Decreased sensitivity to 1-O-octadecyl-2-O-methyl-glycerophosphocholine in MCF-7 cells adapted for serum-free growth correlates with constitutive association of Raf-1 with cellular membranes

Cancer Research

Volumn 59, Issue 19, 1999, Pages 4808-4815

  Samadder, Pranati ^a   Arthur, Gilbert ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EDELFOSINE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN F2 ALPHA; RAF PROTEIN;

ADAPTATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG METABOLISM; DRUG SENSITIVITY; DRUG UPTAKE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CELL DIVISION; CELL MEMBRANE; CLONE CELLS; CULTURE MEDIA, SERUM-FREE; ENZYME ACTIVATION; FEMALE; HUMANS; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOLIPID ETHERS; PROTO-ONCOGENE PROTEINS C-RAF; TUMOR CELLS, CULTURED;

EID: 0033214968     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Lewis, T. S., Shapiro, P. S., and Ahn, N. G. Signal transduction through MAP kinase cascades. Adv. Cancer Res., 74: 49-139, 1998.
2. Daum, G., Eisenmann-Tappe, I., Fries, H. W., Troppmair, J., and Rapp, U. R. The ins and outs of Raf kinases. Trends Biochem. Sci., 19: 474-480, 1994.
3. Morrison, D. B. K., and Cutler, R. E., Jr. The complexity of Raf-1 regulation. Curr. Opin. Cell Biol., 9: 174-179, 1997.
4. Tzivion, G., Luo, Z., and Avruch, J. A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Nature (Lond.), 394: 88-92, 1998.
5. King, A. J., Sun, H., Diaz, B., Barnard, D., Miao, W., Bagrodia, S., and Marshall, M. S. The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature (Lond.), 396: 180-183, 1998.
6. Barnard, D., Diaz, B., Clawson, D., and Marshall, M. Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms. Oncogene, 17: 1539-1547, 1998.
7. Thorson, J. A., Yu, L. W., Hsu, A. L., Shib, N. Y., Graves, P. R., Tanner, J. W., Allen, P. M., Piwnica-Worms, H., and Shaw, A. S. 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity. Mol. Cell. Biol., 18: 5229-5238, 1998.
8. Stokoe, D., and McCormic, F. Activation of c-Raf-1 by ras and src through different mechanisms: activation in vivo and in vitro. EMBO J., 16: 2384-2396, 1997.
9. Ghosh, S., and Bell, R. M. Regulation of Raf-1 kinase by interaction with the lipid second messenger, phosphatidic acid. Biochem. Soc. Trans., 25: 561-565, 1997.
10. Huwiler, A., Brunner, J., Hummel, R., Vervoordeldonk, M., Stabel, S., van den Bosch, H., and Pfeilschifter, J. Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase. Proc. Natl. Acad. Sci. USA, 93: 6959-6963, 1996.
11. Bittman, R., and Arthur, G. Antitumor ether lipids: biological and biochemical effects. In: A. S. Janoff (ed.), Liposomes: Rational Design, pp. 125-144. New York: Marcel Dekker, 1998.
12. Berdel, W. E. Membrane interactive lipids as experimental anticancer drugs. Br. J. Cancer, 64: 208-211, 1991.
13. Houlihan, W. J., Lohmeyer, M., Workman, P., and Cheon, S. H. Phospholipid antitumor agents. Med. Res. Rev., 15: 157-223, 1995.
14. Principe, P., and Braquet, P. Advances in ether phospholipids treatment of cancer. Crit. Rev. Oncol. Hematol., 18: 155-178, 1995.
15. Zhou, X., Lu, X., Richard, C., Xiong, W., Litchfield, D. W., Bittman, R., and Arthur, G. 1-O-Octadecyl-2-O-methyl-glycerophosphocholine inhibits the transduction of growth signals via the MAP kinase cascade in cultured MCF-7 cells. J. Clin. Investig., 98: 937-944, 1996.
16. Ashagbley, A., Samadder, P., Bittman, R., Erukulla, R. K., Byun, H-S., and Arthur, G. Synthesis of ether-linked analogues of lysophosphatidate and their effect on the proliferation of human epithelial cancer cells in vitro. Anticancer Res., 16: 1813-1818, 1996.
17. Lu, X., and Arthur, G. Perturbations of cellular acylation processes by the synthetic alkyllysophospholipid 1-O-octadecyl-2-O-methyl-glycero-3-phosphocholine do not correlate with inhibition of proliferation of MCF-7 and T84 cell lines. Cancer Res., 52: 2806-2812, 1992.
18. Lu, X., Zhou, X., Kardash, D., and Arthur, G. Metabolism of alkyllysophospholipid in epithelial cancer cell lines and inhibition of cell growth. Biochem. Cell. Biol., 71: 122-126, 1993.
19. Wartmann, M., and Davies, R. J. The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex. J. Biol. Chem., 269: 6695-6701, 1994.
20. Barnes, D., and Sato, G. Growth of a human mammary tumor cell line in serum-free medium. Nature (Lond.), 281: 388-389, 1979.
21. Band, V., and Sager, J. Distinctive traits of normal and tumor-derived human mammary epithelial cells expressed in a medium that supports long-term growth of both cell types. Proc. Natl. Acad. Sci. USA, 86: 1249-1253, 1989.
22. Barnes, D., and Sato, G. Methods for growth of cultured cells in serum free medium. Anal. Biochem., 102: 255-270, 1980.
23. Leevers, S. J., Paterson, H. F., and Marshall, C. J. Requirement for ras in Raf activation is overcome by targeting to the plasma membrane. Nature (Lond.), 369: 411-414, 1994.
24. Stokoe, D., Macdonald, S. G., Cadwallader, K., Symons, M., and Hancock, J. F. Activation of Raf-1 as a result of recruitment to the plasma membrane. Science (Washington DC), 264: 1463-1467, 1994.
25. Ito, S., Sakamoto, K., Mochizuki-Oda, N., Ezashi, T., Miwa, K., Okuda-Ashitaka, E., Shevchenko, V. I., Kiso, Y., and Hayaishi, O. Prostaglandin F2α receptor is coupled to Gq in cDNA-transfected Chinese hamster ovary cells. Biochem. Biophys. Res. Commun., 200: 756-762, 1994.
26. Sugimoto, Y., Hasumoto, K., Namba, T., Irie, A., Katsuyama, M., Negishi, M., Kakizuka, A., Narumiya, S., and Ichikawa, A. Cloning and expression of a cDNA for mouse prostaglandin F receptor. J. Biol. Chem., 269: 1356-1360, 1994.
27. Black, F. M., and Wakelam, M. J. Desensitization of prostaglandin F2α-stimulated inositol phosphate generation in NIH-3T3 fibroblasts transformed by overexpression of normal c-Ha-ras-1, c-Ki-ras-2 and c-N-ras genes. Biochem. J., 267: 809-813, 1990.
28. 2+ in bovine luteal cells. Proc. Natl. Acad. Sci. USA, 84: 3728-3732, 1987.
29. Hakeda, Y., Shiokawa, M., Mano, H., Kameda, T., Raisz, L. G., andKumegawa, M.Prostaglandin F2α stimulates tyrosine phosphorylation and mitogen-activated protein kinase in osteoblastic MC3T3-E1 cells via protein kinase C activation. Endocrinology, 138: 1821-1828, 1997.
30. 2+ by prostaglandin F2α can be modulated by fluoride in 3T3-L1fibroblasts Biochem. J., 272: 167-174, 1990.
31. ras-GTP complex and mitogen-activated protein kinase in NIH-3T3 cells via Gq-protein-coupled pathway. J. Biol. Chem., 270: 8984-8990, 1995.