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Volumn 2, Issue 2, 2011, Pages 95-107

Genetic abnormalities and challenges in the treatment of acute myeloid Leukemia

Author keywords

Acute myeloid leukemia; Genetic abnormalities; New drugs

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AMONAFIDE; ANTHRACYCLINE DERIVATIVE; AS 1413; AZACITIDINE; BELINOSTAT; BEVACIZUMAB; CLADRIBINE; CLOFARABINE; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; FLUDARABINE; GEMTUZUMAB OZOGAMICIN; HYDROXYUREA; IDARUBICIN; LENALIDOMIDE; LESTAURTINIB; LINTUZUMAB; LONAFARNIB; MIDOSTAURIN; PANOBINOSTAT; PLACEBO; QUIZARTINIB; RETINOIC ACID; SAPACITABINE; SORAFENIB; SUNITINIB; TIPIFARNIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT;

EID: 79960066925     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601911408076     Document Type: Review
Times cited : (206)

References (75)
  • 2
    • 33751267902 scopus 로고    scopus 로고
    • Acute myeloid leukemia
    • Estey E, Dohner H. Acute myeloid leukemia. Lancet. 2006;368: 1894-907.
    • (2006) Lancet , vol.368 , pp. 1894-1907
    • Estey, E.1    Dohner, H.2
  • 3
    • 65549090436 scopus 로고    scopus 로고
    • Acute myelogenous leukemia
    • Shipley JL, Butera JN. Acute myelogenous leukemia. Exp Hematol.2009;37:649-58.
    • (2009) Exp Hematol , vol.37 , pp. 649-658
    • Shipley, J.L.1    Butera, J.N.2
  • 4
    • 0034984527 scopus 로고    scopus 로고
    • Therapy related leukemias: Susceptibility, prevention and treatment
    • Leone G, Voso MT, Sica S, Morosetti R, Pagano L. Therapy related leukemias: susceptibility, prevention and treatment. Leuk Lymphoma.2001;41:255-76.
    • (2001) Leuk Lymphoma , vol.41 , pp. 255-276
    • Leone, G.1    Voso, M.T.2    Sica, S.3    Morosetti, R.4    Pagano, L.5
  • 5
    • 0032189081 scopus 로고    scopus 로고
    • Secondary leukemias induced by topoisomerase-targeted drugs
    • Felix CA. Secondary leukemias induced by topoisomerase-targeted drugs. Biochim Biophys Acta. 1998;1400:233-55.
    • (1998) Biochim Biophys Acta , vol.1400 , pp. 233-255
    • Felix, C.A.1
  • 6
    • 32144462606 scopus 로고    scopus 로고
    • Acute myeloid leukemia in adults
    • In: Abeloff M, Armitage J, & Kastan M., et al., editors, 3rd edition. Philadelphia: Elsevier Science
    • Appelbaum FR. Acute myeloid leukemia in adults. In: Abeloff M, Armitage J, & Kastan M., et al., editors. Clinical oncology, 3rd edition. Philadelphia: Elsevier Science; 2004. p. 2825-48.
    • (2004) Clinical Oncology , pp. 2825-2848
    • Appelbaum, F.R.1
  • 7
    • 0036848258 scopus 로고    scopus 로고
    • Causality of myelodysplasia and acute myeloid leukemia and their genetic abnormalities
    • Pedersen-Bjergaard J, Christiansen DH, Andersen MK, Skovby F. Causality of myelodysplasia and acute myeloid leukemia and their genetic abnormalities. Leukemia. 2002;16:2177-84.
    • (2002) Leukemia , vol.16 , pp. 2177-2184
    • Pedersen-Bjergaard, J.1    Christiansen, D.H.2    Andersen, M.K.3    Skovby, F.4
  • 8
    • 32044441026 scopus 로고    scopus 로고
    • Reconstructing a disease: What essential features of the retinoic acid receptor fusion oncoproteins generate acute promyelocytic leukemia?
    • Licht JD. Reconstructing a disease: what essential features of the retinoic acid receptor fusion oncoproteins generate acute promyelocytic leukemia? Cancer Cell. 2006;9:73-4.
    • (2006) Cancer Cell , vol.9 , pp. 73-74
    • Licht, J.D.1
  • 9
    • 79952112882 scopus 로고    scopus 로고
    • Prognostic factors and treatment outcome in 1,516 adult patients with de novo and secondary acute myeloid leukemia in 1999-2009 in 5 hematology intensive care centers in the Czech Republic
    • Szotkowski T, Muzik J, Voglova J, et al. Prognostic factors and treatment outcome in 1,516 adult patients with de novo and secondary acute myeloid leukemia in 1999-2009 in 5 hematology intensive care centers in the Czech Republic. Neoplasma. 2010;57(6):578-89.
    • (2010) Neoplasma , vol.57 , Issue.6 , pp. 578-589
    • Szotkowski, T.1    Muzik, J.2    Voglova, J.3
  • 10
    • 0033668778 scopus 로고    scopus 로고
    • Chemokines, chemokine receptors and hematopoiesis
    • Youn B-S, Mantel C, Broxmeyer HE. Chemokines, chemokine receptors and hematopoiesis. Immunol Rev. 2000;17:150-74.
    • (2000) Immunol Rev , vol.17 , pp. 150-174
    • Youn, B.-S.1    Mantel, C.2    Broxmeyer, H.E.3
  • 11
    • 20044371173 scopus 로고    scopus 로고
    • Outcome of induction and postremission therapy in younger adults with acute myeloid leukemia with normal karyotype: A Cancer and Leukemia Group B study
    • Farag SS, Ruppert AS, Mrozek K, et al. Outcome of induction and postremission therapy in younger adults with acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study. J Clin Oncol. 2005;23:482.
    • (2005) J Clin Oncol , vol.23 , pp. 482
    • Farag, S.S.1    Ruppert, A.S.2    Mrozek, K.3
  • 12
    • 64049092296 scopus 로고    scopus 로고
    • Acute myelogenous leukemia in older adults
    • Klepin HD, Balducci L. Acute myelogenous leukemia in older adults. Oncologist. 2009;14:222-32.
    • (2009) Oncologist , vol.14 , pp. 222-232
    • Klepin, H.D.1    Balducci, L.2
  • 13
    • 65649101923 scopus 로고    scopus 로고
    • Chemotherapy of acute leukemias in adults
    • Thomas X. Chemotherapy of acute leukemias in adults. Exp Opin Pharmacother. 2009;10:221-37.
    • (2009) Exp Opin Pharmacother , vol.10 , pp. 221-237
    • Thomas, X.1
  • 14
    • 84867907562 scopus 로고    scopus 로고
    • National Cancer Institute, Available from
    • National Cancer Institute. Acute myeloid leukemia. Available from: http://www.Seer.cancer.gov/statfacts/html/amyl.htm?statfacts_page=amyl.html&x=15&y=17
    • Acute Myeloid Leukemia
  • 16
    • 0034653494 scopus 로고    scopus 로고
    • Cytogenetic abnormalities in the myelodysplastic syndromes and occupational or environmental exposure
    • West RR, Stafford DA, White AD, Bowen DT, Padua RA. Cytogenetic abnormalities in the myelodysplastic syndromes and occupational or environmental exposure. Blood. 2000;95:2093-7.
    • (2000) Blood , vol.95 , pp. 2093-2097
    • West, R.R.1    Stafford, D.A.2    White, A.D.3    Bowen, D.T.4    Padua, R.A.5
  • 17
    • 0029814178 scopus 로고    scopus 로고
    • Correlation between selected environmental exposures and karyotype in acute myelocytic leukemia
    • Crane MM, Strom SS, Halabi S, et al. Correlation between selected environmental exposures and karyotype in acute myelocytic leukemia. Cancer Epidemiol Biomarkers Prev. 1996;5:639-44.
    • (1996) Cancer Epidemiol Biomarkers Prev , vol.5 , pp. 639-644
    • Crane, M.M.1    Strom, S.S.2    Halabi, S.3
  • 18
    • 0027972308 scopus 로고
    • Cancer incidence in atomic bomb survivors: Part III-leukemia, lymphoma and multiple myeloma, 1950-1987
    • Preston DL, Kusumi S, Tomonaga M, et al. Cancer incidence in atomic bomb survivors: part III-leukemia, lymphoma and multiple myeloma, 1950-1987. Radiat Res. 1994;137:S68-97.
    • (1994) Radiat Res , vol.137 , pp. 68-97
    • Preston, D.L.1    Kusumi, S.2    Tomonaga, M.3
  • 19
    • 27244452986 scopus 로고    scopus 로고
    • Genetics of myeloid malignancies: Pathogenetic and clinical implications
    • Frohling S, Scholl C, Gilliland DG, Levine RL. Genetics of myeloid malignancies: pathogenetic and clinical implications. J Clin Oncol.2005;23:6285-95.
    • (2005) J Clin Oncol , vol.23 , pp. 6285-6295
    • Frohling, S.1    Scholl, C.2    Gilliland, D.G.3    Levine, R.L.4
  • 20
    • 0022135739 scopus 로고
    • Proposed revised criteria for the classification of acute myeloid leukemia: A report of the French- American-British Cooperative Group
    • Bennett JM, Catovsky D, Daniel MT, et al. Proposed revised criteria for the classification of acute myeloid leukemia: a report of the French- American-British Cooperative Group. Ann Intern Med. 1985;103:620-5.
    • (1985) Ann Intern Med , vol.103 , pp. 620-625
    • Bennett, J.M.1    Catovsky, D.2    Daniel, M.T.3
  • 21
    • 0032784783 scopus 로고    scopus 로고
    • WHO classification of neoplastic disease of the hematopoietic and lymphoid tissues: Report of the clinical advisory committee meeting-Airlie House, Virginia
    • Harris N, Jaffe E, Diebold J, et al. WHO classification of neoplastic disease of the hematopoietic and lymphoid tissues: report of the clinical advisory committee meeting-Airlie House, Virginia. J Clin Oncol.1999;17:3835-49.
    • (1999) J Clin Oncol , vol.17 , pp. 3835-3849
    • Harris, N.1    Jaffe, E.2    Diebold, J.3
  • 22
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
    • Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood.2009;114:937-51.
    • (2009) Blood , vol.114 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3
  • 23
    • 77953135667 scopus 로고    scopus 로고
    • The molecular signature of oncofusion proteins in acute myeloid leukemia
    • Martens JHA, Stunnenberg HG. The molecular signature of oncofusion proteins in acute myeloid leukemia. FEBS Lett. 2010;584:2662-9.
    • (2010) FEBS Lett , vol.584 , pp. 2662-2669
    • Martens, J.H.A.1    Stunnenberg, H.G.2
  • 24
    • 0037114753 scopus 로고    scopus 로고
    • Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461)
    • Byrd JC, Mrózek K, Dodge RK, et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood. 2002;100:4325-36.
    • (2002) Blood , vol.100 , pp. 4325-4336
    • Byrd, J.C.1    Mrózek, K.2    Dodge, R.K.3
  • 26
    • 0033561797 scopus 로고    scopus 로고
    • Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia
    • Melnick A, Licht JD. Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood. 1999;93:3167-215.
    • (1999) Blood , vol.93 , pp. 3167-3215
    • Melnick, A.1    Licht, J.D.2
  • 27
    • 0030658039 scopus 로고    scopus 로고
    • Oncogenic transcription factors in the human acute leukemias
    • Look AT. Oncogenic transcription factors in the human acute leukemias. Science. 1997;278:1059-64.
    • (1997) Science , vol.278 , pp. 1059-1064
    • Look, A.T.1
  • 28
    • 33947581390 scopus 로고    scopus 로고
    • The impact of translocations and gene fusions on cancer causation
    • Mitelman F, Johansson B, Mertens F. The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer. 2007;7:233-45.
    • (2007) Nat Rev Cancer , vol.7 , pp. 233-245
    • Mitelman, F.1    Johansson, B.2    Mertens, F.3
  • 30
    • 2942548983 scopus 로고    scopus 로고
    • The Runx genes: Lineage-specific oncogenes and tumor suppressors
    • Cameron ER, Neil JC. The Runx genes: lineage-specific oncogenes and tumor suppressors. Oncogene. 2004;23:4308-14.
    • (2004) Oncogene , vol.23 , pp. 4308-4314
    • Cameron, E.R.1    Neil, J.C.2
  • 31
    • 2942547444 scopus 로고    scopus 로고
    • Core-binding factors in hematopoiesis and immune function
    • de Bruijn MF, Speck NA. Core-binding factors in hematopoiesis and immune function. Oncogene. 2004;23:4238-48.
    • (2004) Oncogene , vol.23 , pp. 4238-4248
    • de Bruijn, M.F.1    Speck, N.A.2
  • 32
    • 0037448601 scopus 로고    scopus 로고
    • The ETO (MTG8) gene family
    • Davis JN, McGhee L, Meyers S. The ETO (MTG8) gene family. Gene. 2003;303:1-10.
    • (2003) Gene , vol.303 , pp. 1-10
    • Davis, J.N.1    McGhee, L.2    Meyers, S.3
  • 33
    • 0028925282 scopus 로고
    • The t (8;21) fusion protein interferes with AML-1B-dependent transcriptional activation
    • Meyers S, Lenny N, Hiebert SW. The t (8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol Cell Biol.1995;15:1974-82.
    • (1995) Mol Cell Biol , vol.15 , pp. 1974-1982
    • Meyers, S.1    Lenny, N.2    Hiebert, S.W.3
  • 34
    • 0029616633 scopus 로고
    • The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B
    • Frank R, Zhang J, Uchida H, Meyers S, Hiebert SW, Nimer SD. The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B. Oncogene. 1995;11:2667-74.
    • (1995) Oncogene , vol.11 , pp. 2667-2674
    • Frank, R.1    Zhang, J.2    Uchida, H.3    Meyers, S.4    Hiebert, S.W.5    Nimer, S.D.6
  • 35
    • 0034696627 scopus 로고    scopus 로고
    • Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation
    • Lutterbach B, Hiebert SW. Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation. Gene.2000;245:223-35.
    • (2000) Gene , vol.245 , pp. 223-235
    • Lutterbach, B.1    Hiebert, S.W.2
  • 36
    • 0033607165 scopus 로고    scopus 로고
    • The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor
    • Lutterbach B, Hou Y, Durst KL, Hiebert SW. The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor. Proc Natl Acad Sci U S A. 1999;96:12822-7.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12822-12827
    • Lutterbach, B.1    Hou, Y.2    Durst, K.L.3    Hiebert, S.W.4
  • 37
    • 27244458612 scopus 로고    scopus 로고
    • Molecular pathogenesis of MLL-associated leukemias
    • Eguchi M, Eguchi-Ishimae M, Greaves M. Molecular pathogenesis of MLL-associated leukemias. Int J Hematol. 2005;82:9-20.
    • (2005) Int J Hematol , vol.82 , pp. 9-20
    • Eguchi, M.1    Eguchi-Ishimae, M.2    Greaves, M.3
  • 38
    • 35548934558 scopus 로고    scopus 로고
    • MLL translocations, histone modifications and leukaemia stem-cell development
    • Krivtsov AV, Armstrong SA. MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer.2007;7:823-33.
    • (2007) Nat Rev Cancer , vol.7 , pp. 823-833
    • Krivtsov, A.V.1    Armstrong, S.A.2
  • 39
    • 33846635060 scopus 로고    scopus 로고
    • Influence of new molecular prognostic markers in patients with karyotypically normal acute myeloid leukemia: Recent advances
    • Mrózek K, Dohner H, Bloomfield CD. Influence of new molecular prognostic markers in patients with karyotypically normal acute myeloid leukemia: recent advances. Curr Opin Hematol. 2007;14:106-14.
    • (2007) Curr Opin Hematol , vol.14 , pp. 106-114
    • Mrózek, K.1    Dohner, H.2    Bloomfield, C.D.3
  • 40
    • 33748467435 scopus 로고    scopus 로고
    • Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8:21): a Cancer and Leukemia Group B study
    • Patscka P, Marucci G, Rupport AS, et al. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8:21): a Cancer and Leukemia Group B study. J Clin Oncol.2006;24:3904-11.
    • (2006) J Clin Oncol , vol.24 , pp. 3904-3911
    • Patscka, P.1    Marucci, G.2    Rupport, A.S.3
  • 41
    • 50049097137 scopus 로고    scopus 로고
    • Targeting FLT3 for the treatment of leukemia
    • Small D. Targeting FLT3 for the treatment of leukemia. Semin Hematol.2008;45:S17-21.
    • (2008) Semin Hematol , vol.45 , pp. 17-21
    • Small, D.1
  • 42
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer. 2003;3:650-65.
    • (2003) Nat Rev Cancer , vol.3 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 43
    • 61849150985 scopus 로고    scopus 로고
    • High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients
    • Tyner JW, Erikson H, Deininger MW, et al. High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients. Blood. 2009;113:1749-55.
    • (2009) Blood , vol.113 , pp. 1749-1755
    • Tyner, J.W.1    Erikson, H.2    Deininger, M.W.3
  • 44
    • 2342544921 scopus 로고    scopus 로고
    • C/EBPalpha mutations in acute myeloid leukaemias
    • Nerlov C. C/EBPalpha mutations in acute myeloid leukaemias. Nat Rev Cancer. 2004;4:394-400.
    • (2004) Nat Rev Cancer , vol.4 , pp. 394-400
    • Nerlov, C.1
  • 45
    • 0036014973 scopus 로고    scopus 로고
    • The role of MLL in hematopoiesis and leukemia
    • Ernst P, Wang J, Korsmeyer SJ. The role of MLL in hematopoiesis and leukemia. Curr Opin Hematol. 2002;9:282-7.
    • (2002) Curr Opin Hematol , vol.9 , pp. 282-287
    • Ernst, P.1    Wang, J.2    Korsmeyer, S.J.3
  • 47
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010;363:2424-33.
    • (2010) N Engl J Med , vol.363 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 48
    • 14644438479 scopus 로고    scopus 로고
    • Secondary AML has a worse outcome than de novo AML even taking into account cytogenetics and age
    • Goldstone AH, Burnett AK, Avivi I, et al. Secondary AML has a worse outcome than de novo AML even taking into account cytogenetics and age. Blood. 2002;100:88.
    • (2002) Blood , vol.100 , pp. 88
    • Goldstone, A.H.1    Burnett, A.K.2    Avivi, I.3
  • 49
    • 33745191374 scopus 로고    scopus 로고
    • Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid leukemia: Results from Cancer and Leukemia Group B 8461
    • Farag SS, Archer KJ, Mrozek K, et al. Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid leukemia: results from Cancer and Leukemia Group B 8461. Blood. 2006;108:63-7.
    • (2006) Blood , vol.108 , pp. 63-67
    • Farag, S.S.1    Archer, K.J.2    Mrozek, K.3
  • 50
    • 0031467498 scopus 로고    scopus 로고
    • Implications of potential cure in acute myelogenous leukemia: Development of subsequent cancer and return to work
    • de Lima M, Strom S, Keating M, et al. Implications of potential cure in acute myelogenous leukemia: development of subsequent cancer and return to work. Blood. 1997;90:4719-24.
    • (1997) Blood , vol.90 , pp. 4719-4724
    • de Lima, M.1    Strom, S.2    Keating, M.3
  • 51
    • 23644455476 scopus 로고    scopus 로고
    • Drug therapy of acute myeloid leukemia
    • Tallman MS, Gilliland DG, Rowe JM. Drug therapy of acute myeloid leukemia. Blood. 2005;106:1154-63.
    • (2005) Blood , vol.106 , pp. 1154-1163
    • Tallman, M.S.1    Gilliland, D.G.2    Rowe, J.M.3
  • 52
    • 84896820280 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network, Available from
    • National Comprehensive Cancer Network. Home page. Available from: www.nccn.org
    • Home Page
  • 53
    • 78649962923 scopus 로고    scopus 로고
    • Has there been progress in the treatment of older patients with acute myeloid leukemia?
    • Erba HP. Has there been progress in the treatment of older patients with acute myeloid leukemia? Best Pract Res Clin Haematol. 2010;23:495-501.
    • (2010) Best Pract Res Clin Haematol , vol.23 , pp. 495-501
    • Erba, H.P.1
  • 54
    • 33646472600 scopus 로고    scopus 로고
    • Intensive consolidation versus oral maintenance therapy in patients 61 years or older with acute myeloid leukemia in first remission: Results of second randomization of AML HD98-B treatment trial
    • Schlenk RF, Frohling S, Hartmann F, et al. Intensive consolidation versus oral maintenance therapy in patients 61 years or older with acute myeloid leukemia in first remission: results of second randomization of AML HD98-B treatment trial. Leukemia. 2006;20:748-50.
    • (2006) Leukemia , vol.20 , pp. 748-750
    • Schlenk, R.F.1    Frohling, S.2    Hartmann, F.3
  • 55
    • 57549110059 scopus 로고    scopus 로고
    • Optimizing therapy for acute myeloid leukemia
    • Kohrt HE, Coutre SE. Optimizing therapy for acute myeloid leukemia. J Natl Compr Canc Netw. 2008;6:1003-16.
    • (2008) J Natl Compr Canc Netw , vol.6 , pp. 1003-1016
    • Kohrt, H.E.1    Coutre, S.E.2
  • 56
    • 67651227639 scopus 로고    scopus 로고
    • Treatment of acute myeloid leukemia with hematopoietic stem cell transplantation
    • Jones CV, Copelan EA. Treatment of acute myeloid leukemia with hematopoietic stem cell transplantation. Future Oncol. 2009;5: 559-68.
    • (2009) Future Oncol , vol.5 , pp. 559-568
    • Jones, C.V.1    Copelan, E.A.2
  • 57
    • 33750949551 scopus 로고    scopus 로고
    • Treatment decision-making for older patients with high-risk myelodysplastic syndrome or acute myeloid leukemia: Problems and approaches
    • Deschler B, de Witte T, Mertelsmann R, Lübbert M. Treatment decision-making for older patients with high-risk myelodysplastic syndrome or acute myeloid leukemia: problems and approaches. Haematologica.2006;91:1513-22.
    • (2006) Haematologica , vol.91 , pp. 1513-1522
    • Deschler, B.1    de Witte, T.2    Mertelsmann, R.3    Lübbert, M.4
  • 58
    • 45549083917 scopus 로고    scopus 로고
    • Treatment of relapsed acute myeloid leukemia
    • Kell J. Treatment of relapsed acute myeloid leukemia. Rev Recent Clin Trials. 2006;1:103-11.
    • (2006) Rev Recent Clin Trials , vol.1 , pp. 103-111
    • Kell, J.1
  • 59
    • 67649628149 scopus 로고    scopus 로고
    • Targeted therapy in acute myeloid leukaemia: Current status and future directions
    • Stapnes C, Gjertsen BG, Reikvam H, Bruserud O. Targeted therapy in acute myeloid leukaemia: current status and future directions. Expert Opin Investig Drugs. 2009;18:433-55.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 433-455
    • Stapnes, C.1    Gjertsen, B.G.2    Reikvam, H.3    Bruserud, O.4
  • 60
    • 19944427559 scopus 로고    scopus 로고
    • Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412
    • Stone RM, DeAngelo DJ, Klimek V, et al. Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood. 2005;105:54-60.
    • (2005) Blood , vol.105 , pp. 54-60
    • Stone, R.M.1    Deangelo, D.J.2    Klimek, V.3
  • 61
    • 77952288527 scopus 로고    scopus 로고
    • Lestaurtinib: A multi-targeted FLT3 inhibitor
    • Fathi AT, Levis M. Lestaurtinib: a multi-targeted FLT3 inhibitor. Expert Rev Hematol. 2008;2:17-26.
    • (2008) Expert Rev Hematol , vol.2 , pp. 17-26
    • Fathi, A.T.1    Levis, M.2
  • 62
    • 33751173636 scopus 로고    scopus 로고
    • A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy
    • Knapper S, Burnett AK, Littlewood T, et al. A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. Blood. 2006;108:3262-70.
    • (2006) Blood , vol.108 , pp. 3262-3270
    • Knapper, S.1    Burnett, A.K.2    Littlewood, T.3
  • 63
    • 70449475105 scopus 로고    scopus 로고
    • AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
    • Zarrinkar PP, Gunawardane RN, Cramer MD, et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood. 2009;114:2984-92.
    • (2009) Blood , vol.114 , pp. 2984-2992
    • Zarrinkar, P.P.1    Gunawardane, R.N.2    Cramer, M.D.3
  • 64
    • 77953271584 scopus 로고    scopus 로고
    • Patterns of molecular response to and relapse after combination of sorafenib, idarubicin, and cytarabine in patients with newly diagnosed FLT3-mutant acute myeloid leukemia (AML)
    • Abstract 2079
    • Al-Kali A, Jones D, Cortes J, et al. Patterns of molecular response to and relapse after combination of sorafenib, idarubicin, and cytarabine in patients with newly diagnosed FLT3-mutant acute myeloid leukemia (AML). Blood. 2009;114. Abstract 2079.
    • (2009) Blood , vol.114
    • Al-Kali, A.1    Jones, D.2    Cortes, J.3
  • 65
    • 79955726330 scopus 로고    scopus 로고
    • Sorafenib in combination with standard induction and consolidation therapy in elderly AML patients: Results from a randomized, placebo-controlled phase II trial
    • Serve H, Wagner R, Sauerland C, et al. Sorafenib in combination with standard induction and consolidation therapy in elderly AML patients: results from a randomized, placebo-controlled phase II trial. Blood.2010;116:333.
    • (2010) Blood , vol.116 , pp. 333
    • Serve, H.1    Wagner, R.2    Sauerland, C.3
  • 66
    • 81255127741 scopus 로고    scopus 로고
    • Phase 2B randomized study of CPX-351 vs. cytarabine (CYT) + daunorubicin (DNR) (7 + 3 regimen) in newly diagnosed AML patients aged 60-75. Program and abstracts from the 52nd American Society of Hematology Annual Meeting and Exposition
    • Lancet JE, Cortes JE, Hogge DE, et al. Phase 2B randomized study of CPX-351 vs. cytarabine (CYT) + daunorubicin (DNR) (7 + 3 regimen) in newly diagnosed AML patients aged 60-75. Program and abstracts from the 52nd American Society of Hematology Annual Meeting and Exposition. Blood. 2010;116:655.
    • (2010) Blood , vol.116 , pp. 655
    • Lancet, J.E.1    Cortes, J.E.2    Hogge, D.E.3
  • 67
    • 79960052520 scopus 로고    scopus 로고
    • Frontline therapy for older patients (pts) with acute myeloid leukemia (AML): Clofarabine plus low-dose cytarabine induction followed by prolonged consolidation with clofarabine plus low-dose cytarabine alternating with decitabine
    • Faderl S, Ravandi F, Garcia-Manero G, et al. Frontline therapy for older patients (pts) with acute myeloid leukemia (AML): clofarabine plus low-dose cytarabine induction followed by prolonged consolidation with clofarabine plus low-dose cytarabine alternating with decitabine. Blood. 2010;116:336.
    • (2010) Blood , vol.116 , pp. 336
    • Faderl, S.1    Ravandi, F.2    Garcia-Manero, G.3
  • 68
    • 79955872823 scopus 로고    scopus 로고
    • A phase II study of lenalidomide for previously untreated deletion (del) 5q acute myeloid leukemia (AML) patients age 60 or older who are not candidates for remission induction chemotherapy (Southwest Oncology Group Study S0605)
    • Abstract 332
    • Sekeres MA, Gundacker H, Lancet J, et al. A phase II study of lenalidomide for previously untreated deletion (del) 5q acute myeloid leukemia (AML) patients age 60 or older who are not candidates for remission induction chemotherapy (Southwest Oncology Group Study S0605). Blood. 2010;116. Abstract 332.
    • (2010) Blood , pp. 116
    • Sekeres, M.A.1    Gundacker, H.2    Lancet, J.3
  • 69
    • 79960034446 scopus 로고    scopus 로고
    • Final report of a phase II trial of vorinostat, idarubicin and cytarabine in previously untreated acute myelogenous leukemia (AML) or high risk myelodysplastic syndrome (MDS)
    • Garcia-Manero G, Tambaro FP, Bekele NB, et al. Final report of a phase II trial of vorinostat, idarubicin and cytarabine in previously untreated acute myelogenous leukemia (AML) or high risk myelodysplastic syndrome (MDS). Blood. 2010;116:2189.
    • (2010) Blood , vol.116 , pp. 2189
    • Garcia-Manero, G.1    Tambaro, F.P.2    Bekele, N.B.3
  • 70
    • 70349633604 scopus 로고    scopus 로고
    • A phase 2 study of vorinostat in acute myeloid leukemia
    • Schaefer EW, Loaiza-Bonilla A, Juckett M, et al. A phase 2 study of vorinostat in acute myeloid leukemia. Haematologica. 2009;94:1375-82.
    • (2009) Haematologica , vol.94 , pp. 1375-1382
    • Schaefer, E.W.1    Loaiza-Bonilla, A.2    Juckett, M.3
  • 71
    • 77953283741 scopus 로고    scopus 로고
    • Amonafide L-malate (AS1413) in combination with cytarabine is equally effective in older and younger patients with secondary acute myeloid leukemia (AML): Final data from a phase II study
    • Abstract 1047
    • Erba HP, O'Donnell M, Allen SL, et al. Amonafide L-malate (AS1413) in combination with cytarabine is equally effective in older and younger patients with secondary acute myeloid leukemia (AML): final data from a phase II study. Blood. 2009;114. Abstract 1047.
    • (2009) Blood , vol.114
    • Erba, H.P.1    O'Donnell, M.2    Allen, S.L.3
  • 72
    • 77950992731 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: Results of a multicenter phase 3 study
    • Löwenberg B, Beck J, Graux C, et al. Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: results of a multicenter phase 3 study. Blood. 2010;115:2586-91.
    • (2010) Blood , vol.115 , pp. 2586-2591
    • Löwenberg, B.1    Beck, J.2    Graux, C.3
  • 73
    • 48949096705 scopus 로고    scopus 로고
    • Evaluation of Polo-like kinase 1 inhibition on the G2/M checkpoint in acute myelocytic leukaemia
    • Didier C, Cavelier C, Quaranta M, et al. Evaluation of Polo-like kinase 1 inhibition on the G2/M checkpoint in acute myelocytic leukaemia. Eur J Pharmacol. 2008;591:102-5.
    • (2008) Eur J Pharmacol , vol.591 , pp. 102-105
    • Didier, C.1    Cavelier, C.2    Quaranta, M.3
  • 74
    • 79960055044 scopus 로고    scopus 로고
    • Evaluation of ON01910.Na in patients with a myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) relapsed or refractory to hypomethylating agents: A phase I study
    • Silverman LR, Navada SC, Odchimara-Reissig R, et al. Evaluation of ON01910.Na in patients with a myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) relapsed or refractory to hypomethylating agents: a phase I study. Blood. 2010;116:2944.
    • (2010) Blood , vol.116 , pp. 2944
    • Silverman, L.R.1    Navada, S.C.2    Odchimara-Reissig, R.3
  • 75
    • 45549092335 scopus 로고    scopus 로고
    • Review: Genetic models of acute myeloid leukemia
    • McCormack E, Bruserud O, Gjertsen BT. Review: genetic models of acute myeloid leukemia. Oncogene. 2008;27:3765-79.
    • (2008) Oncogene , vol.27 , pp. 3765-3779
    • McCormack, E.1    Bruserud, O.2    Gjertsen, B.T.3


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