CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly

Journal of Experimental Medicine

Volumn 196, Issue 3, 2002, Pages 335-348

  Jones, Russell G ^a   Elford, Alisha R ^a   Parsons, Michael J ^a   Wu, Linda ^a   Krawczyk, Connie M ^a   Yeh, Wen Chen ^a   Hakem, Razqallah ^a   Rottapel, Robert ^a   Woodgett, James R ^a   Ohashi, Pamela S ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Apoptosis; Caspase 8; CD28; Fas; PKB Akt

Indexed keywords

CASPASE 3; CASPASE 8; CD28 ANTIGEN; FAS ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, CD28; ANTIGENS, CD95; APOPTOSIS; AUTOIMMUNITY; CASPASE 8; CASPASE 9; CASPASES; ENZYME ACTIVATION; HOMEOSTASIS; MICE; MICE, INBRED C57BL; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 0037025948     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020307     Document Type: Article

References (85)

1. CD28/B7 system of T cell costimulation
2. T-cell regulation by CD28 and CTLA-4
3. L
4. CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response
5. CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation
6. L restores cell survival, but not proliferation and effector differentiation, in CD28-deficient T lymphocytes
7. A point mutation in CD28 distinguishes proliferative signals from survival signals
8. Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo
9. Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene
10. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death
11. IL-2 and related cytokines can promote T cell survival by activating AKT
12. PKB/AKT: Functional insights from genetic models
13. AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
14. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
15. The tumor suppressor, PTEN/MMACI, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
16. Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B
17. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines
18. Selection of the T cell repertoire
19. Mature T lymphocyte apoptosis - Immune regulation in a dynamic and unpredictable environment
20. The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity
21. Fas and Fas ligand: Lpr and gld mutations
22. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity
23. Dominant interfering Fas gene mutations
24. Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity
25. Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
26. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
27. Mature T cell reactivity altered by a peptide agonist that induces positive selection
28. Ligation of CD28 receptor by B7 induces formation of D-3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation
29. Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide
30. The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice
31. Programmed cell death and extrathymic reduction of Vβ8+ CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B
32. Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells
33. TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions
34. Immune down-regulation and peripheral deletion of CD8 T cells does not require TNF receptor-ligand interactions nor CD95
35. Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Fas lpr mice
36. Expression of active PKB in T cells perturbs both T and B cell homeostasis and promotes inflammation
37. CD95's deadly mission in the immune system
38. Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis
39. The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis
40. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
41. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
42. +/- mice
43. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
44. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death
45. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
46. NF-κB antiapoptosis: Induction of TRAF1 and TRAF2 and c-lAP1 and c-lAP2 to suppress caspase-8 activation
47. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
48. Inhibition of JNK activation through NF-kappaB target genes
49. Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP)
50. Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells
51. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis reduced by death receptors
52. Inhibition of death receptor signals by cellular FLIP
53. Cell death attenuation by 'Usurpin', a DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD95 (Fas, APO-1) receptor complex
54. Analysis of the CD4 coreceptor and activation-induced costimulatory molecules in antigen-mediated mature T lymphocyte death
55. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance
56. CD28 can promote T cell survival through a phosphatidylinositol 3-kinase-independent mechanism
57. L
58. Two CD95 (APO-1/Fas) signaling pathways
59. nul T cells are associated with defects in apoptotic pathways
60. Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-costimulated human T cells
61. Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B
62. The opposing roles of the Akt and c-Myc signalling pathways in survival from CD95-mediated apoptosis
63. Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex
64. Interleukin-2 programs mouse alpha/beta T lymphocytes for apoptosis
65. Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes
66. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
67. Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo
68. Selective up-regulation of phosphatidylinositol 3′-kinase activity in Th2 cells inhibits caspase-8 cleavage at the death-inducing complex: A mechanism for Th2 resistance from Fas-mediated apoptosis
69. Forkhead transcription factors: New insights into protein kinase B (c-akt) signaling
70. c-myb transcription is activated by protein kinase B (PKB) following interleukin-2 stimulation of T cells and is required for PKB-mediated protection from apoptosis
71. NF-κB activation by tumor necrosis factor requires the Akt serine-threonine kinase
72. NF-κB is a target of AKT in anti-apoptotic PDGF signalling
73. Induction of NF-κB by the Akt/PKB kinase
74. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
75. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
76. Regulation of cell death protease caspase-9 by phosphorylation
77. Bad can act as a key regulator of T cell apoptosis and T cell development
78. Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9
79. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase
80. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NF-kappaB activation
81. FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation
82. Regulation of lymphocyte proliferation and death by FLIP
83. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
84. A role for CD95 ligand in preventing graft rejection
85. Costimulation blockade promotes the apoptotic death of graft-infiltrating T cells and prolongs survival of hepatic allografts from FLT3L-treated donors