Brief report: Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)

Blood

Volumn 109, Issue 6, 2007, Pages 2327-2330

  Moorman, Anthony V ^a   Richards, Susan M ^b   Robinson, Hazel M ^a   Strefford, Jon C ^a   Gibson, Brenda E S ^c   Kinsey, Sally E ^d   Eden, Tim O B ^e   Vora, Ajay J ^f   Mitchell, Christopher D ^g   Harrison, Christine J ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c NHS GREATER GLASGOW AND CLYDE   (United Kingdom)

^d ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

^f SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

^g JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BONE MARROW TRANSPLANTATION; CHILD; CHROMOSOME 21; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; FEMALE; GENE AMPLIFICATION; HUMAN; INTRACHROMOSOMAL AMPLIFICATION OF CHROMOSOME 21; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECURRENT DISEASE; RISK FACTOR; ACUTE LYMPHOCYTIC LEUKEMIA; CYTOGENETICS; GENETICS; INFANT; PATHOLOGY; PRESCHOOL CHILD; PROGNOSIS; SURVIVAL RATE;

CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 21; CYTOGENETICS; FEMALE; GENE AMPLIFICATION; HUMANS; INFANT; LEUKEMIA, LYMPHOCYTIC, ACUTE; MALE; PROGNOSIS; SURVIVAL RATE;

EID: 33947257508     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-08-040436     Document Type: Article

References (9)

1. Harewood L, Robinson H, Harris R, et al. Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases. Leukemia. 2003;17:547-553.
2. Robinson HM, Broadfield ZJ, Cheung KL, et al. Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome. Leukemia. 2003;17:2249-2250.
3. Strefford JC, van Delft FW, Robinson HM, et al. Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. Proc Natl Acad Sci U S A. 2006;103:8167-8172.
4. Mitchell CD, Richards SM, Kinsey SE, et al. Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial. Br J Haematol. 2005;129:734-745.
5. Schrappe M, Reiter A, Zimmermann M, et al. Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Leukemia. 2000;14:2205-2222.
6. Harrison CJ, Martineau M, Secker-Walker LM. The Leukaemia Research Fund/United Kingdom Cancer Cytogenetics Group karyotype database in acute lymphoblastic leukaemia: a valuable resource for patient management. Br J Haematol. 2001;113:3-10.
7. Harrison CJ, Moorman AV, Barber KE, et al. Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study. Br J Haematol. 2005;129:520-530.
8. Soulier J, Trakhtenbrot L, Najfeld V, et al. Amplification of band q22 of chromosome 21, including AML1, in older children with acute lymphoblastic leukemia: an emerging molecular cytogenetic subgroup. Leukemia. 2003;17:1679-1682.
9. Vora AJ, Mitchell CD, Goulden NJ, et al. Medical Research Council (MRC) Working Party on Leukaemia in Children: UK National Randomised Trial for Children and Young Adults with Acute Lymphoblastic Leukaemia (ALL)-UKALL 2003. http://www.ctsu.ox.ac.uk/projects/leuk/ukall2003/2003.