Fas/CD95 down-regulation in lymphoma cells through acquired alkyl-lysophospholipid resistance: Partial role of associated sphingomyelin deficiency

Biochemical Journal

Volumn 425, Issue 1, 2010, Pages 225-234

  Van Blitterswijk, Wim J ^a   Klarenbeek, Jeffrey B ^a   Van Der Luit, Arnold H ^a,b   Anderliesten, Maaike C ^a   Van Lummel, Menno ^a,c   Verheij, Marcel ^a  

^a ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^b Oncodesign   (France)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Alkyl lysophospholipid; Apoptosis resistance; Fas CD95; Lipid raft; Proteasome; Sphingomyelin synthase

Indexed keywords

ACQUIRED RESISTANCE; APOPTOSIS; APOPTOTIC PATHWAYS; CASPASES; CELL LINES; CELL SURFACE EXPRESSION; CELL SURFACES; CELL SYSTEM; CONVERTING ENZYME; DEATH DOMAIN; DOWN-REGULATION; EDELFOSINE; FAS LIGAND; GENE TRANSCRIPTIONS; INDUCED APOPTOSIS; INHIBITORY PROTEINS; INTERLEUKIN-1; LIPID RAFT; LYMPHOMA CELLS; MRNA LEVEL; OCTADECYL; PARENTAL CELLS; PHOSPHOCHOLINE; PROTEASOME INHIBITORS; PROTEASOMES; PROTEIN LEVEL; RESISTANT CELLS; SPHINGOMYELIN; SPHINGOMYELIN SYNTHASES; UNIQUE FEATURES;

ALKYLATION; BODY FLUIDS; CELL CULTURE; CELL MEMBRANES; ENZYMES; GROWTH KINETICS; ONCOLOGY; PROTEINS; RESTORATION; TRANSCRIPTION;

CELL DEATH;

ALKYLLYSOPHOSPHOLIPID; FAS ANTIGEN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CELL GROWTH; CELL SURFACE; CONTROLLED STUDY; CROSS RESISTANCE; DOWN REGULATION; GENETIC TRANSCRIPTION; GROWTH RATE; IMMUNOPRECIPITATION; LIPID ANALYSIS; LIPID RAFT; LIPID TRANSPORT; LIPOGENESIS; LYMPHOMA; MOUSE; NIEMANN PICK DISEASE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; FAS LIGAND PROTEIN; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; FLOW CYTOMETRY; GREEN FLUORESCENT PROTEINS; IMMUNOBLOTTING; LEUPEPTINS; LYMPHOMA; LYSOPHOSPHOLIPIDS; MEMBRANE MICRODOMAINS; MICE; MICROSCOPY, CONFOCAL; PROTEASOME ENDOPEPTIDASE COMPLEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SPHINGOMYELINS; TRANSFECTION;

EID: 72449168537     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090455     Document Type: Article

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