Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 14, 2010, Pages 5202-5207

  Horti, Andrew G ^a   Gao, Yongjun ^a   Ravert, Hayden T ^a   Finley, Paige ^a   Valentine, Heather ^a   Wong, Dean F ^a   Endres, Christopher J ^a   Savonenko, Alena V ^a   Dannals, Robert F ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Alzheimer's disease; Cannabinoid receptor; CB2 receptor; Neuroinflammation; PET; Positron emission tomography

Indexed keywords

1 (2,3 DICHLOROBENZOYL) 5 METHOXY 2 METHYL 3 (2 MORPHOLINOETHYL)INDOLE; 2,2,3,3 TETRAMETHYLCYCLOPROPANECARBOXYLIC ACID [3 (2 METHOXYETHYL) 4,5 DIMETHYL 3H THIAZOL YLIDENE]AMIDE C 11; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; A 836339; AMYLOID BETA PROTEIN; CANNABINOID 2 RECEPTOR; LIPOPOLYSACCHARIDE; RADIOLIGAND; UNCLASSIFIED DRUG; A-836339; CARBON; DIAGNOSTIC AGENT; THIAZOLE DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; BRAIN STEM; CEREBELLUM; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG UPTAKE; IN VIVO STUDY; INFLAMMATION; MALE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RECEPTOR AFFINITY; SENILE PLAQUE; SPLEEN; AMYLOIDOSIS; ANIMAL; BRAIN; DRUG POTENTIATION; FEMALE; METABOLISM; METHODOLOGY; SCINTISCANNING; SYNTHESIS;

MUS;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMALS; BRAIN; CARBON RADIOISOTOPES; FEMALE; INFLAMMATION; MALE; MICE; POSITRON-EMISSION TOMOGRAPHY; RECEPTOR, CANNABINOID, CB2; THIAZOLES;

EID: 77955323562     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.05.058     Document Type: Article

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