메뉴 건너뛰기




Volumn 46, Issue 8-9, 2009, Pages 1736-1743

Stage specific over-expression of the dominant negative Ikaros 6 reveals distinct role of Ikaros throughout human B-cell differentiation

Author keywords

B lymphocytes; Human hematopoietic differentiation; Ikaros; Lentiviral vectors; Transcription factors; Xeno transplantation

Indexed keywords

CD19 ANTIGEN; IKAROS TRANSCRIPTION FACTOR; IKAROS TRANSCRIPTION FACTOR 6; IMMUNOGLOBULIN M; LENTIVIRUS VECTOR; UNCLASSIFIED DRUG;

EID: 64549083639     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.02.004     Document Type: Article
Times cited : (13)

References (59)
  • 2
    • 0036199657 scopus 로고    scopus 로고
    • PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors
    • DeKoter R.P., Lee H.J., and Singh H. PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors. Immunity 16 (2002) 297-309
    • (2002) Immunity , vol.16 , pp. 297-309
    • DeKoter, R.P.1    Lee, H.J.2    Singh, H.3
  • 4
    • 0027230072 scopus 로고
    • Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene
    • Ernst P., Hahm K., and Smale S.T. Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene. Mol. Cell. Biol. 13 (1993) 2982-2992
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 2982-2992
    • Ernst, P.1    Hahm, K.2    Smale, S.T.3
  • 5
    • 32544437957 scopus 로고    scopus 로고
    • Initiation of pre-B cell receptor signaling: common and distinctive features in human and mouse
    • Espeli M., Rossi B., Mancini S.J., Roche P., Gauthier L., and Schiff C. Initiation of pre-B cell receptor signaling: common and distinctive features in human and mouse. Semin. Immunol. 18 (2006) 56-66
    • (2006) Semin. Immunol. , vol.18 , pp. 56-66
    • Espeli, M.1    Rossi, B.2    Mancini, S.J.3    Roche, P.4    Gauthier, L.5    Schiff, C.6
  • 6
    • 0033966367 scopus 로고    scopus 로고
    • Distinct signals control the hematopoiesis of lymphoid-related dendritic cells
    • Galy A., Christopherson I., Ferlazzo G., Liu G., Spits H., and Georgopoulos K. Distinct signals control the hematopoiesis of lymphoid-related dendritic cells. Blood 95 (2000) 128-137
    • (2000) Blood , vol.95 , pp. 128-137
    • Galy, A.1    Christopherson, I.2    Ferlazzo, G.3    Liu, G.4    Spits, H.5    Georgopoulos, K.6
  • 7
    • 0036519296 scopus 로고    scopus 로고
    • Haematopoietic cell-fate decisions, chromatin regulation and ikaros
    • Georgopoulos K. Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat. Rev. Immunol. 2 (2002) 162-174
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 162-174
    • Georgopoulos, K.1
  • 9
    • 0026451087 scopus 로고
    • Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment
    • Georgopoulos K., Moore D.D., and Derfler B. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science 258 (1992) 808-812
    • (1992) Science , vol.258 , pp. 808-812
    • Georgopoulos, K.1    Moore, D.D.2    Derfler, B.3
  • 10
    • 0028152483 scopus 로고
    • The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene
    • Hahm K., Ernst P., Lo K., Kim G.S., Turck C., and Smale S.T. The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. Mol. Cell. Biol. 14 (1994) 7111-7123
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7111-7123
    • Hahm, K.1    Ernst, P.2    Lo, K.3    Kim, G.S.4    Turck, C.5    Smale, S.T.6
  • 11
    • 0034235797 scopus 로고    scopus 로고
    • Members of the Ikaros gene family are present in early representative vertebrates
    • Haire R.N., Miracle A.L., Rast J.P., and Litman G.W. Members of the Ikaros gene family are present in early representative vertebrates. J. Immunol. 165 (2000) 306-312
    • (2000) J. Immunol. , vol.165 , pp. 306-312
    • Haire, R.N.1    Miracle, A.L.2    Rast, J.P.3    Litman, G.W.4
  • 12
    • 34250205544 scopus 로고    scopus 로고
    • The protean nature of cells in the B lymphocyte lineage
    • Hardy R.R., Kincade P.W., and Dorshkind K. The protean nature of cells in the B lymphocyte lineage. Immunity 26 (2007) 703-714
    • (2007) Immunity , vol.26 , pp. 703-714
    • Hardy, R.R.1    Kincade, P.W.2    Dorshkind, K.3
  • 14
    • 0042243661 scopus 로고    scopus 로고
    • Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model
    • Hiramatsu H., Nishikomori R., Heike T., Ito M., Kobayashi K., Katamura K., and Nakahata T. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model. Blood 102 (2003) 873-880
    • (2003) Blood , vol.102 , pp. 873-880
    • Hiramatsu, H.1    Nishikomori, R.2    Heike, T.3    Ito, M.4    Kobayashi, K.5    Katamura, K.6    Nakahata, T.7
  • 15
    • 37849015433 scopus 로고    scopus 로고
    • The regulation of the B-cell gene expression programme by Pax5
    • Holmes M.L., Pridans C., and Nutt S.L. The regulation of the B-cell gene expression programme by Pax5. Immunol. Cell. Biol. 86 (2008) 47-53
    • (2008) Immunol. Cell. Biol. , vol.86 , pp. 47-53
    • Holmes, M.L.1    Pridans, C.2    Nutt, S.L.3
  • 17
    • 0032560018 scopus 로고    scopus 로고
    • Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors
    • Kelley C.M., Ikeda T., Koipally J., Avitahl N., Wu L., Georgopoulos K., and Morgan B.A. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr. Biol. 8 (1998) 508-515
    • (1998) Curr. Biol. , vol.8 , pp. 508-515
    • Kelley, C.M.1    Ikeda, T.2    Koipally, J.3    Avitahl, N.4    Wu, L.5    Georgopoulos, K.6    Morgan, B.A.7
  • 19
    • 0037189516 scopus 로고    scopus 로고
    • Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression
    • Koipally J., and Georgopoulos K. Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression. J. Biol. Chem. 277 (2002) 23143-23149
    • (2002) J. Biol. Chem. , vol.277 , pp. 23143-23149
    • Koipally, J.1    Georgopoulos, K.2
  • 20
    • 0026710736 scopus 로고
    • The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP
    • Kozmik Z., Wang S., Dorfler P., Adams B., and Busslinger M. The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. Mol. Cell. Biol. 12 (1992) 2662-2672
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 2662-2672
    • Kozmik, Z.1    Wang, S.2    Dorfler, P.3    Adams, B.4    Busslinger, M.5
  • 21
    • 0036811540 scopus 로고    scopus 로고
    • Advances in lentiviral vector design for gene-modification of hematopoietic stem cells
    • Logan A.C., Lutzko C., and Kohn D.B. Advances in lentiviral vector design for gene-modification of hematopoietic stem cells. Curr. Opin. Biotechnol. 13 (2002) 429-436
    • (2002) Curr. Opin. Biotechnol. , vol.13 , pp. 429-436
    • Logan, A.C.1    Lutzko, C.2    Kohn, D.B.3
  • 22
    • 38949178110 scopus 로고    scopus 로고
    • Interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B-cell receptor and promote cell-cycle withdrawal in pre-B-cell development
    • Ma S., Pathak S., Trinh L., and Lu R. Interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B-cell receptor and promote cell-cycle withdrawal in pre-B-cell development. Blood 111 (2008) 1396-1403
    • (2008) Blood , vol.111 , pp. 1396-1403
    • Ma, S.1    Pathak, S.2    Trinh, L.3    Lu, R.4
  • 24
    • 0028019274 scopus 로고
    • The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins
    • Molnar A., and Georgopoulos K. The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol. Cell. Biol. 14 (1994) 8292-8303
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 8292-8303
    • Molnar, A.1    Georgopoulos, K.2
  • 26
    • 3042856076 scopus 로고    scopus 로고
    • Restriction of transgene expression to the B-lymphoid progeny of human lentivirally transduced CD34+ cells
    • Moreau T., Bardin F., Imbert J., Chabannon C., and Tonnelle C. Restriction of transgene expression to the B-lymphoid progeny of human lentivirally transduced CD34+ cells. Mol. Ther. 10 (2004) 45-56
    • (2004) Mol. Ther. , vol.10 , pp. 45-56
    • Moreau, T.1    Bardin, F.2    Imbert, J.3    Chabannon, C.4    Tonnelle, C.5
  • 27
    • 44849103042 scopus 로고    scopus 로고
    • Development of an enhanced B-specific lentiviral vector expressing BTK: a tool for gene therapy of XLA
    • Moreau T., Barlogis V., Bardin F., Nunes J.A., Calmels B., Chabannon C., and Tonnelle C. Development of an enhanced B-specific lentiviral vector expressing BTK: a tool for gene therapy of XLA. Gene Ther. 15 (2008) 942-952
    • (2008) Gene Ther. , vol.15 , pp. 942-952
    • Moreau, T.1    Barlogis, V.2    Bardin, F.3    Nunes, J.A.4    Calmels, B.5    Chabannon, C.6    Tonnelle, C.7
  • 28
    • 0030972497 scopus 로고    scopus 로고
    • Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation
    • Morgan B., Sun L., Avitahl N., Andrikopoulos K., Ikeda T., Gonzales E., Wu P., Neben S., and Georgopoulos K. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 16 (1997) 2004-2013
    • (1997) EMBO J. , vol.16 , pp. 2004-2013
    • Morgan, B.1    Sun, L.2    Avitahl, N.3    Andrikopoulos, K.4    Ikeda, T.5    Gonzales, E.6    Wu, P.7    Neben, S.8    Georgopoulos, K.9
  • 29
    • 2942740853 scopus 로고    scopus 로고
    • Proteins of the Ikaros family control dendritic cell maturation required to induce optimal Th1 T cell differentiation
    • Movassagh M., Laderach D., and Galy A. Proteins of the Ikaros family control dendritic cell maturation required to induce optimal Th1 T cell differentiation. Int. Immunol. 16 (2004) 867-875
    • (2004) Int. Immunol. , vol.16 , pp. 867-875
    • Movassagh, M.1    Laderach, D.2    Galy, A.3
  • 32
    • 36049032122 scopus 로고    scopus 로고
    • Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression
    • Naito T., Gomez-Del Arco P., Williams C.J., and Georgopoulos K. Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression. Immunity 27 (2007) 723-734
    • (2007) Immunity , vol.27 , pp. 723-734
    • Naito, T.1    Gomez-Del Arco, P.2    Williams, C.J.3    Georgopoulos, K.4
  • 33
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini L., Blomer U., Gallay P., Ory D., Mulligan R., Gage F.H., Verma I.M., and Trono D. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272 (1996) 263-267
    • (1996) Science , vol.272 , pp. 263-267
    • Naldini, L.1    Blomer, U.2    Gallay, P.3    Ory, D.4    Mulligan, R.5    Gage, F.H.6    Verma, I.M.7    Trono, D.8
  • 36
    • 0030000729 scopus 로고    scopus 로고
    • Cloning and sequencing of hIk-1, a cDNA encoding a human homologue of mouse Ikaros/LyF-1
    • Nietfeld W., and Meyerhans A. Cloning and sequencing of hIk-1, a cDNA encoding a human homologue of mouse Ikaros/LyF-1. Immunol. Lett. 49 (1996) 139-141
    • (1996) Immunol. Lett. , vol.49 , pp. 139-141
    • Nietfeld, W.1    Meyerhans, A.2
  • 37
    • 0036839069 scopus 로고    scopus 로고
    • Adult acute myeloid leukemia cells do not express nonfunctional Ikaros isoforms
    • Nishii K., Katayama N., and Shiku H. Adult acute myeloid leukemia cells do not express nonfunctional Ikaros isoforms. Blood 100 (2002) 3436-3437
    • (2002) Blood , vol.100 , pp. 3436-3437
    • Nishii, K.1    Katayama, N.2    Shiku, H.3
  • 38
    • 34250212629 scopus 로고    scopus 로고
    • The transcriptional regulation of B cell lineage commitment
    • Nutt S.L., and Kee B.L. The transcriptional regulation of B cell lineage commitment. Immunity 26 (2007) 715-725
    • (2007) Immunity , vol.26 , pp. 715-725
    • Nutt, S.L.1    Kee, B.L.2
  • 42
    • 0035355509 scopus 로고    scopus 로고
    • Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation
    • Sabbattini P., Lundgren M., Georgiou A., Chow C., Warnes G., and Dillon N. Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation. EMBO J. 20 (2001) 2812-2822
    • (2001) EMBO J. , vol.20 , pp. 2812-2822
    • Sabbattini, P.1    Lundgren, M.2    Georgiou, A.3    Chow, C.4    Warnes, G.5    Dillon, N.6
  • 43
    • 0024421220 scopus 로고
    • Isolation of early immunoglobulin lambda-like gene transcripts in human fetal liver
    • Schiff C., Milili M., and Fougereau M. Isolation of early immunoglobulin lambda-like gene transcripts in human fetal liver. Eur. J. Immunol. 19 (1989) 1873-1878
    • (1989) Eur. J. Immunol. , vol.19 , pp. 1873-1878
    • Schiff, C.1    Milili, M.2    Fougereau, M.3
  • 44
    • 0034985720 scopus 로고    scopus 로고
    • Enhanced transgene expression in cord blood CD34(+)-derived hematopoietic cells, including developing T cells and NOD/SCID mouse repopulating cells, following transduction with modified trip lentiviral vectors
    • Sirven A., Ravet E., Charneau P., Zennou V., Coulombel L., Guetard D., Pflumio F., and Dubart-Kupperschmitt A. Enhanced transgene expression in cord blood CD34(+)-derived hematopoietic cells, including developing T cells and NOD/SCID mouse repopulating cells, following transduction with modified trip lentiviral vectors. Mol. Ther. 3 (2001) 438-448
    • (2001) Mol. Ther. , vol.3 , pp. 438-448
    • Sirven, A.1    Ravet, E.2    Charneau, P.3    Zennou, V.4    Coulombel, L.5    Guetard, D.6    Pflumio, F.7    Dubart-Kupperschmitt, A.8
  • 45
    • 0033582324 scopus 로고    scopus 로고
    • Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukaemia
    • Sun L., Heerema N., Crotty L., Wu X., Navara C., Vassilev A., Sensel M., Reaman G.H., and Uckun F.M. Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukaemia. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 680-685
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 680-685
    • Sun, L.1    Heerema, N.2    Crotty, L.3    Wu, X.4    Navara, C.5    Vassilev, A.6    Sensel, M.7    Reaman, G.H.8    Uckun, F.M.9
  • 46
    • 0029831978 scopus 로고    scopus 로고
    • Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development
    • Sun L., Liu A., and Georgopoulos K. Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J. 15 (1996) 5358-5369
    • (1996) EMBO J. , vol.15 , pp. 5358-5369
    • Sun, L.1    Liu, A.2    Georgopoulos, K.3
  • 47
    • 0026048130 scopus 로고
    • A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells
    • Tanaka T., Tsudo M., Karasuyama H., Kitamura F., Kono T., Hatakeyama M., Taniguchi T., and Miyasaka M. A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells. J. Immunol. 147 (1991) 2222-2228
    • (1991) J. Immunol. , vol.147 , pp. 2222-2228
    • Tanaka, T.1    Tsudo, M.2    Karasuyama, H.3    Kitamura, F.4    Kono, T.5    Hatakeyama, M.6    Taniguchi, T.7    Miyasaka, M.8
  • 48
    • 38849128861 scopus 로고    scopus 로고
    • Ikaros enforces the costimulatory requirement for IL2 gene expression and is required for anergy induction in CD4+ T lymphocytes
    • Thomas R.M., Chunder N., Chen C., Umetsu S.E., Winandy S., and Wells A.D. Ikaros enforces the costimulatory requirement for IL2 gene expression and is required for anergy induction in CD4+ T lymphocytes. J. Immunol. 179 (2007) 7305-7315
    • (2007) J. Immunol. , vol.179 , pp. 7305-7315
    • Thomas, R.M.1    Chunder, N.2    Chen, C.3    Umetsu, S.E.4    Winandy, S.5    Wells, A.D.6
  • 50
    • 0031038886 scopus 로고    scopus 로고
    • Pax-5 is identical to EBB-1/KLP and binds to the VpreB and lambda5 promoters as well as the KI and KII sites upstream of the Jkappa genes
    • Tian J., Okabe T., Miyazaki T., Takeshita S., and Kudo A. Pax-5 is identical to EBB-1/KLP and binds to the VpreB and lambda5 promoters as well as the KI and KII sites upstream of the Jkappa genes. Eur. J. Immunol. 27 (1997) 750-755
    • (1997) Eur. J. Immunol. , vol.27 , pp. 750-755
    • Tian, J.1    Okabe, T.2    Miyazaki, T.3    Takeshita, S.4    Kudo, A.5
  • 51
    • 0035525762 scopus 로고    scopus 로고
    • Forced expression of the Ikaros 6 isoform in human placental blood CD34(+) cells impairs their ability to differentiate toward the B-lymphoid lineage
    • Tonnelle C., Bardin F., Maroc C., Imbert A.M., Campa F., Dalloul A., Schmitt C., and Chabannon C. Forced expression of the Ikaros 6 isoform in human placental blood CD34(+) cells impairs their ability to differentiate toward the B-lymphoid lineage. Blood 98 (2001) 2673-2680
    • (2001) Blood , vol.98 , pp. 2673-2680
    • Tonnelle, C.1    Bardin, F.2    Maroc, C.3    Imbert, A.M.4    Campa, F.5    Dalloul, A.6    Schmitt, C.7    Chabannon, C.8
  • 53
    • 0038677916 scopus 로고    scopus 로고
    • Overexpression of dominant-negative Ikaros 6 protein is restricted to a subset of B common adult acute lymphoblastic leukemias that express high levels of the CD34 antigen
    • Tonnelle C., Imbert M.C., Sainty D., Granjeaud S., N'Guyen C., and Chabannon C. Overexpression of dominant-negative Ikaros 6 protein is restricted to a subset of B common adult acute lymphoblastic leukemias that express high levels of the CD34 antigen. Hematol. J. 4 (2003) 104-109
    • (2003) Hematol. J. , vol.4 , pp. 104-109
    • Tonnelle, C.1    Imbert, M.C.2    Sainty, D.3    Granjeaud, S.4    N'Guyen, C.5    Chabannon, C.6
  • 57
    • 0030498975 scopus 로고    scopus 로고
    • Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation
    • Wang J.H., Nichogiannopoulou A., Wu L., Sun L., Sharpe A.H., Bigby M., and Georgopoulos K. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity 5 (1996) 537-549
    • (1996) Immunity , vol.5 , pp. 537-549
    • Wang, J.H.1    Nichogiannopoulou, A.2    Wu, L.3    Sun, L.4    Sharpe, A.H.5    Bigby, M.6    Georgopoulos, K.7
  • 58
    • 0028866897 scopus 로고
    • A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma
    • Winandy S., Wu P., and Georgopoulos K. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 83 (1995) 289-299
    • (1995) Cell , vol.83 , pp. 289-299
    • Winandy, S.1    Wu, P.2    Georgopoulos, K.3
  • 59
    • 0032978712 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
    • Zufferey R., Donello J.E., Trono D., and Hope T.J. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J. Virol. 73 (1999) 2886-2892
    • (1999) J. Virol. , vol.73 , pp. 2886-2892
    • Zufferey, R.1    Donello, J.E.2    Trono, D.3    Hope, T.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.