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Volumn 14, Issue 4, 2014, Pages 509-527

Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine

Author keywords

Apoptosis; CASMER; Death receptor; Edelfosine; Endoplasmic reticulum stress; Ether phospholipid; Lipid rafts; Mitochondria

Indexed keywords

DEATH RECEPTOR; EDELFOSINE; EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; RAF PROTEIN;

EID: 84908121687     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520614666140309222259     Document Type: Article
Times cited : (57)

References (216)
  • 1
    • 0025177753 scopus 로고
    • Antitumoral and other biomedical activities of synthetic ether lysophospholipids
    • Munder, P.G.; Westphal, O. Antitumoral and other biomedical activities of synthetic ether lysophospholipids. Chem. Immunol., 1990, 49, 206-235.
    • (1990) Chem. Immunol , vol.49 , pp. 206-235
    • Munder, P.G.1    Westphal, O.2
  • 2
    • 0036783411 scopus 로고    scopus 로고
    • Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH3 (edelfosine), a proapoptotic agent in tumor cells
    • Gajate, C.; Mollinedo, F. Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH3 (edelfosine), a proapoptotic agent in tumor cells. Curr. Drug Metab., 2002, 3, 491-525.
    • (2002) Curr. Drug Metab , vol.3 , pp. 491-525
    • Gajate, C.1    Mollinedo, F.2
  • 3
    • 0018326122 scopus 로고
    • Selective sensitivity of chronic myelogenous leukemia cell populations to alkyl-lysophospholipids
    • Andreesen, R.; Modolell, M.; Munder, P.G. Selective sensitivity of chronic myelogenous leukemia cell populations to alkyl-lysophospholipids. Blood, 1979, 54, 519-523.
    • (1979) Blood , vol.54 , pp. 519-523
    • Andreesen, R.1    Modolell, M.2    Munder, P.G.3
  • 5
    • 0025679466 scopus 로고
    • Hexadecylphosphocholine: A new and selective antitumor drug
    • Eibl, H.; Unger, C. Hexadecylphosphocholine: a new and selective antitumor drug. Cancer Treat. Rev., 1990, 17, 233-242.
    • (1990) Cancer Treat. Rev , vol.17 , pp. 233-242
    • Eibl, H.1    Unger, C.2
  • 6
    • 0035503414 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, multicenter trial of 6% miltefosine solution, a topical chemotherapy in cutaneous metastases from breast cancer
    • Leonard, R.; Hardy, J.; Van Tienhoven, G.; Houston, S.; Simmonds, P.; David, M.; Mansi, J. Randomized, double-blind, placebo-controlled, multicenter trial of 6% miltefosine solution, a topical chemotherapy in cutaneous metastases from breast cancer. J. Clin. Oncol., 2001, 19, 4150-4159.
    • (2001) J. Clin. Oncol , vol.19 , pp. 4150-4159
    • Leonard, R.1    Hardy, J.2    van Tienhoven, G.3    Houston, S.4    Simmonds, P.5    David, M.6    Mansi, J.7
  • 7
    • 34147130359 scopus 로고    scopus 로고
    • Antitumor ether lipids: Proapoptotic agents with multiple therapeutic indications
    • Mollinedo, F. Antitumor ether lipids: proapoptotic agents with multiple therapeutic indications. Exp. Opin. Ther. Patents, 2007, 17, 385-405.
    • (2007) Exp. Opin. Ther. Patents , vol.17 , pp. 385-405
    • Mollinedo, F.1
  • 9
    • 0027455786 scopus 로고
    • Induction of apoptosis in human leukemic cells by the ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine. A possible basis for its selective action
    • Diomede, L.; Colotta, F.; Piovani, B.; Re, F.; Modest, E.J.; Salmona, M. Induction of apoptosis in human leukemic cells by the ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine. A possible basis for its selective action. Int. J. Cancer, 1993, 53, 124-130.
    • (1993) Int. J. Cancer , vol.53 , pp. 124-130
    • Diomede, L.1    Colotta, F.2    Piovani, B.3    Re, F.4    Modest, E.J.5    Salmona, M.6
  • 10
    • 0027280181 scopus 로고
    • Early and selective induction of apoptosis in human leukemic cells by the alkyl-lysophospholipid ET-18-OCH3
    • Mollinedo, F.; Martinez-Dalmau, R.; Modolell, M. Early and selective induction of apoptosis in human leukemic cells by the alkyl-lysophospholipid ET-18-OCH3. Biochem. Biophys. Res. Commun., 1993, 192, 603-609.
    • (1993) Biochem. Biophys. Res. Commun , vol.192 , pp. 603-609
    • Mollinedo, F.1    Martinez-Dalmau, R.2    Modolell, M.3
  • 11
    • 1842290345 scopus 로고    scopus 로고
    • Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): Molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-XL
    • Mollinedo, F.; Fernandez-Luna, J.L.; Gajate, C.; Martin-Martin, B.; Benito, A.; Martinez-Dalmau, R.; Modolell, M. Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-XL. Cancer Res., 1997, 57, 1320-1328.
    • (1997) Cancer Res , vol.57 , pp. 1320-1328
    • Mollinedo, F.1    Fernandez-Luna, J.L.2    Gajate, C.3    Martin-Martin, B.4    Benito, A.5    Martinez-Dalmau, R.6    Modolell, M.7
  • 13
    • 0041384191 scopus 로고    scopus 로고
    • Membrane targeted anticancer drugs: Potent inducers of apoptosis and putative radiosensitisers
    • Jendrossek, V.; Handrick, R. Membrane targeted anticancer drugs: potent inducers of apoptosis and putative radiosensitisers. Curr. Med. Chem. Anti-Canc Agents, 2003, 3, 343-353.
    • (2003) Curr. Med. Chem. Anti-Canc Agents , vol.3 , pp. 343-353
    • Jendrossek, V.1    Handrick, R.2
  • 14
    • 9144229513 scopus 로고    scopus 로고
    • ET-18-OCH3 (edelfosine): A selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor
    • Mollinedo, F.; Gajate, C.; Martin-Santamaria, S.; Gago, F. ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor. Curr. Med. Chem., 2004, 11, 3163-3184.
    • (2004) Curr. Med. Chem , vol.11 , pp. 3163-3184
    • Mollinedo, F.1    Gajate, C.2    Martin-Santamaria, S.3    Gago, F.4
  • 15
    • 84873163534 scopus 로고    scopus 로고
    • Anticancer mechanisms and clinical application of alkylphospholipids
    • Van Blitterswijk, W.J.; Verheij, M. Anticancer mechanisms and clinical application of alkylphospholipids. Biochim. Biophys. Acta, 2013, 1831, 663-674.
    • (2013) Biochim. Biophys. Acta , vol.1831 , pp. 663-674
    • van Blitterswijk, W.J.1    Verheij, M.2
  • 16
    • 0028170274 scopus 로고
    • The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of FOS and JUN proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells
    • Mollinedo, F.; Gajate, C.; Modolell, M. The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of FOS and JUN proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells. Biochem. J., 1994, 302, 325-329.
    • (1994) Biochem. J , vol.302 , pp. 325-329
    • Mollinedo, F.1    Gajate, C.2    Modolell, M.3
  • 17
    • 0031968488 scopus 로고    scopus 로고
    • Involvement of c-Jun NH2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
    • Gajate, C.; Santos-Beneit, A.; Modolell, M.; Mollinedo, F. Involvement of c-Jun NH2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine. Mol. Pharmacol., 1998, 53, 602-612.
    • (1998) Mol. Pharmacol , vol.53 , pp. 602-612
    • Gajate, C.1    Santos-Beneit, A.2    Modolell, M.3    Mollinedo, F.4
  • 18
    • 0033563010 scopus 로고    scopus 로고
    • Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis
    • Ruiter, G.A.; Zerp, S.F.; Bartelink, H.; Van Blitterswijk, W.J.; Verheij, M. Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis. Cancer Res., 1999, 59, 2457-2463.
    • (1999) Cancer Res , vol.59 , pp. 2457-2463
    • Ruiter, G.A.1    Zerp, S.F.2    Bartelink, H.3    van Blitterswijk, W.J.4    Verheij, M.5
  • 19
    • 0028145780 scopus 로고
    • Involvement of phospholipase D in the activation of transcription factor AP-1 in human T lymphoid Jurkat cells
    • Mollinedo, F.; Gajate, C.; Flores I. Involvement of phospholipase D in the activation of transcription factor AP-1 in human T lymphoid Jurkat cells. J. Immunol., 1994, 153, 2457-2469.
    • (1994) J. Immunol , vol.153 , pp. 2457-2469
    • Mollinedo, F.1    Gajate, C.2    Flores, I.3
  • 20
    • 0028970963 scopus 로고
    • ET-18-OCH3 inhibits nuclear factor-kappa B activation by 12-O-tetradecanoylphorbol-13-acetate but not by tumor necrosis factor-alpha or interleukin 1 alpha
    • Daniel, L.W.; Civoli, F.; Rogers, M.A.; Smitherman, P.K.; Raju, P.A.; Roederer, M. ET-18-OCH3 inhibits nuclear factor-kappa B activation by 12-O-tetradecanoylphorbol-13-acetate but not by tumor necrosis factor-alpha or interleukin 1 alpha. Cancer Res., 1995, 55, 4844-4849.
    • (1995) Cancer Res , vol.55 , pp. 4844-4849
    • Daniel, L.W.1    Civoli, F.2    Rogers, M.A.3    Smitherman, P.K.4    Raju, P.A.5    Roederer, M.6
  • 21
    • 3543078747 scopus 로고    scopus 로고
    • Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis
    • Gajate, C.; Del Canto-Janez, E.; Acuna, A.U.; Amat-Guerri, F.; Geijo, E.; Santos-Beneit, A.M.; Veldman, R.J.; Mollinedo, F. Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis. J. Exp. Med., 2004, 200, 353-365.
    • (2004) J. Exp. Med , vol.200 , pp. 353-365
    • Gajate, C.1    Del Canto-Janez, E.2    Acuna, A.U.3    Amat-Guerri, F.4    Geijo, E.5    Santos-Beneit, A.M.6    Veldman, R.J.7    Mollinedo, F.8
  • 22
    • 0035895097 scopus 로고    scopus 로고
    • The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells
    • Gajate, C.; Mollinedo, F. The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells. Blood, 2001, 98, 3860-3863.
    • (2001) Blood , vol.98 , pp. 3860-3863
    • Gajate, C.1    Mollinedo, F.2
  • 24
    • 35948946873 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells
    • Nieto-Miguel, T.; Fonteriz, R.I.; Vay, L.; Gajate, C.; Lopez-Hernandez, S.; Mollinedo, F. Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells. Cancer Res., 2007, 67, 10368-10378.
    • (2007) Cancer Res , vol.67 , pp. 10368-10378
    • Nieto-Miguel, T.1    Fonteriz, R.I.2    Vay, L.3    Gajate, C.4    Lopez-Hernandez, S.5    Mollinedo, F.6
  • 25
    • 0032981815 scopus 로고    scopus 로고
    • Induction of apoptosis in human mitogen-activated peripheral blood T-lymphocytes by the ether phospholipid ET-18-OCH3: Involvement of the Fas receptor/ligand system
    • Cabaner, C.; Gajate, C.; Macho, A.; Munoz, E.; Modolell, M.; Mollinedo, F. Induction of apoptosis in human mitogen-activated peripheral blood T-lymphocytes by the ether phospholipid ET-18-OCH3: involvement of the Fas receptor/ligand system. Br. J. Pharmacol., 1999, 127, 813-825.
    • (1999) Br. J. Pharmacol , vol.127 , pp. 813-825
    • Cabaner, C.1    Gajate, C.2    Macho, A.3    Munoz, E.4    Modolell, M.5    Mollinedo, F.6
  • 27
    • 33846243705 scopus 로고    scopus 로고
    • Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts
    • Gajate, C.; Mollinedo, F. Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts. Blood, 2007, 109, 711-719.
    • (2007) Blood , vol.109 , pp. 711-719
    • Gajate, C.1    Mollinedo, F.2
  • 30
    • 34250003198 scopus 로고    scopus 로고
    • Surface-active properties of the antitumour ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (edelfosine)
    • Busto, J.V.; Sot, J.; Goni, F.M.; Mollinedo, F.; Alonso, A. Surface-active properties of the antitumour ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (edelfosine). Biochim. Biophys. Acta, 2007, 1768, 1855-1860.
    • (2007) Biochim. Biophys. Acta , vol.1768 , pp. 1855-1860
    • Busto, J.V.1    Sot, J.2    Goni, F.M.3    Mollinedo, F.4    Alonso, A.5
  • 32
    • 0023804402 scopus 로고
    • Reduction of epidermal growth factor binding in human breast cancer cell lines by an alkyl-lysophospholipid
    • Kosano, H.; Takatani, O. Reduction of epidermal growth factor binding in human breast cancer cell lines by an alkyl-lysophospholipid. Cancer Res., 1988, 48, 6033-6036.
    • (1988) Cancer Res , vol.48 , pp. 6033-6036
    • Kosano, H.1    Takatani, O.2
  • 33
    • 0029787879 scopus 로고    scopus 로고
    • 1-O-octadecyl-2-O-methyl-glycerophosphocholine inhibits the transduction of growth signals via the MAPK cascade in cultured MCF-7 cells
    • Zhou, X.; Lu, X.; Richard, C.; Xiong, W.; Litchfield, D.W.; Bittman, R.; Arthur, G. 1-O-octadecyl-2-O-methyl-glycerophosphocholine inhibits the transduction of growth signals via the MAPK cascade in cultured MCF-7 cells. J. Clin. Invest., 1996, 98, 937-944.
    • (1996) J. Clin. Invest , vol.98 , pp. 937-944
    • Zhou, X.1    Lu, X.2    Richard, C.3    Xiong, W.4    Litchfield, D.W.5    Bittman, R.6    Arthur, G.7
  • 34
    • 0041305056 scopus 로고    scopus 로고
    • The antitumor ether lipid 1-O-octadecyl-2-O-methyl-rac-glycerophosphocholine (ET-18-OCH3) inhibits the association between Ras and Raf-1
    • Samadder, P.; Richards, C.; Bittman, R.; Bhullar, R.P.; Arthur, G. The antitumor ether lipid 1-O-octadecyl-2-O-methyl-rac-glycerophosphocholine (ET-18-OCH3) inhibits the association between Ras and Raf-1. Anticancer Res., 2003, 23, 2291-2295.
    • (2003) Anticancer Res , vol.23 , pp. 2291-2295
    • Samadder, P.1    Richards, C.2    Bittman, R.3    Bhullar, R.P.4    Arthur, G.5
  • 35
    • 0033214968 scopus 로고    scopus 로고
    • Decreased sensitivity to 1-O-octadecyl-2-O-methyl-glycerophosphocholine in MCF-7 cells adapted for serum-free growth correlates with constitutive association of Raf-1 with cellular membranes
    • Samadder, P.; Arthur, G. Decreased sensitivity to 1-O-octadecyl-2-O-methyl-glycerophosphocholine in MCF-7 cells adapted for serum-free growth correlates with constitutive association of Raf-1 with cellular membranes. Cancer Res., 1999, 59, 4808-4815.
    • (1999) Cancer Res , vol.59 , pp. 4808-4815
    • Samadder, P.1    Arthur, G.2
  • 36
    • 0034658432 scopus 로고    scopus 로고
    • Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma
    • Strassheim, D.; Shafer, S.H.; Phelps, S.H.; Williams, C.L. Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma. Cancer Res., 2000, 60, 2730-2736.
    • (2000) Cancer Res , vol.60 , pp. 2730-2736
    • Strassheim, D.1    Shafer, S.H.2    Phelps, S.H.3    Williams, C.L.4
  • 37
    • 0026742177 scopus 로고
    • Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues
    • Powis, G.; Seewald, M.J.; Gratas, C.; Melder, D.; Riebow, J.; Modest, E.J. Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res., 1992, 52, 2835-2840.
    • (1992) Cancer Res , vol.52 , pp. 2835-2840
    • Powis, G.1    Seewald, M.J.2    Gratas, C.3    Melder, D.4    Riebow, J.5    Modest, E.J.6
  • 38
    • 1542707232 scopus 로고    scopus 로고
    • Non-small and small cell lung carcinoma cell lines exhibit cell type-specific sensitivity to edelfosine-induced cell death and different cell line-specific responses to edelfosine treatment
    • Shafer, S.H.; Williams, C.L. Non-small and small cell lung carcinoma cell lines exhibit cell type-specific sensitivity to edelfosine-induced cell death and different cell line-specific responses to edelfosine treatment. Int. J. Oncol., 2003, 23, 389-400.
    • (2003) Int. J. Oncol , vol.23 , pp. 389-400
    • Shafer, S.H.1    Williams, C.L.2
  • 39
    • 0030843306 scopus 로고    scopus 로고
    • Alkyl lysophospholipids inhibit phorbol ester-stimulated phospholipase D activity and DNA synthesis in fibroblasts
    • Kiss, Z.; Crilly, K.S. Alkyl lysophospholipids inhibit phorbol ester-stimulated phospholipase D activity and DNA synthesis in fibroblasts. FEBS Lett., 1997, 412, 313-317.
    • (1997) FEBS Lett , vol.412 , pp. 313-317
    • Kiss, Z.1    Crilly, K.S.2
  • 40
    • 0027313540 scopus 로고
    • Inhibition of phospholipase D by agents that inhibit cell growth
    • Gratas, C.; Powis, G. Inhibition of phospholipase D by agents that inhibit cell growth. Anticancer Res., 1993, 13, 1239-1244.
    • (1993) Anticancer Res , vol.13 , pp. 1239-1244
    • Gratas, C.1    Powis, G.2
  • 41
    • 0037064024 scopus 로고    scopus 로고
    • Differential partitioning of lipids metabolized by separate yeast glycerol-3-phosphate acyltransferases reveals that phospholipase D generation of phosphatidic acid mediates sensitivity to choline-containing lysolipids and drugs
    • Zaremberg, V.; McMaster, C.R. Differential partitioning of lipids metabolized by separate yeast glycerol-3-phosphate acyltransferases reveals that phospholipase D generation of phosphatidic acid mediates sensitivity to choline-containing lysolipids and drugs. J. Biol. Chem., 2002, 277, 39035-39044.
    • (2002) J. Biol. Chem , vol.277 , pp. 39035-39044
    • Zaremberg, V.1    McMaster, C.R.2
  • 42
    • 0031918590 scopus 로고    scopus 로고
    • Relocalization of phospholipase D activity mediates membrane formation during meiosis
    • Rudge, S.A.; Morris, A.J.; Engebrecht, J. Relocalization of phospholipase D activity mediates membrane formation during meiosis. J. Cell Biol., 1998, 140, 81-90.
    • (1998) J. Cell Biol , vol.140 , pp. 81-90
    • Rudge, S.A.1    Morris, A.J.2    Engebrecht, J.3
  • 43
    • 0037331989 scopus 로고    scopus 로고
    • Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway
    • Ruiter, G.A.; Zerp, S.F.; Bartelink, H.; Van Blitterswijk, W.J.; Verheij, M. Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway. Anticancer Drugs, 2003, 14, 167-173.
    • (2003) Anticancer Drugs , vol.14 , pp. 167-173
    • Ruiter, G.A.1    Zerp, S.F.2    Bartelink, H.3    van Blitterswijk, W.J.4    Verheij, M.5
  • 45
    • 60349088457 scopus 로고    scopus 로고
    • Perifosine: Update on a novel Akt inhibitor
    • Gills, J.J.; Dennis, P.A. Perifosine: update on a novel Akt inhibitor. Curr. Oncol. Rep., 2009, 11, 102-110.
    • (2009) Curr. Oncol. Rep , vol.11 , pp. 102-110
    • Gills, J.J.1    Dennis, P.A.2
  • 46
    • 52949108830 scopus 로고    scopus 로고
    • Anticancer alkylphospholipids: Mechanisms of action, cellular sensitivity and resistance, and clinical prospects
    • Van Blitterswijk, W.J.; Verheij, M. Anticancer alkylphospholipids: Mechanisms of action, cellular sensitivity and resistance, and clinical prospects. Curr. Pharm. Des., 2008, 14, 2061-2074.
    • (2008) Curr. Pharm. Des , vol.14 , pp. 2061-2074
    • van Blitterswijk, W.J.1    Verheij, M.2
  • 49
    • 84875209641 scopus 로고    scopus 로고
    • Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines
    • Alam, M.M.; Joh, E.H.; Park, H.; Kim, B.; Kim, D.H.; Lee, Y.S. Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines. Bioorg. Med. Chem., 2013, 21, 2018-2024.
    • (2013) Bioorg. Med. Chem , vol.21 , pp. 2018-2024
    • Alam, M.M.1    Joh, E.H.2    Park, H.3    Kim, B.4    Kim, D.H.5    Lee, Y.S.6
  • 50
    • 0035336166 scopus 로고    scopus 로고
    • Phosphatidylinositol 3'-kinase blocks CD95 aggregation and caspase-8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD95
    • Varadhachary, A.S.; Edidin, M.; Hanlon, A.M.; Peter, M.E.; Krammer, P.H.; Salgame, P. Phosphatidylinositol 3'-kinase blocks CD95 aggregation and caspase-8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD95. J. Immunol., 2001, 166, 6564-6569.
    • (2001) J. Immunol , vol.166 , pp. 6564-6569
    • Varadhachary, A.S.1    Edidin, M.2    Hanlon, A.M.3    Peter, M.E.4    Krammer, P.H.5    Salgame, P.6
  • 51
    • 0032711440 scopus 로고    scopus 로고
    • Selective up-regulation of phosphatidylinositol 3'-kinase activity in Th2 cells inhibits caspase-8 cleavage at the death-inducing complex: A mechanism for Th2 resistance from Fas-mediated apoptosis
    • Varadhachary, A.S.; Peter, M.E.; Perdow, S.N.; Krammer, P.H.; Salgame, P. Selective up-regulation of phosphatidylinositol 3'-kinase activity in Th2 cells inhibits caspase-8 cleavage at the death-inducing complex: A mechanism for Th2 resistance from Fas-mediated apoptosis. J. Immunol., 1999, 163, 4772-4779.
    • (1999) J. Immunol , vol.163 , pp. 4772-4779
    • Varadhachary, A.S.1    Peter, M.E.2    Perdow, S.N.3    Krammer, P.H.4    Salgame, P.5
  • 52
  • 53
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco, I.; Sawyers, C.L. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer, 2002, 2, 489-501.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 54
    • 1542328927 scopus 로고    scopus 로고
    • Structure, regulation and function of PKB/AKT - a major therapeutic target
    • Hanada, M.; Feng, J.; Hemmings, B.A. Structure, regulation and function of PKB/AKT - a major therapeutic target. Biochim. Biophys. Acta, 2004, 1697, 3-16.
    • (2004) Biochim. Biophys. Acta , vol.1697 , pp. 3-16
    • Hanada, M.1    Feng, J.2    Hemmings, B.A.3
  • 55
    • 0038549067 scopus 로고    scopus 로고
    • PI3K in lymphocyte development, differentiation and activation
    • Okkenhaug, K.; Vanhaesebroeck, B. PI3K in lymphocyte development, differentiation and activation. Nat. Rev. Immunol., 2003, 3, 317-330.
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 317-330
    • Okkenhaug, K.1    Vanhaesebroeck, B.2
  • 56
    • 13844273087 scopus 로고    scopus 로고
    • PI3K-Akt pathway: Its functions and alterations in human cancer
    • Osaki, M.; Oshimura, M.; Ito, H. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis, 2004, 9, 667-676.
    • (2004) Apoptosis , vol.9 , pp. 667-676
    • Osaki, M.1    Oshimura, M.2    Ito, H.3
  • 57
    • 33847314539 scopus 로고    scopus 로고
    • The phosphatidyl inositol 3-kinase signaling network: Implications for human breast cancer
    • Dillon, R.L.; White, D.E.; Muller, W.J. The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. Oncogene, 2007, 26, 1338-1345.
    • (2007) Oncogene , vol.26 , pp. 1338-1345
    • Dillon, R.L.1    White, D.E.2    Muller, W.J.3
  • 58
    • 54949109808 scopus 로고    scopus 로고
    • PI3K/Akt: Getting it right matters
    • Franke, T.F. PI3K/Akt: Getting it right matters. Oncogene, 2008, 27, 6473-6488.
    • (2008) Oncogene , vol.27 , pp. 6473-6488
    • Franke, T.F.1
  • 59
    • 73449084413 scopus 로고    scopus 로고
    • Regulation and importance of the PI3K/Akt/mTOR signaling pathway in hematologic malignancies
    • Kawauchi, K.; Ogasawara, T.; Yasuyama, M.; Otsuka, K.; Yamada, O. Regulation and importance of the PI3K/Akt/mTOR signaling pathway in hematologic malignancies. Anticancer Agents Med. Chem., 2009, 9, 1024-1038.
    • (2009) Anticancer Agents Med. Chem , vol.9 , pp. 1024-1038
    • Kawauchi, K.1    Ogasawara, T.2    Yasuyama, M.3    Otsuka, K.4    Yamada, O.5
  • 61
    • 77950914672 scopus 로고    scopus 로고
    • PI3K/Akt signalling pathway specific inhibitors: A novel strategy to sensitize cancer cells to anti-cancer drugs
    • Falasca, M. PI3K/Akt signalling pathway specific inhibitors: a novel strategy to sensitize cancer cells to anti-cancer drugs. Curr. Pharm. Des., 2010, 16, 1410-1416.
    • (2010) Curr. Pharm. Des , vol.16 , pp. 1410-1416
    • Falasca, M.1
  • 62
    • 84855178664 scopus 로고    scopus 로고
    • Targeting AKT protein kinase in gastric cancer
    • Almhanna, K.; Strosberg, J.; Malafa, M. Targeting AKT protein kinase in gastric cancer. Anticancer Res., 2011, 31, 4387-4392.
    • (2011) Anticancer Res , vol.31 , pp. 4387-4392
    • Almhanna, K.1    Strosberg, J.2    Malafa, M.3
  • 63
    • 79960716001 scopus 로고    scopus 로고
    • Akt signalling in health and disease
    • Hers, I.; Vincent, E.E.; Tavare, J.M. Akt signalling in health and disease. Cell Signal., 2011, 23, 1515-1527.
    • (2011) Cell Signal , vol.23 , pp. 1515-1527
    • Hers, I.1    Vincent, E.E.2    Tavare, J.M.3
  • 64
    • 0032484590 scopus 로고    scopus 로고
    • The antiproliferative effect of hexadecylphosphocholine toward HL60 cells is prevented by exogenous lysophosphatidylcholine
    • Boggs, K.; Rock, C.O.; Jackowski, S. The antiproliferative effect of hexadecylphosphocholine toward HL60 cells is prevented by exogenous lysophosphatidylcholine. Biochim. Biophys. Acta, 1998, 1389, 1-12.
    • (1998) Biochim. Biophys. Acta , vol.1389 , pp. 1-12
    • Boggs, K.1    Rock, C.O.2    Jackowski, S.3
  • 65
    • 0029019501 scopus 로고
    • Lysophosphatidylcholine attenuates the cytotoxic effects of the antineoplastic phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3- phosphocholine
    • Boggs, K.P.; Rock, C.O.; Jackowski, S. Lysophosphatidylcholine attenuates the cytotoxic effects of the antineoplastic phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3- phosphocholine. J. Biol. Chem., 1995, 270, 11612-11618.
    • (1995) J. Biol. Chem , vol.270 , pp. 11612-11618
    • Boggs, K.P.1    Rock, C.O.2    Jackowski, S.3
  • 66
    • 0028987154 scopus 로고
    • Lysophosphatidylcholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine inhibit the CDP-choline pathway of phosphatidylcholine synthesis at the CTP: Phosphocholine cytidylyltransferase step
    • Boggs, K.P.; Rock, C.O.; Jackowski, S. Lysophosphatidylcholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine inhibit the CDP-choline pathway of phosphatidylcholine synthesis at the CTP: Phosphocholine cytidylyltransferase step. J. Biol. Chem., 1995, 270, 7757-7764.
    • (1995) J. Biol. Chem , vol.270 , pp. 7757-7764
    • Boggs, K.P.1    Rock, C.O.2    Jackowski, S.3
  • 67
    • 0031892176 scopus 로고    scopus 로고
    • Apoptosis triggered by 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine is prevented by increased expression of CTP: Phosphocholine cytidylyltransferase
    • Baburina, I.; Jackowski, S. Apoptosis triggered by 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine is prevented by increased expression of CTP: Phosphocholine cytidylyltransferase. J. Biol. Chem., 1998, 273, 2169-2173.
    • (1998) J. Biol. Chem , vol.273 , pp. 2169-2173
    • Baburina, I.1    Jackowski, S.2
  • 68
    • 0037131168 scopus 로고    scopus 로고
    • Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis
    • Van der Luit, A.H.; Budde, M.; Ruurs, P.; Verheij, M.; Van Blitterswijk, W.J. Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis. J. Biol. Chem., 2002, 277, 39541-39547.
    • (2002) J. Biol. Chem , vol.277 , pp. 39541-39547
    • van der Luit, A.H.1    Budde, M.2    Ruurs, P.3    Verheij, M.4    van Blitterswijk, W.J.5
  • 69
    • 0000749205 scopus 로고
    • The function of cytidine coenzymes in the biosynthesis of phospholipides
    • Kennedy, E.P.; Weiss, S.B. The function of cytidine coenzymes in the biosynthesis of phospholipides. J. Biol. Chem., 1956, 222, 193-214.
    • (1956) J. Biol. Chem , vol.222 , pp. 193-214
    • Kennedy, E.P.1    Weiss, S.B.2
  • 70
    • 0025610139 scopus 로고
    • Regulation of phosphatidylcholine biosynthesis
    • Kent, C. Regulation of phosphatidylcholine biosynthesis. Prog. Lipid Res., 1990, 29, 87-105.
    • (1990) Prog. Lipid Res , vol.29 , pp. 87-105
    • Kent, C.1
  • 71
    • 0029026637 scopus 로고
    • Eukaryotic phospholipid biosynthesis
    • Kent, C. Eukaryotic phospholipid biosynthesis. Annu. Rev. Biochem., 1995, 64, 315-343.
    • (1995) Annu. Rev. Biochem , vol.64 , pp. 315-343
    • Kent, C.1
  • 72
    • 0031553042 scopus 로고    scopus 로고
    • Phosphocholine cytidylyltransferase
    • Kent, C. CTP: Phosphocholine cytidylyltransferase. Biochim. Biophys. Acta, 1997, 1348, 79-90.
    • (1997) Biochim. Biophys. Acta , vol.1348 , pp. 79-90
    • Kent, C.C.T.P.1
  • 73
    • 0019061277 scopus 로고
    • Autoradiographic detection of animal cell membrane mutants altered in phosphatidylcholine synthesis
    • Esko, J.D.; Raetz, C.R. Autoradiographic detection of animal cell membrane mutants altered in phosphatidylcholine synthesis. Proc. Natl. Acad. Sci. USA, 1980, 77, 5192-5196.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 5192-5196
    • Esko, J.D.1    Raetz, C.R.2
  • 74
    • 0019888255 scopus 로고
    • Thermolabile CDP-choline synthetase in an animal cell mutant defective in lecithin formation
    • Esko, J.D.; Wermuth, M.M.; Raetz, C.R. Thermolabile CDP-choline synthetase in an animal cell mutant defective in lecithin formation. J. Biol. Chem., 1981, 256, 7388-7393.
    • (1981) J. Biol. Chem , vol.256 , pp. 7388-7393
    • Esko, J.D.1    Wermuth, M.M.2    Raetz, C.R.3
  • 75
    • 0033578749 scopus 로고    scopus 로고
    • Distribution of CTP:Phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant
    • Lykidis, A.; Baburina, I.; Jackowski, S. Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant. J. Biol. Chem., 1999, 274, 26992-27001.
    • (1999) J. Biol. Chem , vol.274 , pp. 26992-27001
    • Lykidis, A.1    Baburina, I.2    Jackowski, S.3
  • 76
    • 0033543697 scopus 로고    scopus 로고
    • Shuttling of CTP: Phosphocholine cytidylyltransferase between the nucleus and endoplasmic reticulum accompanies the wave of phosphatidylcholine synthesis during the G0 --> G1 transition
    • Northwood, I.C.; Tong, A.H.; Crawford, B.; Drobnies, A.E.; Cornell, R.B. Shuttling of CTP: Phosphocholine cytidylyltransferase between the nucleus and endoplasmic reticulum accompanies the wave of phosphatidylcholine synthesis during the G0 --> G1 transition. J. Biol. Chem., 1999, 274, 26240-26248.
    • (1999) J. Biol. Chem , vol.274 , pp. 26240-26248
    • Northwood, I.C.1    Tong, A.H.2    Crawford, B.3    Drobnies, A.E.4    Cornell, R.B.5
  • 77
    • 0034284083 scopus 로고    scopus 로고
    • Regulation of CTP:Phosphocholine cytidylyltransferase by amphitropism and relocalization
    • Cornell, R.B.; Northwood, I.C. Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization. Trends Biochem. Sci., 2000, 25, 441-447.
    • (2000) Trends Biochem. Sci , vol.25 , pp. 441-447
    • Cornell, R.B.1    Northwood, I.C.2
  • 78
    • 0035966013 scopus 로고    scopus 로고
    • CTP: Phosphocholine cytidylyltransferase alpha is a cytosolic protein in pulmonary epithelial cells and tissues
    • Ridsdale, R.; Tseu, I.; Wang, J.; Post, M. CTP: Phosphocholine cytidylyltransferase alpha is a cytosolic protein in pulmonary epithelial cells and tissues. J. Biol. Chem., 2001, 276, 49148-49155.
    • (2001) J. Biol. Chem , vol.276 , pp. 49148-49155
    • Ridsdale, R.1    Tseu, I.2    Wang, J.3    Post, M.4
  • 79
    • 0026747863 scopus 로고
    • Association and metabolism of exogenously-derived lysophosphatidylcholine by cultured mammalian cells: Kinetics and mechanisms
    • Besterman, J.M.; Domanico, P.L. Association and metabolism of exogenously-derived lysophosphatidylcholine by cultured mammalian cells: kinetics and mechanisms. Biochemistry, 1992, 31, 2046-2056.
    • (1992) Biochemistry , vol.31 , pp. 2046-2056
    • Besterman, J.M.1    Domanico, P.L.2
  • 80
    • 0028979984 scopus 로고
    • Effect of 1-O-octadecyl-2-O-methyl- glycerophosphocholine on phosphatidylcholine and phosphatidylethanolamine synthesis in MCF-7 and A549 cells and its relationship to inhibition of cell proliferation
    • Zhou, X.; Arthur, G. Effect of 1-O-octadecyl-2-O-methyl- glycerophosphocholine on phosphatidylcholine and phosphatidylethanolamine synthesis in MCF-7 and A549 cells and its relationship to inhibition of cell proliferation. Eur. J. Biochem., 1995, 232, 881-888.
    • (1995) Eur. J. Biochem , vol.232 , pp. 881-888
    • Zhou, X.1    Arthur, G.2
  • 81
    • 0026720439 scopus 로고
    • The differential susceptibility of A427 and A549 cell lines to the growth-inhibitory effects of ET-18-OCH3 does not correlate with the relative effects of the alkyl-lysophospholipid on the incorporation of fatty acids into cellular phospholipids
    • Lu, X.; Arthur, G. The differential susceptibility of A427 and A549 cell lines to the growth-inhibitory effects of ET-18-OCH3 does not correlate with the relative effects of the alkyl-lysophospholipid on the incorporation of fatty acids into cellular phospholipids. Cancer Res., 1992, 52, 2813-2817.
    • (1992) Cancer Res , vol.52 , pp. 2813-2817
    • Lu, X.1    Arthur, G.2
  • 82
    • 0026711062 scopus 로고
    • Perturbations of cellular acylation processes by the synthetic alkyl-lysophospholipid 1-O-octadecyl-2-O-methylglycero-3-phosphocholine do not correlate with inhibition of proliferation of MCF7 and T84 cell lines
    • Lu, X.; Arthur, G. Perturbations of cellular acylation processes by the synthetic alkyl-lysophospholipid 1-O-octadecyl-2-O-methylglycero-3-phosphocholine do not correlate with inhibition of proliferation of MCF7 and T84 cell lines. Cancer Res., 1992, 52, 2806-2812.
    • (1992) Cancer Res , vol.52 , pp. 2806-2812
    • Lu, X.1    Arthur, G.2
  • 83
    • 0029786402 scopus 로고    scopus 로고
    • Cell cycle regulation of membrane phospholipid metabolism
    • Jackowski, S. Cell cycle regulation of membrane phospholipid metabolism. J. Biol. Chem., 1996, 271, 20219-20222.
    • (1996) J. Biol. Chem , vol.271 , pp. 20219-20222
    • Jackowski, S.1
  • 84
    • 0028146621 scopus 로고
    • Coordination of membrane phospholipid synthesis with the cell cycle
    • Jackowski, S. Coordination of membrane phospholipid synthesis with the cell cycle. J. Biol. Chem., 1994, 269, 3858-3867.
    • (1994) J. Biol. Chem , vol.269 , pp. 3858-3867
    • Jackowski, S.1
  • 85
    • 0029025348 scopus 로고
    • Lipid activation of CTP: Phosphocholine cytidylyltransferase is regulated by the phosphorylated carboxyl-terminal domain
    • Yang W.; Jackowski S. Lipid activation of CTP: Phosphocholine cytidylyltransferase is regulated by the phosphorylated carboxyl-terminal domain. J. Biol. Chem., 1995, 270, 16503-16506.
    • (1995) J. Biol. Chem , vol.270 , pp. 16503-16506
    • Yang, W.1    Jackowski, S.2
  • 86
    • 0033491995 scopus 로고    scopus 로고
    • Inhibition of cell division but not nuclear division by 1-O-octadecyl-2-O-methyl-Sn-glycero-3-phosphocholine
    • Pushkareva, M.Y.; Janoff, A.S.; Mayhew, E. Inhibition of cell division but not nuclear division by 1-O-octadecyl-2-O-methyl-Sn-glycero-3-phosphocholine. Cell Biol. Int., 1999, 23, 817-828.
    • (1999) Cell Biol. Int , vol.23 , pp. 817-828
    • Pushkareva, M.Y.1    Janoff, A.S.2    Mayhew, E.3
  • 87
    • 0037364871 scopus 로고    scopus 로고
    • Growth suppression of a tumorigenic rat liver cell line by the anticancer agent, ET-18-O-CH3, is mediated by inhibition of cytokinesis
    • Na, H.K.; Chang, C.C.; Trosko, J.E. Growth suppression of a tumorigenic rat liver cell line by the anticancer agent, ET-18-O-CH3, is mediated by inhibition of cytokinesis. Cancer Chemother. Pharmacol., 2003, 51, 209-215.
    • (2003) Cancer Chemother. Pharmacol , vol.51 , pp. 209-215
    • Na, H.K.1    Chang, C.C.2    Trosko, J.E.3
  • 88
    • 2942674883 scopus 로고    scopus 로고
    • Inhibition of phosphatidylcholine synthesis is not the primary pathway in hexadecylphosphocholine-induced apoptosis
    • Van der Sanden, M.H.; Houweling, M.; Duijsings, D.; Vaandrager, A.B.; Van Golde, L.M. Inhibition of phosphatidylcholine synthesis is not the primary pathway in hexadecylphosphocholine-induced apoptosis. Biochim. Biophys. Acta, 2004, 1636, 99-107.
    • (2004) Biochim. Biophys. Acta , vol.1636 , pp. 99-107
    • van der Sanden, M.H.1    Houweling, M.2    Duijsings, D.3    Vaandrager, A.B.4    van Golde, L.M.5
  • 89
    • 0032079477 scopus 로고    scopus 로고
    • Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine
    • Wieder, T.; Orfanos, C.E.; Geilen, C.C. Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine. J. Biol. Chem., 1998, 273, 11025-11031.
    • (1998) J. Biol. Chem , vol.273 , pp. 11025-11031
    • Wieder, T.1    Orfanos, C.E.2    Geilen, C.C.3
  • 90
  • 91
    • 0036027864 scopus 로고    scopus 로고
    • Cholesterol and other membrane active sterols: From membrane evolution to rafts
    • Barenholz, Y. Cholesterol and other membrane active sterols: from membrane evolution to rafts. Prog. Lipid Res., 2002, 41, 1-5.
    • (2002) Prog. Lipid Res , vol.41 , pp. 1-5
    • Barenholz, Y.1
  • 92
    • 0036733578 scopus 로고    scopus 로고
    • Cholesterol, lipid rafts, and disease
    • Simons, K.; Ehehalt, R. Cholesterol, lipid rafts, and disease. J. Clin. Invest., 2002, 110, 597-603.
    • (2002) J. Clin. Invest , vol.110 , pp. 597-603
    • Simons, K.1    Ehehalt, R.2
  • 93
    • 56249124005 scopus 로고    scopus 로고
    • Lipid rafts, cholesterol, and the brain
    • Korade, Z.; Kenworthy, A.K. Lipid rafts, cholesterol, and the brain. Neuropharmacology, 2008, 55, 1265-1273.
    • (2008) Neuropharmacology , vol.55 , pp. 1265-1273
    • Korade, Z.1    Kenworthy, A.K.2
  • 94
    • 0344585437 scopus 로고    scopus 로고
    • Lipid rafts: Elusive or illusive?
    • Munro, S. Lipid rafts: Elusive or illusive? Cell, 2003, 115, 377-388.
    • (2003) Cell , vol.115 , pp. 377-388
    • Munro, S.1
  • 95
    • 33746855864 scopus 로고    scopus 로고
    • Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders
    • Megha, Bakht O., London, E. Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders. J. Biol. Chem., 2006, 281, 21903-21913.
    • (2006) J. Biol. Chem , vol.281 , pp. 21903-21913
    • Megha, B.O.1    London, E.2
  • 96
    • 0034707082 scopus 로고    scopus 로고
    • Insolubility of lipids in triton X-100: Physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts)
    • London, E.; Brown, D.A. Insolubility of lipids in triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts). Biochim. Biophys. Acta, 2000, 1508, 182-195.
    • (2000) Biochim. Biophys. Acta , vol.1508 , pp. 182-195
    • London, E.1    Brown, D.A.2
  • 97
    • 0036702299 scopus 로고    scopus 로고
    • Plasma membrane microdomains
    • Maxfield, F.R. Plasma membrane microdomains. Curr. Opin. Cell Biol., 2002, 14, 483-487.
    • (2002) Curr. Opin. Cell Biol , vol.14 , pp. 483-487
    • Maxfield, F.R.1
  • 98
    • 77957167810 scopus 로고    scopus 로고
    • Revitalizing membrane rafts: New tools and insights
    • Simons, K.; Gerl, M.J. Revitalizing membrane rafts: New tools and insights. Nat. Rev. Mol. Cell Biol., 2010, 11, 688-699.
    • (2010) Nat. Rev. Mol. Cell Biol , vol.11 , pp. 688-699
    • Simons, K.1    Gerl, M.J.2
  • 99
    • 34248195469 scopus 로고    scopus 로고
    • Lipid rafts and membrane traffic
    • Hanzal-Bayer, M.F.; Hancock, J.F. Lipid rafts and membrane traffic. FEBS Lett., 2007, 581, 2098-2104.
    • (2007) FEBS Lett , vol.581 , pp. 2098-2104
    • Hanzal-Bayer, M.F.1    Hancock, J.F.2
  • 100
    • 84861770491 scopus 로고    scopus 로고
    • Lipid rafts generate digital-like signal transduction in cell plasma membranes
    • Suzuki, K.G. Lipid rafts generate digital-like signal transduction in cell plasma membranes. Biotechnol. J., 2012, 7, 753-761.
    • (2012) Biotechnol. J , vol.7 , pp. 753-761
    • Suzuki, K.G.1
  • 101
    • 77954236441 scopus 로고    scopus 로고
    • Combination of the anti-tumour cell ether lipid edelfosine with sterols abolishes haemolytic side effects of the drug
    • Busto, J.V.; Del Canto-Jañez, E.; Goñi, F.M.; Mollinedo, F.; Alonso, A. Combination of the anti-tumour cell ether lipid edelfosine with sterols abolishes haemolytic side effects of the drug. J. Chem. Biol., 2008, 1, 89-94.
    • (2008) J. Chem. Biol , vol.1 , pp. 89-94
    • Busto, J.V.1    Del Canto-Jañez, E.2    Goñi, F.M.3    Mollinedo, F.4    Alonso, A.5
  • 107
    • 10644246821 scopus 로고    scopus 로고
    • Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells
    • Delmas, D.; Rebe, C.; Micheau, O.; Athias, A.; Gambert, P.; Grazide, S.; Laurent, G.; Latruffe, N.; Solary, E. Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells. Oncogene, 2004, 23, 8979-8986.
    • (2004) Oncogene , vol.23 , pp. 8979-8986
    • Delmas, D.1    Rebe, C.2    Micheau, O.3    Athias, A.4    Gambert, P.5    Grazide, S.6    Laurent, G.7    Latruffe, N.8    Solary, E.9
  • 108
    • 70349104624 scopus 로고    scopus 로고
    • Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions
    • Reis-Sobreiro, M.; Gajate, C.; Mollinedo, F. Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions. Oncogene, 2009, 28, 3221-3234.
    • (2009) Oncogene , vol.28 , pp. 3221-3234
    • Reis-Sobreiro, M.1    Gajate, C.2    Mollinedo, F.3
  • 110
    • 15744405757 scopus 로고    scopus 로고
    • Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy
    • Gajate, C.; Mollinedo, F. Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J. Biol. Chem., 2005, 280, 11641-11647.
    • (2005) J. Biol. Chem , vol.280 , pp. 11641-11647
    • Gajate, C.1    Mollinedo, F.2
  • 111
    • 77949512481 scopus 로고    scopus 로고
    • Avicin D, a plant triterpenoid, induces cell apoptosis by recruitment of Fas and downstream signaling molecules into lipid rafts
    • Xu, Z.X.; Ding, T.; Haridas, V.; Connolly, F.; Gutterman, J.U. Avicin D, a plant triterpenoid, induces cell apoptosis by recruitment of Fas and downstream signaling molecules into lipid rafts. PLoS One, 2009, 4, e8532.
    • (2009) PLoS One , vol.e8532 , pp. 4
    • Xu, Z.X.1    Ding, T.2    Haridas, V.3    Connolly, F.4    Gutterman, J.U.5
  • 112
    • 33846920348 scopus 로고    scopus 로고
    • Fas receptor clustering and involvement of the death receptor pathway in rituximab-mediated apoptosis with concomitant sensitization of lymphoma B cells to Fas-induced apoptosis
    • Stel, A.J.; Cate, T.B.; Jacobs, S.; Kok, J.W.; Spierings, D.C.; Dondorff, M.; Helfrich, W.; Kluin-Nelemans, H.C.; De Leij, L.F.; Withoff, S.; Kroesen, B.J. Fas receptor clustering and involvement of the death receptor pathway in rituximab-mediated apoptosis with concomitant sensitization of lymphoma B cells to Fas-induced apoptosis. J. Immunol., 2007, 178, 2287-2295.
    • (2007) J. Immunol , vol.178 , pp. 2287-2295
    • Stel, A.J.1    Cate, T.B.2    Jacobs, S.3    Kok, J.W.4    Spierings, D.C.5    Dondorff, M.6    Helfrich, W.7    Kluin-Nelemans, H.C.8    de Leij, L.F.9    Withoff, S.10    Kroesen, B.J.11
  • 113
    • 34250378332 scopus 로고    scopus 로고
    • Opposing actions of endocannabinoids on cholangiocarcinoma growth: Recruitment of Fas and Fas ligand to lipid rafts
    • DeMorrow, S.; Glaser, S.; Francis, H.; Venter, J.; Vaculin, B.; Vaculin, S.; Alpini, G. Opposing actions of endocannabinoids on cholangiocarcinoma growth: Recruitment of Fas and Fas ligand to lipid rafts. J. Biol. Chem., 2007, 282, 13098-13113.
    • (2007) J. Biol. Chem , vol.282 , pp. 13098-13113
    • Demorrow, S.1    Glaser, S.2    Francis, H.3    Venter, J.4    Vaculin, B.5    Vaculin, S.6    Alpini, G.7
  • 114
    • 84865727534 scopus 로고    scopus 로고
    • MS-275 sensitizes osteosarcoma cells to Fas ligand-induced cell death by increasing the localization of Fas in membrane lipid rafts
    • Rao-Bindal, K.; Zhou, Z.; Kleinerman, E.S. MS-275 sensitizes osteosarcoma cells to Fas ligand-induced cell death by increasing the localization of Fas in membrane lipid rafts. Cell Death Dis., 2012, 3, e369.
    • (2012) Cell Death Dis , vol.3
    • Rao-Bindal, K.1    Zhou, Z.2    Kleinerman, E.S.3
  • 115
    • 0028883850 scopus 로고
    • Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
    • Kischkel, F.C.; Hellbardt, S.; Behrmann, I.; Germer, M.; Pawlita, M.; Krammer, P.H.; Peter, M.E. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. Embo J., 1995, 14, 5579-5588.
    • (1995) Embo J , vol.14 , pp. 5579-5588
    • Kischkel, F.C.1    Hellbardt, S.2    Behrmann, I.3    Germer, M.4    Pawlita, M.5    Krammer, P.H.6    Peter, M.E.7
  • 117
    • 77957794023 scopus 로고    scopus 로고
    • Solution NMR investigation of the CD95/FADD homotypic death domain complex suggests lack of engagement of the CD95 C terminus
    • Esposito, D.; Sankar, A.; Morgner, N.; Robinson, C.V.; Rittinger, K.; Driscoll, P.C. Solution NMR investigation of the CD95/FADD homotypic death domain complex suggests lack of engagement of the CD95 C terminus. Structure, 2010, 18, 1378-1390.
    • (2010) Structure , vol.18 , pp. 1378-1390
    • Esposito, D.1    Sankar, A.2    Morgner, N.3    Robinson, C.V.4    Rittinger, K.5    Driscoll, P.C.6
  • 118
    • 78549275798 scopus 로고    scopus 로고
    • Unleashing cell death: The Fas-FADD complex
    • Hymowitz, S.G.; Dixit, V.M. Unleashing cell death: The Fas-FADD complex. Nat. Struct. Mol. Biol., 2010, 17, 1289-1290.
    • (2010) Nat. Struct. Mol. Biol , vol.17 , pp. 1289-1290
    • Hymowitz, S.G.1    Dixit, V.M.2
  • 119
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi, A.; Dixit, V.M. Death receptors: Signaling and modulation. Science, 1998, 281, 1305-1308.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 120
    • 0033613143 scopus 로고    scopus 로고
    • Caspase activation: The induced-proximity model
    • Salvesen, G.S.; Dixit, V.M. Caspase activation: the induced-proximity model. Proc. Natl. Acad. Sci. USA, 1999, 96, 10964-10967.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 10964-10967
    • Salvesen, G.S.1    Dixit, V.M.2
  • 121
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Li, H.; Zhu, H.; Xu, C.J.; Yuan, J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell, 1998, 94, 491-501.
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 122
    • 0032555716 scopus 로고    scopus 로고
    • Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
    • Luo, X.; Budihardjo, I.; Zou, H.; Slaughter, C.; Wang, X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell, 1998, 94, 481-490.
    • (1998) Cell , vol.94 , pp. 481-490
    • Luo, X.1    Budihardjo, I.2    Zou, H.3    Slaughter, C.4    Wang, X.5
  • 123
    • 33745254719 scopus 로고    scopus 로고
    • Fas/CD95 death receptor and lipid rafts: New targets for apoptosis-directed cancer therapy
    • Mollinedo, F.; Gajate, C. Fas/CD95 death receptor and lipid rafts: New targets for apoptosis-directed cancer therapy. Drug Resist., Updat, 2006, 9, 51-73.
    • (2006) Drug Resist., Updat , vol.9 , pp. 51-73
    • Mollinedo, F.1    Gajate, C.2
  • 124
    • 64549139703 scopus 로고    scopus 로고
    • Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells
    • Gajate, C.; Gonzalez-Camacho, F.; Mollinedo, F. Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells. PLoS One, 2009, 4, e5044.
    • (2009) PLoS One , vol.e5044 , pp. 4
    • Gajate, C.1    Gonzalez-Camacho, F.2    Mollinedo, F.3
  • 125
    • 40749130495 scopus 로고    scopus 로고
    • Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy
    • Nieto-Miguel, T.; Gajate, C.; Gonzalez-Camacho, F.; Mollinedo, F. Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy. Oncogene, 2008, 27, 1779-1787.
    • (2008) Oncogene , vol.27 , pp. 1779-1787
    • Nieto-Miguel, T.1    Gajate, C.2    Gonzalez-Camacho, F.3    Mollinedo, F.4
  • 126
    • 60849124194 scopus 로고    scopus 로고
    • Lipid raft connection between extrinsic and intrinsic apoptotic pathways
    • Gajate, C.; Gonzalez-Camacho, F.; Mollinedo, F. Lipid raft connection between extrinsic and intrinsic apoptotic pathways. Biochem. Biophys. Res. Commun., 2009, 380, 780-784.
    • (2009) Biochem. Biophys. Res. Commun , vol.380 , pp. 780-784
    • Gajate, C.1    Gonzalez-Camacho, F.2    Mollinedo, F.3
  • 127
    • 0029753773 scopus 로고    scopus 로고
    • The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
    • Chen, Y.R.; Wang, X.; Templeton, D.; Davis, R.J.; Tan, T.H. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J. Biol. Chem., 1996, 271, 31929-31936.
    • (1996) J. Biol. Chem , vol.271 , pp. 31929-31936
    • Chen, Y.R.1    Wang, X.2    Templeton, D.3    Davis, R.J.4    Tan, T.H.5
  • 128
    • 0037388458 scopus 로고    scopus 로고
    • Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95-and mitochondrial-mediated mechanism
    • Gajate, C.; An, F.; Mollinedo, F. Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95-and mitochondrial-mediated mechanism. Clin. Cancer Res., 2003, 9, 1535-1545.
    • (2003) Clin. Cancer Res , vol.9 , pp. 1535-1545
    • Gajate, C.1    An, F.2    Mollinedo, F.3
  • 129
    • 84861220296 scopus 로고    scopus 로고
    • Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum
    • Gajate, C.; Matos-da-Silva, M.; Dakir, E.L.; Fonteriz, R.I.; Alvarez, J.; Mollinedo, F. Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum. Oncogene, 2012, 31, 2627-2639.
    • (2012) Oncogene , vol.31 , pp. 2627-2639
    • Gajate, C.1    Matos-da-Silva, M.2    Dakir, E.L.3    Fonteriz, R.I.4    Alvarez, J.5    Mollinedo, F.6
  • 130
    • 0036195136 scopus 로고    scopus 로고
    • An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes
    • Hueber, A.O.; Bernard, A.M.; Herincs, Z.; Couzinet, A.; He, H.T. An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes. EMBO Rep., 2002, 3, 190-196.
    • (2002) EMBO Rep , vol.3 , pp. 190-196
    • Hueber, A.O.1    Bernard, A.M.2    Herincs, Z.3    Couzinet, A.4    He, H.T.5
  • 132
    • 0029935682 scopus 로고    scopus 로고
    • Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells
    • Friesen, C.; Herr, I.; Krammer, P.H.; Debatin, K.M. Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat. Med., 1996, 2, 574-577.
    • (1996) Nat. Med , vol.2 , pp. 574-577
    • Friesen, C.1    Herr, I.2    Krammer, P.H.3    Debatin, K.M.4
  • 133
    • 0040419494 scopus 로고    scopus 로고
    • Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53
    • Muller, M.; Strand, S.; Hug, H.; Heinemann, E.M.; Walczak, H.; Hofmann, W.J.; Stremmel, W.; Krammer, P.H.; Galle, P.R. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J. Clin. Invest., 1997, 99, 403-413.
    • (1997) J. Clin. Invest , vol.99 , pp. 403-413
    • Muller, M.1    Strand, S.2    Hug, H.3    Heinemann, E.M.4    Walczak, H.5    Hofmann, W.J.6    Stremmel, W.7    Krammer, P.H.8    Galle, P.R.9
  • 134
    • 0032742205 scopus 로고    scopus 로고
    • Cytotoxic drugs and the CD95 pathway
    • Friesen, C.; Fulda, S.; Debatin, K.M. Cytotoxic drugs and the CD95 pathway. Leukemia, 1999, 13, 1854-1858.
    • (1999) Leukemia , vol.13 , pp. 1854-1858
    • Friesen, C.1    Fulda, S.2    Debatin, K.M.3
  • 135
    • 70349103059 scopus 로고    scopus 로고
    • In: Wajant H, editor. Fas Signaling. Georgetown, TX: Landes Bioscience and Springer Science
    • Mollinedo, F.; Gajate, C. FasL-independent activation of Fas. In: Wajant H, editor. Fas Signaling. Georgetown, TX: Landes Bioscience and Springer Science, 2006. p. Chapter 2, pp. 13-27.
    • (2006) FasL-independent Activation of Fas , pp. 13-27
    • Mollinedo, F.1    Gajate, C.2
  • 136
  • 138
    • 0034022160 scopus 로고    scopus 로고
    • Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
    • Jo, M.; Kim, T.H.; Seol, D.W.; Esplen, J.E.; Dorko, K.; Billiar, T.R.; Strom, S.C. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat. Med., 2000, 6, 564-567.
    • (2000) Nat. Med , vol.6 , pp. 564-567
    • Jo, M.1    Kim, T.H.2    Seol, D.W.3    Esplen, J.E.4    Dorko, K.5    Billiar, T.R.6    Strom, S.C.7
  • 140
    • 0037111475 scopus 로고    scopus 로고
    • Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors
    • Freeburn, R.W.; Wright, K.L.; Burgess, S.J.; Astoul, E.; Cantrell, D.A.; Ward, S.G. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors. J. Immunol., 2002, 169, 5441-5450.
    • (2002) J. Immunol , vol.169 , pp. 5441-5450
    • Freeburn, R.W.1    Wright, K.L.2    Burgess, S.J.3    Astoul, E.4    Cantrell, D.A.5    Ward, S.G.6
  • 141
    • 0032717188 scopus 로고    scopus 로고
    • TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells
    • Gazitt, Y. TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells. Leukemia, 1999, 13, 1817-1824.
    • (1999) Leukemia , vol.13 , pp. 1817-1824
    • Gazitt, Y.1
  • 142
    • 0033370411 scopus 로고    scopus 로고
    • Apoptosis-induced by TRAIL and TNF-alpha in human multiple myeloma cells is not blocked by BCL-2
    • Gazitt, Y.; Shaughnessy P.; Montgomery W. Apoptosis-induced by TRAIL and TNF-alpha in human multiple myeloma cells is not blocked by BCL-2. Cytokine, 1999, 11, 1010-1019.
    • (1999) Cytokine , vol.11 , pp. 1010-1019
    • Gazitt, Y.1    Shaughnessy, P.2    Montgomery, W.3
  • 143
    • 0035437171 scopus 로고    scopus 로고
    • TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: Therapeutic applications
    • Mitsiades, C.S.; Treon, S.P.; Mitsiades, N.; Shima, Y.; Richardson, P.; Schlossman, R.; Hideshima, T.; Anderson, K.C. TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. Blood, 2001, 98, 795-804.
    • (2001) Blood , vol.98 , pp. 795-804
    • Mitsiades, C.S.1    Treon, S.P.2    Mitsiades, N.3    Shima, Y.4    Richardson, P.5    Schlossman, R.6    Hideshima, T.7    Anderson, K.C.8
  • 144
    • 61349112191 scopus 로고    scopus 로고
    • Antitumor alkyl ether lipid edelfosine: Tissue distribution and pharmacokinetic behavior in healthy and tumor-bearing immunosuppressed mice
    • De Mendoza, A.E.; Campanero, M.A.; De la Iglesia-Vicente, J.; Gajate, C.; Mollinedo, F.; Blanco-Prieto, M.J. Antitumor alkyl ether lipid edelfosine: tissue distribution and pharmacokinetic behavior in healthy and tumor-bearing immunosuppressed mice. Clin. Cancer Res., 2009, 15, 858-864.
    • (2009) Clin. Cancer Res , vol.15 , pp. 858-864
    • de Mendoza, A.E.1    Campanero, M.A.2    de la Iglesia-Vicente, J.3    Gajate, C.4    Mollinedo, F.5    Blanco-Prieto, M.J.6
  • 147
    • 33846450280 scopus 로고    scopus 로고
    • Dominant-negative Fas mutation is reversed by down-expression of c-FLIP
    • Beneteau, M.; Daburon, S.; Moreau, J.F.; Taupin, J.L.; Legembre, P. Dominant-negative Fas mutation is reversed by down-expression of c-FLIP. Cancer Res., 2007, 67, 108-115.
    • (2007) Cancer Res , vol.67 , pp. 108-115
    • Beneteau, M.1    Daburon, S.2    Moreau, J.F.3    Taupin, J.L.4    Legembre, P.5
  • 148
    • 72449168537 scopus 로고    scopus 로고
    • Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: Partial role of associated sphingomyelin deficiency
    • Van Blitterswijk, W.J.; Klarenbeek, J.B.; Van der Luit, A.H.; Alderliesten, M.C.; Van Lummel, M.; Verheij, M. Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency. Biochem. J., 2009, 425, 225-234.
    • (2009) Biochem. J , vol.425 , pp. 225-234
    • van Blitterswijk, W.J.1    Klarenbeek, J.B.2    van der Luit, A.H.3    Alderliesten, M.C.4    van Lummel, M.5    Verheij, M.6
  • 149
    • 0033556310 scopus 로고    scopus 로고
    • The role of c-FLIP in modulation of CD95-induced apoptosis
    • Scaffidi, C.; Schmitz, I.; Krammer, P.H.; Peter, M.E. The role of c-FLIP in modulation of CD95-induced apoptosis. J. Biol. Chem., 1999, 274, 1541-1548.
    • (1999) J. Biol. Chem , vol.274 , pp. 1541-1548
    • Scaffidi, C.1    Schmitz, I.2    Krammer, P.H.3    Peter, M.E.4
  • 151
    • 0033529534 scopus 로고    scopus 로고
    • Differential modulation of apoptosis sensitivity in CD95 type I and type II cells
    • Scaffidi, C.; Schmitz, I.; Zha, J.; Korsmeyer, S.J.; Krammer, P.H.; Peter, M.E. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J. Biol. Chem., 1999, 274, 22532-22538.
    • (1999) J. Biol. Chem , vol.274 , pp. 22532-22538
    • Scaffidi, C.1    Schmitz, I.2    Zha, J.3    Korsmeyer, S.J.4    Krammer, P.H.5    Peter, M.E.6
  • 154
    • 0141456089 scopus 로고    scopus 로고
    • Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine
    • Van Der Luit, A.H.; Budde, M.; Verheij, M.; Van Blitterswijk, W.J. Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine. Biochem. J., 2003, 374, 747-753.
    • (2003) Biochem. J , vol.374 , pp. 747-753
    • van der Luit, A.H.1    Budde, M.2    Verheij, M.3    van Blitterswijk, W.J.4
  • 155
    • 27844522310 scopus 로고    scopus 로고
    • Cytotoxicity of an anti-cancer lysophospholipid through selective modification of lipid raft composition
    • Zaremberg, V.; Gajate, C.; Cacharro, L.M.; Mollinedo, F.; McMaster, C.R. Cytotoxicity of an anti-cancer lysophospholipid through selective modification of lipid raft composition. J. Biol. Chem., 2005, 280, 38047-38058.
    • (2005) J. Biol. Chem , vol.280 , pp. 38047-38058
    • Zaremberg, V.1    Gajate, C.2    Cacharro, L.M.3    Mollinedo, F.4    McMaster, C.R.5
  • 158
    • 33646083929 scopus 로고    scopus 로고
    • Effect of anti-tumor ether lipids on ordered domains in model membranes
    • Heczkova, B.; Slotte, J.P. Effect of anti-tumor ether lipids on ordered domains in model membranes. FEBS Lett., 2006, 580, 2471-2476.
    • (2006) FEBS Lett , vol.580 , pp. 2471-2476
    • Heczkova, B.1    Slotte, J.P.2
  • 159
    • 80052919692 scopus 로고    scopus 로고
    • Edelfosine disturbs the sphingomyelin-cholesterol model membrane system in a cholesterol-dependent way - the Langmuir monolayer study
    • Hac-Wydro, K.; Dynarowicz-Latka, P.; Wydro, P.; Bak, K. Edelfosine disturbs the sphingomyelin-cholesterol model membrane system in a cholesterol-dependent way - the Langmuir monolayer study. Colloids Surf. B Biointerf., 2011, 88, 635-640.
    • (2011) Colloids Surf. B Biointerf , vol.88 , pp. 635-640
    • Hac-Wydro, K.1    Dynarowicz-Latka, P.2    Wydro, P.3    Bak, K.4
  • 160
    • 77956648461 scopus 로고    scopus 로고
    • Searching for the role of membrane sphingolipids in selectivity of antitumor ether lipid-edelfosine
    • Hac-Wydro, K.; Dynarowicz-Latka, P. Searching for the role of membrane sphingolipids in selectivity of antitumor ether lipid-edelfosine. Colloids Surf. B Biointerf., 2010, 81, 492-497.
    • (2010) Colloids Surf. B Biointerf , vol.81 , pp. 492-497
    • Hac-Wydro, K.1    Dynarowicz-Latka, P.2
  • 161
    • 77956012645 scopus 로고    scopus 로고
    • The relationship between the concentration of ganglioside GM1 and antitumor activity of edelfosine--the Langmuir monolayer study
    • Hac-Wydro, K.; Dynarowicz-Latka, P. The relationship between the concentration of ganglioside GM1 and antitumor activity of edelfosine--the Langmuir monolayer study. Colloids Surf. B Biointerfaces, 2010, 81, 385-388.
    • (2010) Colloids Surf. B Biointerfaces , vol.81 , pp. 385-388
    • Hac-Wydro, K.1    Dynarowicz-Latka, P.2
  • 162
    • 0031750335 scopus 로고    scopus 로고
    • Lipid domain structure of the plasma membrane revealed by patching of membrane components
    • Harder, T.; Scheiffele, P.; Verkade, P.; Simons, K. Lipid domain structure of the plasma membrane revealed by patching of membrane components. J. Cell Biol., 1998, 141, 929-942.
    • (1998) J. Cell Biol , vol.141 , pp. 929-942
    • Harder, T.1    Scheiffele, P.2    Verkade, P.3    Simons, K.4
  • 163
    • 0033732176 scopus 로고    scopus 로고
    • Condensed complexes, rafts, and the chemical activity of cholesterol in membranes
    • Radhakrishnan, A.; Anderson, T.G.; McConnell, H.M. Condensed complexes, rafts, and the chemical activity of cholesterol in membranes. Proc. Natl. Acad. Sci USA, 2000, 97, 12422-12427.
    • (2000) Proc. Natl. Acad. Sci USA , vol.97 , pp. 12422-12427
    • Radhakrishnan, A.1    Anderson, T.G.2    McConnell, H.M.3
  • 164
    • 0035203504 scopus 로고    scopus 로고
    • The role of lipid rafts in signalling and membrane trafficking in T lymphocytes
    • Alonso, M.A.; Millan, J. The role of lipid rafts in signalling and membrane trafficking in T lymphocytes. J. Cell Sci., 2001, 114, 3957-3965.
    • (2001) J. Cell Sci , vol.114 , pp. 3957-3965
    • Alonso, M.A.1    Millan, J.2
  • 165
    • 0035105237 scopus 로고    scopus 로고
    • Segregation of co-stimulatory components into specific T cell surface lipid rafts
    • Millan, J.; Qaidi, M.; Alonso, M.A. Segregation of co-stimulatory components into specific T cell surface lipid rafts. Eur. J. Immunol., 2001, 31, 467-473.
    • (2001) Eur. J. Immunol , vol.31 , pp. 467-473
    • Millan, J.1    Qaidi, M.2    Alonso, M.A.3
  • 166
    • 13244272410 scopus 로고    scopus 로고
    • Structural membrane alterations in Alzheimer brains found to be associated with regional disease development.; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent-resistant membrane domains
    • Molander-Melin, M.; Blennow, K.; Bogdanovic, N.; Dellheden, B.; Mansson, J.E.; Fredman, P. Structural membrane alterations in Alzheimer brains found to be associated with regional disease development.; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent-resistant membrane domains. J. Neurochem., 2005, 92, 171-182.
    • (2005) J. Neurochem , vol.92 , pp. 171-182
    • Molander-Melin, M.1    Blennow, K.2    Bogdanovic, N.3    Dellheden, B.4    Mansson, J.E.5    Fredman, P.6
  • 168
    • 0028349595 scopus 로고
    • Role of gangliosides in tumor progression
    • Hakomori, S. Role of gangliosides in tumor progression. Prog
    • Hakomori, S. Role of gangliosides in tumor progression. Prog. Brain Res., 1994, 101, 241-250.
    • (1994) Brain Res , vol.101 , pp. 241-250
    • Hakomori, S.1
  • 169
    • 0030480250 scopus 로고    scopus 로고
    • Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism
    • Hakomori, S. Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism. Cancer Res., 1996, 56, 5309-5318.
    • (1996) Cancer Res , vol.56 , pp. 5309-5318
    • Hakomori, S.1
  • 170
    • 84940260223 scopus 로고    scopus 로고
    • Expression of gangliosides, GD1a and sialyl paragloboside, is regulated by NF-kappaB-dependent transcriptional control of alpha2,3-sialyltransferase I, II and VI in human castration-resistant prostate cancer cells
    • In Press
    • Hatano, K.; Miyamoto, Y.; Nonomura, N.; Kaneda, Y. Expression of gangliosides, GD1a and sialyl paragloboside, is regulated by NF-kappaB-dependent transcriptional control of alpha2,3-sialyltransferase I, II and VI in human castration-resistant prostate cancer cells. Int. J. Cancer, 2010, In Press,
    • (2010) Int. J. Cancer
    • Hatano, K.1    Miyamoto, Y.2    Nonomura, N.3    Kaneda, Y.4
  • 171
    • 77950599535 scopus 로고    scopus 로고
    • Lipid rafts, death receptors and CASMERs: New insights for cancer therapy
    • Mollinedo, F.; Gajate, C. Lipid rafts, death receptors and CASMERs: new insights for cancer therapy. Future Oncol., 2010, 6, 491-494.
    • (2010) Future Oncol , vol.6 , pp. 491-494
    • Mollinedo, F.1    Gajate, C.2
  • 172
    • 77952487833 scopus 로고    scopus 로고
    • Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy
    • Mollinedo, F.; Gajate, C. Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy. Future Oncol., 2010, 6, 811-821.
    • (2010) Future Oncol , vol.6 , pp. 811-821
    • Mollinedo, F.1    Gajate, C.2
  • 173
    • 80052323127 scopus 로고    scopus 로고
    • The plasma membrane: A catalyst in the decision to die or not to die?
    • Legembre, P.; Mollinedo, F. The plasma membrane: A catalyst in the decision to die or not to die? Rec. Pat Anticancer Drug Discov., 2011, 6, 271-273.
    • (2011) Rec. Pat Anticancer Drug Discov , vol.6 , pp. 271-273
    • Legembre, P.1    Mollinedo, F.2
  • 174
    • 80052341675 scopus 로고    scopus 로고
    • Lipid rafts and Fas/CD95 signaling in cancer chemotherapy
    • Gajate, C.; Mollinedo, F. Lipid rafts and Fas/CD95 signaling in cancer chemotherapy. Rec. Pat. Anticancer Drug Discov., 2011, 6, 274-283.
    • (2011) Rec. Pat. Anticancer Drug Discov , vol.6 , pp. 274-283
    • Gajate, C.1    Mollinedo, F.2
  • 176
    • 25844519550 scopus 로고    scopus 로고
    • HSP90 and the chaperoning of cancer
    • Whitesell, L.; Lindquist, S.L. HSP90 and the chaperoning of cancer. Nat. Rev. Cancer, 2005, 5, 761-772.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 761-772
    • Whitesell, L.1    Lindquist, S.L.2
  • 177
    • 24044439753 scopus 로고    scopus 로고
    • Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily
    • Remacle-Bonnet, M.; Garrouste, F.; Baillat, G.; Andre, F.; Marvaldi, J.; Pommier, G. Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily. Am. J. Pathol., 2005, 167, 761-773.
    • (2005) Am. J. Pathol , vol.167 , pp. 761-773
    • Remacle-Bonnet, M.1    Garrouste, F.2    Baillat, G.3    Andre, F.4    Marvaldi, J.5    Pommier, G.6
  • 179
    • 84875442887 scopus 로고    scopus 로고
    • Alteration of plasma membrane organization by an anticancer lysophosphatidylcholine analogue induces intracellular acidification and internalization of plasma membrane transporters in yeast
    • Czyz, O.; Bitew, T.; Cuesta-Marban, A.; McMaster, C.R.; Mollinedo, F.; Zaremberg, V. Alteration of plasma membrane organization by an anticancer lysophosphatidylcholine analogue induces intracellular acidification and internalization of plasma membrane transporters in yeast. J. Biol. Chem., 2013, 288, 8419-8432.
    • (2013) J. Biol. Chem , vol.288 , pp. 8419-8432
    • Czyz, O.1    Bitew, T.2    Cuesta-Marban, A.3    McMaster, C.R.4    Mollinedo, F.5    Zaremberg, V.6
  • 180
    • 84885163914 scopus 로고    scopus 로고
    • Lipid raft involvement in yeast cell growth and death
    • Mollinedo, F. Lipid raft involvement in yeast cell growth and death. Front. Oncol., 2012, 2, 140.
    • (2012) Front. Oncol , vol.2 , pp. 140
    • Mollinedo, F.1
  • 181
    • 0029926710 scopus 로고    scopus 로고
    • Inhibition of Na+/H+ exchanger activity by an alkyl-lysophospholipid analogue in a human breast cancer cell line
    • Besson, P.; Gore, J.; Vincent, E.; Hoinard, C.; Bougnoux, P. Inhibition of Na+/H+ exchanger activity by an alkyl-lysophospholipid analogue in a human breast cancer cell line. Biochem Pharmacol, 1996, 51, 1153-1158.
    • (1996) Biochem Pharmacol , vol.51 , pp. 1153-1158
    • Besson, P.1    Gore, J.2    Vincent, E.3    Hoinard, C.4    Bougnoux, P.5
  • 182
    • 33744957442 scopus 로고    scopus 로고
    • Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells
    • Nieto-Miguel, T.; Gajate, C.; Mollinedo, F. Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells. J. Biol. Chem., 2006, 281, 14833-14840.
    • (2006) J. Biol. Chem , vol.281 , pp. 14833-14840
    • Nieto-Miguel, T.1    Gajate, C.2    Mollinedo, F.3
  • 183
    • 0026546365 scopus 로고
    • CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription
    • Ron, D.; Habener, J.F. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev., 1992, 6, 439-453.
    • (1992) Genes Dev , vol.6 , pp. 439-453
    • Ron, D.1    Habener, J.F.2
  • 184
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • Urano F.; Wang X.; Bertolotti A.; Zhang Y.; Chung P.; Harding HP.; Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science, 2000, 287, 664-666.
    • (2000) Science , vol.287 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3    Zhang, Y.4    Chung, P.5    Harding, H.P.6    Ron, D.7
  • 188
    • 0037417334 scopus 로고    scopus 로고
    • Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol
    • Breckenridge DG.; Stojanovic M.; Marcellus RC.; Shore GC. Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. J Cell Biol, 2003, 160, 1115-1127.
    • (2003) J Cell Biol , vol.160 , pp. 1115-1127
    • Breckenridge, D.G.1    Stojanovic, M.2    Marcellus, R.C.3    Shore, G.C.4
  • 189
    • 6044275973 scopus 로고    scopus 로고
    • Fluorescent phenylpolyene analogues of the ether phospholipid edelfosine for the selective labeling of cancer cells
    • Quesada E.; Delgado J.; Gajate C.; Mollinedo F.; Acuna AU.; Amat-Guerri F. Fluorescent phenylpolyene analogues of the ether phospholipid edelfosine for the selective labeling of cancer cells. J Med Chem, 2004, 47, 5333-5335.
    • (2004) J Med Chem , vol.47 , pp. 5333-5335
    • Quesada, E.1    Delgado, J.2    Gajate, C.3    Mollinedo, F.4    Acuna, A.U.5    Amat-Guerri, F.6
  • 191
    • 0035102918 scopus 로고    scopus 로고
    • Plasmalogens: Biosynthesis and functions
    • Nagan N.; Zoeller RA. Plasmalogens: biosynthesis and functions. Prog Lipid Res, 2001, 40, 199-229.
    • (2001) Prog Lipid Res , vol.40 , pp. 199-229
    • Nagan, N.1    Zoeller, R.A.2
  • 192
    • 84873287256 scopus 로고    scopus 로고
    • Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition
    • Burgeiro A.; Pereira CV.; Carvalho FS.; Pereira GC.; Mollinedo F.; Oliveira PJ. Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition. Mitochondrion, 2013, 13, 25-35.
    • (2013) Mitochondrion , vol.13 , pp. 25-35
    • Burgeiro, A.1    Pereira, C.V.2    Carvalho, F.S.3    Pereira, G.C.4    Mollinedo, F.5    Oliveira, P.J.6
  • 194
    • 67849133020 scopus 로고    scopus 로고
    • Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria
    • Sorice M.; Manganelli V.; Matarrese P.; Tinari A.; Misasi R.; Malorni W.; Garofalo T. Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria. FEBS Lett., 2009, 583, 2447-2450.
    • (2009) FEBS Lett , vol.583 , pp. 2447-2450
    • Sorice, M.1    Manganelli, V.2    Matarrese, P.3    Tinari, A.4    Misasi, R.5    Malorni, W.6    Garofalo, T.7
  • 195
    • 66449090816 scopus 로고    scopus 로고
    • Mitochondria do not contain lipid rafts, and lipid rafts do not contain mitochondrial proteins
    • Zheng, Y.Z.; Berg, K.B.; Foster, L.J. Mitochondria do not contain lipid rafts, and lipid rafts do not contain mitochondrial proteins. J. Lipid Res., 2009, 50, 988-998.
    • (2009) J. Lipid Res , vol.50 , pp. 988-998
    • Zheng, Y.Z.1    Berg, K.B.2    Foster, L.J.3
  • 197
    • 34247540380 scopus 로고    scopus 로고
    • The permeability transition pore in cell death
    • Grimm, S.; Brdiczka, D. The permeability transition pore in cell death. Apoptosis, 2007, 12, 841-855.
    • (2007) Apoptosis , vol.12 , pp. 841-855
    • Grimm, S.1    Brdiczka, D.2
  • 202
    • 17144369859 scopus 로고    scopus 로고
    • Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer
    • Goonesinghe, A.; Mundy, E.S.; Smith, M.; Khosravi-Far, R.; Martinou, J.C.; Esposti, M.D. Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer. Biochem. J., 2005, 387, 109-118.
    • (2005) Biochem. J , vol.387 , pp. 109-118
    • Goonesinghe, A.1    Mundy, E.S.2    Smith, M.3    Khosravi-Far, R.4    Martinou, J.C.5    Esposti, M.D.6
  • 203
    • 33746933765 scopus 로고    scopus 로고
    • The many shapes of mitochondrial death
    • Cereghetti, G.M.; Scorrano, L. The many shapes of mitochondrial death. Oncogene, 2006, 25, 4717-4724.
    • (2006) Oncogene , vol.25 , pp. 4717-4724
    • Cereghetti, G.M.1    Scorrano, L.2
  • 204
    • 57349100367 scopus 로고    scopus 로고
    • Mitofusin 2 tethers endoplasmic reticulum to mitochondria
    • De Brito, O.M.; Scorrano, L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature, 2008, 456, 605-610.
    • (2008) Nature , vol.456 , pp. 605-610
    • de Brito, O.M.1    Scorrano, L.2
  • 205
    • 0025128087 scopus 로고
    • Characterization of phosphatidylserine synthesis and translocation in permeabilized animal cells
    • Voelker, D.R. Characterization of phosphatidylserine synthesis and translocation in permeabilized animal cells. J. Biol. Chem., 1990, 265, 14340-14346.
    • (1990) J. Biol. Chem , vol.265 , pp. 14340-14346
    • Voelker, D.R.1
  • 206
    • 0025302296 scopus 로고
    • Lipid transport pathways in mammalian cells
    • Voelker, D.R. Lipid transport pathways in mammalian cells. Experientia, 1990, 46, 569-579.
    • (1990) Experientia , vol.46 , pp. 569-579
    • Voelker, D.R.1
  • 207
    • 0025273937 scopus 로고
    • Phospholipid synthesis in a membrane fraction associated with mitochondria
    • Vance, J.E. Phospholipid synthesis in a membrane fraction associated with mitochondria. J. Biol. Chem., 1990, 265, 7248-7256.
    • (1990) J. Biol. Chem , vol.265 , pp. 7248-7256
    • Vance, J.E.1
  • 208
    • 0027377058 scopus 로고
    • Involvement of mitochondrial contact sites in the subcellular compartmentalization of phospholipid biosynthetic enzymes
    • Ardail, D.; Gasnier, F.; Lerme, F.; Simonot, C.; Louisot, P.; Gateau-Roesch, O. Involvement of mitochondrial contact sites in the subcellular compartmentalization of phospholipid biosynthetic enzymes. J. Biol. Chem., 1993, 268, 25985-25992.
    • (1993) J. Biol. Chem , vol.268 , pp. 25985-25992
    • Ardail, D.1    Gasnier, F.2    Lerme, F.3    Simonot, C.4    Louisot, P.5    Gateau-Roesch, O.6
  • 209
    • 0027373703 scopus 로고
    • Further evidence for both functional and structural microcompartmentation within the membranes of two associated organelles, mitochondrion and endoplasmic reticulum
    • Gasnier, F.; Ardail, D.; Febvay, G.; Simonot, C.; Lerme, F.; Guillaud, J.; Louisot, P.; Gateau-Roesch, O. Further evidence for both functional and structural microcompartmentation within the membranes of two associated organelles, mitochondrion and endoplasmic reticulum. Biochem. Biophys. Res. Commun., 1993, 195, 1365-1370.
    • (1993) Biochem. Biophys. Res. Commun , vol.195 , pp. 1365-1370
    • Gasnier, F.1    Ardail, D.2    Febvay, G.3    Simonot, C.4    Lerme, F.5    Guillaud, J.6    Louisot, P.7    Gateau-Roesch, O.8
  • 210
    • 0028916511 scopus 로고
    • Characterization of a microsomal subfraction associated with mitochondria of the yeast, Saccharomyces cerevisiae. Involvement in synthesis and import of phospholipids into mitochondria
    • Gaigg, B.; Simbeni, R.; Hrastnik, C.; Paltauf, F.; Daum, G. Characterization of a microsomal subfraction associated with mitochondria of the yeast, Saccharomyces cerevisiae. Involvement in synthesis and import of phospholipids into mitochondria. Biochim. Biophys. Acta, 1995, 1234, 214-220.
    • (1995) Biochim. Biophys. Acta , vol.1234 , pp. 214-220
    • Gaigg, B.1    Simbeni, R.2    Hrastnik, C.3    Paltauf, F.4    Daum, G.5
  • 211
    • 0029055754 scopus 로고
    • Evidence that phosphatidylserine is imported into mitochondria via a mitochondria-associated membrane and that the majority of mitochondrial phosphatidylethanolamine is derived from decarboxylation of phosphatidylserine
    • Shiao, Y.J.; Lupo, G.; Vance, J.E. Evidence that phosphatidylserine is imported into mitochondria via a mitochondria-associated membrane and that the majority of mitochondrial phosphatidylethanolamine is derived from decarboxylation of phosphatidylserine. J. Biol. Chem., 1995, 270, 11190-11198.
    • (1995) J. Biol. Chem , vol.270 , pp. 11190-11198
    • Shiao, Y.J.1    Lupo, G.2    Vance, J.E.3
  • 213
    • 77951716870 scopus 로고    scopus 로고
    • ERMES-mediated ER-mitochondria contacts: Molecular hubs for the regulation of mitochondrial biology
    • Kornmann, B.; Walter, P. ERMES-mediated ER-mitochondria contacts: molecular hubs for the regulation of mitochondrial biology. J. Cell Sci, 2010, 123, 1389-1393.
    • (2010) J. Cell Sci , vol.123 , pp. 1389-1393
    • Kornmann, B.1    Walter, P.2
  • 214
    • 78651287877 scopus 로고    scopus 로고
    • Making heads or tails of phospholipids in mitochondria
    • Osman, C.; Voelker, D.R.; Langer, T. Making heads or tails of phospholipids in mitochondria. J. Cell Biol., 2011, 192, 7-16.
    • (2011) J. Cell Biol , vol.192 , pp. 7-16
    • Osman, C.1    Voelker, D.R.2    Langer, T.3
  • 215
    • 45149121372 scopus 로고    scopus 로고
    • The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism
    • Chiarini, F.; Del Sole, M.; Mongiorgi, S.; Gaboardi G; Cappellini, A.; Mantovani, I.; Follo, M.Y.; McCubrey, J.A.; Martelli, A.M. The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism. Leukemia, 2008, 22, 1106-1116.
    • (2008) Leukemia , vol.22 , pp. 1106-1116
    • Chiarini, F.1    Del Sole, M.2    Mongiorgi, S.3    Gaboardi, G.4    Cappellini, A.5    Mantovani, I.6    Follo, M.Y.7    McCubrey, J.A.8    Martelli, A.M.9
  • 216
    • 35348923491 scopus 로고    scopus 로고
    • Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells
    • Vink, S.R.; Van der Luit, A.H.; Klarenbeek, J.B.; Verheij, M.; Van Blitterswijk, W.J. Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells. Biochem. Pharmacol., 2007, 74, 1456-1465.
    • (2007) Biochem. Pharmacol , vol.74 , pp. 1456-1465
    • Vink, S.R.1    van der Luit, A.H.2    Klarenbeek, J.B.3    Verheij, M.4    Blitterswijk, V.W.J.5


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