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Volumn 30, Issue 6, 1998, Pages 560-565

Molecular genetics of Alzheimer's disease

Author keywords

Alzheimer's disease; Genetic association studies; Genetic linkage studies; Molecular genetics

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E4; PRESENILIN 1; PRESENILIN 2;

EID: 0032408458     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: 10.3109/07853899809002605     Document Type: Article
Times cited : (125)

References (70)
  • 1
    • 0022869047 scopus 로고
    • The genetics of Alzheimer's disease: A review and a discussion of the implications
    • Davies P. The genetics of Alzheimer's disease: a review and a discussion of the implications. Neurobiol Aging 1986; 7: 459-66.
    • (1986) Neurobiol Aging , vol.7 , pp. 459-466
    • Davies, P.1
  • 3
    • 0023722471 scopus 로고
    • The inheritance of Alzheimer's disease: A new interpretation
    • Fitch N, Becker R, Heller A. The inheritance of Alzheimer's disease: a new interpretation. Ann Neurol 1988; 23: 14-9.
    • (1988) Ann Neurol , vol.23 , pp. 14-19
    • Fitch, N.1    Becker, R.2    Heller, A.3
  • 4
    • 84936613596 scopus 로고
    • History of dementia and Parkinson's disease in 1st-degree relatives of patients with Alzheimer's disease
    • Hofman A, Schulte W, Tanja TA, et al. History of dementia and Parkinson's disease in 1st-degree relatives of patients with Alzheimer's disease. Neurology 1989; 39: 1589-92.
    • (1989) Neurology , vol.39 , pp. 1589-1592
    • Hofman, A.1    Schulte, W.2    Tanja, T.A.3
  • 5
    • 0027521076 scopus 로고
    • The rise and fall of positional cloning?
    • Ballabio A. The rise and fall of positional cloning? Nat Genet 1994; 3: 277-9.
    • (1994) Nat Genet , vol.3 , pp. 277-279
    • Ballabio, A.1
  • 6
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • Goate A, Chartier-Harlin M-C, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991; 349: 704-6.
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1    Chartier-Harlin, M.-C.2    Mullan, M.3
  • 7
    • 0029004341 scopus 로고
    • Cloning of a gene bearing mis-sense mutations in early-onset familial Alzheimer's disease
    • Sherrington R, Rogaev EI, Liang Y, et al. Cloning of a gene bearing mis-sense mutations in early-onset familial Alzheimer's disease. Nature 1995; 375: 754-60.
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3
  • 8
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995; 269: 973-7.
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Poorkaj, P.3
  • 9
    • 0029101491 scopus 로고
    • Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
    • Rogaev EI, Sherrington R, Rogaeva EA, et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 1995; 376: 775-8.
    • (1995) Nature , vol.376 , pp. 775-778
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.A.3
  • 10
    • 0027407565 scopus 로고
    • Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
    • Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A 1993; 90: 1977-81.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 1977-1981
    • Strittmatter, W.J.1    Saunders, A.M.2    Schmechel, D.3
  • 11
    • 0028026997 scopus 로고
    • Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease
    • van Duijn CM, de Knijff P, Cruts M, et al. Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease. Nat Genet 1994; 7: 74-8.
    • (1994) Nat Genet , vol.7 , pp. 74-78
    • Van Duijn, C.M.1    De Knijff, P.2    Cruts, M.3
  • 13
    • 0023889961 scopus 로고
    • The pathological association between Down syndrome and Alzheimer disease
    • Mann DAM. The pathological association between Down syndrome and Alzheimer disease. Mech Ageing Dev 1988; 43: 99-136.
    • (1988) Mech Ageing Dev , vol.43 , pp. 99-136
    • Mann, D.A.M.1
  • 14
    • 0023103748 scopus 로고
    • The genetic defect causing familial Alzheimer's disease maps on chromosome 21
    • St George-Hyslop PH, Tanzi RE, Polinsky PJ, et al. The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science 1987; 235: 885-90.
    • (1987) Science , vol.235 , pp. 885-890
    • St George-Hyslop, P.H.1    Tanzi, R.E.2    Polinsky, P.J.3
  • 15
    • 0023109592 scopus 로고
    • Amyloid β protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
    • Tanzi RE, Gusella JF, Watkins PC, et al. Amyloid β protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 1987; 235: 880-4.
    • (1987) Science , vol.235 , pp. 880-884
    • Tanzi, R.E.1    Gusella, J.F.2    Watkins, P.C.3
  • 16
    • 0025296269 scopus 로고
    • Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
    • Levy E, Carman MD, Fernandez-Madrid IJ, et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 1990; 248: 1124-6.
    • (1990) Science , vol.248 , pp. 1124-1126
    • Levy, E.1    Carman, M.D.2    Fernandez-Madrid, I.J.3
  • 17
    • 0025989981 scopus 로고
    • DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type)
    • Bakker E, Van Broeckhoven C, Haan J, et al. DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type). Am J Hum Genet 1991; 49: 518-21.
    • (1991) Am J Hum Genet , vol.49 , pp. 518-521
    • Bakker, E.1    Van Broeckhoven, C.2    Haan, J.3
  • 18
    • 0025735626 scopus 로고
    • Hereditary cerebral hemorrhage with amyloidosis-Dutch type: Its importance for Alzheimer research
    • Haan J, Hardy JA, Roos RAC. Hereditary cerebral hemorrhage with amyloidosis-Dutch type: its importance for Alzheimer research. Trends Neurosci 1991; 14: 231-4.
    • (1991) Trends Neurosci , vol.14 , pp. 231-234
    • Haan, J.1    Hardy, J.A.2    Roos, R.A.C.3
  • 19
    • 0031938304 scopus 로고    scopus 로고
    • Presenilin mutations in Alzheimer's disease
    • Cruts M, Van Broeckhoven C. Presenilin mutations in Alzheimer's disease. Hum Mutat 1998; 11: 183-90.
    • (1998) Hum Mutat , vol.11 , pp. 183-190
    • Cruts, M.1    Van Broeckhoven, C.2
  • 20
    • 0031052381 scopus 로고    scopus 로고
    • Amyloid, the presenilins and Alzheimer disease
    • Hardy J. Amyloid, the presenilins and Alzheimer disease. Trends Neurosci 1997; 20: 154-9.
    • (1997) Trends Neurosci , vol.20 , pp. 154-159
    • Hardy, J.1
  • 21
    • 0023870043 scopus 로고
    • A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors
    • Ponte P, Gonzalez-De Whitt P, Shilling J, et al. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 1988; 331: 525-7.
    • (1988) Nature , vol.331 , pp. 525-527
    • Ponte, P.1    Gonzalez-De Whitt, P.2    Shilling, J.3
  • 22
    • 0026670809 scopus 로고
    • Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells
    • Konig G, Monning U, Czech C, et al. Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells. J Biol Chem 1992; 267: 10804-9.
    • (1992) J Biol Chem , vol.267 , pp. 10804-10809
    • Konig, G.1    Monning, U.2    Czech, C.3
  • 23
    • 0028174106 scopus 로고
    • Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons
    • Sandbrink R, Masters CL, Beyreuther K. Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons. J Biol Chem 1994; 269: 1510-7.
    • (1994) J Biol Chem , vol.269 , pp. 1510-1517
    • Sandbrink, R.1    Masters, C.L.2    Beyreuther, K.3
  • 24
    • 0026471656 scopus 로고
    • Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14
    • Schellenberg GD, Bird TD, Wijsman EM, et al. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 1992; 258: 668-71.
    • (1992) Science , vol.258 , pp. 668-671
    • Schellenberg, G.D.1    Bird, T.D.2    Wijsman, E.M.3
  • 25
    • 0027032695 scopus 로고
    • Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14
    • St George-Hyslop P, Haines J, Rogaev E, et al. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat Genet 1992; 2: 330-4.
    • (1992) Nat Genet , vol.2 , pp. 330-334
    • St George-Hyslop, P.1    Haines, J.2    Rogaev, E.3
  • 26
    • 0027031612 scopus 로고
    • Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3
    • Van Broeckhoven C, Backhovens H, Cruts M, et al. Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3. Nat Genet 1992; 2: 335-9.
    • (1992) Nat Genet , vol.2 , pp. 335-339
    • Van Broeckhoven, C.1    Backhovens, H.2    Cruts, M.3
  • 27
    • 0027024651 scopus 로고
    • A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the α1-antichymotrypsin gene
    • Mullan M, Houlden H, Windelspecht M, et al. A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the α1-antichymotrypsin gene. Nat Genet 1992; 2: 340-2.
    • (1992) Nat Genet , vol.2 , pp. 340-342
    • Mullan, M.1    Houlden, H.2    Windelspecht, M.3
  • 28
    • 0030293854 scopus 로고    scopus 로고
    • Protein topology of presenilin 1
    • Doan A, Thinakaran G, Borchelt DR, et al. Protein topology of presenilin 1. Neuron 1996; 17: 1023-30.
    • (1996) Neuron , vol.17 , pp. 1023-1030
    • Doan, A.1    Thinakaran, G.2    Borchelt, D.R.3
  • 29
    • 0030922146 scopus 로고    scopus 로고
    • Evidence for a six-transmembrane domain structure of presenilin 1
    • Lehman S, Chiesa R, Harris DA. Evidence for a six-transmembrane domain structure of presenilin 1. J Biol Chem 1997; 272: 12047-51.
    • (1997) J Biol Chem , vol.272 , pp. 12047-12051
    • Lehman, S.1    Chiesa, R.2    Harris, D.A.3
  • 30
    • 0029150716 scopus 로고
    • A familial Alzheimer's disease locus on chromosome 1
    • Levy-Lahad E, Wijsman EM, Nemens E, et al. A familial Alzheimer's disease locus on chromosome 1. Science 1995; 269: 970-3.
    • (1995) Science , vol.269 , pp. 970-973
    • Levy-Lahad, E.1    Wijsman, E.M.2    Nemens, E.3
  • 31
    • 0029813255 scopus 로고    scopus 로고
    • The presenilin genes: A new gene family involved in Alzheimer disease pathology
    • Spec No
    • Cruts M, Hendriks L, Van Broeckhoven C. The presenilin genes: a new gene family involved in Alzheimer disease pathology (review). Hum Mol Genet 1996; 5 Spec No: 1449-55.
    • (1996) Hum Mol Genet , vol.5 , pp. 1449-1455
    • Cruts, M.1    Hendriks, L.2    Van Broeckhoven, C.3
  • 32
    • 0030293676 scopus 로고    scopus 로고
    • Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
    • Borchelt DR, Thinakaran G, Eckman C, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 1996; 17: 1005-13.
    • (1996) Neuron , vol.17 , pp. 1005-1013
    • Borchelt, D.R.1    Thinakaran, G.2    Eckman, C.3
  • 33
    • 16944362157 scopus 로고    scopus 로고
    • Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
    • Citron M, Westaway D, Xia W, et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med 1997; 3: 67-72.
    • (1997) Nat Med , vol.3 , pp. 67-72
    • Citron, M.1    Westaway, D.2    Xia, W.3
  • 34
    • 18544411933 scopus 로고    scopus 로고
    • Mutant presenilin 2 transgenic mouse: Effect on an age-dependent increase of amyloid beta-protein 42 in the brain
    • Oyama F, Sawamura N, Kobayashi K, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. J Neurochem 1998; 71: 313-22.
    • (1998) J Neurochem , vol.71 , pp. 313-322
    • Oyama, F.1    Sawamura, N.2    Kobayashi, K.3
  • 35
    • 12644258498 scopus 로고    scopus 로고
    • The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
    • Tomita T, Maruyama K, Saido TC, et al. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc Natl Acad Sci U S A 1997; 94: 2025-30.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 2025-2030
    • Tomita, T.1    Maruyama, K.2    Saido, T.C.3
  • 36
    • 16044366039 scopus 로고    scopus 로고
    • Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
    • Duff K, Eckman C, Zehr C, et al. Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature 1996; 383: 710-3.
    • (1996) Nature , vol.383 , pp. 710-713
    • Duff, K.1    Eckman, C.2    Zehr, C.3
  • 37
    • 16044373524 scopus 로고    scopus 로고
    • The amyloid β protein deposited in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner D, Eckman C, Jensen M, et al. The amyloid β protein deposited in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 1996; 2: 864-70.
    • (1996) Nat Med , vol.2 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3
  • 38
    • 0025735884 scopus 로고
    • Linkage studies in familial Alzheimer disease: Evidence for chromosome 19 linkage
    • Pericak-Vance MA, Bebout JL, Gaskell PC Jr, et al. Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. Am J Hum Genet 1991; 48: 1034-50.
    • (1991) Am J Hum Genet , vol.48 , pp. 1034-1050
    • Pericak-Vance, M.A.1    Bebout, J.L.2    Gaskell Jr., P.C.3
  • 39
    • 0023090682 scopus 로고
    • Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type
    • Schellenberg GD, Deeb SS, Boehnke M, et al. Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type. J Neurogenet 1987; 4: 97-108.
    • (1987) J Neurogenet , vol.4 , pp. 97-108
    • Schellenberg, G.D.1    Deeb, S.S.2    Boehnke, M.3
  • 40
    • 0025971426 scopus 로고
    • Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeld-Jacob disease
    • Namba Y, Tomonaga M, Kawasaki H, Otomo E, Ikeda K. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeld-Jacob disease. Brain Res 1991; 641: 163-6.
    • (1991) Brain Res , vol.641 , pp. 163-166
    • Namba, Y.1    Tomonaga, M.2    Kawasaki, H.3    Otomo, E.4    Ikeda, K.5
  • 41
    • 0026542786 scopus 로고
    • Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid
    • Wisniewski T, Frangione B. Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett 1992; 135: 235-8.
    • (1992) Neurosci Lett , vol.135 , pp. 235-238
    • Wisniewski, T.1    Frangione, B.2
  • 42
    • 0027327267 scopus 로고
    • Association of apolipoprotein E allele E4 with late-onset familial and sporadic Alzheimer's disease
    • Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele E4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993; 43: 1467-72.
    • (1993) Neurology , vol.43 , pp. 1467-1472
    • Saunders, A.M.1    Strittmatter, W.J.2    Schmechel, D.3
  • 43
    • 0028305380 scopus 로고
    • Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
    • Corder EH, Saunders AM, Risch NJ, et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 1994; 7: 180-4.
    • (1994) Nat Genet , vol.7 , pp. 180-184
    • Corder, E.H.1    Saunders, A.M.2    Risch, N.J.3
  • 44
    • 0028988736 scopus 로고
    • The apolipoprotein E ε2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival
    • van Duijn CM, de Knijff P, Wehnert A, et al. The apolipoprotein E ε2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival. Ann Neurol 1995; 37: 605-10.
    • (1995) Ann Neurol , vol.37 , pp. 605-610
    • Van Duijn, C.M.1    De Knijff, P.2    Wehnert, A.3
  • 45
    • 12044254746 scopus 로고
    • Binding of human apolipoprotein E to synthetic amyloid β peptide: Isoform-specific effects and implications for late-onset Alzheimer disease
    • Strittmatter WJ, Weisgraber KH, Huang D, et al. Binding of human apolipoprotein E to synthetic amyloid β peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci U S A 1993; 90: 8098-102.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 8098-8102
    • Strittmatter, W.J.1    Weisgraber, K.H.2    Huang, D.3
  • 46
    • 0030028429 scopus 로고    scopus 로고
    • Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease
    • Wragg M, Hutton M, Talbot C, et al. Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Lancet 1996; 347: 509-12.
    • (1996) Lancet , vol.347 , pp. 509-512
    • Wragg, M.1    Hutton, M.2    Talbot, C.3
  • 47
    • 0028990941 scopus 로고
    • APOE*4-associated Alzheimer's disease risk is modified by α1-antichymotrypsin polymorphism
    • Kamboh MI, Sanghera DK, Ferrell RE, DeKosky ST. APOE*4-associated Alzheimer's disease risk is modified by α1-antichymotrypsin polymorphism. Nat Genet 1995; 10: 486-8.
    • (1995) Nat Genet , vol.10 , pp. 486-488
    • Kamboh, M.I.1    Sanghera, D.K.2    Ferrell, R.E.3    DeKosky, S.T.4
  • 48
    • 0029118873 scopus 로고
    • Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease
    • Okuizumi K, Onodera O, Namba Y, et al. Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease. Nat Genet 1995; 11: 207-9.
    • (1995) Nat Genet , vol.11 , pp. 207-209
    • Okuizumi, K.1    Onodera, O.2    Namba, Y.3
  • 49
    • 10144219962 scopus 로고    scopus 로고
    • Polymorphisms in the human apolipoprotein-J/clusterin gene: Ethnic variation and distribution in Alzheimer's disease
    • Tycko B, Feng L, Nguyen L, et al. Polymorphisms in the human apolipoprotein-J/clusterin gene: ethnic variation and distribution in Alzheimer's disease. Hum Genet 1996; 98: 430-6.
    • (1996) Hum Genet , vol.98 , pp. 430-436
    • Tycko, B.1    Feng, L.2    Nguyen, L.3
  • 50
    • 14444278967 scopus 로고    scopus 로고
    • Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease
    • Li T, Holmes C, Sham PC, et al. Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease. Neuroreport 1997; 8: 683-6.
    • (1997) Neuroreport , vol.8 , pp. 683-686
    • Li, T.1    Holmes, C.2    Sham, P.C.3
  • 51
    • 0030905730 scopus 로고    scopus 로고
    • HLA-DR antigens associated with major genetic risk for late-onset Alzheimer's disease
    • Curran M, Middleton D, Edwardson J, et al. HLA-DR antigens associated with major genetic risk for late-onset Alzheimer's disease. Neuroreport 1997; 8: 1467-9.
    • (1997) Neuroreport , vol.8 , pp. 1467-1469
    • Curran, M.1    Middleton, D.2    Edwardson, J.3
  • 52
    • 0030816559 scopus 로고    scopus 로고
    • Evidence for association of HLA-A2 allele with onset age of Alzheimer's disease
    • Payami H, Schellenberg GD, Zareparsi S, et al. Evidence for association of HLA-A2 allele with onset age of Alzheimer's disease. Neurology 1997; 49: 512-8.
    • (1997) Neurology , vol.49 , pp. 512-518
    • Payami, H.1    Schellenberg, G.D.2    Zareparsi, S.3
  • 53
    • 0028921457 scopus 로고
    • The CYP2D6B mutant allele is overrepresented in the Lewy body variant of Alzheimer's disease
    • Saitoh T, Xia Y, Chen X, et al. The CYP2D6B mutant allele is overrepresented in the Lewy body variant of Alzheimer's disease. Ann Neurol 1995; 37: 110-2.
    • (1995) Ann Neurol , vol.37 , pp. 110-112
    • Saitoh, T.1    Xia, Y.2    Chen, X.3
  • 54
    • 9444298408 scopus 로고    scopus 로고
    • Genetic studies in Alzheimer's disease with an NACP/alpha-synuclein polymorphism
    • Xia Y, Rohan DSH, Rosi BL, et al. Genetic studies in Alzheimer's disease with an NACP/alpha-synuclein polymorphism. Ann Neurol 1996; 40: 207-15.
    • (1996) Ann Neurol , vol.40 , pp. 207-215
    • Xia, Y.1    Rohan, D.S.H.2    Rosi, B.L.3
  • 55
    • 0030731562 scopus 로고    scopus 로고
    • Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease
    • Lehmann DJ, Johnston C, Smith AD. Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease. Hum Mol Genet 1997; 6: 1933-6.
    • (1997) Hum Mol Genet , vol.6 , pp. 1933-1936
    • Lehmann, D.J.1    Johnston, C.2    Smith, A.D.3
  • 57
    • 8944241774 scopus 로고    scopus 로고
    • Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant
    • Sherrington R, Froelich S, Sorbi S, et al. Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. Hum Mol Genet 1996; 5: 985-8.
    • (1996) Hum Mol Genet , vol.5 , pp. 985-988
    • Sherrington, R.1    Froelich, S.2    Sorbi, S.3
  • 58
    • 0014481635 scopus 로고
    • Presenile dementia and Alzheimer's disease in mongolism
    • Olson MI, Shaw CM. Presenile dementia and Alzheimer's disease in mongolism. Brain 1969; 92: 147-56.
    • (1969) Brain , vol.92 , pp. 147-156
    • Olson, M.I.1    Shaw, C.M.2
  • 59
    • 0028350675 scopus 로고
    • APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease
    • Van Broeckhoven C, Backhovens H, Cruts M, et al. APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease. Neurosci Lett 1994; 169: 179-80.
    • (1994) Neurosci Lett , vol.169 , pp. 179-180
    • Van Broeckhoven, C.1    Backhovens, H.2    Cruts, M.3
  • 60
    • 0029166112 scopus 로고
    • Apolipoprotein E genotypes and age of onset in early-onset familial Alzheimer's disease
    • Levy-Lahad E, Lahad A, Wijsman EM, Bird TD, Schellenberg GD. Apolipoprotein E genotypes and age of onset in early-onset familial Alzheimer's disease. Ann Neurol 1995; 38: 678-80.
    • (1995) Ann Neurol , vol.38 , pp. 678-680
    • Levy-Lahad, E.1    Lahad, A.2    Wijsman, E.M.3    Bird, T.D.4    Schellenberg, G.D.5
  • 61
    • 0030020713 scopus 로고    scopus 로고
    • Apolipoprotein E genotype does not affect age at onset in patients with chromosome 14 encoded Alzheimer's disease
    • French Alzheimer's Disease Collaborative Study Group. Apolipoprotein E genotype does not affect age at onset in patients with chromosome 14 encoded Alzheimer's disease. J Med Genet 1996; 33: 174-5.
    • (1996) J Med Genet , vol.33 , pp. 174-175
  • 62
    • 6844255860 scopus 로고    scopus 로고
    • Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease
    • Cruts M, van Duijn CM, Backhovens H, et al. Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease. Hum Mol Genet 1998; 7: 43-51.
    • (1998) Hum Mol Genet , vol.7 , pp. 43-51
    • Cruts, M.1    Van Duijn, C.M.2    Backhovens, H.3
  • 63
    • 85038202442 scopus 로고    scopus 로고
    • Association of the presenilin 1 Glu318Gly mutation with dementia in a population-based sample of the elderly: The Rotterdam Study
    • Dermaut B, Cruts M, Slooter AJC, et al. Association of the presenilin 1 Glu318Gly mutation with dementia in a population-based sample of the elderly: the Rotterdam Study (abstract). Neurobiol Aging 1998; 19: S68.
    • (1998) Neurobiol Aging , vol.19
    • Dermaut, B.1    Cruts, M.2    Slooter, A.J.C.3
  • 64
    • 0029899593 scopus 로고    scopus 로고
    • Incomplete penetrance of familial Alzheimer's disease in a pedigree with a novel presenilin-1 gene mutation
    • Rossor MN, Fox NC, Beck J, Campbell TC, Collinge J. Incomplete penetrance of familial Alzheimer's disease in a pedigree with a novel presenilin-1 gene mutation. Lancet 1996; 347: 1560.
    • (1996) Lancet , vol.347 , pp. 1560
    • Rossor, M.N.1    Fox, N.C.2    Beck, J.3    Campbell, T.C.4    Collinge, J.5
  • 65
    • 0028812820 scopus 로고
    • Mutations of the Presenilin-1 gene in families with early-onset Alzheimer's disease
    • Campion D, Flaman J-M, Brice A, et al. Mutations of the Presenilin-1 gene in families with early-onset Alzheimer's disease. Hum Mol Genet 1995; 4: 2373-7.
    • (1995) Hum Mol Genet , vol.4 , pp. 2373-2377
    • Campion, D.1    Flaman, J.-M.2    Brice, A.3
  • 66
    • 9344237637 scopus 로고    scopus 로고
    • Complete analysis of the presenilin 1 gene in families with early onset Alzheimer's disease
    • Hutton M, Busfield F, Wragg M, et al. Complete analysis of the presenilin 1 gene in families with early onset Alzheimer's disease. Neuroreport 1996; 7: 801-5.
    • (1996) Neuroreport , vol.7 , pp. 801-805
    • Hutton, M.1    Busfield, F.2    Wragg, M.3
  • 67
    • 2442768339 scopus 로고    scopus 로고
    • Estimation of the frequency of presenilin-1 mutations in a population-based sample of early-onset Alzheimer dementia
    • Cruts M, Backhovens H, Van den Broeck M, et al. Estimation of the frequency of presenilin-1 mutations in a population-based sample of early-onset Alzheimer dementia (abstract). Medizinishe Genetik 1997; 9: 149.
    • (1997) Medizinishe Genetik , vol.9 , pp. 149
    • Cruts, M.1    Backhovens, H.2    Van Den Broeck, M.3
  • 68
    • 0028883252 scopus 로고
    • Molecular genetics of Alzheimer disease: Identification of genes and gene mutations
    • Van Broeckhoven C. Molecular genetics of Alzheimer disease: identification of genes and gene mutations. Eur Neurol 1995; 35: 8-19.
    • (1995) Eur Neurol , vol.35 , pp. 8-19
    • Van Broeckhoven, C.1
  • 69
    • 0026879650 scopus 로고
    • Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene
    • Hendriks L, van Duijn CM, Cras P, et al. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene. Nat Genet 1992; 1: 218-21.
    • (1992) Nat Genet , vol.1 , pp. 218-221
    • Hendriks, L.1    Van Duijn, C.M.2    Cras, P.3
  • 70
    • 0030770726 scopus 로고    scopus 로고
    • Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12
    • Pericak-Vance MA, Bass MP, Yamaoka LH, et al. Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. JAMA 1997; 278: 1237-41.
    • (1997) JAMA , vol.278 , pp. 1237-1241
    • Pericak-Vance, M.A.1    Bass, M.P.2    Yamaoka, L.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.