Phosphatidylinositol 3′-kinase blocks CD95 aggregation and caspase-8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD95

Journal of Immunology

Volumn 166, Issue 11, 2001, Pages 6564-6569

  Varadhachary, Arun S ^a   Edidin, Michael ^b   Hanlon, Allison M ^a   Peter, Marcus E ^c   Krammer, Peter H ^d   Salgame, Padmini ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; CD8 ANTIGEN; CYTOCHALASIN D; FAS ANTIGEN; HYBRID PROTEIN; NERVE GROWTH FACTOR; PHOSPHATIDYLINOSITOL KINASE; TETANUS TOXOID; ACTIN; CARRIER PROTEIN; CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE; CASPASE 9; FADD PROTEIN, HUMAN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANTIGEN ANTIBODY COMPLEX; APOPTOSIS; ARTICLE; CYTOSKELETON; DIFFUSION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIGATION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL; CAPPING PHENOMENON; CELL CLONE; CELL MEMBRANE; DRUG ANTAGONISM; ENZYMOLOGY; HYDROLYSIS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIGENS, CD95; APOPTOSIS; CARRIER PROTEINS; CASPASE 8; CASPASE 9; CASPASES; CELL MEMBRANE; CLONE CELLS; CYTOSKELETON; DIFFUSION; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HUMANS; HYDROLYSIS; RECEPTOR AGGREGATION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0035336166     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.11.6564     Document Type: Article

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