메뉴 건너뛰기




Volumn 23, Issue 6, 2014, Pages 487-506

Genomic characterization of acute leukemias

Author keywords

Acute leukemias; Genomic aberrations; Next generation sequencing

Indexed keywords

BCR ABL PROTEIN; MICRORNA; MOLECULAR MARKER; NOTCH1 RECEPTOR; PROTEIN P53;

EID: 84911422625     PISSN: 10117571     EISSN: 14230151     Source Type: Journal    
DOI: 10.1159/000362793     Document Type: Review
Times cited : (23)

References (215)
  • 1
    • 84878341989 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia
    • Inaba H, Greaves M, Mullighan CG: Acute lymphoblastic leukemia. Lancet 2013;381:1943-1955.
    • (2013) Lancet , vol.381 , pp. 1943-1955
    • Inaba, H.1    Greaves, M.2    Mullighan, C.G.3
  • 2
    • 0000286732 scopus 로고
    • A minute chromosome in human chronic granulocytic leukemia
    • Nowell PC, Hungerford DA: A minute chromosome in human chronic granulocytic leukemia. Science 1960;132:1497-1499.
    • (1960) Science , vol.132 , pp. 1497-1499
    • Nowell, P.C.1    Hungerford, D.A.2
  • 3
    • 0038100233 scopus 로고    scopus 로고
    • Molecular mechanisms of transformation by the BCR-ABL oncogene
    • Sattler M, Griffin JD: Molecular mechanisms of transformation by the BCR-ABL oncogene. Semin Hematol 2003;40:4-10.
    • (2003) Semin Hematol , vol.40 , pp. 4-10
    • Sattler, M.1    Griffin, J.D.2
  • 4
    • 3242804413 scopus 로고    scopus 로고
    • Biology of chronic myelogenous leukemia - Signaling pathways of initiation and transformation
    • vii-viii
    • Melo JV, Deininger MW: Biology of chronic myelogenous leukemia - signaling pathways of initiation and transformation. Hematol Oncol Clin North Am 2004;18:545-568, vii-viii.
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 545-568
    • Melo, J.V.1    Deininger, M.W.2
  • 5
    • 0036341359 scopus 로고    scopus 로고
    • Philadelphia chromosome-positive acute lymphoblastic leukemia - Current concepts and future perspectives
    • Faderl S, Garcia-Manero G, Thomas DA, et al: Philadelphia chromosome-positive acute lymphoblastic leukemia - current concepts and future perspectives. Rev Clin Exp Hematol 2002;6:142-160.
    • (2002) Rev Clin Exp Hematol , vol.6 , pp. 142-160
    • Faderl, S.1    Garcia-Manero, G.2    Thomas, D.A.3
  • 6
    • 10144254429 scopus 로고    scopus 로고
    • Neutrophilicchronic myeloid leukemia: A distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction)
    • Pane F, Frigeri F, Sindona M, et al: Neutrophilicchronic myeloid leukemia: a distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction). Blood 1996;88:2410-2414.
    • (1996) Blood , vol.88 , pp. 2410-2414
    • Pane, F.1    Frigeri, F.2    Sindona, M.3
  • 7
    • 84886684836 scopus 로고    scopus 로고
    • Clinicobiologic features of 5, 202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stratified in age-cohorts
    • Chiaretti S, Vitale A, Cazzaniga G, et al: Clinicobiologic features of 5, 202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stratified in age-cohorts. Haematologica 2013;98:1702-1710.
    • (2013) Haematologica , vol.98 , pp. 1702-1710
    • Chiaretti, S.1    Vitale, A.2    Cazzaniga, G.3
  • 8
    • 34247359952 scopus 로고    scopus 로고
    • Imatinib plus steroids induces complete remissions and prolonged survival in elderly Philadelphia chromosome-positive patients with acute lymphoblastic leukemia without additional chemotherapy: Results of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) LAL0201-B protocol
    • Vignetti M, Fazi P, Cimino G, et al: Imatinib plus steroids induces complete remissions and prolonged survival in elderly Philadelphia chromosome-positive patients with acute lymphoblastic leukemia without additional chemotherapy: results of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) LAL0201-B protocol. Blood 2007;109:3676-3678.
    • (2007) Blood , vol.109 , pp. 3676-3678
    • Vignetti, M.1    Fazi, P.2    Cimino, G.3
  • 9
    • 34948829146 scopus 로고    scopus 로고
    • Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: Interim results of a phase 2 study
    • Ottmann O, Dombret H, Martinelli G, et al: Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study. Blood 2007:110:2309-2315.
    • (2007) Blood , vol.110 , pp. 2309-2315
    • Ottmann, O.1    Dombret, H.2    Martinelli, G.3
  • 10
    • 70449711127 scopus 로고    scopus 로고
    • Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: A Children's Oncology Group study
    • Schultz KR, Bowman WP, Aledo A, et al: Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a Children's Oncology Group study. J Clin Oncol 2009;27:5175-5181.
    • (2009) J Clin Oncol , vol.27 , pp. 5175-5181
    • Schultz, K.R.1    Bowman, W.P.2    Aledo, A.3
  • 11
    • 70349754444 scopus 로고    scopus 로고
    • Philadelphia chromosomepositive acute lymphoblastic leukemia
    • Ravandi F, Kebriaei P: Philadelphia chromosomepositive acute lymphoblastic leukemia. Hematol Oncol Clin North Am 2009;23:1043-1063.
    • (2009) Hematol Oncol Clin North Am , vol.23 , pp. 1043-1063
    • Ravandi, F.1    Kebriaei, P.2
  • 12
    • 66149170248 scopus 로고    scopus 로고
    • Impact of tyrosine kinase inhibitors on patient outcomes in Philadelphia chromosome-positive acute lymphoblastic leukaemia
    • Gruber F, Mustjoki S, Porkka K: Impact of tyrosine kinase inhibitors on patient outcomes in Philadelphia chromosome-positive acute lymphoblastic leukaemia. Br J Haematol 2009;145:581-597.
    • (2009) Br J Haematol , vol.145 , pp. 581-597
    • Gruber, F.1    Mustjoki, S.2    Porkka, K.3
  • 13
    • 82155175738 scopus 로고    scopus 로고
    • Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia
    • Foà R, Vitale A, Vignetti M, et al; GIMEMA Acute Leukemia Working Party: Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 2011;118:6521-6528.
    • (2011) Blood , vol.118 , pp. 6521-6528
    • GIMEMA Acute Leukemia Working Party1    Foà, R.2    Vitale, A.3    Vignetti, M.4
  • 14
    • 58149095544 scopus 로고    scopus 로고
    • Cytogenetics of paediatric and adolescent acute lymphoblastic leukaemia
    • Harrison CJ: Cytogenetics of paediatric and adolescent acute lymphoblastic leukaemia. Br J Haematol 2009;144:147-156.
    • (2009) Br J Haematol , vol.144 , pp. 147-156
    • Harrison, C.J.1
  • 15
    • 0036014993 scopus 로고    scopus 로고
    • TEL/AML1-positive pediatric leukemia: Prognostic significance and therapeutic approaches
    • Loh ML, Rubnitz JE: TEL/AML1-positive pediatric leukemia: prognostic significance and therapeutic approaches. Curr Opin Hematol 2002;9:345-352.
    • (2002) Curr Opin Hematol , vol.9 , pp. 345-352
    • Loh, M.L.1    Rubnitz, J.E.2
  • 16
    • 0036636857 scopus 로고    scopus 로고
    • Core-binding factors in haematopoiesis and leukaemia
    • Speck NA, Gilliland DG: Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer 2002;2:502-513.
    • (2002) Nat Rev Cancer , vol.2 , pp. 502-513
    • Speck, N.A.1    Gilliland, D.G.2
  • 17
    • 9044231364 scopus 로고    scopus 로고
    • The t (12; 21) translocation converts AML-1B from an activator to a repressor of transcription
    • Hiebert SW, Sun W, Davis JN, et al: The t (12; 21) translocation converts AML-1B from an activator to a repressor of transcription. Mol Cell Biol 1996;16:1349-1355.
    • (1996) Mol Cell Biol , vol.16 , pp. 1349-1355
    • Hiebert, S.W.1    Sun, W.2    Davis, J.N.3
  • 18
    • 68749120703 scopus 로고    scopus 로고
    • New insights to the MLL recombinome of acute leukemias
    • Meyer C, Kowarz E, Hofmann J, et al: New insights to the MLL recombinome of acute leukemias. Leukemia 2009;23:1490-1499.
    • (2009) Leukemia , vol.23 , pp. 1490-1499
    • Meyer, C.1    Kowarz, E.2    Hofmann, J.3
  • 19
    • 84887320453 scopus 로고    scopus 로고
    • The MLL recombinome of acute leukemias in 2013
    • Meyer C, Hofmann J, Burmeister T, et al: The MLL recombinome of acute leukemias in 2013. Leukemia 2013;27:2165-2176.
    • (2013) Leukemia , vol.27 , pp. 2165-2176
    • Meyer, C.1    Hofmann, J.2    Burmeister, T.3
  • 20
    • 15844394270 scopus 로고    scopus 로고
    • An MIIAF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes
    • Corral J, Lavenir I, Impey H, et al: An MIIAF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes. Cell 1996;85:853-861.
    • (1996) Cell , vol.85 , pp. 853-861
    • Corral, J.1    Lavenir, I.2    Impey, H.3
  • 21
    • 0033168716 scopus 로고    scopus 로고
    • The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis
    • Dobson CL, Warren AJ, Pannell R, et al: The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis. EMBO J 1999;18:3564-3574.
    • (1999) EMBO J , vol.18 , pp. 3564-3574
    • Dobson, C.L.1    Warren, A.J.2    Pannell, R.3
  • 22
    • 0041370095 scopus 로고    scopus 로고
    • Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
    • Ayton PM, Cleary ML: Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev 2003;17:2298-2307.
    • (2003) Genes Dev , vol.17 , pp. 2298-2307
    • Ayton, P.M.1    Cleary, M.L.2
  • 23
    • 0021354188 scopus 로고
    • Pre-B cell leukemia associated with chromosome translocation 1; 19
    • Carroll AJ, Crist WM, Parmley RT, et al: Pre-B cell leukemia associated with chromosome translocation 1; 19. Blood 1984;63:721-724.
    • (1984) Blood , vol.63 , pp. 721-724
    • Carroll, A.J.1    Crist, W.M.2    Parmley, R.T.3
  • 24
    • 0030056354 scopus 로고    scopus 로고
    • Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: Clinical features and molecular pathogenesis
    • Hunger SP: Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis. Blood 1996;87:1211-1224.
    • (1996) Blood , vol.87 , pp. 1211-1224
    • Hunger, S.P.1
  • 25
    • 0035839891 scopus 로고    scopus 로고
    • The role of E2A-PBX1 in leukemogenesis
    • Aspland S, Bendall HH, Murre C: The role of E2A-PBX1 in leukemogenesis. Oncogene 2001;20:5708-5711.
    • (2001) Oncogene , vol.20 , pp. 5708-5711
    • Aspland, S.1    Bendall, H.H.2    Murre, C.3
  • 26
    • 30444437486 scopus 로고    scopus 로고
    • Treatment of acute lymphoblastic leukemia
    • Pui CH, Evans WE: Treatment of acute lymphoblastic leukemia. N Engl J Med 2006;354:166-1678.
    • (2006) N Engl J Med , vol.354 , pp. 166-1678
    • Pui, C.H.1    Evans, W.E.2
  • 27
    • 0037329249 scopus 로고    scopus 로고
    • E2A-PBX1 fusion in adult acute lymphoblastic leukaemia: Biological and clinical features
    • Foa R, Vitale A, Mancini M, et al: E2A-PBX1 fusion in adult acute lymphoblastic leukaemia: biological and clinical features. Br J Haematol 2003;120:484-487.
    • (2003) Br J Haematol , vol.120 , pp. 484-487
    • Foa, R.1    Vitale, A.2    Mancini, M.3
  • 28
    • 76549104445 scopus 로고    scopus 로고
    • Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia
    • Burmeister T, Gökbuget N, Schwartz S, et al: Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia. Haematologica 2010;95:241-246.
    • (2010) Haematologica , vol.95 , pp. 241-246
    • Burmeister, T.1    Gökbuget, N.2    Schwartz, S.3
  • 29
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • Golub TR, Slonim DK, Tamayo P, et al: Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999;286:531-537.
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1    Slonim, D.K.2    Tamayo, P.3
  • 30
    • 19044399684 scopus 로고    scopus 로고
    • Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling
    • Yeoh EJ, Ross ME, Shurtleff SA, et al: Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 2002;1:133-143.
    • (2002) Cancer Cell , vol.1 , pp. 133-143
    • Yeoh, E.J.1    Ross, M.E.2    Shurtleff, S.A.3
  • 31
    • 0141993002 scopus 로고    scopus 로고
    • Classification of pediatric acute lymphoblastic leukemia by gene expression profiling
    • Ross ME, Zhou X, Song G, et al: Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood 2003;102:2951-2959.
    • (2003) Blood , vol.102 , pp. 2951-2959
    • Ross, M.E.1    Zhou, X.2    Song, G.3
  • 32
    • 0742289562 scopus 로고    scopus 로고
    • Pediatric acute lymphoblastic leukemia (ALL) gene expression signatures classify an independent cohort of adult ALL patients
    • Kohlmann A, Schoch C, Schnittger S, et al: Pediatric acute lymphoblastic leukemia (ALL) gene expression signatures classify an independent cohort of adult ALL patients. Leukemia 2004;18:63-71.
    • (2004) Leukemia , vol.18 , pp. 63-71
    • Kohlmann, A.1    Schoch, C.2    Schnittger, S.3
  • 33
    • 27144468989 scopus 로고    scopus 로고
    • Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation
    • Chiaretti S, Li X, Gentleman R, et al: Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation. Clin Cancer Res 2005;11:7209-7219.
    • (2005) Clin Cancer Res , vol.11 , pp. 7209-7219
    • Chiaretti, S.1    Li, X.2    Gentleman, R.3
  • 34
    • 23644438883 scopus 로고    scopus 로고
    • Global approach to the diagnosis of leukemia using gene expression profiling
    • Haferlach T, Kohlmann A, Schnittger S, et al: Global approach to the diagnosis of leukemia using gene expression profiling. Blood 2005;106:1189-1198.
    • (2005) Blood , vol.106 , pp. 1189-1198
    • Haferlach, T.1    Kohlmann, A.2    Schnittger, S.3
  • 35
    • 17144422895 scopus 로고    scopus 로고
    • Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysis
    • Irving JA, Bloodworth L, Bown NP, et al: Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysis. Cancer Res 2005;65:3053-3058.
    • (2005) Cancer Res , vol.65 , pp. 3053-3058
    • Irving, J.A.1    Bloodworth, L.2    Bown, N.P.3
  • 36
    • 34147224008 scopus 로고    scopus 로고
    • Genomewide analysis of genetic alterations in acute lymphoblastic leukaemia
    • Mullighan CG, Goorha S, Radtke I, et al: Genomewide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007;446:758-764.
    • (2007) Nature , vol.446 , pp. 758-764
    • Mullighan, C.G.1    Goorha, S.2    Radtke, I.3
  • 37
    • 44349174780 scopus 로고    scopus 로고
    • Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease
    • Paulsson K, Cazier JB, Macdougall F, et al: Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: unexpected similarities with pediatric disease. Proc Natl Acad Sci USA 2008;105:6708-6713.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 6708-6713
    • Paulsson, K.1    Cazier, J.B.2    Macdougall, F.3
  • 38
    • 38349177862 scopus 로고    scopus 로고
    • Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray
    • Kawamata N, Ogawa S, Zimmermann M, et al: Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray. Blood 2008;111:776-784.
    • (2008) Blood , vol.111 , pp. 776-784
    • Kawamata, N.1    Ogawa, S.2    Zimmermann, M.3
  • 39
    • 34249733805 scopus 로고    scopus 로고
    • High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression
    • Kuiper RP, Schoenmakers EF, van Reijmersdal SV, et al: High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia 2007;21:1258-1266.
    • (2007) Leukemia , vol.21 , pp. 1258-1266
    • Kuiper, R.P.1    Schoenmakers, E.F.2    Van Reijmersdal, S.V.3
  • 40
    • 40749150603 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia
    • Pui CH, Robison LL, Look AT: Acute lymphoblastic leukemia. Lancet 2008;371:1030-1043.
    • (2008) Lancet , vol.371 , pp. 1030-1043
    • Pui, C.H.1    Robison, L.L.2    Look, A.T.3
  • 41
    • 0028001362 scopus 로고
    • The Ikaros gene is required for the development of all lymphoid lineages
    • Georgopoulos K, Bigby M, Wang JH, et al: The Ikaros gene is required for the development of all lymphoid lineages. Cell 1994;79:143-156.
    • (1994) Cell , vol.79 , pp. 143-156
    • Georgopoulos, K.1    Bigby, M.2    Wang, J.H.3
  • 42
    • 0035525762 scopus 로고    scopus 로고
    • Forced expression of the Ikaros 6 isoform in human placental blood CD34 (+) cells impairs their ability to differentiate toward the B-lymphoid lineage
    • Tonnelle C, Bardin F, Maroc C, et al: Forced expression of the Ikaros 6 isoform in human placental blood CD34 (+) cells impairs their ability to differentiate toward the B-lymphoid lineage. Blood 2001;98:2673-2680.
    • (2001) Blood , vol.98 , pp. 2673-2680
    • Tonnelle, C.1    Bardin, F.2    Maroc, C.3
  • 43
    • 64549083639 scopus 로고    scopus 로고
    • Stage specific over-expression of the dominant negative Ikaros 6 reveals distinct role of Ikaros throughout human B-cell differentiation
    • Tonnelle C, Dijon M, Moreau T, et al: Stage specific over-expression of the dominant negative Ikaros 6 reveals distinct role of Ikaros throughout human B-cell differentiation. Mol Immunol 2009;46:1736-1743.
    • (2009) Mol Immunol , vol.46 , pp. 1736-1743
    • Tonnelle, C.1    Dijon, M.2    Moreau, T.3
  • 44
    • 68149098480 scopus 로고    scopus 로고
    • Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function
    • Trageser D, Iacobucci I, Nahar R, et al: Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function. J Exp Med 2009;206:1739-1753.
    • (2009) J Exp Med , vol.206 , pp. 1739-1753
    • Trageser, D.1    Iacobucci, I.2    Nahar, R.3
  • 45
    • 77957995706 scopus 로고    scopus 로고
    • Ikzf1 haploinsufficiency contributes to the pathogenesis of BCR-ABL1 positive acute lymphoblastic leukemia (abstract 678)
    • Collins-Underwood JR, Miller CB, Downing JR, et al: Ikzf1 haploinsufficiency contributes to the pathogenesis of BCR-ABL1 positive acute lymphoblastic leukemia (abstract 678). Blood 2009;114:283.
    • (2009) Blood , vol.114 , pp. 283
    • Collins-Underwood, J.R.1    Miller, C.B.2    Downing, J.R.3
  • 46
    • 43049139905 scopus 로고    scopus 로고
    • BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
    • Mullighan CG, Miller CB, Radtke I, et al: BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 2008;453:110-114.
    • (2008) Nature , vol.453 , pp. 110-114
    • Mullighan, C.G.1    Miller, C.B.2    Radtke, I.3
  • 47
    • 70349242044 scopus 로고    scopus 로고
    • Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: On behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP)
    • Iacobucci I, Storlazzi CT, Cilloni D, et al: Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP). Blood 2009;114:2159-2167.
    • (2009) Blood , vol.114 , pp. 2159-2167
    • Iacobucci, I.1    Storlazzi, C.T.2    Cilloni, D.3
  • 48
    • 70449719091 scopus 로고    scopus 로고
    • IKZF1 (Ikaros) deletions in BCRABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: A GIMEMA AL WP report
    • Martinelli G, Iacobucci I, Storlazzi CT, et al: IKZF1 (Ikaros) deletions in BCRABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report. J Clin Oncol 2009;27:5202-5207.
    • (2009) J Clin Oncol , vol.27 , pp. 5202-5207
    • Martinelli, G.1    Iacobucci, I.2    Storlazzi, C.T.3
  • 49
    • 58749109707 scopus 로고    scopus 로고
    • Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia
    • Mullighan CG, Su X, Zhang J, et al; Children's Oncology Group: Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 2009;360:470-480.
    • (2009) N Engl J Med , vol.360 , pp. 470-480
    • Mullighan, C.G.1    Su, X.2    Zhang, J.3
  • 50
    • 77954659221 scopus 로고    scopus 로고
    • IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL
    • Kuiper RP, Waanders E, van der Velden VH, et al: IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL. Leukemia 2010;24:1258-1264.
    • (2010) Leukemia , vol.24 , pp. 1258-1264
    • Kuiper, R.P.1    Waanders, E.2    Van Der Velden, V.H.3
  • 51
    • 0033555804 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin: A cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism
    • Levin SD, Koelling RM, Friend SL, et al: Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism. J Immunol 1999;162:677-683.
    • (1999) J Immunol , vol.162 , pp. 677-683
    • Levin, S.D.1    Koelling, R.M.2    Friend, S.L.3
  • 52
    • 35448953345 scopus 로고    scopus 로고
    • Thymic stromalderived lymphopoietin induces proliferation of pre-B leukemia and antagonizes mTOR inhibitors, suggesting a role for interleukin-7Ralpha signaling
    • Brown VI, Hulitt J, Fish J, et al: Thymic stromalderived lymphopoietin induces proliferation of pre-B leukemia and antagonizes mTOR inhibitors, suggesting a role for interleukin-7Ralpha signaling. Cancer Res 2007;67:9963-9970.
    • (2007) Cancer Res , vol.67 , pp. 9963-9970
    • Brown, V.I.1    Hulitt, J.2    Fish, J.3
  • 53
    • 70350680415 scopus 로고    scopus 로고
    • Rearrangement of CRLF2 in Bprogenitorand Down syndrome-associated acute lymphoblastic leukemia
    • Mullighan CG, Collins-Underwood JR, Phillips LA, et al: Rearrangement of CRLF2 in Bprogenitorand Down syndrome-associated acute lymphoblastic leukemia. Nat Genet 2009;41:1243-1246.
    • (2009) Nat Genet , vol.41 , pp. 1243-1246
    • Mullighan, C.G.1    Collins-Underwood, J.R.2    Phillips, L.A.3
  • 54
    • 77649214639 scopus 로고    scopus 로고
    • Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: A report from the International BFM Study Group
    • Hertzberg L, Vendramini E, Ganmore I, et al: Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group. Blood 2010;115:1006-1117.
    • (2010) Blood , vol.115 , pp. 1006-1117
    • Hertzberg, L.1    Vendramini, E.2    Ganmore, I.3
  • 55
    • 70350519430 scopus 로고    scopus 로고
    • Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia
    • Russell LJ, Capasso M, Vater I, et al: Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. Blood 2009;114:2688-2698.
    • (2009) Blood , vol.114 , pp. 2688-2698
    • Russell, L.J.1    Capasso, M.2    Vater, I.3
  • 56
    • 77954500629 scopus 로고    scopus 로고
    • Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol
    • Cario G, Zimmermann M, Romey R, et al: Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol. Blood 2010;115:5393-5397.
    • (2010) Blood , vol.115 , pp. 5393-5397
    • Cario, G.1    Zimmermann, M.2    Romey, R.3
  • 57
    • 77954516863 scopus 로고    scopus 로고
    • Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia
    • Harvey RC, Mullighan CG, Chen IM, et al: Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. Blood 2010;115:5312-5321.
    • (2010) Blood , vol.115 , pp. 5312-5321
    • Harvey, R.C.1    Mullighan, C.G.2    Chen, I.M.3
  • 58
    • 76249096219 scopus 로고    scopus 로고
    • Functional screening identifies CRLF2 in precursor Bcell acute lymphoblastic leukemia
    • Yoda A, Yoda Y, Chiaretti S, et al: Functional screening identifies CRLF2 in precursor Bcell acute lymphoblastic leukemia. Proc Natl Acad Sci USA 2010;107:252-257.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 252-257
    • Yoda, A.1    Yoda, Y.2    Chiaretti, S.3
  • 59
    • 58749097408 scopus 로고    scopus 로고
    • A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: A genome-wide classification study
    • Den Boer ML, van Slegtenhorst M, De Menezes RX, et al: A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol 2009;10:125-134.
    • (2009) Lancet Oncol , vol.10 , pp. 125-134
    • Den Boer, M.L.1    Van Slegtenhorst, M.2    De Menezes, R.X.3
  • 60
    • 78649742010 scopus 로고    scopus 로고
    • Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: Correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome
    • Harvey RC, Mullighan CG, Wang X, et al: Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood 2010;116:4874-4884.
    • (2010) Blood , vol.116 , pp. 4874-4884
    • Harvey, R.C.1    Mullighan, C.G.2    Wang, X.3
  • 61
    • 84865118132 scopus 로고    scopus 로고
    • Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia
    • Roberts KG, Morin RD, Zhang J, et al: Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. Cancer Cell 2012;22:153-166.
    • (2012) Cancer Cell , vol.22 , pp. 153-166
    • Roberts, K.G.1    Morin, R.D.2    Zhang, J.3
  • 62
    • 10744223283 scopus 로고    scopus 로고
    • Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome
    • Robinson HM, Broadfield ZJ, Cheung KL, et al: Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome. Leukemia 2003;17:2249-2250.
    • (2003) Leukemia , vol.17 , pp. 2249-2250
    • Robinson, H.M.1    Broadfield, Z.J.2    Cheung, K.L.3
  • 63
    • 0037348975 scopus 로고    scopus 로고
    • Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: A study of 20 cases
    • Harewood L, Robinson H, Harris R, et al: Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases. Leukemia 2003;17:547-553.
    • (2003) Leukemia , vol.17 , pp. 547-553
    • Harewood, L.1    Robinson, H.2    Harris, R.3
  • 64
    • 33744474290 scopus 로고    scopus 로고
    • Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21
    • Strefford JC, van Delft FW, Robinson HM, et al: Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. Proc Natl Acad Sci USA 2006;103:8167-8172.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8167-8172
    • Strefford, J.C.1    Van Delft, F.W.2    Robinson, H.M.3
  • 65
    • 33947257508 scopus 로고    scopus 로고
    • Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)
    • Moorman AV, Richards SM, Robinson HM, et al; UK Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Childhood Leukaemia Working Party (CLWP): Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21). Blood 2007;109:2327-2330.
    • (2007) Blood , vol.109 , pp. 2327-2330
    • Moorman, A.V.1    Richards, S.M.2    Robinson, H.M.3
  • 66
    • 79959510774 scopus 로고    scopus 로고
    • Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia
    • Rand V, Parker H, Russell LJ, et al: Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia. Blood 2011;117:6848-6855.
    • (2011) Blood , vol.117 , pp. 6848-6855
    • Rand, V.1    Parker, H.2    Russell, L.J.3
  • 67
    • 84874647204 scopus 로고    scopus 로고
    • The genomic landscape of hypodiploid acute lymphoblastic leukemia
    • Holmfeldt L, Wei L, Diaz-Flores E, et al: The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat Genet 2013;45:242-252.
    • (2013) Nat Genet , vol.45 , pp. 242-252
    • Holmfeldt, L.1    Wei, L.2    Diaz-Flores, E.3
  • 68
    • 80051828388 scopus 로고    scopus 로고
    • Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia
    • Hof J, Krentz S, van Schewick, et al: Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia. J Clin Oncol 2011;29:3185-3193.
    • (2011) J Clin Oncol , vol.29 , pp. 3185-3193
    • Hof, J.1    Krentz, S.2    Van Schewick3
  • 69
    • 84873567677 scopus 로고    scopus 로고
    • Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia
    • Krentz S, Hof J, Mendioroz A, et al: Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia. Leukemia 2013;27:295-304.
    • (2013) Leukemia , vol.27 , pp. 295-304
    • Krentz, S.1    Hof, J.2    Mendioroz, A.3
  • 70
    • 84877077826 scopus 로고    scopus 로고
    • TP53 mutations are frequent in adult acute lymphoblastic leukemia cases negative for recurrent fusion genes and correlate with poor response to induction therapy
    • Chiaretti S, Brugnoletti F, Tavolaro S, et al: TP53 mutations are frequent in adult acute lymphoblastic leukemia cases negative for recurrent fusion genes and correlate with poor response to induction therapy. Haematologica 2013;98:e59-e61.
    • (2013) Haematologica , vol.98 , pp. e59-e61
    • Chiaretti, S.1    Brugnoletti, F.2    Tavolaro, S.3
  • 71
    • 0029956081 scopus 로고    scopus 로고
    • Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
    • Aas T, Børresen AL, Geisler S, et al: Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nat Med 1996;2:811-814.
    • (1996) Nat Med , vol.2 , pp. 811-814
    • Aas, T.1    Børresen, A.L.2    Geisler, S.3
  • 72
    • 37349055876 scopus 로고    scopus 로고
    • TP53 mutations and survival in squamouscell carcinoma of the head and neck
    • Poeta ML, Manola J, Goldwasser MA, et al: TP53 mutations and survival in squamouscell carcinoma of the head and neck. N Engl J Med 2007;357:2552-2561.
    • (2007) N Engl J Med , vol.357 , pp. 2552-2561
    • Poeta, M.L.1    Manola, J.2    Goldwasser, M.A.3
  • 73
    • 0026528809 scopus 로고
    • Mutations of the P53 gene in acute myeloid leukaemia
    • Fenaux P, Preudhomme C, Quiquandon I, et al: Mutations of the P53 gene in acute myeloid leukaemia. Br J Hematol 1992;80:178-183.
    • (1992) Br J Hematol , vol.80 , pp. 178-183
    • Fenaux, P.1    Preudhomme, C.2    Quiquandon, I.3
  • 74
    • 49349140725 scopus 로고    scopus 로고
    • Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype
    • Haferlach C, Dicker F, Herholz H, et al: Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype. Leukemia 2008;22:1539-1541.
    • (2008) Leukemia , vol.22 , pp. 1539-1541
    • Haferlach, C.1    Dicker, F.2    Herholz, H.3
  • 75
    • 17744410949 scopus 로고    scopus 로고
    • P53 expression in B-cell chronic lymphocytic leukemia: A marker of disease progression and poor prognosis
    • Cordone I, Masi S, Mauro FR, et al: p53 expression in B-cell chronic lymphocytic leukemia: a marker of disease progression and poor prognosis. Blood 1998;91:4342-4349.
    • (1998) Blood , vol.91 , pp. 4342-4349
    • Cordone, I.1    Masi, S.2    Mauro, F.R.3
  • 76
    • 61549089361 scopus 로고    scopus 로고
    • The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: Implications for overall survival and chemorefractoriness
    • Rossi D, Cerri M, Deambrogi C, et al: The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness. Clin Cancer Res 2009;15:995-1004.
    • (2009) Clin Cancer Res , vol.15 , pp. 995-1004
    • Rossi, D.1    Cerri, M.2    Deambrogi, C.3
  • 77
    • 79551504914 scopus 로고    scopus 로고
    • TP53 mutation and survival in chronic lymphocytic leukemia
    • Zenz T, Eichhorst B, Busch R, et al: TP53 mutation and survival in chronic lymphocytic leukemia. J Clin Oncol 2010;28:4473-4479.
    • (2010) J Clin Oncol , vol.28 , pp. 4473-4479
    • Zenz, T.1    Eichhorst, B.2    Busch, R.3
  • 78
    • 79952381408 scopus 로고    scopus 로고
    • CREBBP mutations in relapsed acute lymphoblastic leukaemia
    • Mullighan CG, Zhang J, Kasper LH, et al: CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature 2011;471:235-239.
    • (2011) Nature , vol.471 , pp. 235-239
    • Mullighan, C.G.1    Zhang, J.2    Kasper, L.H.3
  • 79
    • 0034234237 scopus 로고    scopus 로고
    • CBP/p300 in cell growth, transformation, and development
    • Goodman RH, Smolik S: CBP/p300 in cell growth, transformation, and development. Genes Dev 2000;14:1553-1577.
    • (2000) Genes Dev , vol.14 , pp. 1553-1577
    • Goodman, R.H.1    Smolik, S.2
  • 80
    • 84874663688 scopus 로고    scopus 로고
    • Relapsespecific mutations in NT5C2 in childhood acute lymphoblastic leukemia
    • Meyer JA, Wang J, Hogan LE, et al: Relapsespecific mutations in NT5C2 in childhood acute lymphoblastic leukemia. Nat Genet 2013;45:290-294.
    • (2013) Nat Genet , vol.45 , pp. 290-294
    • Meyer, J.A.1    Wang, J.2    Hogan, L.E.3
  • 81
    • 33745207170 scopus 로고    scopus 로고
    • Molecular cytogenetic study of 126 unselected TALL cases reveals high incidence of TCRbeta locus rearrangements and putative new T-cell oncogenes
    • Cauwelier B, Dastugue N, Cools J, et al: Molecular cytogenetic study of 126 unselected TALL cases reveals high incidence of TCRbeta locus rearrangements and putative new T-cell oncogenes. Leukemia 2006;20:1238-1244.
    • (2006) Leukemia , vol.20 , pp. 1238-1244
    • Cauwelier, B.1    Dastugue, N.2    Cools, J.3
  • 82
    • 0027201165 scopus 로고
    • SILTAL1 deletion in T-cell acute lymphoblastic leukemia
    • Janssen JW, Ludwig WD, Sterry W, et al: SILTAL1 deletion in T-cell acute lymphoblastic leukemia. Leukemia 1993;7:1204-1210.
    • (1993) Leukemia , vol.7 , pp. 1204-1210
    • Janssen, J.W.1    Ludwig, W.D.2    Sterry, W.3
  • 83
    • 77956182564 scopus 로고    scopus 로고
    • Genetic aberrations in paediatric acute leukaemias and implications for management of patients
    • Szczepanski T, Harrison CJ, van Dongen JJ: Genetic aberrations in paediatric acute leukaemias and implications for management of patients. Lancet Oncol 2010;11:880-889.
    • (2010) Lancet Oncol , vol.11 , pp. 880-889
    • Szczepanski, T.1    Harrison, C.J.2    Van Dongen, J.J.3
  • 84
    • 6944252248 scopus 로고    scopus 로고
    • Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia
    • Graux C, Cools J, Melotte C, et al: Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. Nat Genet 2004;36:1084-1089.
    • (2004) Nat Genet , vol.36 , pp. 1084-1089
    • Graux, C.1    Cools, J.2    Melotte, C.3
  • 85
    • 34447345438 scopus 로고    scopus 로고
    • Characterization of ABL1 expression in adult Tcell acute lymphoblastic leukemia by oligonucleotide arrays analysis
    • Chiaretti S, Tavolaro S, Ghia EM, et al: Characterization of ABL1 expression in adult Tcell acute lymphoblastic leukemia by oligonucleotide arrays analysis. Haematologica 2007;92:619-626.
    • (2007) Haematologica , vol.92 , pp. 619-626
    • Chiaretti, S.1    Tavolaro, S.2    Ghia, E.M.3
  • 86
    • 20444378917 scopus 로고    scopus 로고
    • Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t (9; 14) (q34;q32)
    • De Keersmaecker K, Graux C, Odero MD, et al: Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t (9; 14) (q34;q32). Blood 2005;105:4849-4852.
    • (2005) Blood , vol.105 , pp. 4849-4852
    • De Keersmaecker, K.1    Graux, C.2    Odero, M.D.3
  • 87
    • 17144474314 scopus 로고    scopus 로고
    • Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia
    • Ferrando AA, Neuberg DS, Staunton J, et al: Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 2002;1:75-87.
    • (2002) Cancer Cell , vol.1 , pp. 75-87
    • Ferrando, A.A.1    Neuberg, D.S.2    Staunton, J.3
  • 88
    • 0038240453 scopus 로고    scopus 로고
    • Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: Dominance of HOX dysregulation
    • Ferrando AA, Armstrong SA, Neuberg DS, et al: Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood 2003;102:262-268.
    • (2003) Blood , vol.102 , pp. 262-268
    • Ferrando, A.A.1    Armstrong, S.A.2    Neuberg, D.S.3
  • 89
    • 20144363957 scopus 로고    scopus 로고
    • A new recurrent inversion, inv (7) (p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias
    • Speleman F, Cauwelier B, Dastugue N, et al: A new recurrent inversion, inv (7) (p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias. Leukemia 2005;19:358-366.
    • (2005) Leukemia , vol.19 , pp. 358-366
    • Speleman, F.1    Cauwelier, B.2    Dastugue, N.3
  • 90
    • 27644484043 scopus 로고    scopus 로고
    • CALMAF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes
    • Dik WA, Brahim W, Braun C, et al: CALMAF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes. Leukemia 2005;19:1948-1957.
    • (2005) Leukemia , vol.19 , pp. 1948-1957
    • Dik, W.A.1    Brahim, W.2    Braun, C.3
  • 91
    • 47149084727 scopus 로고    scopus 로고
    • The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia
    • Van Vlierberghe P, van Grotel M, Tchinda J, et al: The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia. Blood 2008;111:4668-4680.
    • (2008) Blood , vol.111 , pp. 4668-4680
    • Van Vlierberghe, P.1    Van Grotel, M.2    Tchinda, J.3
  • 92
    • 58749095816 scopus 로고    scopus 로고
    • Early T-cell precursor leukaemia: A subtype of very high-risk acute lymphoblastic leukaemia
    • Coustan-Smith E, Mullighan CG, Onciu M, et al: Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol 2009;10:147-156.
    • (2009) Lancet Oncol , vol.10 , pp. 147-156
    • Coustan-Smith, E.1    Mullighan, C.G.2    Onciu, M.3
  • 93
    • 77954522198 scopus 로고    scopus 로고
    • Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223
    • Chiaretti S, Messina M, Tavolaro S, et al: Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223. Haematologica 2010;95:1114-1121.
    • (2010) Haematologica , vol.95 , pp. 1114-1121
    • Chiaretti, S.1    Messina, M.2    Tavolaro, S.3
  • 94
    • 28344438648 scopus 로고    scopus 로고
    • A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis
    • Fazi F, Rosa A, Fatica A, et al: A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell 2005;123:819-831.
    • (2005) Cell , vol.123 , pp. 819-831
    • Fazi, F.1    Rosa, A.2    Fatica, A.3
  • 96
    • 84862907593 scopus 로고    scopus 로고
    • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
    • Zhang J, Ding L, Holmfeldt L, et al: The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 2012;481:157-163.
    • (2012) Nature , vol.481 , pp. 157-163
    • Zhang, J.1    Ding, L.2    Holmfeldt, L.3
  • 98
    • 34547780475 scopus 로고    scopus 로고
    • FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gammasecretase inhibitors
    • O'Neil J, Grim J, Strack P, et al: FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gammasecretase inhibitors. J Exp Med 2007;204:1813-1824.
    • (2007) J Exp Med , vol.204 , pp. 1813-1824
    • O'Neil, J.1    Grim, J.2    Strack, P.3
  • 99
    • 34547820257 scopus 로고    scopus 로고
    • The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
    • Thompson BJ, Buonamici S, Sulis ML, et al: The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J Exp Med 2007;204:1825-1835.
    • (2007) J Exp Med , vol.204 , pp. 1825-1835
    • Thompson, B.J.1    Buonamici, S.2    Sulis, M.L.3
  • 100
    • 65449135968 scopus 로고    scopus 로고
    • NOTCH1/FBXW7 mutation identifies a large subgroup with favourable outcome in adult Tcell acute lymphoblastic leukemia (TALL): A GRAALL study
    • Asnafi V, Buzyn A, Le Noir S, et al: NOTCH1/FBXW7 mutation identifies a large subgroup with favourable outcome in adult Tcell acute lymphoblastic leukemia (TALL): a GRAALL study. Blood 2009;113:3918-3924.
    • (2009) Blood , vol.113 , pp. 3918-3924
    • Asnafi, V.1    Buzyn, A.2    Le Noir, S.3
  • 101
    • 81055149624 scopus 로고    scopus 로고
    • Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BAALC expression: A GRAALL study
    • Ben Abdelali R, Asnafi V, Leguay T, et al; Group for Research on Adult Acute Lymphoblastic Leukemia: Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BAALC expression: a GRAALL study. Blood 2011;118:5099-5107.
    • (2011) Blood , vol.118 , pp. 5099-5107
    • Ben Abdelali, R.1    Asnafi, V.2    Leguay, T.3
  • 102
    • 63149134997 scopus 로고    scopus 로고
    • FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma
    • Park MJ, Tak T, Oda M, et al: FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma. Br J Haematol 2009;145:198-206.
    • (2009) Br J Haematol , vol.145 , pp. 198-206
    • Park, M.J.1    Tak, T.2    Oda, M.3
  • 103
    • 70349334513 scopus 로고    scopus 로고
    • Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol
    • Mansour MR, Sulis ML, Duke V, et al: Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol. J Clin Oncol 2009;27:4352-4356.
    • (2009) J Clin Oncol , vol.27 , pp. 4352-4356
    • Mansour, M.R.1    Sulis, M.L.2    Duke, V.3
  • 104
    • 78650305754 scopus 로고    scopus 로고
    • The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function
    • Kox C, Zimmermann M, Stanulla M, et al: The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function. Leukemia 2010;24:2005-2013.
    • (2010) Leukemia , vol.24 , pp. 2005-2013
    • Kox, C.1    Zimmermann, M.2    Stanulla, M.3
  • 105
    • 77958553288 scopus 로고    scopus 로고
    • Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity
    • Liu P, Li P, Burke S: Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity. Immunol Rev 2010;238:138-149.
    • (2010) Immunol Rev , vol.238 , pp. 138-149
    • Liu, P.1    Li, P.2    Burke, S.3
  • 106
    • 13544267777 scopus 로고    scopus 로고
    • Disruption of the BCL11B gene through inv (14) (q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wildtype BCL11B transcripts in T-ALL
    • Przybylski GK, Dik WA, Wanzeck J, et al: Disruption of the BCL11B gene through inv (14) (q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wildtype BCL11B transcripts in T-ALL. Leukemia 2005;19:201-208.
    • (2005) Leukemia , vol.19 , pp. 201-208
    • Przybylski, G.K.1    Dik, W.A.2    Wanzeck, J.3
  • 107
    • 0034781537 scopus 로고    scopus 로고
    • A new recurrent and specific cryptic translocation, t (5; 14) (q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia
    • Bernard OA, Busson-LeConiat M, Ballerini P, et al: A new recurrent and specific cryptic translocation, t (5; 14) (q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia. Leukemia 2001;15:1495-1504.
    • (2001) Leukemia , vol.15 , pp. 1495-1504
    • Bernard, O.A.1    Busson-LeConiat, M.2    Ballerini, P.3
  • 108
    • 78149348102 scopus 로고    scopus 로고
    • The TLX1 oncogene drives aneuploidy in T cell transformation
    • De Keersmaecker K, Real PJ, Gatta GD, et al: The TLX1 oncogene drives aneuploidy in T cell transformation. Nat Med 2010;16:1321-1327.
    • (2010) Nat Med , vol.16 , pp. 1321-1327
    • De Keersmaecker, K.1    Real, P.J.2    Gatta, G.D.3
  • 109
    • 80054121003 scopus 로고    scopus 로고
    • The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia
    • Gutierrez A, Kentsis A, Sanda T, et al: The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood 2011;118:4169-4173.
    • (2011) Blood , vol.118 , pp. 4169-4173
    • Gutierrez, A.1    Kentsis, A.2    Sanda, T.3
  • 110
    • 84855771076 scopus 로고    scopus 로고
    • T-cell acute lymphoblastic leukaemia: Recent molecular biology findings
    • Kraszewska MD, Dawidowska M, Szczepański T, et al: T-cell acute lymphoblastic leukaemia: recent molecular biology findings. Br J Haematol 2012;156:303-315.
    • (2012) Br J Haematol , vol.156 , pp. 303-315
    • Kraszewska, M.D.1    Dawidowska, M.2    Szczepański, T.3
  • 111
    • 42249091014 scopus 로고    scopus 로고
    • Somatically acquired Jak1 mutation in adult acute lymphoblastic leukemia
    • Flex E, Petrangeli V, Stella L, et al: Somatically acquired Jak1 mutation in adult acute lymphoblastic leukemia. J Exp Med 2008;205:751-758.
    • (2008) J Exp Med , vol.205 , pp. 751-758
    • Flex, E.1    Petrangeli, V.2    Stella, L.3
  • 112
    • 52449119447 scopus 로고    scopus 로고
    • Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers
    • Jeong EG, Kim MS, Nam HK, et al: Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers. Clin Cancer Res 2008;14:3716-3721.
    • (2008) Clin Cancer Res , vol.14 , pp. 3716-3721
    • Jeong, E.G.1    Kim, M.S.2    Nam, H.K.3
  • 113
    • 72249120192 scopus 로고    scopus 로고
    • JAK1 mutations are not frequent events in adult T-ALL: A GRAALL study
    • Asnafi V, Le Noir S, Lhermitte L, et al: JAK1 mutations are not frequent events in adult T-ALL: a GRAALL study. Br J Haematol 2010;148:178-179.
    • (2010) Br J Haematol , vol.148 , pp. 178-179
    • Asnafi, V.1    Le Noir, S.2    Lhermitte, L.3
  • 114
    • 77952887619 scopus 로고    scopus 로고
    • Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia
    • Kleppe M, Lahortiga I, El Chaar T, et al: Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. Nat Genet 2010;42:530-535.
    • (2010) Nat Genet , vol.42 , pp. 530-535
    • Kleppe, M.1    Lahortiga, I.2    El Chaar, T.3
  • 115
    • 79959826613 scopus 로고    scopus 로고
    • PTPN2 negatively regulates oncogenic JAK1 in Tcell acute lymphoblastic leukemia
    • Kleppe M, Soulier J, Asnafi V, et al: PTPN2 negatively regulates oncogenic JAK1 in Tcell acute lymphoblastic leukemia. Blood 2011;117:7090-7098.
    • (2011) Blood , vol.117 , pp. 7090-7098
    • Kleppe, M.1    Soulier, J.2    Asnafi, V.3
  • 116
    • 0027988545 scopus 로고
    • Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
    • Peschon JJ, Morrissey PJ, Grabstein KH, et al: Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med 1994;180:1955-1960.
    • (1994) J Exp Med , vol.180 , pp. 1955-1960
    • Peschon, J.J.1    Morrissey, P.J.2    Grabstein, K.H.3
  • 117
    • 0031740732 scopus 로고    scopus 로고
    • Defective IL7R expression in T (.) B (+) NK (+) severe combined immunodeficiency
    • Puel A, Ziegler SF, Buckley RH, et al: Defective IL7R expression in T (.) B (+) NK (+) severe combined immunodeficiency. Nat Genet 1998;20:394-397.
    • (1998) Nat Genet , vol.20 , pp. 394-397
    • Puel, A.1    Ziegler, S.F.2    Buckley, R.H.3
  • 118
    • 79956108320 scopus 로고    scopus 로고
    • Gainoffunction mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias
    • Shochat C, Tal N, Bandapalli OR, et al: Gainoffunction mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias. J Exp Med 2011;208:1333.
    • (2011) J Exp Med , vol.208 , pp. 1333
    • Shochat, C.1    Tal, N.2    Bandapalli, O.R.3
  • 119
    • 80053385665 scopus 로고    scopus 로고
    • Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
    • Zenatti PP, Ribeiro D, Li W, et al: Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat Genet 2011;43:932-939.
    • (2011) Nat Genet , vol.43 , pp. 932-939
    • Zenatti, P.P.1    Ribeiro, D.2    Li, W.3
  • 120
    • 77950299929 scopus 로고    scopus 로고
    • PHF6 mutations in T-cell acute lymphoblastic leukemia
    • Van Vlierberghe P, Palomero T, Khiabanian H, et al: PHF6 mutations in T-cell acute lymphoblastic leukemia. Nat Genet 2010;42:338-342.
    • (2010) Nat Genet , vol.42 , pp. 338-342
    • Van Vlierberghe, P.1    Palomero, T.2    Khiabanian, H.3
  • 121
    • 18744393073 scopus 로고    scopus 로고
    • Mutations in PHF6 are associated with Borjeson-Forssman-Lehmann syndrome
    • Lower KM, Turner G, Kerr BA, et al: Mutations in PHF6 are associated with Borjeson-Forssman-Lehmann syndrome. Nat Genet 2002;32:661-665.
    • (2002) Nat Genet , vol.32 , pp. 661-665
    • Lower, K.M.1    Turner, G.2    Kerr, B.A.3
  • 122
    • 82855168107 scopus 로고    scopus 로고
    • Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SETNUP214 in T-cell acute lymphoblastic leukemia
    • Wang Q, Qiu H, Jiang H, et al: Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SETNUP214 in T-cell acute lymphoblastic leukemia. Haematologica 2011;96:1808-1814.
    • (2011) Haematologica , vol.96 , pp. 1808-1814
    • Wang, Q.1    Qiu, H.2    Jiang, H.3
  • 123
    • 84861070995 scopus 로고    scopus 로고
    • Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia
    • Porcu M, Kleppe M, Gianfelici V, et al: Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia. Blood 2012;119:4476-4479.
    • (2012) Blood , vol.119 , pp. 4476-4479
    • Porcu, M.1    Kleppe, M.2    Gianfelici, V.3
  • 124
    • 84873084751 scopus 로고    scopus 로고
    • Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
    • De Keersmaecker K, Atak ZK, Li N, et al: Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nat Genet 2013;45:186-190.
    • (2013) Nat Genet , vol.45 , pp. 186-190
    • De Keersmaecker, K.1    Atak, Z.K.2    Li, N.3
  • 125
    • 84875158235 scopus 로고    scopus 로고
    • Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL
    • Tzoneva G, Perez-Garcia A, Carpenter Z, et al: Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL. Nat Med 2013;19:368-371.
    • (2013) Nat Med , vol.19 , pp. 368-371
    • Tzoneva, G.1    Perez-Garcia, A.2    Carpenter, Z.3
  • 126
    • 79958083987 scopus 로고    scopus 로고
    • Notching from T-cell to B-cell lymphoid malignancies
    • Mirandola L, Comi P, Cobos E, et al: Notching from T-cell to B-cell lymphoid malignancies. Cancer Lett 2011;308:1-13.
    • (2011) Cancer Lett , vol.308 , pp. 1-13
    • Mirandola, L.1    Comi, P.2    Cobos, E.3
  • 127
    • 66149151737 scopus 로고    scopus 로고
    • Structure of the Notch1-negative regulatory region: Implications for normal activation and pathogenic signaling in T-ALL
    • Gordon WR, Roy M, Vardar-Ulu D, et al: Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood 2009;113:4381-4390.
    • (2009) Blood , vol.113 , pp. 4381-4390
    • Gordon, W.R.1    Roy, M.2    Vardar-Ulu, D.3
  • 128
    • 77956270129 scopus 로고    scopus 로고
    • Molecular structure and dimeric organization of the Notch extracellular domain as revealed by electron microscopy
    • Kelly DF, Lake RJ, Middelkoop TC, et al: Molecular structure and dimeric organization of the Notch extracellular domain as revealed by electron microscopy. PLoS One 2010;5:e10532.
    • (2010) PLoS One , vol.5 , pp. e10532
    • Kelly, D.F.1    Lake, R.J.2    Middelkoop, T.C.3
  • 129
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • Artavanis-Tsakonas S, Rand MD, Lake RJ: Notch signaling: cell fate control and signal integration in development. Science 1999;284:770-776.
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 130
    • 1642382833 scopus 로고    scopus 로고
    • Notch signaling: Control of cell communication and cell fate
    • Lai EC: Notch signaling: control of cell communication and cell fate. Development 2004;131:965-973.
    • (2004) Development , vol.131 , pp. 965-973
    • Lai, E.C.1
  • 131
    • 33644673860 scopus 로고    scopus 로고
    • Induction of chemokine receptor expression during early stages of T cell development
    • Maerki S, Ceredig R, Rolink A: Induction of chemokine receptor expression during early stages of T cell development. Immunol Lett 2006;104:110-117.
    • (2006) Immunol Lett , vol.104 , pp. 110-117
    • Maerki, S.1    Ceredig, R.2    Rolink, A.3
  • 132
    • 67649249962 scopus 로고    scopus 로고
    • CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
    • Buonamici S, Trimarchi T, Ruocco MG, et al: CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature 2009;459:1000-1004.
    • (2009) Nature , vol.459 , pp. 1000-1004
    • Buonamici, S.1    Trimarchi, T.2    Ruocco, M.G.3
  • 133
    • 33748507998 scopus 로고    scopus 로고
    • Notch1 and IL-7 receptor interplay maintains proliferation of human thymic progenitors while suppressing non-T cell fates
    • Garcia-Peydro M, de Yebenes VG, Toribio ML: Notch1 and IL-7 receptor interplay maintains proliferation of human thymic progenitors while suppressing non-T cell fates. J Immunol 2006;177:3711-3720.
    • (2006) J Immunol , vol.177 , pp. 3711-3720
    • Garcia-Peydro, M.1    De Yebenes, V.G.2    Toribio, M.L.3
  • 134
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    • Ellisen LW, Bird J, West DC, et al: TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991;66:649-661.
    • (1991) Cell , vol.66 , pp. 649-661
    • Ellisen, L.W.1    Bird, J.2    West, D.C.3
  • 135
    • 0029942842 scopus 로고    scopus 로고
    • Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
    • Pear WS, Aster JC, Scott ML, et al: Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 1996;183:2283-2291.
    • (1996) J Exp Med , vol.183 , pp. 2283-2291
    • Pear, W.S.1    Aster, J.C.2    Scott, M.L.3
  • 136
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng AP, Ferrando AA, Lee W, et al: Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004;306:269-271.
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.P.1    Ferrando, A.A.2    Lee, W.3
  • 137
    • 33747155025 scopus 로고    scopus 로고
    • Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia
    • Breit S, Stanulla M, Flohr T, et al: Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia. Blood 2006;108:1151-1157.
    • (2006) Blood , vol.108 , pp. 1151-1157
    • Breit, S.1    Stanulla, M.2    Flohr, T.3
  • 138
    • 0041355557 scopus 로고    scopus 로고
    • Notch and Presenilin: Regulated intramembrane proteolysis links development and degeneration
    • Selkoe D, Kopan R: Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu Rev Neurosci 2003;26:565-597.
    • (2003) Annu Rev Neurosci , vol.26 , pp. 565-597
    • Selkoe, D.1    Kopan, R.2
  • 139
    • 42149109062 scopus 로고    scopus 로고
    • In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia
    • De Keersmaecker K, Lahortiga I, Mentens N, et al: In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia. Haematologica 2008;93:533-542.
    • (2008) Haematologica , vol.93 , pp. 533-542
    • De Keersmaecker, K.1    Lahortiga, I.2    Mentens, N.3
  • 140
    • 33845306813 scopus 로고    scopus 로고
    • NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
    • Palomero T, Lim WK, Odom DT, et al: NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci USA 2006;103:18261-18266.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 18261-18266
    • Palomero, T.1    Lim, W.K.2    Odom, D.T.3
  • 141
    • 34948908663 scopus 로고    scopus 로고
    • Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
    • Palomero T, Sulis ML, Cortina M, et al: Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med 2007;13:1203-1210.
    • (2007) Nat Med , vol.13 , pp. 1203-1210
    • Palomero, T.1    Sulis, M.L.2    Cortina, M.3
  • 142
    • 58149336788 scopus 로고    scopus 로고
    • Gammasecretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
    • Real PJ, Tosello V, Palomero T, et al: Gammasecretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat Med 2009;15:50-58.
    • (2009) Nat Med , vol.15 , pp. 50-58
    • Real, P.J.1    Tosello, V.2    Palomero, T.3
  • 143
    • 79960066925 scopus 로고    scopus 로고
    • Genetic abnormalities and challenges in the treatment of acute myeloid leukemia
    • Kumar CC: Genetic abnormalities and challenges in the treatment of acute myeloid leukemia. Genes Cancer 2011;2:95-107.
    • (2011) Genes Cancer , vol.2 , pp. 95-107
    • Kumar, C.C.1
  • 144
    • 65649101923 scopus 로고    scopus 로고
    • Chemotherapy of acute leukemias in adults
    • Thomas X: Chemotherapy of acute leukemias in adults. Exp Opin Pharmacother 2009;10:221-237.
    • (2009) Exp Opin Pharmacother , vol.10 , pp. 221-237
    • Thomas, X.1
  • 145
    • 20044371173 scopus 로고    scopus 로고
    • Outcome of induction and postremission therapy in younger adults with acute myeloid leukemia with normal karyotype: A Cancer and Leukemia Group B study
    • Farag SS, Ruppert AS, Mrozek K, et al: Outcome of induction and postremission therapy in younger adults with acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study. J Clin Oncol 2005;23:482-483.
    • (2005) J Clin Oncol , vol.23 , pp. 482-483
    • Farag, S.S.1    Ruppert, A.S.2    Mrozek, K.3
  • 146
    • 64049092296 scopus 로고    scopus 로고
    • Acute myelogenous leukemia in older adults
    • Klepin HD, Balducci L: Acute myelogenous leukemia in older adults. Oncologist 2009;14:222-232.
    • (2009) Oncologist , vol.14 , pp. 222-232
    • Klepin, H.D.1    Balducci, L.2
  • 147
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
    • Vardiman JW, Thiele J, Arber DA, et al: The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009;114:937-951.
    • (2009) Blood , vol.114 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3
  • 148
    • 77953135667 scopus 로고    scopus 로고
    • The molecular signature of oncofusion proteins in acute myeloid leukemia
    • Martens J H A, Stunnenberg HG: The molecular signature of oncofusion proteins in acute myeloid leukemia. FEBS Lett 2010;584:2662-2669.
    • (2010) FEBS Lett , vol.584 , pp. 2662-2669
    • Martens, J.H.A.1    Stunnenberg, H.G.2
  • 149
    • 0037114753 scopus 로고    scopus 로고
    • Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461)
    • Byrd JC, Mrozek K, Dodge RK, et al; Cancer and Leukemia Group B (CALGB 8461): Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood 2002;100:4325-4336.
    • (2002) Blood , vol.100 , pp. 4325-4336
    • Byrd, J.C.1    Mrozek, K.2    Dodge, R.K.3
  • 150
    • 0025043959 scopus 로고
    • The t (15; 17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor α gene to a novel transcribed locus
    • de The H, Chomienne C, Lanotte M, et al: The t (15; 17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor α gene to a novel transcribed locus. Nature 1990;347:358-361.
    • (1990) Nature , vol.347 , pp. 358-361
    • De The, H.1    Chomienne, C.2    Lanotte, M.3
  • 152
    • 0030923479 scopus 로고    scopus 로고
    • All-trans-retinoic acid in acute promyelocytic leukemia
    • Tallman MS, Andersen JW, Schiffer CA, et al: All-trans-retinoic acid in acute promyelocytic leukemia. N Engl J Med 1997:337:1639-1646.
    • (1997) N Engl J Med , vol.337 , pp. 1639-1646
    • Tallman, M.S.1    Andersen, J.W.2    Schiffer, C.A.3
  • 153
    • 0029819203 scopus 로고    scopus 로고
    • AIDA (all-trans retinoic acid + idarubicin) in newly diagnosed acute promyelocytic leukemia: A Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) pilot study
    • Avvisati G, Lo Coco F, Diverio D, et al: AIDA (all-trans retinoic acid + idarubicin) in newly diagnosed acute promyelocytic leukemia: a Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) pilot study. Blood 1996;88:1390-1398.
    • (1996) Blood , vol.88 , pp. 1390-1398
    • Avvisati, G.1    Coco, F.L.2    Diverio, D.3
  • 154
    • 17044409146 scopus 로고    scopus 로고
    • GIMEMA-AIEOPAIDA protocol for the treatment of newly diagnosed acute promyelocytic leukemia (APL) in children
    • Testi AM, Biondi A, Lo Coco F, et al: GIMEMA-AIEOPAIDA protocol for the treatment of newly diagnosed acute promyelocytic leukemia (APL) in children. Blood 2005;106:447-453.
    • (2005) Blood , vol.106 , pp. 447-453
    • Testi, A.M.1    Biondi, A.2    Coco, F.L.3
  • 155
    • 79955991053 scopus 로고    scopus 로고
    • AIDA 0493 protocol for newly diagnosed acute promyelocytic leukemia: Very long-term results and role of maintenance
    • Avvisati G, Lo-Coco F, Paoloni FP, et al; GIMEMA, AIEOP, and EORTC Cooperative Groups: AIDA 0493 protocol for newly diagnosed acute promyelocytic leukemia: very long-term results and role of maintenance. Blood 2011;117:4716-4725.
    • (2011) Blood , vol.117 , pp. 4716-4725
    • Avvisati, G.1    Lo-Coco, F.2    Paoloni, F.P.3
  • 156
    • 32044441026 scopus 로고    scopus 로고
    • Reconstructing a disease: What essential features of the retinoic acid receptor fusion oncoproteins generate acute promyelocytic leukemia?
    • Licht JD: Reconstructing a disease: what essential features of the retinoic acid receptor fusion oncoproteins generate acute promyelocytic leukemia? Cancer Cell 2006;9:73-74.
    • (2006) Cancer Cell , vol.9 , pp. 73-74
    • Licht, J.D.1
  • 157
    • 84880287051 scopus 로고    scopus 로고
    • Retinoic acid and arsenic trioxide for acute promyelocytic leukemia
    • Lo-Coco F, Avvisati G, Vignetti M, et al: Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med 2013;369:111-121.
    • (2013) N Engl J Med , vol.369 , pp. 111-121
    • Lo-Coco, F.1    Avvisati, G.2    Vignetti, M.3
  • 158
    • 0037448601 scopus 로고    scopus 로고
    • The ETO (MTG8) gene family
    • Davis JN, McGhee L, Meyers S: The ETO (MTG8) gene family. Gene 2003;303:1-10.
    • (2003) Gene , vol.303 , pp. 1-10
    • Davis, J.N.1    McGhee, L.2    Meyers, S.3
  • 159
    • 16544385074 scopus 로고    scopus 로고
    • Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years: Final induction results of Cancer and Leukemia Group B study 9621
    • Kolitz JE, George SL, Dodge RK, et al; Cancer and Leukemia Group B: Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years: final induction results of Cancer and Leukemia Group B study 9621. J Clin Oncol 2004;22:4290-4301.
    • (2004) J Clin Oncol , vol.22 , pp. 4290-4301
    • Kolitz, J.E.1    George, S.L.2    Dodge, R.K.3
  • 160
    • 0034696627 scopus 로고    scopus 로고
    • Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation
    • Lutterbach B, Hiebert SW: Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation. Gene 2000;245:223-235.
    • (2000) Gene , vol.245 , pp. 223-235
    • Lutterbach, B.1    Hiebert, S.W.2
  • 161
    • 27244458612 scopus 로고    scopus 로고
    • Molecular pathogenesis of MLL-associated leukemias
    • Eguchi M, Eguchi-Ishimae M, Greaves M: Molecular pathogenesis of MLL-associated leukemias. Int J Hematol 2005;82:9-20.
    • (2005) Int J Hematol , vol.82 , pp. 9-20
    • Eguchi, M.1    Eguchi-Ishimae, M.2    Greaves, M.3
  • 162
    • 78649753896 scopus 로고    scopus 로고
    • Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia
    • Parkin B, Erba H, Ouillette P, et al: Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia. Blood 2010;116:4958-4967.
    • (2010) Blood , vol.116 , pp. 4958-4967
    • Parkin, B.1    Erba, H.2    Ouillette, P.3
  • 163
    • 27244452986 scopus 로고    scopus 로고
    • Genetics of myeloid malignancies: Pathogenetic and clinical implications
    • Frohling S, Scholl C, Gilliland DG, et al: Genetics of myeloid malignancies: pathogenetic and clinical implications. J Clin Oncol 2005;23:6285-6295.
    • (2005) J Clin Oncol , vol.23 , pp. 6285-6295
    • Frohling, S.1    Scholl, C.2    Gilliland, D.G.3
  • 164
    • 42949142189 scopus 로고    scopus 로고
    • Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
    • Schlenk RF, Dohner K, Krauter J, et al; German-Austrian Acute Myeloid Leukemia Study Group: Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008;358:1909-1918.
    • (2008) N Engl J Med , vol.358 , pp. 1909-1918
    • Schlenk, R.F.1    Dohner, K.2    Krauter, J.3
  • 165
    • 79952092487 scopus 로고    scopus 로고
    • Molecular genetics of adult acute myeloid leukemia: Prognostic and therapeutic implications
    • Marcucci G, Haferlach T, Dohner H: Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol 2011;29:475-486.
    • (2011) J Clin Oncol , vol.29 , pp. 475-486
    • Marcucci, G.1    Haferlach, T.2    Dohner, H.3
  • 166
    • 59149096563 scopus 로고    scopus 로고
    • Dysregulation of the C/EBPalpha differentiation pathway in human cancer
    • Koschmieder S, Halmos B, Levantini E, et al: Dysregulation of the C/EBPalpha differentiation pathway in human cancer. J Clin Oncol 2009;27:619-628.
    • (2009) J Clin Oncol , vol.27 , pp. 619-628
    • Koschmieder, S.1    Halmos, B.2    Levantini, E.3
  • 167
    • 63849241865 scopus 로고    scopus 로고
    • Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome
    • Wouters BJ, Lowenberg B, Erpelinck-Verschueren CA, et al: Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Blood 2009;113:3088-3091.
    • (2009) Blood , vol.113 , pp. 3088-3091
    • Wouters, B.J.1    Lowenberg, B.2    Erpelinck-Verschueren, C.A.3
  • 168
    • 33846876123 scopus 로고    scopus 로고
    • Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc + AML): Biologic and clinical features
    • Falini B, Nicoletti I, Martelli MF, et al: Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc + AML): biologic and clinical features. Blood 2007;109:874-885.
    • (2007) Blood , vol.109 , pp. 874-885
    • Falini, B.1    Nicoletti, I.2    Martelli, M.F.3
  • 169
  • 170
    • 28444449081 scopus 로고    scopus 로고
    • Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
    • Schnittger S, Schoch C, Kern W, et al: Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood 2005;106:3733-3739.
    • (2005) Blood , vol.106 , pp. 3733-3739
    • Schnittger, S.1    Schoch, C.2    Kern, W.3
  • 171
    • 46849122024 scopus 로고    scopus 로고
    • Molecular characterization of acute myeloid leukemia
    • Döhner K, Döhner H: Molecular characterization of acute myeloid leukemia. Haematologica 2008;93:976-982.
    • (2008) Haematologica , vol.93 , pp. 976-982
    • Döhner, K.1    Döhner, H.2
  • 172
    • 33846230449 scopus 로고    scopus 로고
    • Clinical relevance of mutations and geneexpression changes in adult acute myeloid leukemia with normal cytogenetics: Are we ready for a prognostically prioritized molecular classification?
    • Mrózek K, Marcucci G, Paschka P, et al: Clinical relevance of mutations and geneexpression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood 2007;109:431-448.
    • (2007) Blood , vol.109 , pp. 431-448
    • Mrózek, K.1    Marcucci, G.2    Paschka, P.3
  • 173
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B Study
    • Marcucci G, Maharry K, Wu YZ, et al: IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B Study. J Clin Oncol 2010;28:2348-2355.
    • (2010) J Clin Oncol , vol.28 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3
  • 174
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Döhner H, Estey EH, Amadori S, et al; European LeukemiaNet: Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010;115:453-474.
    • (2010) Blood , vol.115 , pp. 453-474
    • European LeukemiaNet1    Döhner, H.2    Estey, E.H.3    Amadori, S.4
  • 175
    • 28444446313 scopus 로고    scopus 로고
    • Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): Association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
    • Verhaak RG, Goudswaard CS, van Putten W, et al: Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood 2005;106:3747-3754.
    • (2005) Blood , vol.106 , pp. 3747-3754
    • Verhaak, R.G.1    Goudswaard, C.S.2    Van Putten, W.3
  • 176
    • 34548125335 scopus 로고    scopus 로고
    • Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias
    • Mullighan CG, Kennedy A, Zhou X, et al: Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias. Leukemia 2007;21:2000-2009.
    • (2007) Leukemia , vol.21 , pp. 2000-2009
    • Mullighan, C.G.1    Kennedy, A.2    Zhou, X.3
  • 177
    • 41649119008 scopus 로고    scopus 로고
    • Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin
    • Garzon R, Garofalo M, Martelli MP, et al: Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci USA 2008;105:3945-3950.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3945-3950
    • Garzon, R.1    Garofalo, M.2    Martelli, M.P.3
  • 178
    • 81555228429 scopus 로고    scopus 로고
    • Gene mutation and AML pathogenesis
    • Dombret H: Gene mutation and AML pathogenesis. Blood 2011;118:5366-5367.
    • (2011) Blood , vol.118 , pp. 5366-5367
    • Dombret, H.1
  • 179
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis ER, Ding L, Dooling DJ, et al: Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009;361:1058-1066.
    • (2009) N Engl J Med , vol.361 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 180
    • 70249097408 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas
    • Sanson M, Marie Y, Paris S, et al: Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas. J Clin Oncol 2009;27:4150-4154.
    • (2009) J Clin Oncol , vol.27 , pp. 4150-4154
    • Sanson, M.1    Marie, Y.2    Paris, S.3
  • 181
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • Yan H, Parsons DW, Jin G, et al: IDH1 and IDH2 mutations in gliomas. N Engl J Med 2009;360:765-773.
    • (2009) N Engl J Med , vol.360 , pp. 765-773
    • Yan, H.1    Parsons, D.W.2    Jin, G.3
  • 182
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • Paschka P, Schlenk RF, Gaidzik VI, et al: IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol 2010;28:3636-3643.
    • (2010) J Clin Oncol , vol.28 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3
  • 183
    • 80054035931 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in pediatric acute leukemia
    • Andersson AK, Miller DW, Lynch JA, et al: IDH1 and IDH2 mutations in pediatric acute leukemia. Leukemia 2011;25:1570-1577.
    • (2011) Leukemia , vol.25 , pp. 1570-1577
    • Andersson, A.K.1    Miller, D.W.2    Lynch, J.A.3
  • 184
    • 77952481300 scopus 로고    scopus 로고
    • Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor
    • Wagner K, Damm F, Göhring G, et al: Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor. J Clin Oncol 2010;28:2356-2364.
    • (2010) J Clin Oncol , vol.28 , pp. 2356-2364
    • Wagner, K.1    Damm, F.2    Göhring, G.3
  • 185
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa ME, Abdel-Wahab O, Lu C, et al: Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010;18:553-567.
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3
  • 186
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ, Ding L, Walter MJ, et al: DNMT3A mutations in acute myeloid leukemia. N Engl J Med 2010;363:2424-2433.
    • (2010) N Engl J Med , vol.363 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 187
    • 79960735923 scopus 로고    scopus 로고
    • Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia
    • Thol F, Damm F, Lüdeking A, et al: Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia. J Clin Oncol 2011;29:2889-2896.
    • (2011) J Clin Oncol , vol.29 , pp. 2889-2896
    • Thol, F.1    Damm, F.2    Lüdeking, A.3
  • 188
    • 79961085843 scopus 로고    scopus 로고
    • DNMT3A mutations are rare in childhood acute myeloid leukemia
    • Thol F, Heuser M, Damm F, et al: DNMT3A mutations are rare in childhood acute myeloid leukemia. Haematologica 2011;96:1238-1240.
    • (2011) Haematologica , vol.96 , pp. 1238-1240
    • Thol, F.1    Heuser, M.2    Damm, F.3
  • 189
    • 82855172180 scopus 로고    scopus 로고
    • A methyltransferase 3a hot-spot locus is not mutated in pediatric patients affected by acute myeloid or T-cell acute lymphoblastic leukemia: An Italian study
    • Paganin M, Pigazzi M, Bresolin S, et al: A methyltransferase 3a hot-spot locus is not mutated in pediatric patients affected by acute myeloid or T-cell acute lymphoblastic leukemia: an Italian study. Haematologica 2011;96:1886-1887.
    • (2011) Haematologica , vol.96 , pp. 1886-1887
    • Paganin, M.1    Pigazzi, M.2    Bresolin, S.3
  • 190
    • 83055161507 scopus 로고    scopus 로고
    • Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype
    • Grossmann V, Tiacci E, Holmes AB, et al: Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. Blood 2011;118:6153-6163.
    • (2011) Blood , vol.118 , pp. 6153-6163
    • Grossmann, V.1    Tiacci, E.2    Holmes, A.B.3
  • 191
    • 12144287606 scopus 로고    scopus 로고
    • Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR
    • Ng D, Thakker N, Corcoran CM, et al: Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR. Nat Genet 2004;36:411-416.
    • (2004) Nat Genet , vol.36 , pp. 411-416
    • Ng, D.1    Thakker, N.2    Corcoran, C.M.3
  • 192
    • 66249137734 scopus 로고    scopus 로고
    • Mutation in TET2 in myeloid cancers
    • Delhommeau F, Dupont S, Della Valle V, et al: Mutation in TET2 in myeloid cancers. N Engl J Med 2009;360:2289-2301.
    • (2009) N Engl J Med , vol.360 , pp. 2289-2301
    • Delhommeau, F.1    Dupont, S.2    Valle, V.D.3
  • 193
    • 67651065502 scopus 로고    scopus 로고
    • Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
    • Abdel-Wahab O, Mullally A, Hedvat C, et al: Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood 2009;114:144-147.
    • (2009) Blood , vol.114 , pp. 144-147
    • Abdel-Wahab, O.1    Mullally, A.2    Hedvat, C.3
  • 194
    • 67349124376 scopus 로고    scopus 로고
    • TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis
    • Tefferi A, Pardanani A, Lim KH, et al: TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. Leukemia 2009;23:905-911.
    • (2009) Leukemia , vol.23 , pp. 905-911
    • Tefferi, A.1    Pardanani, A.2    Lim, K.H.3
  • 195
    • 73149094518 scopus 로고    scopus 로고
    • TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia
    • Kosmider O, Gelsi-Boyer V, Ciudad M, et al; Groupe Francophone des Myélodysplasies: TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia. Haematologica 2009;94:1676-1681.
    • (2009) Haematologica , vol.94 , pp. 1676-1681
    • Kosmider, O.1    Gelsi-Boyer, V.2    Ciudad, M.3
  • 196
    • 84864255882 scopus 로고    scopus 로고
    • The origin and evolution of mutations in acute myeloid leukemia
    • Welch JS, Ley TJ, Link DC, et al: The origin and evolution of mutations in acute myeloid leukemia. Cell 2012;150:264-278.
    • (2012) Cell , vol.150 , pp. 264-278
    • Welch, J.S.1    Ley, T.J.2    Link, D.C.3
  • 197
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • Cancer Genome Atlas Research Network: Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013;368:2059-2074.
    • (2013) N Engl J Med , vol.368 , pp. 2059-2074
    • Cancer Genome Atlas Research Network1
  • 198
    • 18444388287 scopus 로고    scopus 로고
    • Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles
    • Schoch C, Kohlmann A, Schnittger S, et al: Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles. Proc Natl Acad Sci USA 2002;99:10008-10013.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10008-10013
    • Schoch, C.1    Kohlmann, A.2    Schnittger, S.3
  • 199
    • 16544369516 scopus 로고    scopus 로고
    • Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia
    • Bullinger L, Döhner K, Bair E, et al: Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. N Engl J Med 2004;350:1605-1616.
    • (2004) N Engl J Med , vol.350 , pp. 1605-1616
    • Bullinger, L.1    Döhner, K.2    Bair, E.3
  • 200
    • 11144358111 scopus 로고    scopus 로고
    • Prognostically useful gene-expression profiles in acute myeloid leukemia
    • Valk PJ, Verhaak RG, Beijen MA, et al: Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 2004;350:1617-1628.
    • (2004) N Engl J Med , vol.350 , pp. 1617-1628
    • Valk, P.J.1    Verhaak, R.G.2    Beijen, M.A.3
  • 201
    • 19444370843 scopus 로고    scopus 로고
    • Acute myeloid leukemia with a complex aberrant karyotype is a distinct biological entity characterized by genomic imbalances and a specific gene expression profile
    • Schoch C, Kern W, Kohlmann A, et al: Acute myeloid leukemia with a complex aberrant karyotype is a distinct biological entity characterized by genomic imbalances and a specific gene expression profile. Genes Chromosomes Cancer 2005;43:227-238.
    • (2005) Genes Chromosomes Cancer , vol.43 , pp. 227-238
    • Schoch, C.1    Kern, W.2    Kohlmann, A.3
  • 202
    • 33748450145 scopus 로고    scopus 로고
    • Disclosure of candidate genes in acute myeloid leukemia with complex karyotypes using microarray-based molecular characterization
    • Rücker FG, Bullinger L, Schwaenen C, et al: Disclosure of candidate genes in acute myeloid leukemia with complex karyotypes using microarray-based molecular characterization. J Clin Oncol 2006;24:3887-3894.
    • (2006) J Clin Oncol , vol.24 , pp. 3887-3894
    • Rücker, F.G.1    Bullinger, L.2    Schwaenen, C.3
  • 203
    • 55549103713 scopus 로고    scopus 로고
    • Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with highrisk molecular features: A Cancer and Leukemia Group B Study
    • Marcucci G, Maharry K, Radmacher MD: Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with highrisk molecular features: a Cancer and Leukemia Group B Study. J Clin Oncol 2008;26:5078-5087.
    • (2008) J Clin Oncol , vol.26 , pp. 5078-5087
    • Marcucci, G.1    Maharry, K.2    Radmacher, M.D.3
  • 204
    • 35348896184 scopus 로고    scopus 로고
    • Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1
    • Wouters BJ, Jordà MA, Keeshan K, et al: Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood 2007;110:3706-3714.
    • (2007) Blood , vol.110 , pp. 3706-3714
    • Wouters, B.J.1    Jordà, M.A.2    Keeshan, K.3
  • 205
    • 20144381877 scopus 로고    scopus 로고
    • Distinct gene expression patterns associated with FLT3- and NRAS-activating mutations in acute myeloid leukemia with normal karyotype
    • Neben K, Schnittger S, Brors B: Distinct gene expression patterns associated with FLT3- and NRAS-activating mutations in acute myeloid leukemia with normal karyotype. Oncogene 2005;24:1580-1588.
    • (2005) Oncogene , vol.24 , pp. 1580-1588
    • Neben, K.1    Schnittger, S.2    Brors, B.3
  • 206
    • 45949110015 scopus 로고    scopus 로고
    • High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: A Cancer and Leukemia Group B (CALGB) study
    • Langer C, Radmacher MD, Ruppert AS, et al; Cancer and Leukemia Group B (CALGB): High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) study. Blood 2008;111:5371-5379.
    • (2008) Blood , vol.111 , pp. 5371-5379
    • Langer, C.1    Radmacher, M.D.2    Ruppert, A.S.3
  • 207
    • 67650312343 scopus 로고    scopus 로고
    • Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: A cancer and leukemia group B study
    • Langer C, Marcucci G, Holland KB, et al: Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol 2009;27:3198-3204.
    • (2009) J Clin Oncol , vol.27 , pp. 3198-3204
    • Langer, C.1    Marcucci, G.2    Holland, K.B.3
  • 208
    • 33747420007 scopus 로고    scopus 로고
    • Independent confirmation of a prognostic gene expression signature in adult acute myeloid leukemia with a normal karyotype: A Cancer and Leukemia Group B study
    • Radmacher MD, Marcucci G, Ruppert AS, et al; Cancer and Leukemia Group B: Independent confirmation of a prognostic gene expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study. Blood 2006;108:1677-1683.
    • (2006) Blood , vol.108 , pp. 1677-1683
    • Radmacher, M.D.1    Marcucci, G.2    Ruppert, A.S.3
  • 209
    • 38049123402 scopus 로고    scopus 로고
    • RNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia
    • Mi S, Lu J, Sun M, et al: RNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci USA 2007;104:19971-19976.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19971-19976
    • Mi, S.1    Lu, J.2    Sun, M.3
  • 210
    • 77649241350 scopus 로고    scopus 로고
    • Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia
    • Mi S, Li Z, Chen P, et al: Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proc Natl Acad Sci USA 2010;107:3710-3715.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 3710-3715
    • Mi, S.1    Li, Z.2    Chen, P.3
  • 211
    • 55749099505 scopus 로고    scopus 로고
    • Distinct microRNA expression profiles in acute myeloid leukemia with common translocations
    • Li Z, Lu J, Sun M, et al: Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci USA 2008;105:15535-15540.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15535-15540
    • Li, Z.1    Lu, J.2    Sun, M.3
  • 212
    • 47749117212 scopus 로고    scopus 로고
    • Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia
    • Dixon-McIver A, East P, Mein CA, et al: Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia. PLoS One 2008;14;3:e2141.
    • (2008) PLoS One , vol.14 , Issue.3 , pp. e2141
    • Dixon-McIver, A.1    East, P.2    Mein, C.A.3
  • 213
    • 66349137358 scopus 로고    scopus 로고
    • Inositol phosphatase SHIP1 is a primary target of miR-155
    • O'Connell RM, Chaudhuri AA, Rao DS, et al: Inositol phosphatase SHIP1 is a primary target of miR-155. Proc Natl Acad Sci USA 2009;106:7113-7118.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 7113-7118
    • O'Connell, R.M.1    Chaudhuri, A.A.2    Rao, D.S.3
  • 214
    • 42449141513 scopus 로고    scopus 로고
    • Micro-RNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
    • Garzon R, Volinia S, Liu CG, et al.: Micro-RNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood 2008;111:3183-3189.
    • (2008) Blood , vol.111 , pp. 3183-3189
    • Garzon, R.1    Volinia, S.2    Liu, C.G.3
  • 215
    • 42949083345 scopus 로고    scopus 로고
    • MicroRNA expression in cytogenetically normal acute myeloid leukemia
    • Marcucci G, Radmacher MD, Maharry K, et al.: MicroRNA expression in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008;358:1919-1928.
    • (2008) N Engl J Med , vol.358 , pp. 1919-1928
    • Marcucci, G.1    Radmacher, M.D.2    Maharry, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.