메뉴 건너뛰기




Volumn 113, Issue 18, 2009, Pages 4381-4390

Structure of the Notch1-negative regulatory region: Implications for normal activation and pathogenic signaling in T-ALL

Author keywords

[No Author keywords available]

Indexed keywords

HETERODIMER; NOTCH1 RECEPTOR; LUCIFERASE; NOTCH1 PROTEIN, HUMAN; NOTCH2 PROTEIN, HUMAN; NOTCH2 RECEPTOR;

EID: 66149151737     PISSN: 00064971     EISSN: 15280020     Source Type: None    
DOI: 10.1182/blood-2008-08-174748     Document Type: Article
Times cited : (137)

References (50)
  • 1
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: A simple pathway becomes complex
    • Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol. 2006;7: 678-689.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 678-689
    • Bray, S.J.1
  • 2
    • 0030877659 scopus 로고    scopus 로고
    • Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
    • DOI 10.1016/S0092-8674(00)80336-0
    • Blaumueller CM, Qi H, Zagouras P, Artavanis- Tsakonas S. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell. 1997;90:281-291. (Pubitemid 27329713)
    • (1997) Cell , vol.90 , Issue.2 , pp. 281-291
    • Blaumueller, C.M.1    Qi, H.2    Zagouras, P.3    Artavanis-Tsakonas, S.4
  • 5
    • 6344251643 scopus 로고    scopus 로고
    • Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats
    • DOI 10.1128/MCB.24.21.9265-9273.2004
    • Sanchez-Irizarry C, Carpenter AC, Weng AP, Pear WS, Aster JC, Blacklow SC. Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol Cell Biol. 2004;24:9265-9273. (Pubitemid 39391665)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.21 , pp. 9265-9273
    • Sanchez-Irizarry, C.1    Carpenter, A.C.2    Weng, A.P.3    Pear, W.S.4    Aster, J.C.5    Blacklow, S.C.6
  • 6
    • 0025277746 scopus 로고
    • Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
    • DOI 10.1016/0092-8674(90)90534-L
    • Fehon R, Kooh P, Rebay I, et al. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell. 1990;61:523-534. (Pubitemid 20169007)
    • (1990) Cell , vol.61 , Issue.3 , pp. 523-534
    • Fehon, R.G.1    Kooh, P.J.2    Rebay, I.3    Regan, C.L.4    Xu, T.5    Muskavitch, M.A.T.6    Artavanis-Tsakonas, S.7
  • 8
    • 0033867521 scopus 로고    scopus 로고
    • A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
    • Mumm JS, Schroeter EH, Saxena MT, et al. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol Cell. 2000;5:197-206.
    • (2000) Mol Cell , vol.5 , pp. 197-206
    • Mumm, J.S.1    Schroeter, E.H.2    Saxena, M.T.3
  • 10
    • 0041355557 scopus 로고    scopus 로고
    • Notch and Presenilin: Regulated intramembrane proteolysis links development and degeneration
    • DOI 10.1146/annurev.neuro.26.041002.131334
    • Selkoe D, Kopan R. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu Rev Neurosci. 2003;26:565-597. (Pubitemid 37064944)
    • (2003) Annual Review of Neuroscience , vol.26 , pp. 565-597
    • Selkoe, D.1    Kopan, R.2
  • 11
    • 0033535508 scopus 로고    scopus 로고
    • Presenilin is required for activity and nuclear access of Notch in Drosophila
    • Struhl G, Greenwald I. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature. 1999;398:522-525. (Pubitemid 129523591)
    • (1999) Nature , vol.398 , Issue.6727 , pp. 522-525
    • Struhl, G.1    Greenwald, I.2
  • 14
    • 33644749306 scopus 로고    scopus 로고
    • Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
    • DOI 10.1016/j.cell.2005.12.037, PII S009286740600122X
    • Nam Y, Sliz P, Song L, Aster JC, Blacklow SC. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 2006;124:973-983. (Pubitemid 43344237)
    • (2006) Cell , vol.124 , Issue.5 , pp. 973-983
    • Nam, Y.1    Sliz, P.2    Song, L.3    Aster, J.C.4    Blacklow, S.C.5
  • 15
    • 0032574993 scopus 로고    scopus 로고
    • Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
    • DOI 10.1038/30756
    • Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature. 1998;393: 382-386. (Pubitemid 28269713)
    • (1998) Nature , vol.393 , Issue.6683 , pp. 382-386
    • Schroeter, E.H.1    Kisslinger, J.A.2    Kopan, R.3
  • 16
    • 33644761961 scopus 로고    scopus 로고
    • Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA
    • Wilson JJ, Kovall RA. Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell. 2006;124:985-996.
    • (2006) Cell , vol.124 , pp. 985-996
    • Wilson, J.J.1    Kovall, R.A.2
  • 17
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    • Ellisen LW, Bird J, West DC, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell. 1991;66:649-661. (Pubitemid 121001701)
    • (1991) Cell , vol.66 , Issue.4 , pp. 649-661
    • Ellisen, L.W.1    Bird, J.2    West, D.C.3    Soreng, A.L.4    Reynolds, T.C.5    Smith, S.D.6    Sklar, J.7
  • 19
    • 33747155025 scopus 로고    scopus 로고
    • Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia
    • DOI 10.1182/blood-2005-12-4956
    • Breit S, Stanulla M, Flohr T, et al. Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia. Blood. 2006;108:1151-1157. (Pubitemid 44232009)
    • (2006) Blood , vol.108 , Issue.4 , pp. 1151-1157
    • Breit, S.1    Stanulla, M.2    Flohr, T.3    Schrappe, M.4    Ludwig, W.-D.5    Tolle, G.6    Happich, M.7    Muckenthaler, M.U.8    Kulozik, A.E.9
  • 20
    • 42149109062 scopus 로고    scopus 로고
    • In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia
    • De Keersmaecker K, Lahortiga I, Mentens N, et al. In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia. Haematologica. 2008;93: 533-542.
    • (2008) Haematologica , vol.93 , pp. 533-542
    • De Keersmaecker, K.1    Lahortiga, I.2    Mentens, N.3
  • 22
    • 33644523406 scopus 로고    scopus 로고
    • High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia [12]
    • DOI 10.1038/sj.leu.2404101, PII 2404101
    • Mansour MR, Linch DC, Foroni L, Goldstone AH, Gale RE. High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia. Leukemia. 2006;20:537-539. (Pubitemid 43291764)
    • (2006) Leukemia , vol.20 , Issue.3 , pp. 537-539
    • Mansour, M.R.1    Linch, D.C.2    Foroni, L.3    Goldstone, A.H.4    Gale, R.E.5
  • 23
    • 50949118936 scopus 로고    scopus 로고
    • NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL
    • Sulis ML, Williams O, Palomero T, et al. NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL. Blood. 2008;112:733-740.
    • (2008) Blood , vol.112 , pp. 733-740
    • Sulis, M.L.1    Williams, O.2    Palomero, T.3
  • 24
    • 33744812702 scopus 로고    scopus 로고
    • NOTCH1 mutations in T-cell acute lymphoblastic leukemia: Prognostic significance and implication in multifactorial leukemogenesis
    • Zhu YM, Zhao WL, Fu JF, et al. NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis. Clin Cancer Res. 2006; 12:3043-3049.
    • (2006) Clin Cancer Res , vol.12 , pp. 3043-3049
    • Zhu, Y.M.1    Zhao, W.L.2    Fu, J.F.3
  • 29
    • 70449332853 scopus 로고    scopus 로고
    • Accessed August 2008
    • National Center for Biotechnology Information. GenBank. http://www.ncbi.nlm.nih.gov/Genbank. Accessed August 2008.
    • GenBank
  • 30
    • 0031059866 scopus 로고    scopus 로고
    • Processing of X-ray diffraction data collected in oscillation mode
    • DOI 10.1016/S0076-6879(97)76066-X
    • Otwinowsk Z, Minor W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 1997;276:307-326. (Pubitemid 27085611)
    • (1997) Methods in Enzymology , vol.276 , pp. 307-326
    • Otwinowski, Z.1    Minor, W.2
  • 35
    • 0033824470 scopus 로고    scopus 로고
    • DaliLite workbench for protein structure comparison
    • Holm L, Park J. DaliLite workbench for protein structure comparison. Bioinformatics. 2000;16: 566-567.
    • (2000) Bioinformatics , vol.16 , pp. 566-567
    • Holm, L.1    Park, J.2
  • 36
    • 34548232365 scopus 로고    scopus 로고
    • Inference of Macromolecular Assemblies from Crystalline State
    • DOI 10.1016/j.jmb.2007.05.022, PII S0022283607006420
    • Krissinel E, Henrick K. Inference of macromolecular assemblies from crystalline state. J Mol Biol. 2007;372:774-797. (Pubitemid 47321791)
    • (2007) Journal of Molecular Biology , vol.372 , Issue.3 , pp. 774-797
    • Krissinel, E.1    Henrick, K.2
  • 37
  • 38
    • 0033796150 scopus 로고    scopus 로고
    • Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by Notch1
    • DOI 10.1128/MCB.20.20.7505-7515.2000
    • Aster JC, Xu L, Karnell FG, Patriub V, Pui JC, Pear WS. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1. Mol Cell Biol. 2000;20:7505-7515. (Pubitemid 30736875)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.20 , pp. 7505-7515
    • Aster, J.C.1    Xu, L.2    Karnell, F.G.3    Patriub, V.4    Pui, J.C.5    Pear, W.S.6
  • 39
    • 84870649266 scopus 로고    scopus 로고
    • Research Collaboratory for Structural Bioinformatics. Protein Data Bank. http://www.rcsb.org/pdb.
    • Protein Data Bank
  • 40
    • 55449135598 scopus 로고    scopus 로고
    • The molecular logic of Notch signaling: A structural and biochemical perspective
    • Gordon WR, Arnett KL, Blacklow SC. The molecular logic of Notch signaling: a structural and biochemical perspective. J Cell Sci. 2008;121: 3109-3119.
    • (2008) J Cell Sci , vol.121 , pp. 3109-3119
    • Gordon, W.R.1    Arnett, K.L.2    Blacklow, S.C.3
  • 41
    • 84887158108 scopus 로고    scopus 로고
    • Accessed July 2008
    • European Bioinformatics Institute. ClustalW. http://www.ebi.ac.uk/Tools/ clustalw2/index.html. Accessed July 2008.
    • ClustalW
  • 42
    • 30044448792 scopus 로고    scopus 로고
    • Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin
    • DOI 10.1038/nsmb1035
    • Macao B, Johansson DGA, Hansson GC, Hard T. Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin. Nat Struct Mol Biol. 2006;13:71-76. (Pubitemid 43049405)
    • (2006) Nature Structural and Molecular Biology , vol.13 , Issue.1 , pp. 71-76
    • Macao, B.1    Johansson, D.G.A.2    Hansson, G.C.3    Hard, T.4
  • 44
    • 18544377013 scopus 로고    scopus 로고
    • The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression
    • DOI 10.1111/j.1742-4658.2005.04653.x
    • Maris C, Dominguez C, Allain FH. The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression. FEBS J. 2005;272:2118-2131. (Pubitemid 40655326)
    • (2005) FEBS Journal , vol.272 , Issue.9 , pp. 2118-2131
    • Maris, C.1    Dominguez, C.2    Allain, F.H.-T.3
  • 45
    • 41949112734 scopus 로고    scopus 로고
    • Structure of the mature ectodomain of the human receptortype protein-tyrosine phosphatase IA-2
    • Primo ME, Klinke S, Sica MP, et al. Structure of the mature ectodomain of the human receptortype protein-tyrosine phosphatase IA-2. J Biol Chem. 2008;283:4674-4681.
    • (2008) J Biol Chem , vol.283 , pp. 4674-4681
    • Primo, M.E.1    Klinke, S.2    Sica, M.P.3
  • 46
    • 10944258798 scopus 로고    scopus 로고
    • Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization
    • DOI 10.1074/jbc.M409430200
    • Vooijs M, Schroeter EH, Pan Y, Blandford M, Kopan R. Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol Chem. 2004;279:50864-50873. (Pubitemid 40017825)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.49 , pp. 50864-50873
    • Vooijs, M.1    Schroeter, E.H.2    Pan, Y.3    Blandford, M.4    Kopan, R.5
  • 47
    • 33846968807 scopus 로고    scopus 로고
    • DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur
    • DOI 10.1083/jcb.200609014
    • Nichols JT, Miyamoto A, Olsen SL, D'Souza B, Yao C, Weinmaster G. DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur. J Cell Biol. 2007;176:445-458. (Pubitemid 46257272)
    • (2007) Journal of Cell Biology , vol.176 , Issue.4 , pp. 445-458
    • Nichols, J.T.1    Miyamoto, A.2    Olsen, S.L.3    D'Souza, B.4    Yao, C.5    Weinmaster, G.6
  • 48
    • 0034051852 scopus 로고    scopus 로고
    • Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
    • Parks AL, Klueg KM, Stout JR, Muskavitch MA. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development. 2000;127:1373-1385. (Pubitemid 30232589)
    • (2000) Development , vol.127 , Issue.7 , pp. 1373-1385
    • Parks, A.L.1    Klueg, K.M.2    Stout, J.R.3    Muskavitch, M.A.T.4
  • 50
    • 43149113910 scopus 로고    scopus 로고
    • Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3
    • Li K, Li Y, Wu W, et al. Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. J Biol Chem. 2008;283:8046-8054.
    • (2008) J Biol Chem , vol.283 , pp. 8046-8054
    • Li, K.1    Li, Y.2    Wu, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.