Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

Nature Genetics

Volumn 42, Issue 6, 2010, Pages 530-535

  Kleppe, Maria ^a,b   Lahortiga, Idoya ^a,b   El Chaar, Tiama ^c   De Keersmaecker, Kim ^a,b,d   Mentens, Nicole ^a,b   Graux, Carlos ^e   Van Roosbroeck, Katrien ^a,b   Ferrando, Adolfo A ^d   Langerak, Anton W ^f   Meijerink, Jules P P ^g   Sigaux, François ^c   Haferlach, Torsten ^h   Wlodarska, Iwona ^b   Vandenberghe, Peter ^b   Soulier, Jean ^c   Cools, Jan ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c Institut Universitaire d'Hématologie   (France)

^d NewYork Presbyterian Hospital   (United States)

^e UNIVERSITY HOSPITAL OF MONT GODINNE   (Belgium)

^f ERASMUS MEDICAL CENTER   (Netherlands)

^g SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^h MLL MUNICH LEUKEMIA LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; GAMMA INTERFERON; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; IMATINIB; INTERLEUKIN 2; INTERLEUKIN 7; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; STAT1 PROTEIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TLX1; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CHILD; COMPARATIVE GENOMIC HYBRIDIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL LINE; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SCHOOL CHILD; T CELL LEUKEMIA; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL LINE; CELL LINE, TUMOR; CHEMOKINE CCL1; GENE DELETION; GENE KNOCKDOWN TECHNIQUES; HOMEODOMAIN PROTEINS; HUMANS; INTERLEUKIN-2; INTERLEUKIN-7; LEUKEMIA, EXPERIMENTAL; MICE; PIPERAZINES; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 2; PROTO-ONCOGENE PROTEINS; PYRIMIDINES;

EID: 77952887619     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.587     Document Type: Article

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