Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum

Oncogene

Volumn 31, Issue 21, 2012, Pages 2627-2639

  Gajate, C ^a,b   Matos Da Silva, M ^a,b   Dakir, E L H ^a   Fonteriz, R I ^c   Alvarez, J ^c   Mollinedo, F ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^c UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

alkyl lysophospholipid analog; apoptotic signaling; edelfosine; endoplasmic reticulum stress; pancreatic cancer; xenograft animal model

Indexed keywords

CALCIUM ION; CASPASE 10; CASPASE 3; CASPASE 4; CASPASE 8; EDELFOSINE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; PROTEIN; PROTEIN BAP31; PROTEIN BID; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL; CANCER GROWTH; CANCER MODEL; CANCER REGRESSION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FEMALE; GENE; HUMAN; HUMAN CELL; MOUSE; NICK END LABELING; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; RNA SPLICING; TUMOR XENOGRAFT; UPREGULATION; XBP1 GENE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; HUMANS; MICE; MICE, INBRED BALB C; MITOCHONDRIA; PANCREATIC NEOPLASMS; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPID ETHERS; TRANSCRIPTION FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA; EUKARYOTA; MUS;

EID: 84861220296     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.446     Document Type: Article

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