The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

Molecular and Cellular Biology

Volumn 16, Issue 4, 1996, Pages 1349-1355

  Hiebert, Scott W ^a   Sun, Wuhua ^a   Davis, J Nathan ^a   Golub, Todd ^b,c   Shurtleff, Sheila ^a   Buijs, Arjan ^a   Downing, James R ^a   Grosveld, Gerard ^a   Roussel, Martine F ^a   Gilliland, D Gary ^b,c   Lenny, Noel ^a   Meyers, Shari ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HYBRID PROTEIN; T LYMPHOCYTE RECEPTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; B CELL LYMPHOMA; CARBOXY TERMINAL SEQUENCE; CHROMOSOME TRANSLOCATION 12; DIMERIZATION; DNA BINDING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LEUKEMOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; TRANSACTIVATION;

EID: 9044231364     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.4.1349     Document Type: Article

References (55)

1. Ayer, D. E., Q. A. Lawrence, and R. N. Eisenman. 1995 Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3 Cell 80:767-776.
2. Bae, S. C., Y. Yamaguchi-Iwai, E. Ogawa, M. Maruyama, M. Inuzuka, H. Kagoshima, K. Shigesada, M. Satake, and Y. Ito. 1993. Isolation of PEBP2αB cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. Oncogene 8:809-814.
3. Berger, J., J. Hauber, R. Hauber, R. Geiger, and B. R. Cullen. 1988 Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells. Gene 66:1-10.
4. Chumakov, A. M., D. L. Chen, E. A. Chumankova, and H. P. Koeffler. 1993. Localization of the c-ets-2 transactivation domain. J. Virol. 67:2421-2435.
5. Daga, A., J. E. Tighe, and F. Calabi. 1992. Leukaemia/Drosophila homology. Nature (London) 356:484 (Letter.)
6. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei Nucleic Acids Res. 11:1475-1489.
7. Erickson, P., J. Gao, K. S. Chang, T. Look, E. Whisenant, S. Raimondi, R. Lasher, J. Trujillo, J. Rowlev, and H. Drabkin. 1992. Identification of breakpoints in t(8,21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood 80:1825-1831.
8. Fairman, R., R. K. Beran-Steed, S. J. Anthony-Cahill, J. D. Lear, W. F. Stafford, III, W. F. DeGrado, P. A. Benfield, and S. L. Brenner. 1993. Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides Proc Natl. Acad. Sci USA 90:10429-10433.
9. Feinstein, P. G., K. Kornfeld, D. S. Hogness, and R. S. Mann. 1995. Identification of homeotic target genes in Drosophila melanogaster including nervy, a proto-oncogene homologue Genetics 140:573-586.
10. Giese, K., C. Kingsley, J. R. Kirshner, and R. Grosschedl. 1995. Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions Genes Dev. 9:995-1008.
11. Golub, T., T. McLean, K. Stegmaier, J. Ritz, S. Sallen, D. Neuberg, and D. G. Gilliland. 1995. TEL-AML-1, the most common gene rearrangement in childhood ALL Blood 86(Suppl.):597a.
12. Golub, T. R., G. F. Barker, S. K. Bohlander, S. W. Hiebert, D. C. Ward, P. Bray-Ward, S. C. Raimondi, J. D. Rowley, and D. G. Gilliland. 1995. Fusion of the Tel gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc. Natl. Acad. Sci. USA 92:4917-4921
13. Golub, T. R., G. F. Barker, M. Lovett, and D. G. Gilliland. 1994. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5,12) chromosomal translocation. Cell 77:307-316.
14. Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
15. Gottschalk, L. R., and J. M. Leiden. 1990. Identification and functional characterization of the human T-cell receptor β gene transcriptional enhancer, common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor α and β genes. Mol. Cell. Biol. 10:5486-5495
16. Hajra, A., P. P. Liu, Q. Wang, C. A. Kelley, T. Stacy, R. S. Adelstein, N. A. Speck, and F. S. Collins. 1995. The leukemic core binding factor beta-smooth muscle myosin heavy chain (CBFbeta-SMMHC) chimeric protein requires both CBFbeta and myosin heavy chain domains for transformation of NIH 3T3 cells. Proc. Natl. Acad. Sci. USA 92:1926-1930.
17. Hajra, A., P. P. Lui, N. A. Speck, and F. S. Collins. 1995. Overexpression of core-binding factor α (CBFα) reverses cellular transformation by the CBFβ-smooth muscle myosin heavy chain chimeric oncoprotein. Mol. Cell. Biol. 15:4980-4989.
18. Heldin, C.-H., A. Ernlund, C. Rorsman, and L. Ronnstrand. 1989. Dimerization of B-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation. J. Biol. Chem 264:8905-8912.
19. Hernandez-Munain, C., and M. S. Krangel. 1995. c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer. Mol. Cell. Biol 15:3090-3099.
20. Hiebert, S. W. 1993. Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression. Mol. Cell. Biol. 13:3384-3391.
21. Keleher, C. A., M. J. Redd, J. Schultz, M. Carlson, and A. D. Johnson. 1992 Ssn6-Tup1 is a general repressor of transcription in yeast Cell 68:709-719
22. Lenny, N., S. Meyers, and S. W. Hiebert. 1995 Functional domains of the t(8;21) fusion protein, AML-1/ETO. Oncogene 11:1761-1769.
23. Levanon, D., V. Negreanu, Y. Bernstein, I. Bar-Am, L. Avivi, and Y. Groner. 1994. AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. Genomics 23:425-432.
24. Levine, M., and J. L. Manley. 1989. Transcriptional repression of eukaryotic promoters. Cell 59:405-408.
25. Liu, P., S. A. Tarle, A. Hajra, D. F. Claxton, P. Marlton, M. Freedman, M. J. Siciliano, and F. S. Collins. 1993. Fusion between transcription factor CBFβ/ PEBP2β and a myosin heavy chain in acute myeloid leukemia. Science 261:1041-1044.
26. Melnikova, I. N., B. E. Crute, S. Wang, and N. A. Speck. 1993. Sequence specificity of the core-binding factor. J. Virol. 67:2408-2411
27. Meyers, S., J. R. Downing, and S. W. Hiebert. 1993. Identification of AML-1 and the t(8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Mol. Cell. Biol. 13:6336-6345
28. Meyers, S., and S. W. Hiebert. Direct and indirect alteration of transcriptional regulation in cancer. Crit. Rev. Eukaryotic Gene Expression, in press.
29. Meyers, S., and S. W. Hiebert. 1995. Unpublished data.
30. Meyers, S., N. Lenny, and S. W. Hiebert. 1995. The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol. Cell Biol 15:1974-1982.
31. Meyers, S., N. Lenny, W.-H. Sun, and S. W. Hiebert. Unpublished data.
32. Mitani, K., S. Ogawa, T. Tanaka, H. Miyoshi, M. Kurokawa, H. Mano, Y. Yazaki, M. Ohki, and H. Hirai. 1994 Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J. 13:504-510
33. Miyoshi, H., K. Shimizu, T. Kozu, N. Maseki, Y. Kaneko, and M. Ohki. 1991. t(8,21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl. Acad. Sci. USA 88:10431-10434.
34. Morishita, K., D. S. Parker, M. L. Mucenski, N. A. Jenkins, N. G. Copeland, and J. N. Ihle. 1988 Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell 54:831-840
35. Nisson, P. E., P. C. Watkins, and N. Sacchi. 1992 Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells. Cancer Genet Cytogenet. 63: 81-88.
36. Nucifora, G., C. R. Begy, H. Kobayashi, D. Roulston, D. Claxton, J. Pedersen-Bjergaard, E. Parganas, J. N. Ihle, and J. D. Rowley. 1994 Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations. Proc. Natl. Acad Sci. USA 91:4004-4008.
37. Nucifora, G., D. J. Birn, R. I. Espinosa, P. Erickson, M. M. LeBeau, D. Roulston, T. W. McKeithan, H. Drabkin, and J. D. Rowley. 1993 Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. Blood 81:2728-2734.
38. Ogawa, E., M. Maruyama, H. Kagoshima, M. Inuzuka, J. Lu, M. Satake, K. Shigesada, and Y. Ito. 1993. PEPB2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc. Natl. Acad. Sci. USA 90:6859-6863.
39. Rabbits, T. H. 1991. Translocations, master genes, and differences between the origins of acute and chronic leukemias. Cell 67:641-644.
40. Rabbits, T. H. 1994. Chromosomal translocations in human cancer. Nature (London) 372:143-149.
41. Rao, V. N., T. Ohno, D. D. K. Prasad, G. Bhattacharya, and E. S. P. Reddy. 1993. Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein. Oncogene 8:2167-2173.
42. Romana, S. P., M. Mauchauffe, M. Le Coniat, I. Chumakov, D. Le Paslier, R. Berger, and O. A. Bernard. 1995. The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 85:3662-3670
43. Romana, S. P., H. Poirel, M. Leconiat, M.-A. Flexor, M. Mauchauffe, P. Jonveaux, E. A. Macintyre, R. Berger, and O. A. Bernard. 1995. High frequency of t(12;21) in childhood B lineage acute lymphoblastic leukemia. Blood 86:4263-4269.
44. Rubin, C. M., R. A. Larson, J. Anastasi, J. N. Winter, M. Thangavelu, J. W. Vardiman, J. D. Rowley, and M. M. LeBeau. 1990. t(3;21)(q26;q22) translocation: a recurring chromosomal abnormality in therapy-related myelodysplastic syndrome and acute myeloid leukemia. Blood 76:2594-2598.
45. Sacchi, N., P. E. Nisson, P. C. Watkins, F. Faustinella, J. Wijsman, and A. Hagemeijer. 1994. AML1 fusion transcripts in t(3;21) positive leukemia, evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts. Genes Chromosomes Cancer 11:226-236.
46. Schneikert, J., Y. Lutz, and B. Wasylyk. 1992. Two independent activation domains in c-Ets-1 and c-Ets-2 located in non-conserved sequences of the ets gene family. Oncogene 7:249-256.
47. Shurtleff, S. A., A. Buijs, F. G. Behm, J. E. Rubnitz, S. C. Raimondi, M. L. Hancock, G. C.-F. Chan, C.-H. Pui, G. Grosveld, and J. R. Downing. 1995. Tel/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia 9:1985-1989.
48. Speck, N. A. PEBP2/CBF, a new transcription factor family associated with human acute myeloid leukemias. Crit. Rev. Eukaryotic Gene Expression, in press.
49. Tanaka, T., K. Mitani, M. Kurokawa, S. Ogawa, K. Tanaka, J. Nishida, Y. Yazaki, Y. Shibata, and H. Hirai. 1995. Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias Mol. Cell. Biol. 15:2383-2392.
50. The, S. M., X. Xie, F. Smyth, T. S. Papas, D. K. Watson, and R. A. Schulz. 1992. Molecular characterization and structural organization of D-elg, an ets proto-oncogene-related gene of Drosophila. Oncogene 7:2471-2478.
51. Vidal, M., R. Strich, R. E. Exposito, and R. F. Gaber. 1991. RPD1 (SIN3/ UME4) is required for maximal activation and repression of diverse yeast genes Mol. Cell. Biol 11:6306-6316.
52. Wang, H., and D. J. Stillman. 1993. Transcriptional repression in Saccharomyces cerevisiae by a Sin3-LexA fusion protein. Mol. Cell Biol 13:1805-1814.
53. Wang, S., Q. Wang, B. E. Crute, I. N. Melnikova, S. R. Keller, and N. A. Speck. 1993. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. EMBO J 13:3324-3339.
54. Wotton, D., J. Ghysdael, S. Wang, N. A. Speck, and M. J. Owen. 1994. Cooperative binding of ets-1 and core binding factor to DNA. Mol Cell. Biol. 14:840-850
55. Zhang, D.-E., C. J. Hetherington, S. Meyers, K. L. Rhoades, C. J. Larson, H.-M. Chen, S.W. Hiebert, and D. G. Tenen. 1996 CCAAT enhancer-binding protein (C/EBP) and AML1 (CBFα2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol. Cell. Biol. 16:1231-1240.