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Volumn 33, Issue 1, 2012, Pages 138-146

Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro

Author keywords

Amyloid; Cannabinoid; Neuroprotection; Oxidative stress

Indexed keywords

AMYLOID BETA PROTEIN; ANANDAMIDE; CANNABIDIOL; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; HYDROGEN PEROXIDE;

EID: 84855998880     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2011.12.015     Document Type: Article
Times cited : (67)

References (56)
  • 1
    • 0028233494 scopus 로고
    • Hydrogen peroxide mediates amyloid β protein toxicity
    • Behl C., Davis J.B., Lesley R., Schubert D. Hydrogen peroxide mediates amyloid β protein toxicity. Cell 1994, 77:817-827.
    • (1994) Cell , vol.77 , pp. 817-827
    • Behl, C.1    Davis, J.B.2    Lesley, R.3    Schubert, D.4
  • 2
    • 0348010292 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains
    • Benito C., Nunez E., Tolon R.M., Carrier E.J., Rabano A., Hillard C.J., et al. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. J Neurosci 2003, 23:11136-11141.
    • (2003) J Neurosci , vol.23 , pp. 11136-11141
    • Benito, C.1    Nunez, E.2    Tolon, R.M.3    Carrier, E.J.4    Rabano, A.5    Hillard, C.J.6
  • 3
    • 67849106670 scopus 로고    scopus 로고
    • Amyloid-beta protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease
    • Bernstein S.L., Dupuis N.F., Lazo N.D., Wyttenbach T., Condron M.M., Bitan G., et al. Amyloid-beta protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nat Chem 2009, 1:326-331.
    • (2009) Nat Chem , vol.1 , pp. 326-331
    • Bernstein, S.L.1    Dupuis, N.F.2    Lazo, N.D.3    Wyttenbach, T.4    Condron, M.M.5    Bitan, G.6
  • 5
    • 52949112654 scopus 로고    scopus 로고
    • The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses
    • Bisogno T., Di Marzo V. The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses. Curr Pharm Des 2008, 14:2299-3305.
    • (2008) Curr Pharm Des , vol.14 , pp. 2299-3305
    • Bisogno, T.1    Di Marzo, V.2
  • 7
    • 20044366019 scopus 로고    scopus 로고
    • Oxidative stress, antioxidants and neurodegenerative diseases
    • Casetta I., Govoni V., Granieri E. Oxidative stress, antioxidants and neurodegenerative diseases. Curr Pharm Des 2005, 11:2033-2052.
    • (2005) Curr Pharm Des , vol.11 , pp. 2033-2052
    • Casetta, I.1    Govoni, V.2    Granieri, E.3
  • 8
    • 72749107868 scopus 로고    scopus 로고
    • The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors
    • Castillo A., Tolon M.R., Fernandez-Ruiz J., Romero J., Martinez-Orgado J. The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors. Neurobiol Dis 2010, 37:434-440.
    • (2010) Neurobiol Dis , vol.37 , pp. 434-440
    • Castillo, A.1    Tolon, M.R.2    Fernandez-Ruiz, J.3    Romero, J.4    Martinez-Orgado, J.5
  • 9
    • 79551538975 scopus 로고    scopus 로고
    • Revisiting dietary antioxidants, neurodegeneration and dementia
    • Craggs L., Kalaria R.N. Revisiting dietary antioxidants, neurodegeneration and dementia. Neuroreport 2011, 22:1-3.
    • (2011) Neuroreport , vol.22 , pp. 1-3
    • Craggs, L.1    Kalaria, R.N.2
  • 10
    • 77249107540 scopus 로고    scopus 로고
    • Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels
    • De Petrocellis L., Di Marzo V. Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels. J Neuroimmun Pharmacol 2010, 5:103-121.
    • (2010) J Neuroimmun Pharmacol , vol.5 , pp. 103-121
    • De Petrocellis, L.1    Di Marzo, V.2
  • 11
    • 0343133968 scopus 로고    scopus 로고
    • In vitro antioxidant neuroprotective activity of BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation
    • Demerle-Pallardy C., Gillard-Roubert V., Marin J.G., Auguet M., Chabrier P.E. In vitro antioxidant neuroprotective activity of BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation. J Neurochem 2000, 74:2079-2086.
    • (2000) J Neurochem , vol.74 , pp. 2079-2086
    • Demerle-Pallardy, C.1    Gillard-Roubert, V.2    Marin, J.G.3    Auguet, M.4    Chabrier, P.E.5
  • 12
    • 29544446576 scopus 로고    scopus 로고
    • The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells
    • Eljaschewitsch E., Witting A., Mawrin C., Lee T., Schmidt P.M., Wolf S., et al. The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. Neuron 2006, 49:67-79.
    • (2006) Neuron , vol.49 , pp. 67-79
    • Eljaschewitsch, E.1    Witting, A.2    Mawrin, C.3    Lee, T.4    Schmidt, P.M.5    Wolf, S.6
  • 13
    • 33344456093 scopus 로고    scopus 로고
    • The marijuana component cannabidiol inhibits β-amyloid-induced tau protein hyperphosphorylation through Wnt/β-catenin pathway rescue in PC12 cells
    • Esposito G., De Filippis D., Carnuccio R., Izzo A.A., Iuvone T. The marijuana component cannabidiol inhibits β-amyloid-induced tau protein hyperphosphorylation through Wnt/β-catenin pathway rescue in PC12 cells. J Mol Med 2006, 84:253-258.
    • (2006) J Mol Med , vol.84 , pp. 253-258
    • Esposito, G.1    De Filippis, D.2    Carnuccio, R.3    Izzo, A.A.4    Iuvone, T.5
  • 14
    • 33646078800 scopus 로고    scopus 로고
    • Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in b-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kB involvement
    • Esposito G., De Filippis D., Maiuri M.C., De Stefano D., Carnuccio R., Iuvone T. Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in b-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kB involvement. Neurosci Lett 2006, 399:91-95.
    • (2006) Neurosci Lett , vol.399 , pp. 91-95
    • Esposito, G.1    De Filippis, D.2    Maiuri, M.C.3    De Stefano, D.4    Carnuccio, R.5    Iuvone, T.6
  • 15
    • 34547878297 scopus 로고    scopus 로고
    • Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression
    • Esposito G., Scuderi C., Savani C., Steardo L., De Filippis D., Cottone P., et al. Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression. Br J Pharmacol 2007, 151:1272-1279.
    • (2007) Br J Pharmacol , vol.151 , pp. 1272-1279
    • Esposito, G.1    Scuderi, C.2    Savani, C.3    Steardo, L.4    De Filippis, D.5    Cottone, P.6
  • 16
    • 33846150057 scopus 로고    scopus 로고
    • A molecular link between the active component of marijuana and Alzheimer's disease pathology
    • Eubanks L.M., Rogers C.J., Beuscher Koob G.F., Olson A.J., Dickerson T.J., et al. A molecular link between the active component of marijuana and Alzheimer's disease pathology. Mol Pharm 2006, 3:773-777.
    • (2006) Mol Pharm , vol.3 , pp. 773-777
    • Eubanks, L.M.1    Rogers, C.J.2    Beuscher Koob, G.F.3    Olson, A.J.4    Dickerson, T.J.5
  • 18
    • 35649011495 scopus 로고    scopus 로고
    • The contribution of cyclooxygenase-2 to endocannabinoid metabolism and action
    • Fowler C.J. The contribution of cyclooxygenase-2 to endocannabinoid metabolism and action. Br J Pharmacol 2007, 152:594-601.
    • (2007) Br J Pharmacol , vol.152 , pp. 594-601
    • Fowler, C.J.1
  • 19
    • 77953712552 scopus 로고    scopus 로고
    • Modulation of the endocannabinoid system: neuroprotection or neurotoxicity
    • Fowler C.J., Rojo M.L., Rodriguez-Gaztelumendi A. Modulation of the endocannabinoid system: neuroprotection or neurotoxicity. Exp Neurol 2010, 224:37-47.
    • (2010) Exp Neurol , vol.224 , pp. 37-47
    • Fowler, C.J.1    Rojo, M.L.2    Rodriguez-Gaztelumendi, A.3
  • 20
    • 33745013111 scopus 로고    scopus 로고
    • Oxidative stress and neurodegeneration: where are we now
    • Halliwell B. Oxidative stress and neurodegeneration: where are we now. J Neurochem 2006, 97:1634-1658.
    • (2006) J Neurochem , vol.97 , pp. 1634-1658
    • Halliwell, B.1
  • 22
    • 0033789365 scopus 로고    scopus 로고
    • In vivo metabolism of tert-butyl hydroperoxide to methyl radicals, EPR spin-trapping and DNA methylation studies
    • Hix S., Kadiiska M.B., Mason R.P., Augusto O. In vivo metabolism of tert-butyl hydroperoxide to methyl radicals, EPR spin-trapping and DNA methylation studies. Chem Res Toxicol 2000, 13:1056-1064.
    • (2000) Chem Res Toxicol , vol.13 , pp. 1056-1064
    • Hix, S.1    Kadiiska, M.B.2    Mason, R.P.3    Augusto, O.4
  • 23
    • 73949089674 scopus 로고    scopus 로고
    • Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide
    • Hu X., Crick S.L., Bu G., Frieden C., Pappu R.V., Lee J-M. Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide. Proc Natl Acad Sci USA 2009, 106:20324-20329.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20324-20329
    • Hu, X.1    Crick, S.L.2    Bu, G.3    Frieden, C.4    Pappu, R.V.5    Lee, J.-M.6
  • 24
    • 70349481513 scopus 로고    scopus 로고
    • The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds
    • Hudson S.A., Ecroyd H., Kee T.W., Carver J.A. The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds. FEBS J 2009, 276:5960-5972.
    • (2009) FEBS J , vol.276 , pp. 5960-5972
    • Hudson, S.A.1    Ecroyd, H.2    Kee, T.W.3    Carver, J.A.4
  • 25
    • 69349098271 scopus 로고    scopus 로고
    • (-)-Epigallocatechin-3-Gallate (EGCG) maintains κ-casein in Its pre-fibrillar state without redirecting Its aggregation pathway
    • Hudson S.A., Ecroyd H., Musgrave I.F., Dehle F.C., Carver J.A. (-)-Epigallocatechin-3-Gallate (EGCG) maintains κ-casein in Its pre-fibrillar state without redirecting Its aggregation pathway. J Mol Biol 2009, 392:689-700.
    • (2009) J Mol Biol , vol.392 , pp. 689-700
    • Hudson, S.A.1    Ecroyd, H.2    Musgrave, I.F.3    Dehle, F.C.4    Carver, J.A.5
  • 26
    • 36849012987 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro
    • Iuvone T., Esposito G., De Filippis D., Bisogno T., Petrosino S., Scuderi C., et al. Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro. J Mol Med 2007, 85:1379-1392.
    • (2007) J Mol Med , vol.85 , pp. 1379-1392
    • Iuvone, T.1    Esposito, G.2    De Filippis, D.3    Bisogno, T.4    Petrosino, S.5    Scuderi, C.6
  • 28
    • 1842510018 scopus 로고    scopus 로고
    • Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
    • Iuvone T., Esposito G., Esposito R., Santamaria R., Di Rosa M., Izzo A.A. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. J Neurochem 2004, 89:134-141.
    • (2004) J Neurochem , vol.89 , pp. 134-141
    • Iuvone, T.1    Esposito, G.2    Esposito, R.3    Santamaria, R.4    Di Rosa, M.5    Izzo, A.A.6
  • 29
    • 15744395868 scopus 로고    scopus 로고
    • Involvement of protein kinase A in cannabinoid receptor-mediated protection from oxidative neuronal injury
    • Kim S.H., Won S.J., Mao X.O., Jin K., Greenberg D.A. Involvement of protein kinase A in cannabinoid receptor-mediated protection from oxidative neuronal injury. J Pharmacol Exp Ther 2005, 313:88-94.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 88-94
    • Kim, S.H.1    Won, S.J.2    Mao, X.O.3    Jin, K.4    Greenberg, D.A.5
  • 30
    • 0038678773 scopus 로고    scopus 로고
    • Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor
    • Klegeris A., Bissonnette C.J., McGeer P.L. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. Br J Pharmacol 2003, 139:775-786.
    • (2003) Br J Pharmacol , vol.139 , pp. 775-786
    • Klegeris, A.1    Bissonnette, C.J.2    McGeer, P.L.3
  • 31
    • 27844477768 scopus 로고    scopus 로고
    • Protective effects of hyperoside (quercetin-3-o-galactoside) to PC12 cells against cytotoxicity induced by hydrogen peroxide and tert-butyl hydroperoxide
    • Liu Z., Tao X., Zhang C., Lu Y., Wei D. Protective effects of hyperoside (quercetin-3-o-galactoside) to PC12 cells against cytotoxicity induced by hydrogen peroxide and tert-butyl hydroperoxide. Biomed Pharmacother 2005, 59:481-490.
    • (2005) Biomed Pharmacother , vol.59 , pp. 481-490
    • Liu, Z.1    Tao, X.2    Zhang, C.3    Lu, Y.4    Wei, D.5
  • 32
    • 0034644769 scopus 로고    scopus 로고
    • Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors
    • Maccarrone M., Lorenzon T., Bari M., Melino G., Finazzi-Agro A. Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. J Biol Chem 2000, 275:31938-31945.
    • (2000) J Biol Chem , vol.275 , pp. 31938-31945
    • Maccarrone, M.1    Lorenzon, T.2    Bari, M.3    Melino, G.4    Finazzi-Agro, A.5
  • 33
    • 67649387953 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor elevation of intracellular calcium in neuroblastoma SH-SY5Y cells: interactions with muscarinic and delta-opioid receptors
    • Marini P., Moriello A.S., Cristino L., Palmery M., De Petrocellis L., Di Marzo V. Cannabinoid CB1 receptor elevation of intracellular calcium in neuroblastoma SH-SY5Y cells: interactions with muscarinic and delta-opioid receptors. Biochim Biophys Acta 2009, 1793:1289-1303.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1289-1303
    • Marini, P.1    Moriello, A.S.2    Cristino, L.3    Palmery, M.4    De Petrocellis, L.5    Di Marzo, V.6
  • 34
    • 0037206662 scopus 로고    scopus 로고
    • Anandamide and noladin ether prevent neurotoxicity of the human amyloid-β peptide
    • Milton N.G.N. Anandamide and noladin ether prevent neurotoxicity of the human amyloid-β peptide. Neurosci Lett 2002, 332:127-130.
    • (2002) Neurosci Lett , vol.332 , pp. 127-130
    • Milton, N.G.N.1
  • 35
    • 77955948472 scopus 로고    scopus 로고
    • Inhibition by anandamide of 6-hydroxydopamine-induced cell death in PC12 cells
    • Mnich K., Finn D.P., Dowd E., Gorman A.M. Inhibition by anandamide of 6-hydroxydopamine-induced cell death in PC12 cells. Int J Cell Biol 2010, 2010:818497.
    • (2010) Int J Cell Biol , vol.2010 , pp. 818497
    • Mnich, K.1    Finn, D.P.2    Dowd, E.3    Gorman, A.M.4
  • 36
    • 78649638441 scopus 로고    scopus 로고
    • Endocannabinoids prevent beta-amyloid-mediated lysosomal destabilization in cultured neurons
    • Noonan J., Tanveer R., Klompas A., Gowran A., McKiernan J., Campbell V.A. Endocannabinoids prevent beta-amyloid-mediated lysosomal destabilization in cultured neurons. J Biol Chem 2010, 285:38543-38554.
    • (2010) J Biol Chem , vol.285 , pp. 38543-38554
    • Noonan, J.1    Tanveer, R.2    Klompas, A.3    Gowran, A.4    McKiernan, J.5    Campbell, V.A.6
  • 37
    • 0035168757 scopus 로고    scopus 로고
    • N-acetyl-l-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on beta-amyloid secretion and tau phosphorylation
    • Olivieri G., Baysang G., Meier F., Muller-Spahn F., Stahelin H.B., Brockhaus M., et al. N-acetyl-l-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on beta-amyloid secretion and tau phosphorylation. J Neurochem 2001, 76:224-233.
    • (2001) J Neurochem , vol.76 , pp. 224-233
    • Olivieri, G.1    Baysang, G.2    Meier, F.3    Muller-Spahn, F.4    Stahelin, H.B.5    Brockhaus, M.6
  • 38
    • 0041765742 scopus 로고    scopus 로고
    • Beta-amyloid modulates tyrosine kinase B receptor expression in SHSY5Y neuroblastoma cells: influence of the antioxidant melatonin
    • Olivieri G., Otten U., Meier F., Baysang G., Dimitriades-Schmutz B., Muller-Spahn F., et al. Beta-amyloid modulates tyrosine kinase B receptor expression in SHSY5Y neuroblastoma cells: influence of the antioxidant melatonin. Neuroscience 2003, 120:659-665.
    • (2003) Neuroscience , vol.120 , pp. 659-665
    • Olivieri, G.1    Otten, U.2    Meier, F.3    Baysang, G.4    Dimitriades-Schmutz, B.5    Muller-Spahn, F.6
  • 39
    • 33845603466 scopus 로고    scopus 로고
    • Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation
    • Palazuelos J., Aguado T., Egia A., Mechoulam R., Guzman M., Galve-Roperh I. Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation. FASEB J 2006, 20:2405-2407.
    • (2006) FASEB J , vol.20 , pp. 2405-2407
    • Palazuelos, J.1    Aguado, T.2    Egia, A.3    Mechoulam, R.4    Guzman, M.5    Galve-Roperh, I.6
  • 40
    • 0035449164 scopus 로고    scopus 로고
    • Tert-Butylhydroperoxide induces peroxynitrite-dependent mitochondrial permeability transition leading PC12 cells to necrosis
    • Palomba L., Sestili P., Cantoni O. tert-Butylhydroperoxide induces peroxynitrite-dependent mitochondrial permeability transition leading PC12 cells to necrosis. J Neurosci Res 2001, 65:387-395.
    • (2001) J Neurosci Res , vol.65 , pp. 387-395
    • Palomba, L.1    Sestili, P.2    Cantoni, O.3
  • 41
    • 14244264502 scopus 로고    scopus 로고
    • Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation
    • Ramirez B.G., Blazquez C., del Pulgar T.G., Guzman N., de Ceballos M.A.L. Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J Neurosci 2005, 25:1904-1913.
    • (2005) J Neurosci , vol.25 , pp. 1904-1913
    • Ramirez, B.G.1    Blazquez, C.2    del Pulgar, T.G.3    Guzman, N.4    de Ceballos, M.A.L.5
  • 43
    • 84859098610 scopus 로고    scopus 로고
    • Compartmentalization of endocannabinoids into lipid rafts in a microglial cell line, which is devoid of caveolin-1
    • Rimmerman N., Bradshaw H.B., Kozela E., Levy R., Juknat A., Vogel Z. Compartmentalization of endocannabinoids into lipid rafts in a microglial cell line, which is devoid of caveolin-1. Br J Pharmacol 2011, 10.1111/j. 1476-5381.2011.01380.x.
    • (2011) Br J Pharmacol
    • Rimmerman, N.1    Bradshaw, H.B.2    Kozela, E.3    Levy, R.4    Juknat, A.5    Vogel, Z.6
  • 44
    • 33846828453 scopus 로고    scopus 로고
    • Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and -independent action
    • Saito Y., Nishio K., Ogawa Y., Kinumi T., Yoshida Y., Masuo Y., et al. Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and -independent action. Free Radic Biol Med 2007, 42:675-685.
    • (2007) Free Radic Biol Med , vol.42 , pp. 675-685
    • Saito, Y.1    Nishio, K.2    Ogawa, Y.3    Kinumi, T.4    Yoshida, Y.5    Masuo, Y.6
  • 45
    • 0038723739 scopus 로고    scopus 로고
    • Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts
    • Sarker K.P., Maruyama I. Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts. Cell Mol Life Sci 2003, 60:1200-1208.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 1200-1208
    • Sarker, K.P.1    Maruyama, I.2
  • 46
    • 0034696960 scopus 로고    scopus 로고
    • Anandamide induces apoptosis of PC-12 cells: involvement of superoxide and caspase-3
    • Sarker K.P., Obara S., Nakata M., Kitajima I., Maruyama I. Anandamide induces apoptosis of PC-12 cells: involvement of superoxide and caspase-3. FEBS Lett 2000, 472:39-44.
    • (2000) FEBS Lett , vol.472 , pp. 39-44
    • Sarker, K.P.1    Obara, S.2    Nakata, M.3    Kitajima, I.4    Maruyama, I.5
  • 50
    • 0026937954 scopus 로고
    • Cytoskeletal organization following cannabinoid treatment in undifferentiated and differentiated PC12 cells
    • Tahir S.K., Trogadis J.E., Stevens J.K., Zimmerman A.M. Cytoskeletal organization following cannabinoid treatment in undifferentiated and differentiated PC12 cells. Biochem Cell Biol 1992, 70:1159-1173.
    • (1992) Biochem Cell Biol , vol.70 , pp. 1159-1173
    • Tahir, S.K.1    Trogadis, J.E.2    Stevens, J.K.3    Zimmerman, A.M.4
  • 51
    • 33847653702 scopus 로고    scopus 로고
    • Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
    • Thomas A., Baillie G.L., Phillips A.M., Razdan R.K., Ross R.A., Pertwee R.G. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol 2007, 150:613-623.
    • (2007) Br J Pharmacol , vol.150 , pp. 613-623
    • Thomas, A.1    Baillie, G.L.2    Phillips, A.M.3    Razdan, R.K.4    Ross, R.A.5    Pertwee, R.G.6
  • 52
    • 67651121672 scopus 로고    scopus 로고
    • The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages
    • Tolon R.M., Nunez E., Pazos M.R., Benito C., Castillo A.I., Martinez-Orgado J.A., et al. The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages. Brain Res 2009, 1283:148-154.
    • (2009) Brain Res , vol.1283 , pp. 148-154
    • Tolon, R.M.1    Nunez, E.2    Pazos, M.R.3    Benito, C.4    Castillo, A.I.5    Martinez-Orgado, J.A.6
  • 53
    • 77957845422 scopus 로고    scopus 로고
    • Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure
    • Velez-Pardo C., Jimenez-Del-Rio M., Lores-Arnaiz S., Bustamante J. Protective effects of the synthetic cannabinoids CP55,940 and JWH-015 on rat brain mitochondria upon paraquat exposure. Neurochem Res 2010, 35:1323-1332.
    • (2010) Neurochem Res , vol.35 , pp. 1323-1332
    • Velez-Pardo, C.1    Jimenez-Del-Rio, M.2    Lores-Arnaiz, S.3    Bustamante, J.4
  • 54
    • 77957983169 scopus 로고    scopus 로고
    • Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners
    • Wollen K.A. Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners. Altern Med Rev 2010, 15:223-244.
    • (2010) Altern Med Rev , vol.15 , pp. 223-244
    • Wollen, K.A.1
  • 55
    • 64149132721 scopus 로고    scopus 로고
    • β-Protein toxicity and the pathogenesis of Alzheimer disease
    • Yankner B.A., Lu Amyloid T. β-Protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem 2009, 284:4755-4759.
    • (2009) J Biol Chem , vol.284 , pp. 4755-4759
    • Yankner, B.A.1    Lu, A.T.2
  • 56
    • 35548972034 scopus 로고    scopus 로고
    • Expression of cannabinoid CB1 receptors in models of diabetic neuropathy
    • Zhang F., Hong S., Stone V., Smith P.J.W. Expression of cannabinoid CB1 receptors in models of diabetic neuropathy. J Pharmacol Exp Ther 2007, 323:508-515.
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 508-515
    • Zhang, F.1    Hong, S.2    Stone, V.3    Smith, P.J.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.