilam, R.5
Zangen, A.6
Vogel, Z.7
-
209
-
-
0141865717
-
CB1 cannabinoid receptors and on-demand defense against excitotoxicity
-
doi:10.1126/science.1088208
-
Marsicano, G. et al. 2003 CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science 302, 84-88. (doi:10.1126/science.1088208)
-
(2003)
Science
, vol.302
, pp. 84-88
-
-
Marsicano, G.1
-
210
-
-
0037444557
-
Regulation of extracellular signalregulated kinase by cannabinoids in hippocampus
-
Derkinderen, P., Valjent, E., Toutant, M., Corvol, J. C., Enslen, H., Ledent, C., Trzaskos, J., Caboche, J. & Girault, J. A. 2003 Regulation of extracellular signalregulated kinase by cannabinoids in hippocampus. J. Neurosci. 23, 2371-2382.
-
(2003)
J. Neurosci
, vol.23
, pp. 2371-2382
-
-
Derkinderen, P.1
Valjent, E.2
Toutant, M.3
Corvol, J.C.4
Enslen, H.5
Ledent, C.6
Trzaskos, J.7
Caboche, J.8
Girault, J.A.9
-
211
-
-
30044439768
-
Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor
-
doi:10.1073/pnas.0509494102
-
Berghuis, P. et al. 2005 Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc. Natl Acad. Sci. USA 102, 19115-19120. (doi:10.1073/pnas.0509494102)
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 19115-19120
-
-
Berghuis, P.1
-
212
-
-
41749106682
-
1 knockout mice
-
doi:10.1111/j.1471-4159.2007.05149.x
-
Aso, E., Ozaita, A., Valdizan, E. M., Ledent, C., Pazos, A., Maldonado, R. & Valverde, O. 2008 BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice. J. Neurochem. 105, 565-572. (doi:10.1111/j.1471-4159.2007.05149.x)
-
(2008)
J. Neurochem
, vol.105
, pp. 565-572
-
-
Aso, E.1
Ozaita, A.2
Valdizan, E.M.3
Ledent, C.4
Pazos, A.5
Maldonado, R.6
Valverde, O.7
-
213
-
-
59949096898
-
Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans
-
doi:10.1007/s00213-008-1333-2
-
D'Souza, D. C., Pittman, B., Perry, E. & Simen, A. 2009 Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans. Psychopharmacology (Berl.) 202, 569-578. (doi:10.1007/s00213-008-1333-2)
-
(2009)
Psychopharmacology (Berl.)
, vol.202
, pp. 569-578
-
-
D'souza, D.C.1
Pittman, B.2
Perry, E.3
Simen, A.4
-
214
-
-
26444557412
-
The endocannabinoid system drives neural progenitor proliferation
-
Aguado, T. et al. 2005 The endocannabinoid system drives neural progenitor proliferation. FASEB J. 19, 1704-1706.
-
(2005)
FASEB J
, vol.19
, pp. 1704-1706
-
-
Aguado, T.1
-
215
-
-
47749088572
-
A diacylglycerol lipase- CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner
-
doi:10.1016/j.mcn.2008.05.001
-
Goncalves, M. B. et al. 2008 A diacylglycerol lipase- CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner. Mol. Cell Neurosci. 38, 526-536. (doi:10.1016/j.mcn.2008.05.001)
-
(2008)
Mol. Cell Neurosci
, vol.38
, pp. 526-536
-
-
Goncalves, M.B.1
-
216
-
-
70449836471
-
Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain
-
doi:10.1038/mp.2009.62
-
Marchalant, Y., Brothers, H. M. & Wenk, G. L. 2009 Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain. Mol. Psychiatry 14, 1068-1069. (doi:10.1038/mp.2009.62)
-
(2009)
Mol. Psychiatry
, vol.14
, pp. 1068-1069
-
-
Marchalant, Y.1
Brothers, H.M.2
Wenk, G.L.3
-
217
-
-
33750060283
-
Endocannabinoids modulate stress-induced suppression of hippocampal cell proliferation and activation of defensive behaviours
-
doi:10.1111/j.1460-9568.2006.05061.x
-
Hill, M. N., Kambo, J. S., Sun, J. C., Gorzalka, B. B. & Galea, L. A. 2006 Endocannabinoids modulate stress-induced suppression of hippocampal cell proliferation and activation of defensive behaviours. Eur. J. Neurosci. 24, 1845-1849. (doi:10.1111/j.1460-9568.2006.05061.x)
-
(2006)
Eur. J. Neurosci
, vol.24
, pp. 1845-1849
-
-
Hill, M.N.1
Kambo, J.S.2
Sun, J.C.3
Gorzalka, B.B.4
Galea, L.A.5
-
218
-
-
81855185433
-
DAGLdependent endocannabinoid signalling: Roles in axonal pathfinding, synaptic plasticity and adult neurogenesis
-
doi:10.1111/j.1460-9568.2011.07831.x
-
Oudin, M. J., Hobbs, C. & Doherty, P. 2011 DAGLdependent endocannabinoid signalling: roles in axonal pathfinding, synaptic plasticity and adult neurogenesis. Eur. J. Neurosci. 34, 1634-1646. (doi:10.1111/j.1460-9568.2011.07831.x)
-
(2011)
Eur. J. Neurosci
, vol.34
, pp. 1634-1646
-
-
Oudin, M.J.1
Hobbs, C.2
Doherty, P.3
-
219
-
-
47249108485
-
Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning
-
doi:10.1073/pnas.0803545105
-
Mulder, J. et al. 2008 Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning. Proc. Natl Acad. Sci. USA 105, 8760-8765. (doi:10.1073/pnas.0803545105)
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 8760-8765
-
-
Mulder, J.1
-
220
-
-
34548241342
-
The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis
-
doi:10.1074/jbc.M700678200
-
Aguado, T., Romero, E., Monory, K., Palazuelos, J., Sendtner, M., Marsicano, G., Lutz, B., Guzman, M. & Galve-Roperh, I. 2007 The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis. J. Biol. Chem. 282, 23892-23898. (doi:10.1074/jbc.M700678200)
-
(2007)
J. Biol. Chem
, vol.282
, pp. 23892-23898
-
-
Aguado, T.1
Romero, E.2
Monory, K.3
Palazuelos, J.4
Sendtner, M.5
Marsicano, G.6
Lutz, B.7
Guzman, M.8
Galve-Roperh, I.9
-
221
-
-
3342979420
-
1 cannabinoid receptor knockout mice
-
doi:10.1124/mol.66.2.204
-
Jin, K., Xie, L., Kim, S. H., Parmentier-Batteur, S., Sun, Y., Mao, X. O., Childs, J. & Greenberg, D. A. 2004 Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice. Mol. Pharmacol. 66, 204-208. (doi:10.1124/mol.66.2.204)
-
(2004)
Mol. Pharmacol
, vol.66
, pp. 204-208
-
-
Jin, K.1
Xie, L.2
Kim, S.H.3
Parmentier-Batteur, S.4
Sun, Y.5
Mao, X.O.6
Childs, J.7
Greenberg, D.A.8
-
222
-
-
0032442541
-
Changes in cannabinoid receptor binding and mRNA levels in several brain regions of aged rats
-
doi:10.1016/S0925-4439(98)00042-8
-
Berrendero, F., Romero, J., Garcia-Gil, L., Suarez, I., De la Cruz, P., Ramos, J. A. & Fernandez-Ruiz, J. J. 1998 Changes in cannabinoid receptor binding and mRNA levels in several brain regions of aged rats. Biochim. Biophys. Acta 1407, 205-214. (doi:10.1016/S0925-4439(98)00042-8)
-
(1998)
Biochim. Biophys. Acta
, vol.1407
, pp. 205-214
-
-
Berrendero, F.1
Romero, J.2
Garcia-Gil, L.3
Suarez, I.4
De la Cruz, P.5
Ramos, J.A.6
Fernandez-Ruiz, J.J.7
-
223
-
-
0031982015
-
Loss of cannabinoid receptor binding and messenger RNA levels and cannabinoid agonist-stimulated [35S]guanylyl- 50O-(thio)-triphosphate binding in the basal ganglia of aged rats
-
doi:10.1016/S0306-4522(97)00552-6
-
Romero, J., Berrendero, F., Garcia-Gil, L., de la Cruz, P., Ramos, J. A. & Fernandez-Ruiz, J. J. 1998 Loss of cannabinoid receptor binding and messenger RNA levels and cannabinoid agonist-stimulated [35S]guanylyl- 50O-(thio)-triphosphate binding in the basal ganglia of aged rats. Neuroscience 84, 1075-1083. (doi:10.1016/S0306-4522(97)00552-6)
-
(1998)
Neuroscience
, vol.84
, pp. 1075-1083
-
-
Romero, J.1
Berrendero, F.2
Garcia-Gil, L.3
De la Cruz, P.4
Ramos, J.A.5
Fernandez-Ruiz, J.J.6
-
224
-
-
70049083864
-
Modification upon aging of the density of presynaptic modulation systems in the hippocampus
-
doi:10.1016/j.neurobiolaging.2008.01.003
-
Canas, P. M., Duarte, J. M., Rodrigues, R. J., Kofalvi, A. & Cunha, R. A. 2009 Modification upon aging of the density of presynaptic modulation systems in the hippocampus. Neurobiol. Aging 30, 1877-1884. (doi:10.1016/j.neurobiolaging.2008.01.003)
-
(2009)
Neurobiol. Aging
, vol.30
, pp. 1877-1884
-
-
Canas, P.M.1
Duarte, J.M.2
Rodrigues, R.J.3
Kofalvi, A.4
Cunha, R.A.5
-
225
-
-
0038045491
-
1 receptor protein expression in the rat hippocampus and entorhinal, perirhinal, postrhinal and temporal cortices: Regional variations and age-related changes
-
doi:10.1016/S0006-8993(03)02872-5
-
Liu, P., Bilkey, D. K., Darlington, C. L. & Smith, P. F. 2003 Cannabinoid CB1 receptor protein expression in the rat hippocampus and entorhinal, perirhinal, postrhinal and temporal cortices: regional variations and age-related changes. Brain Res. 979, 235-239. (doi:10.1016/S0006-8993(03)02872-5)
-
(2003)
Brain Res
, vol.979
, pp. 235-239
-
-
Liu, P.1
Bilkey, D.K.2
Darlington, C.L.3
Smith, P.F.4
-
226
-
-
0037417989
-
Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice
-
doi:10.1073/pnas.0336351100
-
Wang, L., Liu, J., Harvey-White, J., Zimmer, A. & Kunos, G. 2003 Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice. Proc. Natl Acad. Sci. USA 100, 1393-1398. (doi:10.1073/pnas.0336351100)
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 1393-1398
-
-
Wang, L.1
Liu, J.2
Harvey-White, J.3
Zimmer, A.4
Kunos, G.5
-
227
-
-
38749128371
-
Gender-dependent increases with healthy aging of the human cerebral cannabinoid-type 1 receptor binding using [(18)F]MK-9470 PET
-
doi:10.1016/j.neuroimage.2007.10.053
-
Van Laere, K., Goffin, K., Casteels, C., Dupont, P., Mortelmans, L., de Hoon, J. & Bormans, G. 2008 Gender-dependent increases with healthy aging of the human cerebral cannabinoid-type 1 receptor binding using [(18)F]MK-9470 PET. Neuroimage 39, 1533-1541. (doi:10.1016/j.neuroimage.2007.10.053)
-
(2008)
Neuroimage
, vol.39
, pp. 1533-1541
-
-
van Laere, K.1
Goffin, K.2
Casteels, C.3
Dupont, P.4
Mortelmans, L.5
de Hoon, J.6
Bormans, G.7
-
228
-
-
0034924282
-
1 cannabinoid receptor knockout mice of different ages
-
doi:10.1046/j.1471-4159.2001.00413.x
-
Maccarrone, M., Attina, M., Bari, M., Cartoni, A., Ledent, C. & Finazzi-Agro, A. 2001 Anandamide degradation and N-acylethanolamines level in wildtype and CB1 cannabinoid receptor knockout mice of different ages. J. Neurochem. 78, 339-348. (doi:10.1046/j.1471-4159.2001.00413.x)
-
(2001)
J. Neurochem
, vol.78
, pp. 339-348
-
-
Maccarrone, M.1
Attina, M.2
Bari, M.3
Cartoni, A.4
Ledent, C.5
Finazzi-Agro, A.6
-
229
-
-
18744396333
-
1 cannabinoid receptor knockout mice: Correlation with behaviour
-
doi:10.1046/j.1460-9568.2002.01957.x
-
Maccarrone, M., Valverde, O., Barbaccia, M. L., Castane, A., Maldonado, R., Ledent, C., Parmentier, M. & Finazzi-Agro, A. 2002 Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour. Eur. J. Neurosci. 15, 1178-1186. (doi:10.1046/j.1460-9568.2002.01957.x)
-
(2002)
Eur. J. Neurosci
, vol.15
, pp. 1178-1186
-
-
Maccarrone, M.1
Valverde, O.2
Barbaccia, M.L.3
Castane, A.4
Maldonado, R.5
Ledent, C.6
Parmentier, M.7
Finazzi-Agro, A.8
-
230
-
-
77952666794
-
Quantification of brain endocannabinoid levels: Methods, interpretations and pitfalls
-
doi:10.1111/j.1476-5381.2010.00787.x
-
Buczynski, M.W. & Parsons, L. H. 2010 Quantification of brain endocannabinoid levels: methods, interpretations and pitfalls. Br. J. Pharmacol. 160, 423-442. (doi:10.1111/j.1476-5381.2010.00787.x)
-
(2010)
Br. J. Pharmacol
, vol.160
, pp. 423-442
-
-
Buczynski, M.W.1
Parsons, L.H.2
-
231
-
-
0032721144
-
1 receptor knock-out mice
-
doi:10.1016/S0014-2999(99)00496-3
-
Reibaud, M., Obinu, M. C., Ledent, C., Parmentier, M., Bohme, G. A. & Imperato, A. 1999 Enhancement of memory in cannabinoid CB1 receptor knock-out mice. Eur. J. Pharmacol. 379, R1-R2. (doi:10.1016/S0014-2999(99)00496-3)
-
(1999)
Eur. J. Pharmacol
, vol.379
-
-
Reibaud, M.1
Obinu, M.C.2
Ledent, C.3
Parmentier, M.4
Bohme, G.A.5
Imperato, A.6
-
232
-
-
27344450242
-
1 receptors
-
doi:10.1073/pnas.0504640102
-
Bilkei-Gorzo, A., Racz, I., Valverde, O., Otto, M., Michel, K., Sastre, M. & Zimmer, A. 2005 Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors. Proc. Natl Acad. Sci. USA 102, 15670-15675. (doi:10.1073/pnas.0504640102)
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 15670-15675
-
-
Bilkei-Gorzo, A.1
Racz, I.2
Valverde, O.3
Otto, M.4
Michel, K.5
Sastre, M.6
Zimmer, A.7
-
233
-
-
0032745087
-
1 receptors
-
doi:10.1016/S0306-4522(99)00483-2
-
Bohme, G. A., Laville, M., Ledent, C., Parmentier, M. & Imperato, A. 2000 Enhanced long-term potentiation in mice lacking cannabinoid CB1 receptors. Neuroscience 95, 5-7. (doi:10.1016/S0306-4522(99)00483-2)
-
(2000)
Neuroscience
, vol.95
, pp. 5-7
-
-
Bohme, G.A.1
Laville, M.2
Ledent, C.3
Parmentier, M.4
Imperato, A.5
-
234
-
-
78650641401
-
Endocannabinoid signaling in the brain: Biosynthetic mechanisms in the limelight
-
doi:10.1038/nn.2720
-
Di Marzo, V. 2011 Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight. Nat. Neurosci. 14, 9-15. (doi:10.1038/nn.2720)
-
(2011)
Nat. Neurosci
, vol.14
, pp. 9-15
-
-
Di Marzo, V.1
-
235
-
-
34547892637
-
Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase
-
doi:10.1152/ajpheart.00373.2007
-
Batkai, S., Rajesh, M., Mukhopadhyay, P., Hasko, G., Liaudet, L., Cravatt, B. F., Csiszar, A., Ungvari, Z. & Pacher, P. 2007 Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. Am. J. Physiol. Heart Circ. Physiol. 293, H909-H918. (doi:10.1152/ajpheart.00373.2007)
-
(2007)
Am. J. Physiol. Heart Circ. Physiol
, vol.293
-
-
Batkai, S.1
Rajesh, M.2
Mukhopadhyay, P.3
Hasko, G.4
Liaudet, L.5
Cravatt, B.F.6
Csiszar, A.7
Ungvari, Z.8
Pacher, P.9
-
236
-
-
78149245168
-
Role of cannabinoid receptor type 1 desensitization in greater tetrahydrocannabinol impairment of memory in adolescent rats
-
doi:10.1124/jpet.110.169359
-
Moore, N. L., Greenleaf, A. L., Acheson, S. K., Wilson, W. A., Swartzwelder, H. S. & Kuhn, C. M. 2010 Role of cannabinoid receptor type 1 desensitization in greater tetrahydrocannabinol impairment of memory in adolescent rats. J. Pharmacol. Exp. Ther. 335, 294-301. (doi:10.1124/jpet.110.169359)
-
(2010)
J. Pharmacol. Exp. Ther
, vol.335
, pp. 294-301
-
-
Moore, N.L.1
Greenleaf, A.L.2
Acheson, S.K.3
Wilson, W.A.4
Swartzwelder, H.S.5
Kuhn, C.M.6
-
237
-
-
43049103458
-
Cannabis and the developing brain: Insights from behavior
-
doi:10.1016/j.ejphar.2008.01.058
-
Trezza, V., Cuomo, V. & Vanderschuren, L. J. 2008 Cannabis and the developing brain: insights from behavior. Eur. J. Pharmacol. 585, 441-452. (doi:10.1016/j.ejphar.2008.01.058)
-
(2008)
Eur. J. Pharmacol
, vol.585
, pp. 441-452
-
-
Trezza, V.1
Cuomo, V.2
Vanderschuren, L.J.3
-
238
-
-
0026599895
-
The human toxicity of marijuana
-
Nahas, G. & Latour, C. 1992 The human toxicity of marijuana. Med. J. Austr. 156, 495-497.
-
(1992)
Med. J. Austr
, vol.156
, pp. 495-497
-
-
Nahas, G.1
Latour, C.2
-
239
-
-
33750861867
-
The endocannabinoid system in ageing: A new target for drug development
-
Paradisi, A., Oddi, S. & Maccarrone, M. 2006 The endocannabinoid system in ageing: a new target for drug development. Curr. Drug Targets 7, 1539-1552.
-
(2006)
Curr. Drug Targets
, vol.7
, pp. 1539-1552
-
-
Paradisi, A.1
Oddi, S.2
Maccarrone, M.3
-
240
-
-
43049149810
-
Inflammation and aging: Can endocannabinoids help?
-
doi:10.1016/j.biopha.2008.02.004
-
Marchalant, Y., Brothers, H. M. & Wenk, G. L. 2008 Inflammation and aging: can endocannabinoids help? Biomed. Pharmacother. 62, 212-217. (doi:10.1016/j.biopha.2008.02.004)
-
(2008)
Biomed. Pharmacother
, vol.62
, pp. 212-217
-
-
Marchalant, Y.1
Brothers, H.M.2
Wenk, G.L.3
-
241
-
-
78649233198
-
Cannabinoid receptors and endocannabinoids: Role in neuroinflammatory and neurodegenerative disorders
-
Bisogno, T. & Di Marzo, V. 2010 Cannabinoid receptors and endocannabinoids: role in neuroinflammatory and neurodegenerative disorders. CNS Neurol. Disord. Drug Targets 9, 564-573.
-
(2010)
CNS Neurol. Disord. Drug Targets
, vol.9
, pp. 564-573
-
-
Bisogno, T.1
Di Marzo, V.2
-
242
-
-
35648993493
-
Endocannabinoids and neurodegenerative diseases
-
doi:10.1016/j.phrs.2007.09.008
-
Micale, V., Mazzola, C. & Drago, F. 2007 Endocannabinoids and neurodegenerative diseases. Pharmacol. Res. 56, 382-392. (doi:10.1016/j.phrs.2007.09.008)
-
(2007)
Pharmacol. Res
, vol.56
, pp. 382-392
-
-
Micale, V.1
Mazzola, C.2
Drago, F.3
-
243
-
-
67649843735
-
The endocannabinoid system as a target for the treatment of motor dysfunction
-
doi:10.1111/j.1476-5381.2008.00088.x
-
Fernandez-Ruiz, J. 2009 The endocannabinoid system as a target for the treatment of motor dysfunction. Br. J. Pharmacol. 156, 1029-1040. (doi:10.1111/j.1476-5381.2008.00088.x)
-
(2009)
Br. J. Pharmacol
, vol.156
, pp. 1029-1040
-
-
Fernandez-Ruiz, J.1
-
244
-
-
77949564177
-
The endocannabinoid system as a target for the treatment of neuronal damage
-
doi:10.1517/14728221003709792
-
Fernandez-Ruiz, J., Garcia, C., Sagredo, O., Gomez-Ruiz, M. & de Lago, E. 2010 The endocannabinoid system as a target for the treatment of neuronal damage. Expert Opin. Ther. Targets 14, 387-404. (doi:10.1517/14728221003709792)
-
(2010)
Expert Opin. Ther. Targets
, vol.14
, pp. 387-404
-
-
Fernandez-Ruiz, J.1
Garcia, C.2
Sagredo, O.3
Gomez-Ruiz, M.4
de Lago, E.5
-
245
-
-
84859614049
-
The therapeutic potential of the endocannabinoid system for Alzheimer's disease
-
doi:10.1517/14728222.2012.671812
-
Karl, T., Cheng, D., Garner, B. & Arnold, J. C. 2012 The therapeutic potential of the endocannabinoid system for Alzheimer's disease. Expert Opin. Ther. Targets 16, 407-420. (doi:10.1517/14728222.2012.671812)
-
(2012)
Expert Opin. Ther. Targets
, vol.16
, pp. 407-420
-
-
Karl, T.1
Cheng, D.2
Garner, B.3
Arnold, J.C.4
-
246
-
-
14244264502
-
Prevention of Alzheimer's disease pathology by cannabinoids: Neuroprotection mediated by blockade of microglial activation
-
doi:10.1523/JNEUROSCI.4540-04.2005
-
Ramirez, B. G., Blazquez, C., Gomez del Pulgar, T., Guzman, M. & de Ceballos, M. L. 2005 Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J. Neurosci. 25, 1904-1913. (doi:10.1523/JNEUROSCI.4540-04.2005)
-
(2005)
J. Neurosci
, vol.25
, pp. 1904-1913
-
-
Ramirez, B.G.1
Blazquez, C.2
del Gomez Pulgar, T.3
Guzman, M.4
de Ceballos, M.L.5
-
247
-
-
84855812968
-
Prolonged oral cannabinoid administration prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in Tg APP 2576 mice
-
doi:10.1186/1742-2094-9-8
-
Martin-Moreno, A. M. et al. 2012 Prolonged oral cannabinoid administration prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in Tg APP 2576 mice. J. Neuroinflammation 9, 8. (doi:10.1186/1742-2094-9-8)
-
(2012)
J. Neuroinflammation
, vol.9
, pp. 8
-
-
Martin-Moreno, A.M.1
-
248
-
-
84861513395
-
CB1 agonist ACEA protects neurons and reduces the cognitive impairment of AbetaPP/ PS1 mice
-
Aso, E., Palomer, E., Juves, S., Maldonado, R., Munoz, F. J. & Ferrer, I. 2012 CB1 agonist ACEA protects neurons and reduces the cognitive impairment of AbetaPP/ PS1 mice. J. Alzheimer's Dis. 30, 439-459.
-
(2012)
J. Alzheimer's Dis
, vol.30
, pp. 439-459
-
-
Aso, E.1
Palomer, E.2
Juves, S.3
Maldonado, R.4
Munoz, F.J.5
Ferrer, I.6
-
249
-
-
33645453054
-
D-9-tetrahydrocannabinol for nighttime agitation in severe dementia
-
doi:10.1007/s00213-006-0343-1
-
Walther, S., Mahlberg, R., Eichmann, U. & Kunz, D. 2006 D-9-tetrahydrocannabinol for nighttime agitation in severe dementia. Psychopharmacology (Berl.) 185, 524-528. (doi:10.1007/s00213-006-0343-1)
-
(2006)
Psychopharmacology (Berl.)
, vol.185
, pp. 524-528
-
-
Walther, S.1
Mahlberg, R.2
Eichmann, U.3
Kunz, D.4
-
250
-
-
84866451855
-
D(9)-THC exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease
-
doi:10.1111/j.1365-2990.2011.01248.x
-
Carroll, C. B., Zeissler, M. L., Hanemann, C. O. & Zajicek, J. P. 2012 D(9)-THC exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease. Neuropathol. Appl. Neurobiol. (doi:10.1111/j.1365-2990.2011.01248.x)
-
(2012)
Neuropathol. Appl. Neurobiol
-
-
Carroll, C.B.1
Zeissler, M.L.2
Hanemann, C.O.3
Zajicek, J.P.4
-
251
-
-
84859924311
-
Cannabinoids prevent lipopolysaccharideinduced neurodegeneration in the rat substantia nigra in vivo through inhibition of microglial activation and NADPH oxidase
-
doi:10.1016/j.brainres.2012.02.058
-
Chung, E. S., Bok, E., Chung, Y. C., Baik, H. H. & Jin, B. K. 2012 Cannabinoids prevent lipopolysaccharideinduced neurodegeneration in the rat substantia nigra in vivo through inhibition of microglial activation and NADPH oxidase. Brain Res. 1451, 110-116. (doi:10.1016/j.brainres.2012.02.058)
-
(2012)
Brain Res
, vol.1451
, pp. 110-116
-
-
Chung, E.S.1
Bok, E.2
Chung, Y.C.3
Baik, H.H.4
Jin, B.K.5
-
252
-
-
0035846577
-
Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: A pilot study
-
doi:10.1212/WNL.57.11.2108
-
Sieradzan, K. A., Fox, S. H., Hill, M., Dick, J. P., Crossman, A. R. & Brotchie, J. M. 2001 Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study. Neurology 57, 2108-2111. (doi:10.1212/WNL.57.11.2108)
-
(2001)
Neurology
, vol.57
, pp. 2108-2111
-
-
Sieradzan, K.A.1
Fox, S.H.2
Hill, M.3
Dick, J.P.4
Crossman, A.R.5
Brotchie, J.M.6
-
253
-
-
20844441058
-
Cannabis for dyskinesia in Parkinson disease: A randomized double-blind crossover study
-
doi:10.1212/01.WNL.0000140288.48796.8E
-
Carroll, C. B. et al. 2004 Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover study. Neurology 63, 1245-1250. (doi:10.1212/01.WNL.0000140288.48796.8E)
-
(2004)
Neurology
, vol.63
, pp. 1245-1250
-
-
Carroll, C.B.1
-
254
-
-
2942597453
-
Neurokinin, B., neurotensin, and cannabinoid receptor antagonists and Parkinson disease
-
doi:10.1097/00002826-200405000-00003
-
Mesnage, V. et al. 2004 Neurokinin, B., neurotensin, and cannabinoid receptor antagonists and Parkinson disease. Clin. Neuropharmacol. 27, 108-110. (doi:10.1097/00002826-200405000-00003)
-
(2004)
Clin. Neuropharmacol
, vol.27
, pp. 108-110
-
-
Mesnage, V.1
-
255
-
-
52949103699
-
The endocannabinoid system in amyotrophic lateral sclerosis
-
doi:10.2174/138161208785740081
-
Bilsland, L. G. & Greensmith, L. 2008 The endocannabinoid system in amyotrophic lateral sclerosis. Curr. Pharm. Des. 14, 2306-2316. (doi:10.2174/138161208785740081)
-
(2008)
Curr. Pharm. Des
, vol.14
, pp. 2306-2316
-
-
Bilsland, L.G.1
Greensmith, L.2
-
256
-
-
52949136295
-
The endocannabinoid system in Huntington's disease
-
doi:10.2174/138161208785740108
-
Pazos, M. R., Sagredo, O. & Fernandez-Ruiz, J. 2008 The endocannabinoid system in Huntington's disease. Curr. Pharm. Des. 14, 2317-2325. (doi:10.2174/138161208785740108)
-
(2008)
Curr. Pharm. Des
, vol.14
, pp. 2317-2325
-
-
Pazos, M.R.1
Sagredo, O.2
Fernandez-Ruiz, J.3
-
257
-
-
79960062773
-
Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease
-
doi:10.1002/jnr.22682
-
Sagredo, O., Pazos, M. R., Satta, V., Ramos, J. A., Pertwee, R. G. & Fernandez-Ruiz, J. 2011 Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease. J. Neurosci. Res. 89, 1509-1518. (doi:10.1002/jnr.22682)
-
(2011)
J. Neurosci. Res
, vol.89
, pp. 1509-1518
-
-
Sagredo, O.1
Pazos, M.R.2
Satta, V.3
Ramos, J.A.4
Pertwee, R.G.5
Fernandez-Ruiz, J.6
-
258
-
-
78650694548
-
Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease
-
doi:10.1093/brain/awq278
-
Blazquez, C. et al. 2011 Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease. Brain 134, 119-136. (doi:10.1093/brain/awq278)
-
(2011)
Brain
, vol.134
, pp. 119-136
-
-
Blazquez, C.1
-
259
-
-
17144462251
-
Therapeutic action of cannabinoids in a murine model of multiple sclerosis
-
Arevalo-Martin, A., Vela, J. M., Molina-Holgado, E., Borrell, J. & Guaza, C. 2003 Therapeutic action of cannabinoids in a murine model of multiple sclerosis. J. Neurosci. 23, 2511-2516.
-
(2003)
J. Neurosci
, vol.23
, pp. 2511-2516
-
-
Arevalo-Martin, A.1
Vela, J.M.2
Molina-Holgado, E.3
Borrell, J.4
Guaza, C.5
-
260
-
-
33845683331
-
Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice
-
doi:10.1096/fj.05-4743fje
-
Bilsland, L. G., Dick, J. R., Pryce, G., Petrosino, S., Di Marzo, V., Baker, D. & Greensmith, L. 2006 Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice. FASEB J. 20, 1003-1005. (doi:10.1096/fj.05-4743fje)
-
(2006)
FASEB J
, vol.20
, pp. 1003-1005
-
-
Bilsland, L.G.1
Dick, J.R.2
Pryce, G.3
Petrosino, S.4
Di Marzo, V.5
Baker, D.6
Greensmith, L.7
-
261
-
-
76449096382
-
The cannabinoid receptor 1 gene (CNR1) and multiple sclerosis: An association study in two case-control groups from Spain
-
doi:10.1177/1352458509355071
-
Ramil, E. et al. 2010 The cannabinoid receptor 1 gene (CNR1) and multiple sclerosis: an association study in two case-control groups from Spain. Mult. Scler. 16, 139-146. (doi:10.1177/1352458509355071)
-
(2010)
Mult. Scler
, vol.16
, pp. 139-146
-
-
Ramil, E.1
-
262
-
-
25444530723
-
Randomized, controlled trial of cannabisbased medicine in central pain in multiple sclerosis
-
doi:10.1212/01.wnl.0000176753.45410.8b
-
Rog, D. J., Nurmikko, T. J., Friede, T. & Young, C. A. 2005 Randomized, controlled trial of cannabisbased medicine in central pain in multiple sclerosis. Neurology 65, 812-819. (doi:10.1212/01.wnl.0000176753.45410.8b)
-
(2005)
Neurology
, vol.65
, pp. 812-819
-
-
Rog, D.J.1
Nurmikko, T.J.2
Friede, T.3
Young, C.A.4
-
263
-
-
0242654882
-
Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): Multicentre randomized placebo-controlled trial
-
doi:10.1016/S0140-6736(03)14738-1
-
Zajicek, J., Fox, P., Sanders, H., Wright, D., Vickery, J., Nunn, A. & Thompson, A. 2003 Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomized placebo-controlled trial. Lancet 362, 1517-1526. (doi:10.1016/S0140-6736(03)14738-1)
-
(2003)
Lancet
, vol.362
, pp. 1517-1526
-
-
Zajicek, J.1
Fox, P.2
Sanders, H.3
Wright, D.4
Vickery, J.5
Nunn, A.6
Thompson, A.7
-
264
-
-
33847766180
-
Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis
-
doi:10.1111/j.1468-1331.2006.01639.x
-
Collin, C., Davies, P., Mutiboko, I. K. & Ratcliffe, S. 2007 Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis. Eur. J. Neurol. 14, 290-296. (doi:10.1111/j.1468-1331.2006.01639.x)
-
(2007)
Eur. J. Neurol
, vol.14
, pp. 290-296
-
-
Collin, C.1
Davies, P.2
Mutiboko, I.K.3
Ratcliffe, S.4
-
265
-
-
72549092256
-
Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: A systematic review
-
59-10 doi:10.1186/1471-2377-9-59
-
Lakhan, S. E. & Rowland, M. 2009 Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review. BMC Neurol. 9, 59-10. (doi:10.1186/1471-2377-9-59)
-
(2009)
BMC Neurol
, vol.9
-
-
Lakhan, S.E.1
Rowland, M.2
-
266
-
-
33745025055
-
Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis
-
doi:10.1177/1352458505070618
-
Wade, D. T., Makela, P. M., House, H., Bateman, C. & Robson, P. 2006 Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis. Mult. Scler. 12, 639-645. (doi:10.1177/1352458505070618
-
(2006)
Mult. Scler
, vol.12
, pp. 639-645
-
-
Wade, D.T.1
Makela, P.M.2
House, H.3
Bateman, C.4
Robson, P.5
|