메뉴 건너뛰기




Volumn 127, Issue 4, 1999, Pages 813-825

Induction of apoptosis in human mitogen-activated peripheral blood T-lymphocytes by the ether phospholipid ET-18-OCH3: Involvement of the Fas receptor/ligand system

Author keywords

Activated T lymphocytes; Antitumour ether lipids; Apoptosis; Autoimmune disease; Edelfosine; ET 18 OCH3; Fas FasL system; Ilmofosine; Miltefosine; Mitochondrial transmembrane potential

Indexed keywords

CELL DNA; CONCANAVALIN A; DNA FRAGMENT; EDELFOSINE; FAS LIGAND; ILMOFOSINE; INTERLEUKIN 2; MESSENGER RNA; MILTEFOSINE; PHYTOHEMAGGLUTININ; REACTIVE OXYGEN METABOLITE;

EID: 0032981815     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702606     Document Type: Article
Times cited : (52)

References (55)
  • 1
    • 0023753713 scopus 로고
    • Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention
    • ACHA-ORBEA, H., MITCHELL, D.J., TIMMERMANN, L., WRAITH, D.C., TAUSCH, G.S., WALDOR, M.K., ZAMVIL, S.S., MCDEVITT, H.O. & STEINMAN, L. (1988). Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell, 54, 263-273.
    • (1988) Cell , vol.54 , pp. 263-273
    • Acha-Orbea, H.1    Mitchell, D.J.2    Timmermann, L.3    Wraith, D.C.4    Tausch, G.S.5    Waldor, M.K.6    Zamvil, S.S.7    Mcdevitt, H.O.8    Steinman, L.9
  • 2
    • 0032519426 scopus 로고    scopus 로고
    • Increased apoptosis of T cell subsets in aging humans: Altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax
    • AGGARWAL, S. & GUPTA, S. (1998). Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax. J. Immunol. 160, 1627-1637.
    • (1998) J. Immunol. , vol.160 , pp. 1627-1637
    • Aggarwal, S.1    Gupta, S.2
  • 3
    • 0018573286 scopus 로고
    • Alkyl-lysophospholipid induced suppression of human lymphocyte response to mitogens and selective killing of lymphoblasts
    • ANDREESEN, R., MODOLELL, M., WELTZIEN, H.U. & MUNDER, P.G. (1979). Alkyl-lysophospholipid induced suppression of human lymphocyte response to mitogens and selective killing of lymphoblasts. Immunobiology, 156, 498-508.
    • (1979) Immunobiology , vol.156 , pp. 498-508
    • Andreesen, R.1    Modolell, M.2    Weltzien, H.U.3    Munder, P.G.4
  • 4
    • 0018149102 scopus 로고
    • Distribution and metabolism of synthetic alkyl analogs of lysophosphatidylcholine in mice
    • ARNOLD, B., REUTHER, R. & WELTZIEN, H.U. (1978). Distribution and metabolism of synthetic alkyl analogs of lysophosphatidylcholine in mice. Biochim. Biophys. Acta., 530, 47-55.
    • (1978) Biochim. Biophys. Acta. , vol.530 , pp. 47-55
    • Arnold, B.1    Reuther, R.2    Weltzien, H.U.3
  • 6
    • 0019465142 scopus 로고
    • The rapid isolation of clonable antigen specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
    • BEN-NUN, A., WERKERLE, H. & COHEN, I.R. (1981). The rapid isolation of clonable antigen specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol., 11, 195-199.
    • (1981) Eur. J. Immunol. , vol.11 , pp. 195-199
    • Ben-Nun, A.1    Werkerle, H.2    Cohen, I.R.3
  • 8
    • 0032484590 scopus 로고    scopus 로고
    • The antiproliferative effect of hexadecylphosphocholine toward HL60 cells is prevented by exogenous lysophosphatidylcholine. Biochim
    • BOGGS, K., ROCK, C.O. & JACKOWSKI, S. (1998). The antiproliferative effect of hexadecylphosphocholine toward HL60 cells is prevented by exogenous lysophosphatidylcholine. Biochim. Biophys. Acta., 1389, 1-12.
    • (1998) Biophys. Acta. , vol.1389 , pp. 1-12
    • Boggs, K.1    Rock, C.O.2    Jackowski, S.3
  • 10
    • 0026506064 scopus 로고
    • 2)-dihydrocyclosporin effects in clinical, functional and histological studies
    • 2)-dihydrocyclosporin effects in clinical, functional and histological studies. J. Autoimmunity., 5, 199-211.
    • (1992) J. Autoimmunity , vol.5 , pp. 199-211
    • Chabannes, D.1    Ryffel, B.2    Borel, J.-F.3
  • 12
    • 0027455786 scopus 로고
    • Induction of apoptosis in human leukemic cells by the ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine: A possible basis for its selective action
    • DIOMEDE, L., COLOTTA, F., PIOVANI, B., RE, F., MODEST, E.J., & SALMONA, M. (1993). Induction of apoptosis in human leukemic cells by the ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine: a possible basis for its selective action. Int. J. Cancer, 53, 124-130.
    • (1993) Int. J. Cancer , vol.53 , pp. 124-130
    • Diomede, L.1    Colotta, F.2    Piovani, B.3    Re, F.4    Modest, E.J.5    Salmona, M.6
  • 13
    • 0028216601 scopus 로고
    • The induction of apoptosis is a common feature of the cytotoxic action of ether-linked glycerophospholipids in human leukemic cells
    • DIOMEDE, L., PIOVANI, B., RE, F., PRINCIPE, P., COLOTTA, F., MODEST, E.J. & SALMONA, M. (1994). The induction of apoptosis is a common feature of the cytotoxic action of ether-linked glycerophospholipids in human leukemic cells. Int. J. Cancer, 57, 645-649.
    • (1994) Int. J. Cancer , vol.57 , pp. 645-649
    • Diomede, L.1    Piovani, B.2    Re, F.3    Principe, P.4    Colotta, F.5    Modest, E.J.6    Salmona, M.7
  • 14
    • 0024614839 scopus 로고
    • Immunotherapy of experimental autoimmune encephalomyelitis (EAE): Differential effect of anti-II.-2 receptor antibody therapy on actively induced and T-line mediated EAE of the Lewis rat
    • ENGELHARDT, B., DIAMANTSTEIN, T. & WERKERLE, H. (1989). Immunotherapy of experimental autoimmune encephalomyelitis (EAE): Differential effect of anti-II.-2 receptor antibody therapy on actively induced and T-line mediated EAE of the Lewis rat. J. Autoimmun., 2, 61-73.
    • (1989) J. Autoimmun. , vol.2 , pp. 61-73
    • Engelhardt, B.1    Diamantstein, T.2    Werkerle, H.3
  • 15
    • 0029935682 scopus 로고    scopus 로고
    • Involvement of CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells
    • FRIESEN, C., HERR, I., KRAMMER, P.H. & DEBATIN, K.-M. (1996). Involvement of CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nature Med., 2, 574-577.
    • (1996) Nature Med. , vol.2 , pp. 574-577
    • Friesen, C.1    Herr, I.2    Krammer, P.H.3    Debatin, K.-M.4
  • 16
    • 0031968488 scopus 로고    scopus 로고
    • 2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid I-O?-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
    • 2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid I-O?-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine. Mol. Pharmacol., 53, 602-612.
    • (1998) Mol. Pharmacol. , vol.53 , pp. 602-612
    • Gajate, C.1    Santos-Beneit, A.2    Modolell, M.3    Mollinedo, F.4
  • 17
    • 0030781018 scopus 로고    scopus 로고
    • Doxorubicin-induced apoptosis in human T-cell leukemia is mediated by caspase-3 activation in a Fas-independent way
    • GAMEN, S., ANEL, A., LASIERRA, P., ALAVA, M.A., MARITINEZ-LORENZO, M.J., PINEIRO, A. & NAVAL, J. (1997). Doxorubicin-induced apoptosis in human T-cell leukemia is mediated by caspase-3 activation in a Fas-independent way. FEBS Lett., 417, 360-364.
    • (1997) FEBS Lett. , vol.417 , pp. 360-364
    • Gamen, S.1    Anel, A.2    Lasierra, P.3    Alava, M.A.4    Maritinez-Lorenzo, M.J.5    Pineiro, A.6    Naval, J.7
  • 18
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • GAVRIELI, Y., SHERMAN, Y. & BEN-SASSON, S.A. (1992). Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell. Biol., 119, 493-501.
    • (1992) J. Cell. Biol. , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 19
    • 0029863534 scopus 로고    scopus 로고
    • Response of human multiple myeloma-derived cell lines to alkyl-lysophospholipids
    • GLASSER, L., DALTON, W.S., FIEDERLEIN, R.L., COOK, P., POWIS, G. & VOGLER, W.R. (1996). Response of human multiple myeloma-derived cell lines to alkyl-lysophospholipids. Exp. Hematol., 24, 253-257.
    • (1996) Exp. Hematol. , vol.24 , pp. 253-257
    • Glasser, L.1    Dalton, W.S.2    Fiederlein, R.L.3    Cook, P.4    Powis, G.5    Vogler, W.R.6
  • 22
    • 0026556898 scopus 로고
    • Alkyllysophospholipid prevents induction of experimental allergic encephalomyclitis
    • KLEIN-FRANKE, A. &MUNDER, P.G. (1992). Alkyllysophospholipid prevents induction of experimental allergic encephalomyclitis. J. Autoimmunity, 5, 83-91.
    • (1992) J. Autoimmunity , vol.5 , pp. 83-91
    • Klein-Franke, A.1    Munder, P.G.2
  • 23
  • 24
    • 0031904988 scopus 로고    scopus 로고
    • Alkylphosphocholines induce apoptosis in HL-60 and U-937 leukemic cells
    • KONSTANTINOV, S.M., EIBL, II. & and BERGER, M.R. (1998). Alkylphosphocholines induce apoptosis in HL-60 and U-937 leukemic cells. Cancer Chemother. Pharmacol., 41, 210-216.
    • (1998) Cancer Chemother. Pharmacol. , vol.41 , pp. 210-216
    • Konstantinov, S.M.1    Eibl, I.I.2    Berger, M.R.3
  • 25
    • 0029076908 scopus 로고
    • Immunoregulation and drug treatment in chronic relapsing experimental allergic encephalomyelitis in the Lewis rat
    • KOVARIK, J., CHABANNES, D. & BOREL, J.F. (1995). Immunoregulation and drug treatment in chronic relapsing experimental allergic encephalomyelitis in the Lewis rat. Int. J. Immunopharmacol., 17, 255-263.
    • (1995) Int. J. Immunopharmacol. , vol.17 , pp. 255-263
    • Kovarik, J.1    Chabannes, D.2    Borel, J.F.3
  • 27
    • 0029788696 scopus 로고    scopus 로고
    • Differential expression of Fas(CD95) and Fas ligand on normal human phagocytes: Implications for the regulation of apoptosis in neutrophils
    • LILES, W.C., KIENER, P.A., LEDBETTER, J.A., ARUFFO, A. & KLEBANOFF, S.J. (1996). Differential expression of Fas(CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils. J. Exp. Med., 184, 429-440.
    • (1996) J. Exp. Med. , vol.184 , pp. 429-440
    • Liles, W.C.1    Kiener, P.A.2    Ledbetter, J.A.3    Aruffo, A.4    Klebanoff, S.J.5
  • 28
    • 0028597086 scopus 로고
    • Antitumor ether lipids and alkylphosphocholines
    • LOHMEYER, M. & BITTMAN, R. (1994). Antitumor ether lipids and alkylphosphocholines. Drugs Future, 19, 1021-1037.
    • (1994) Drugs Future , vol.19 , pp. 1021-1037
    • Lohmeyer, M.1    Bittman, R.2
  • 29
    • 0028802845 scopus 로고
    • Fas and FasL in the homeostatic regulation of immune responses
    • LYNCH, D.H., RAMSDELL, F. & ALDERSON, M.R. (1995). Fas and FasL in the homeostatic regulation of immune responses. Immunol. Today, 16, 569-574.
    • (1995) Immunol. Today , vol.16 , pp. 569-574
    • Lynch, D.H.1    Ramsdell, F.2    Alderson, M.R.3
  • 31
    • 0026749884 scopus 로고
    • Enhancement of human neutrophil functions by a monoclonal antibody directed against a 19-kDa antigen
    • MOLLINEDO, F., BURGALETA, C., VELASCO, G., ARROYO, A.G., ACEVEDO, A. & BARASOAIN, I. (1992). Enhancement of human neutrophil functions by a monoclonal antibody directed against a 19-kDa antigen. J. Immunol., 149, 323-330.
    • (1992) J. Immunol. , vol.149 , pp. 323-330
    • Mollinedo, F.1    Burgaleta, C.2    Velasco, G.3    Arroyo, A.G.4    Acevedo, A.5    Barasoain, I.6
  • 33
    • 0028170274 scopus 로고
    • The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells
    • MOLLINEDO, F., GAJATE, C. & MODOLELL, M. (1994). The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells. Biochem. J., 302, 325-329.
    • (1994) Biochem. J. , vol.302 , pp. 325-329
    • Mollinedo, F.1    Gajate, C.2    Modolell, M.3
  • 35
    • 0001823330 scopus 로고    scopus 로고
    • The human leukemia cell line HL-60 as a cell culture model to study neutrophil functions and inflammatory cell responses
    • ed. Clynes, M. Heidelberg, Germany: Springer-Verlag
    • MOLLINEDO, F., SANTOS-BENETT, A.M. & GAJATE, C. (1998). The human leukemia cell line HL-60 as a cell culture model to study neutrophil functions and inflammatory cell responses. In Animal Cell Culture Techniques. ed. Clynes, M. pp. 264-297. Heidelberg, Germany: Springer-Verlag.
    • (1998) Animal Cell Culture Techniques , pp. 264-297
    • Mollinedo, F.1    Santos-Benett, A.M.2    Gajate, C.3
  • 36
    • 0025177753 scopus 로고
    • Antitumoral and other biomedical activities of synthetic ether lysophospholipids
    • MUNDER, P.G. & WESTPHAL, O. (1990). Antitumoral and other biomedical activities of synthetic ether lysophospholipids. Chem. Immunol., 49, 206-235.
    • (1990) Chem. Immunol. , vol.49 , pp. 206-235
    • Munder, P.G.1    Westphal, O.2
  • 37
    • 0030892234 scopus 로고    scopus 로고
    • Apoptosis by death factor
    • NAGATA, S. (1997). Apoptosis by death factor. Cell, 88, 355-365.
    • (1997) Cell , vol.88 , pp. 355-365
    • Nagata, S.1
  • 38
    • 0025726216 scopus 로고
    • A rapid simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • NICOLETTI, I., MIGLIORATI, G., PAGLIACCI, M.C. & RICCARDI, C. (1991). A rapid simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Meth., 139, 271-280.
    • (1991) J. Immunol. Meth. , vol.139 , pp. 271-280
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Riccardi, C.4
  • 39
    • 0029808372 scopus 로고    scopus 로고
    • The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand
    • O'CONNELL, J., O'SULLIVAN, G.C., COLLINS, J.K. & SHANAHAN, F. (1996). The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand. J. Exp. Med., 184, 1075-1082.
    • (1996) J. Exp. Med. , vol.184 , pp. 1075-1082
    • O'Connell, J.1    O'Sullivan, G.C.2    Collins, J.K.3    Shanahan, F.4
  • 40
    • 0026655823 scopus 로고
    • Apoptosis in interleukin-3-dependent hemopoietic cells. Quantification by two cytometric methods
    • ORMEROD, M.G., COLLINS, M.K.L., RODRIGUEZ-TARDUCHY, G. & ROBERTSON, D. (1992). Apoptosis in interleukin-3-dependent hemopoietic cells. Quantification by two cytometric methods. J. Immunol. Meth., 153, 57-65.
    • (1992) J. Immunol. Meth. , vol.153 , pp. 57-65
    • Ormerod, M.G.1    Collins, M.K.L.2    Rodriguez-Tarduchy, G.3    Robertson, D.4
  • 41
    • 0029993331 scopus 로고    scopus 로고
    • Apoptosis and the maintenance of homeostasis in the immune system
    • OSBORNE, B.A. (1996). Apoptosis and the maintenance of homeostasis in the immune system. Curr. Opin. Immunol., 8, 245-254.
    • (1996) Curr. Opin. Immunol. , vol.8 , pp. 245-254
    • Osborne, B.A.1
  • 42
    • 0032031457 scopus 로고    scopus 로고
    • Functional roles of Fas and Bcl-2-regulated apoptosis in T lymphocytes
    • PARIJS, L.V., BIUCKIANS, A. & ABBAS, A.K. (1998). Functional roles of Fas and Bcl-2-regulated apoptosis in T lymphocytes. J. Immunol., 160, 2065-2071.
    • (1998) J. Immunol. , vol.160 , pp. 2065-2071
    • Parijs, L.V.1    Biuckians, A.2    Abbas, A.K.3
  • 43
    • 0028917643 scopus 로고
    • Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease
    • PEREZ-SALA, D., COLLADO-ESCOBAR, D. & MOLLINEDO, F. (1995). Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease. J. Biol. Chem., 270, 6235-6242.
    • (1995) J. Biol. Chem. , vol.270 , pp. 6235-6242
    • Perez-Sala, D.1    Collado-Escobar, D.2    Mollinedo, F.3
  • 44
    • 0029036412 scopus 로고
    • Alterations of mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis
    • PETIT, P.X., LECOEUR, H., ZORN, E., DAUGUET, C., MIGNOTTE, B. & GOUGEON, M.L. (1995). Alterations of mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis. J. Cell. Biol., 130, 157-167.
    • (1995) J. Cell. Biol. , vol.130 , pp. 157-167
    • Petit, P.X.1    Lecoeur, H.2    Zorn, E.3    Dauguet, C.4    Mignotte, B.5    Gougeon, M.L.6
  • 45
    • 0025690822 scopus 로고
    • Analysis of the membrane potential of rat- and mouse-liver mitochondria by flow cytometry and possible applications
    • PETIT, P.X., O'CONNOR, J.E., GRUNWALD, D. & BROWN, S.C. (1990). Analysis of the membrane potential of rat- and mouse-liver mitochondria by flow cytometry and possible applications. Eur. J. Biochem., 194, 389-397.
    • (1990) Eur. J. Biochem. , vol.194 , pp. 389-397
    • Petit, P.X.1    O'Connor, J.E.2    Grunwald, D.3    Brown, S.C.4
  • 46
    • 0027459908 scopus 로고
    • Phase II study of daily oral miltefosine (hexadecylphosphocholine) in advanced colorectal cancer
    • PLANTING, A.S., STOTER, G. & VERWEI, J. (1993). Phase II study of daily oral miltefosine (hexadecylphosphocholine) in advanced colorectal cancer. Eur. J. Cancer, 29A, 518-519.
    • (1993) Eur. J. Cancer , vol.29 A , pp. 518-519
    • Planting, A.S.1    Stoter, G.2    Verwei, J.3
  • 47
    • 0023272841 scopus 로고
    • Experimental allergic encephalomyelitis mediated by murine encephalitogenic T-cell lines specific for myelin proteolipid apoprotein
    • SATOII, J., SAKAI, K., ENDOII, M., KOIKE, F., KUNISHITA, T., NAMIKAWA, T., YAMAMURA, T. & TABIRA, T. (1987). Experimental allergic encephalomyelitis mediated by murine encephalitogenic T-cell lines specific for myelin proteolipid apoprotein. J. Immunol., 138, 179-184.
    • (1987) J. Immunol. , vol.138 , pp. 179-184
    • Satoii, J.1    Sakai, K.2    Endoii, M.3    Koike, F.4    Kunishita, T.5    Namikawa, T.6    Yamamura, T.7    Tabira, T.8
  • 48
    • 0026355993 scopus 로고
    • Hexadecylphosphocholine: Preclinical and the first clinical results of a new antitumor drug
    • UNGER, C. & EIBL, H. (1991). Hexadecylphosphocholine: preclinical and the first clinical results of a new antitumor drug. Lipids, 26, 1412-1417.
    • (1991) Lipids , vol.26 , pp. 1412-1417
    • Unger, C.1    Eibl, H.2
  • 49
    • 0026621940 scopus 로고
    • Hexadecylphosphocholine in the topical treatment of skin metastases in breast cancer patients
    • UNGER, C., SINDERMANN, H., PEUKERT, M., HILGARD, P., ENGEL, J. & EIBL, H. (1992). Hexadecylphosphocholine in the topical treatment of skin metastases in breast cancer patients. Prog. Exp. Tumor Res., 34, 153-159.
    • (1992) Prog. Exp. Tumor Res. , vol.34 , pp. 153-159
    • Unger, C.1    Sindermann, H.2    Peukert, M.3    Hilgard, P.4    Engel, J.5    Eibl, H.6
  • 53
    • 0031032095 scopus 로고    scopus 로고
    • 3 synergistically enhances the merocyanine 540-mediated photoinactivation of leukemia cells: Implications for the extracorporeal purging of autologous hematopoietic stem cells
    • 3 synergistically enhances the merocyanine 540-mediated photoinactivation of leukemia cells: implications for the extracorporeal purging of autologous hematopoietic stem cells. Bone Marrow Transplant, 19, 113-119.
    • (1997) Bone Marrow Transplant , vol.19 , pp. 113-119
    • Yamazaki, T.1    Sieber, F.2
  • 54
    • 0021966856 scopus 로고
    • T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyclination
    • ZAMVIL, S., NELSON, P., TROTTER, J., MITCHELL, D., KNBLER, R., FRITZ, R. & STEINMAN, L. (1985). T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyclination. Nature, 317, 355-358.
    • (1985) Nature , vol.317 , pp. 355-358
    • Zamvil, S.1    Nelson, P.2    Trotter, J.3    Mitchell, D.4    Knbler, R.5    Fritz, R.6    Steinman, L.7
  • 55
    • 0028903933 scopus 로고
    • Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
    • ZAMZAMI, N., MARCHETTI, P., CASTEDO, M., ZANIN, C., VAYSSIERE, J.L., PETIT, P.X. & KROEMER, G. (1995). Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med., 181, 1661-1672.
    • (1995) J. Exp. Med. , vol.181 , pp. 1661-1672
    • Zamzami, N.1    Marchetti, P.2    Castedo, M.3    Zanin, C.V.J.L.4    Petit, P.X.5    Kroemer, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.