메뉴 건너뛰기




Volumn 27, Issue 31, 2009, Pages 5202-5207

IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: A GIMEMA AL WP report

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; BCR ABL1 PROTEIN; IKAROS TRANSCRIPTION FACTOR; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; IKZF1 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR;

EID: 70449719091     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2008.21.6408     Document Type: Article
Times cited : (262)

References (27)
  • 1
    • 72849159485 scopus 로고
    • Chromosome studies on normal and leukemic human leukocytes
    • Nowell PC, Hungerford DA: Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst 25:85-109, 1960
    • (1960) J Natl Cancer Inst , vol.25 , pp. 85-109
    • Nowell, P.C.1    Hungerford, D.A.2
  • 2
    • 0033616908 scopus 로고    scopus 로고
    • Estimation of failure probabilities in the presence of competing risks: New representations of old estimators
    • Gooley TA, Leisenring W, Crowley J, et al: Estimation of failure probabilities in the presence of competing risks: New representations of old estimators. Stat Med 18:695-706, 1999
    • (1999) Stat Med , vol.18 , pp. 695-706
    • Gooley, T.A.1    Leisenring, W.2    Crowley, J.3
  • 3
    • 0021346853 scopus 로고
    • Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
    • Groffen J, Stephenson JR, Heisterkamp N, et al: Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 36:93-99, 1984
    • (1984) Cell , vol.36 , pp. 93-99
    • Groffen, J.1    Stephenson, J.R.2    Heisterkamp, N.3
  • 4
    • 0023105320 scopus 로고
    • A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia
    • Chan LC, Karhi KK, Rayter SI, et al: A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia. Nature 325: 635-637, 1987
    • (1987) Nature , vol.325 , pp. 635-637
    • Chan, L.C.1    Karhi, K.K.2    Rayter, S.I.3
  • 5
    • 0023133732 scopus 로고
    • Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from Ph1-positive ALL
    • Clark SS, McLaughlin J, Crist WM, et al: Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from Ph1-positive ALL. Science 235:85-88, 1987
    • (1987) Science , vol.235 , pp. 85-88
    • Clark, S.S.1    McLaughlin, J.2    Crist, W.M.3
  • 6
    • 0032916258 scopus 로고    scopus 로고
    • Control of lymphocyte development by the Ikaros gene family
    • Cortes M, Wong E, Koipally J, et al: Control of lymphocyte development by the Ikaros gene family. Curr Opin Immunol 11:167-171, 1999
    • (1999) Curr Opin Immunol , vol.11 , pp. 167-171
    • Cortes, M.1    Wong, E.2    Koipally, J.3
  • 7
    • 34247359952 scopus 로고    scopus 로고
    • Imatinib plus steroids induces complete remissions and prolonged survival in elderly Philadelphia chromosomepositive patients with acute lymphoblastic leukemia without additional chemotherapy: Results of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) LAL0201-B protocol
    • Vignetti M, Fazi P, Cimino G, et al: Imatinib plus steroids induces complete remissions and prolonged survival in elderly Philadelphia chromosomepositive patients with acute lymphoblastic leukemia without additional chemotherapy: Results of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) LAL0201-B protocol. Blood 109:3676-3678, 2007
    • (2007) Blood , vol.109 , pp. 3676-3678
    • Vignetti, M.1    Fazi, P.2    Cimino, G.3
  • 8
    • 41349083969 scopus 로고    scopus 로고
    • Nilotinib (formerly AMN107), a highly selective BCRABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant acceleratedphase chronic myelogenous leukemia
    • le Coutre P, Ottmann OG, Giles F, et al: Nilotinib (formerly AMN107), a highly selective BCRABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant acceleratedphase chronic myelogenous leukemia. Blood 111: 1834-1839, 2008
    • (2008) Blood , vol.111 , pp. 1834-1839
    • le Coutre, P.1    Ottmann, O.G.2    Giles, F.3
  • 9
    • 34548744667 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors for the treatment of Philadelphia chromosome-positive adult acute lymphoblastic leukemia
    • Piccaluga PP, Paolini S, Martinelli G: Tyrosine kinase inhibitors for the treatment of Philadelphia chromosome-positive adult acute lymphoblastic leukemia. Cancer 110:1178-1186, 2007
    • (2007) Cancer , vol.110 , pp. 1178-1186
    • Piccaluga, P.P.1    Paolini, S.2    Martinelli, G.3
  • 10
    • 34948829146 scopus 로고    scopus 로고
    • Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: Interim results of a phase 2 study
    • Ottmann O, Dombret H, Martinelli G, et al: Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: Interim results of a phase 2 study. Blood 110:2309-2315, 2007
    • (2007) Blood , vol.110 , pp. 2309-2315
    • Ottmann, O.1    Dombret, H.2    Martinelli, G.3
  • 11
    • 0036950191 scopus 로고    scopus 로고
    • Imatinib in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia: Current status and evolving concepts
    • Ottmann OG, Wassmann B: Imatinib in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia: Current status and evolving concepts. Best Pract Res Clin Haematol 15:757-769, 2002
    • (2002) Best Pract Res Clin Haematol , vol.15 , pp. 757-769
    • Ottmann, O.G.1    Wassmann, B.2
  • 12
    • 36248953960 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia with Philadelphia chromosome: Treatment with kinase inhibitors
    • Thomas X: Acute lymphoblastic leukemia with Philadelphia chromosome: Treatment with kinase inhibitors. Bull Cancer 94:871-880, 2007
    • (2007) Bull Cancer , vol.94 , pp. 871-880
    • Thomas, X.1
  • 13
    • 20244387988 scopus 로고    scopus 로고
    • Significant reduction of the hybrid BCR/ABL transcripts after induction and consolidation therapy is a powerful predictor of treatment response in adult Philadelphia-positive acute lymphoblastic leukemia
    • Pane F, Cimino G, Izzo B, et al: Significant reduction of the hybrid BCR/ABL transcripts after induction and consolidation therapy is a powerful predictor of treatment response in adult Philadelphia-positive acute lymphoblastic leukemia. Leukemia 19:628-635, 2005
    • (2005) Leukemia , vol.19 , pp. 628-635
    • Pane, F.1    Cimino, G.2    Izzo, B.3
  • 14
    • 43049139905 scopus 로고    scopus 로고
    • BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
    • Mullighan CG, Miller CB, Radtke I, et al: BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 453:110-114, 2008
    • (2008) Nature , vol.453 , pp. 110-114
    • Mullighan, C.G.1    Miller, C.B.2    Radtke, I.3
  • 15
    • 58749109707 scopus 로고    scopus 로고
    • Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia
    • Mullighan CG, Su X, Zhang J, et al: Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 360:470-480, 2009
    • (2009) N Engl J Med , vol.360 , pp. 470-480
    • Mullighan, C.G.1    Su, X.2    Zhang, J.3
  • 16
    • 0028001362 scopus 로고
    • The Ikaros gene is required for the development of all lymphoid lineages
    • Georgopoulos K, Bigby M, Wang JH, et al: The Ikaros gene is required for the development of all lymphoid lineages. Cell 79:143-156, 1994
    • (1994) Cell , vol.79 , pp. 143-156
    • Georgopoulos, K.1    Bigby, M.2    Wang, J.H.3
  • 17
    • 0030044364 scopus 로고    scopus 로고
    • The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse
    • Molnár A, Wu P, Largespada DA, et al: The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. J Immunol 156: 585-592, 1996
    • (1996) J Immunol , vol.156 , pp. 585-592
    • Molnár, A.1    Wu, P.2    Largespada, D.A.3
  • 19
    • 0037544006 scopus 로고    scopus 로고
    • A complex network of regulatory elements in Ikaros and their activity during hemo-lymphopoiesis
    • Kaufmann C, Yoshida T, Perotti EA, et al: A complex network of regulatory elements in Ikaros and their activity during hemo-lymphopoiesis. Embo J 22:2211-2223, 2003
    • (2003) Embo J , vol.22 , pp. 2211-2223
    • Kaufmann, C.1    Yoshida, T.2    Perotti, E.A.3
  • 20
    • 55749102434 scopus 로고    scopus 로고
    • Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: Implications for a new mechanism of resistance
    • Iacobucci I, Lonetti A, Messa F, et al: Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: Implications for a new mechanism of resistance. Blood 112:3847-3855, 2008
    • (2008) Blood , vol.112 , pp. 3847-3855
    • Iacobucci, I.1    Lonetti, A.2    Messa, F.3
  • 21
    • 57349111824 scopus 로고    scopus 로고
    • Highresolution genomic profiling of Ph-positive acute lymphoblastic leukaemia (ALL) identified recurrent copy number anomalies in genes regulating the cell cycle and the B-cell differentiation
    • abstr
    • Iacobucci I, Ottaviani E, Astolfi A, et al: Highresolution genomic profiling of Ph-positive acute lymphoblastic leukaemia (ALL) identified recurrent copy number anomalies in genes regulating the cell cycle and the B-cell differentiation. Haematologica 93:1084, 2008 (abstr)
    • (2008) Haematologica , vol.93 , pp. 1084
    • Iacobucci, I.1    Ottaviani, E.2    Astolfi, A.3
  • 22
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan E, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.1    Meier, P.2
  • 23
    • 70349242044 scopus 로고    scopus 로고
    • Iacobucci I, Storlazzi C, Cilloni D, et al: Identification and molecular characterisation of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukaemia patients: On behalf of GIMEMA ALL WP. Blood 10.1182/blood-2008-08-173963 [epub ahead of print on July 9, 2009]
    • Iacobucci I, Storlazzi C, Cilloni D, et al: Identification and molecular characterisation of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukaemia patients: On behalf of GIMEMA ALL WP. Blood 10.1182/blood-2008-08-173963 [epub ahead of print on July 9, 2009]
  • 24
    • 27644566271 scopus 로고    scopus 로고
    • Dual tyrosine kinase inhibitors in chronic myeloid leukemia
    • Martinelli G, Soverini S, Rosti G, et al: Dual tyrosine kinase inhibitors in chronic myeloid leukemia. Leukemia 19:1872-1879, 2005
    • (2005) Leukemia , vol.19 , pp. 1872-1879
    • Martinelli, G.1    Soverini, S.2    Rosti, G.3
  • 25
    • 0141675132 scopus 로고    scopus 로고
    • The biology and therapy of adult acute lymphoblastic leukemia
    • Faderl S, Jeha S, Kantarjian HM: The biology and therapy of adult acute lymphoblastic leukemia. Cancer 98:1337-1354, 2003
    • (2003) Cancer , vol.98 , pp. 1337-1354
    • Faderl, S.1    Jeha, S.2    Kantarjian, H.M.3
  • 26
    • 33646922044 scopus 로고    scopus 로고
    • Hematopoiesis flies high with Ikaros
    • Smale ST, Dorshkind K: Hematopoiesis flies high with Ikaros. Nat Immunol 7:367-369, 2006
    • (2006) Nat Immunol , vol.7 , pp. 367-369
    • Smale, S.T.1    Dorshkind, K.2
  • 27
    • 12144291320 scopus 로고    scopus 로고
    • Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition
    • Gomez-del Arco P, Maki K, Georgopoulos K: Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition. Mol Cell Biol 24:2797-2807, 2004
    • (2004) Mol Cell Biol , vol.24 , pp. 2797-2807
    • Gomez-del Arco, P.1    Maki, K.2    Georgopoulos, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.