Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells

Cancer Research

Volumn 67, Issue 21, 2007, Pages 10368-10378

  Nieto Miguel, Teresa ^a   Fonteriz, Rosalba I ^c   Vay, Laura ^c   Gajate, Consuelo ^a,b   López Hernández, Silvia ^a   Mollinedo, Faustino ^a,d  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^c Universidad de Valladolid y Consejo Superior de Investigaciones Científicas   (Spain)

^d Centro de Investigacion del Cancer   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLLYSOPHOSPHOLIPID; APOPTOSIS SIGNAL REGULATING KINASE 1; CALCIUM ION; CASPASE 4; CASPASE 8; EDELFOSINE; PHOSPHATIDYLCHOLINE; PROTEIN BAX; PROTEIN BCL XL; STRESS ACTIVATED PROTEIN KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM DEPLETION; CALCIUM TRANSPORT; CELL CYCLE ARREST; CONTROLLED STUDY; DNA DAMAGE; DRUG ACCUMULATION; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; GENE TRANSFER; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOLID TUMOR; WESTERN BLOTTING; WILD TYPE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CALCIUM; CASPASES; CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE; ENDOPLASMIC RETICULUM; HELA CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASE 5; NEOPLASMS; PHOSPHATIDYLCHOLINES; PHOSPHOLIPID ETHERS; PROTEIN SYNTHESIS INHIBITORS;

EID: 35948946873     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-0278     Document Type: Article

References (50)

1. L. Cancer Res 1997;57:1320-8.
2. 3 (Edelfosine), a proapoptotic agent in tumor cells. Curr Drug Metab 2002;3:491-525.
3. 3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor. Curr Med Chem 2004;11:3163-84.
4. Hideshima T, Catley L, Yasui H, et al. Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood 2006;107:4053-62.
5. Gajate C, Mollinedo F. Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts. Blood 2007;109:711-9.
6. 3. Biochem Biophys Res Commun 1993;192:603-9.
7. Gajate C, Santos-Beneit A, Modolell M, Mollinedo F. Involvement of c-Jun NH2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3- phosphocholine. Mol Pharmacol 1998;53:602-12.
8. 3-induced apoptosis of human leukemic cells. Int J Cancer 2000;86:208-18.
9. 3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells. Blood 2001;98:3860-3.
10. Gajate C, Del Canto-Janez E, Acuna AU, et al. Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis. J Exp Med 2004;200:353-65.
11. Nieto-Miguel T, Gajate C, Mollinedo F. Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells. J Biol Chem 2006;281:14833-40.
12. Rao RV, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 2004;11:372-80.
13. Kim R, Emi M, Tanabe K, Murakami S. Role of the unfolded protein response in cell death. Apoptosis 2006;11:5-13.
14. Nishitoh H, Matsuzawa A, Tobiume K, et al. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev 2002;16:1345-55.
15. Hitomi J, Katayama T, Eguchi Y, et al. Involvement of caspase-4 in endoplasmic reticulumstress-induced apoptosis and Abeta-induced cell death. J Cell Biol 2004;165:347-56.
16. Fribley A, Zeng Q, Wang CY. Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells. Mol Cell Biol 2004;24:9695-704.
17. Mimnaugh EG, Xu W, Vos M, et al. Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity. Mol Cancer Ther 2004;3:551-66.
18. Mandic A, Hansson J, Linder S, Shoshan MC. Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem 2003;278:9100-6.
19. Carracedo A, Gironella M, Lorente M, et al. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res 2006;66:6748-55.
20. Wei MC, Zong WX, Cheng EH, et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001;292:727-30.
21. Gajate C, Fonteriz RI, Cabaner C, et al. Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis. Int J Cancer 2000;85:674-82.
22. L and cell cycle arrest. Cancer Res 2000;60:2651-9.
23. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985;260:3440-50.
24. Hoffman DR, Thomas VL, Snyder F. Inhibition of cellular transport systems by alkyl phospholipid analogs in HL-60 human leukemia cells. Biochim Biophys Acta 1992;1127:74-80.
25. Boggs KP, Rock CO, Jackowski S. Lysophosphatidylcholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine inhibit the CDP-choline pathway of phosphatidylcholine synthesis at the CTP:phosphocholine cytidylyltransferase step. J Biol Chem 1995;270:7757-64.
26. Samuel CE. The eIF-2 α protein kinases, regulators of translation in eukaryotes from yeasts to humans. J Biol Chem 1993;268:7603-6.
27. Liu H, Bowes RC III, van de Water B, Sillence C, Nagelkerke JF, Stevens JL. Endoplasmic reticulum chaperones GRP78 and calreticulin prevent oxidative stress, Ca2+ disturbances, and cell death in renal epithelial cells. J Biol Chem 1997;272:21751-9.
28. van der Sanden MH, Houweling M, van Golde LM, Vaandrager AB. Inhibition of phosphatidylcholine synthesis induces expression of the endoplasmic reticulum stress and apoptosis-related protein CCAAT/enhancer-binding protein-homologous protein (CHOP/GADD153). Biochem J 2003;369:643-50.
29. Saleh M, Vaillancourt JP, Graham RK, et al. Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature 2004;429:75-9.
30. Ng FW, Nguyen M, Kwan T, et al. p28 Bap31, a Bcl-2/Bcl-XL-and procaspase-8-associated protein in the endoplasmic reticulum. J Cell Biol 1997;139:327-38.
31. Breckenridge DG, Stojanovic M, Marcellus RC, Shore GC. Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. J Cell Biol 2003;160:1115-27.
32. Zong WX, Li C, Hatzivassiliou G, et al. Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol 2003;162:59-69.
33. Griffiths GJ, Dubrez L, Morgan CP, et al. Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis. J Cell Biol 1999;144:903-14.
34. Scorrano L, Oakes SA, Opferman JT, et al. BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science 2003;300:135-9.
35. 2+ stores. J Biol Chem 2002;277:9219-25.
36. L, but not Bcl-2, to the mitochondrial outer membrane. J Cell Biol 2003;160:53-64.
37. Davies SM, Epand RM, Kraayenhof R, Cornell RB. Regulation of CTP: phosphocholine cytidylyltransferase activity by the physical properties of lipid membranes: an important role for stored curvature strain energy. Biochemistry 2001;40:10522-31.
38. Attard GS, Templer RH, Smith WS, Hunt AN, Jackowski S. Modulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stress. Proc Natl Acad Sci U S A 2000;97:9032-6.
39. van der Sanden MH, Houweling M, Duijsings D, Vaandrager AB, van Golde LM. Inhibition of phosphatidylcholine synthesis is not the primary pathway in hexadecylphosphocholine-induced apoptosis. Biochim Biophys Acta 2004;1636:99-107.
40. Wright MM, Henneberry AL, Lagace TA, Ridgway ND, McMaster CR. Uncoupling farnesol-induced apoptosis from its inhibition of phosphatidylcholine synthesis. J Biol Chem 2001;276:25254-61.
41. Zhou X, Arthur G. Effect of 1-O-octadecyl-2-O-methyl- glycerophosphocholine on phosphatidylcholine and phosphatidylethanolamine synthesis in MCF-7 and A549 cells and its relationship to inhibition of cell proliferation. Eur J Biochem 1995;232:881-8.
42. van der Luit AH, Budde M, Ruurs P, Verheij M, van Blitterswijk WJ. Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis. J Biol Chem 2002;277:39541-7.
43. Zaremberg V, Gajate C, Cacharro LM, Mollinedo F, McMaster CR. Cytotoxicity of an anti-cancer lysophospholipid through selective modification of lipid raft composition. J Biol Chem 2005;280:38047-58.
44. Brenner B, Koppenhoefer U, Weinstock C, Linderkamp O, Lang F, Gulbins E. Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. J Biol Chem 1997;272:22173-81.
45. Mollinedo F, Gajate C. Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy. Drug Resist Updat 2006;9:51-73.
46. Alfalah M, Wetzel G, Fischer I, et al. A novel type of detergent-resistant membranes may contribute to an early protein sorting event in epithelial cells. J Biol Chem 2005;280:42636-43.
47. Browman DT, Resek ME, Zajchowski LD, Robbins SM. Erlin-1 and erlin-2ar e novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER. J Cell Sci 2006;119:3149-60.
48. Obeng EA, Boise LH. Caspase-12and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosis. J Biol Chem 2005;280:29578-87.
49. Lalier L, Cartron PF, Juin P, et al. Bax activation and mitochondrial insertion during apoptosis. Apoptosis 2007;12:887-96.
50. Chandra D, Choy G, Daniel PT, Tang DG. Bax-dependent regulation of Bak by voltage-dependent anion channel 2. J Biol Chem 2005;280:19051-61.