Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells

Journal of Biological Chemistry

Volumn 275, Issue 1, 2000, Pages 605-612

  Sugiura, Takayuki ^a   Kondo, Sachiko ^a   Kishimoto, Seishi ^a   Miyashita, Tomoyuki ^a   Nakane, Shinji ^a   Kodaka, Tomoko ^a   Suhara, Yoshitomo ^a   Takayama, Hiroaki ^a   Waku, Keizo ^a  

^a TEIKYO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ANANDAMIDE; ARACHIDONIC ACID; CANNABINOID RECEPTOR; ETHANOLAMINE DERIVATIVE; LIGAND; LIPOXYGENASE INHIBITOR; MESSENGER RNA; PERTUSSIS TOXIN; PROSTAGLANDIN SYNTHASE INHIBITOR; RIMONABANT;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; HUMAN; HUMAN CELL; NORTHERN BLOTTING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION;

ARACHIDONIC ACIDS; BORNANES; CALCIUM SIGNALING; CANNABINOIDS; CYCLOHEXANOLS; CYCLOOXYGENASE INHIBITORS; DRUG INTERACTIONS; GLYCERIDES; HL-60 CELLS; HUMANS; LIGANDS; LIPOXYGENASE INHIBITORS; MOLECULAR MIMICRY; PALMITIC ACIDS; PERTUSSIS TOXIN; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PYRAZOLES; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; VIRULENCE FACTORS, BORDETELLA;

EID: 0034614374     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.1.605     Document Type: Article

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