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Volumn 307, Issue 8, 2014, Pages R956-R969

Autophagy is essential to support skeletal muscle plasticity in response to endurance exercise

Author keywords

Amino acids; Endurance exercise; Mitophagy; MTOR; Protein turnover

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; TRANSCRIPTION FACTOR FOXO; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE;

EID: 84908080008     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00187.2014     Document Type: Review
Times cited : (107)

References (161)
  • 1
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B
    • Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PRJ, Reese CB, Cohen P. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B. Curr Biol 7: 261-269, 1997.
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.J.5    Reese, C.B.6    Cohen, P.7
  • 4
    • 18144386162 scopus 로고    scopus 로고
    • Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance traininglike electrical muscle stimulation
    • Atherton PJ, Babraj J, Smith K, Singh J, Rennie MJ, Wackerhage H. Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance traininglike electrical muscle stimulation. FASEB J 19: 786-788, 2005.
    • (2005) FASEB J , vol.19 , pp. 786-788
    • Atherton, P.J.1    Babraj, J.2    Smith, K.3    Singh, J.4    Rennie, M.J.5    Wackerhage, H.6
  • 6
    • 0025122063 scopus 로고
    • The effect  ofamino acid infusion on leg protein turnover assessed by L-[15N]phenylalanine and L-[1-13C]leucine exchange
    • Bennet WM, Connacher AA, Scrimgeour CM, Rennie MJ. The effect  ofamino acid infusion on leg protein turnover assessed by L-[15N]phenylalanine and L-[1-13C]leucine exchange. Eur J Clin Invest 20: 41-50, 1990.
    • (1990) Eur J Clin Invest , vol.20 , pp. 41-50
    • Bennet, W.M.1    Connacher, A.A.2    Scrimgeour, C.M.3    Rennie, M.J.4
  • 7
    • 0024567234 scopus 로고
    • Increase in anterior tibialis muscle protein synthesis in healthy man during mixed amino acid infusion: Studies of incorporation of [1-13C]leucine
    • Bennet WM, Connacher AA, Scrimgeour CM, Smith K, Rennie MJ. Increase in anterior tibialis muscle protein synthesis in healthy man during mixed amino acid infusion: studies of incorporation of [1-13C]leucine. Clin Sci Lond Engl (1979) 76: 447-454, 1989.
    • (1979) Clin Sci Lond Engl , vol.447-454 , Issue.1989 , pp. 76
    • Bennet, W.M.1    Connacher, A.A.2    Scrimgeour, C.M.3    Smith, K.4    Rennie, M.J.5
  • 8
    • 0016220406 scopus 로고
    • Intracellular free amino acid concentration in human muscle tissue
    • Bergström J, Fürst P, Norée LO, Vinnars E. Intracellular free amino acid concentration in human muscle tissue. J Appl Physiol 36: 693-697, 1974.
    • (1974) J Appl Physiol , vol.36 , pp. 693-697
    • Bergström, J.1    Fürst, P.2    Norée, L.O.3    Vinnars, E.4
  • 9
    • 0030859081 scopus 로고    scopus 로고
    • An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein
    • Biolo G, Tipton KD, Klein S, Wolfe RR. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am J Physiol Endocrinol Metab 273: E122-E129, 1997.
    • (1997) Am J Physiol Endocrinol Metab , vol.273 , pp. E122-E129
    • Biolo, G.1    Tipton, K.D.2    Klein, S.3    Wolfe, R.R.4
  • 10
    • 84895509212 scopus 로고    scopus 로고
    • Can we optimise the exercise training prescription to maximise improvements in mitochondria function and content?
    • Bishop DJ, Granata C, Eynon N. Can we optimise the exercise training prescription to maximise improvements in mitochondria function and content? Biochim Biophys Acta 1840: 1266-1275, 2014.
    • (2014) Biochim Biophys Acta , vol.1840 , pp. 1266-1275
    • Bishop, D.J.1    Granata, C.2    Eynon, N.3
  • 11
    • 27944504351 scopus 로고    scopus 로고
    • p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 171: 603-614, 2005.
    • (2005) J Cell Biol , vol.171 , pp. 603-614
    • Bjørkøy, G.1    Lamark, T.2    Brech, A.3    Outzen, H.4    Perander, M.5    Overvatn, A.6    Stenmark, H.7    Johansen, T.8
  • 12
    • 31544454965 scopus 로고    scopus 로고
    • Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise
    • Blomstrand E, Eliasson J, Karlsson HKR, Köhnke R. Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr 136: 269S-73S, 2006.
    • (2006) J Nutr , vol.136 , pp. 269S-273S
    • Blomstrand, E.1    Eliasson, J.2    Karlsson, H.K.R.3    Köhnke, R.4
  • 13
    • 0037025356 scopus 로고    scopus 로고
    • AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
    • Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem 277: 23977-23980, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 23977-23980
    • Bolster, D.R.1    Crozier, S.J.2    Kimball, S.R.3    Jefferson, L.S.4
  • 14
    • 67650076601 scopus 로고    scopus 로고
    • MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission
    • Braschi E, Zunino R, McBride HM. MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission. EMBO Rep 10: 748-754, 2009.
    • (2009) EMBO Rep , vol.10 , pp. 748-754
    • Braschi, E.1    Zunino, R.2    McBride, H.M.3
  • 15
    • 66349103681 scopus 로고
    • Exercise training and protein metabolism: Influences of contraction, protein intake, and sexbased differences
    • 2009
    • Burd NA, Tang JE, Moore DR, Phillips SM. Exercise training and protein metabolism: influences of contraction, protein intake, and sexbased differences. J Appl Physiol (1985) 106: 1692-1701, 2009.
    • (1985) J Appl Physiol , pp. 106-1701
    • Burd, N.A.1    Tang, J.E.2    Moore, D.R.3    Phillips, S.M.4
  • 17
    • 0024786438 scopus 로고
    • Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities
    • Carling D, Clarke PR, Zammit VA, Hardie DG. Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities. Eur J Biochem 186: 129-136, 1989.
    • (1989) Eur J Biochem , vol.186 , pp. 129-136
    • Carling, D.1    Clarke, P.R.2    Zammit, V.A.3    Hardie, D.G.4
  • 18
    • 0024335432 scopus 로고
    • The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase
    • Carling D, Hardie DG. The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase. Biochim Biophys Acta 1012: 81-86, 1989.
    • (1989) Biochim Biophys Acta , vol.1012 , pp. 81-86
    • Carling, D.1    Hardie, D.G.2
  • 19
    • 84877577382 scopus 로고    scopus 로고
    • Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy
    • Castets P, Lin S, Rion N, Di Fulvio S, Romanino K, Guridi M, Frank S, Tintignac LA, Sinnreich M, Rüegg MA. Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy. Cell Metab 17: 731-744, 2013.
    • (2013) Cell Metab , vol.17 , pp. 731-744
    • Castets, P.1    Lin, S.2    Rion, N.3    Di Fulvio, S.4    Romanino, K.5    Guridi, M.6    Frank, S.7    Tintignac, L.A.8    Sinnreich, M.9    Rüegg, M.A.10
  • 20
    • 0023642627 scopus 로고
    • A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
    • Carling D, Zammit VA, Hardie DG. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett 223: 217–222, 1987.
    • (1987) FEBS Lett , vol.223 , pp. 217-222
    • Carling, D.1    Zammit, V.A.2    Hardie, D.G.3
  • 21
    • 0041356888 scopus 로고    scopus 로고
    • Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycinand farnesylation-dependent manner
    • Castro AF, Rebhun JF, Clark GJ, Quilliam LA. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycinand farnesylation-dependent manner. J Biol Chem 278: 32493-32496, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 32493-32496
    • Castro, A.F.1    Rebhun, J.F.2    Clark, G.J.3    Quilliam, L.A.4
  • 24
    • 84866417635 scopus 로고    scopus 로고
    • Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy
    • Cohen S, Zhai B, Gygi SP, Goldberg AL. Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy. J Cell Biol 198: 575-589, 2012.
    • (2012) J Cell Biol , vol.198 , pp. 575-589
    • Cohen, S.1    Zhai, B.2    Gygi, S.P.3    Goldberg, A.L.4
  • 25
    • 77749299092 scopus 로고    scopus 로고
    • The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse
    • Csibi A, Cornille K, Leibovitch MP, Poupon A, Tintignac LA, Sanchez AMJ, Leibovitch SA. The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse. PloS One 5: e8994, 2010.
    • (2010) PloS One , vol.5 , pp. e8994
    • Csibi, A.1    Cornille, K.2    Leibovitch, M.P.3    Poupon, A.4    Tintignac, L.A.5    Sanchez, A.M.J.6    Leibovitch, S.A.7
  • 26
    • 63249134179 scopus 로고    scopus 로고
    • MAFbx/Atrogin-1 controls the activity of the initiation factor eIF3-f in skeletal muscle atrophy by targeting multiple C-terminal lysines
    • Csibi A, Leibovitch MP, Cornille K, Tintignac LA, Leibovitch SA. MAFbx/Atrogin-1 controls the activity of the initiation factor eIF3-f in skeletal muscle atrophy by targeting multiple C-terminal lysines. J Biol Chem 284: 4413-4421, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 4413-4421
    • Csibi, A.1    Leibovitch, M.P.2    Cornille, K.3    Tintignac, L.A.4    Leibovitch, S.A.5
  • 30
    • 80053476420 scopus 로고    scopus 로고
    • The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
    • Egan D, Kim J, Shaw RJ, Guan KL. The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR. Autophagy 7: 643-644, 2011.
    • (2011) Autophagy , vol.7 , pp. 643-644
    • Egan, D.1    Kim, J.2    Shaw, R.J.3    Guan, K.L.4
  • 33
    • 84902129468 scopus 로고    scopus 로고
    • Exercise-induced skeletal muscle remodeling and metabolic adaptation: Redox signaling and role of autophagy
    • Ferraro E, Giammarioli AM, Chiandotto S, Spoletini I, Rosano G. Exercise-induced skeletal muscle remodeling and metabolic adaptation: redox signaling and role of autophagy. Antioxid Redox Signal 21: 154-176, 2014.
    • (2014) Antioxid Redox Signal , vol.21 , pp. 154-176
    • Ferraro, E.1    Giammarioli, A.M.2    Chiandotto, S.3    Spoletini, I.4    Rosano, G.5
  • 38
    • 0024516569 scopus 로고
    • Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism
    • Garton AJ, Campbell DG, Carling D, Hardie DG, Colbran RJ, Yeaman SJ. Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. Eur J Biochem 179: 249-254, 1989.
    • (1989) Eur J Biochem , vol.179 , pp. 249-254
    • Garton, A.J.1    Campbell, D.G.2    Carling, D.3    Hardie, D.G.4    Colbran, R.J.5    Yeaman, S.J.6
  • 39
    • 84869005068 scopus 로고    scopus 로고
    • Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2 /calmodulin-dependent kinase kinase)
    • 2+/calmodulin-dependent kinase kinase-β(CaMKK-β). J Biol Chem 287: 38625-38636, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 38625-38636
    • Ghislat, G.1    Patron, M.2    Rizzuto, R.3    Knecht, E.4
  • 40
    • 0035096719 scopus 로고    scopus 로고
    • Regulation of skeletal muscle amino acid metabolism during exercise
    • Gibala MJ. Regulation of skeletal muscle amino acid metabolism during exercise. Int J Sport Nutr Exerc Metab 11: 87-108, 2001.
    • (2001) Int J Sport Nutr Exerc Metab , vol.11 , pp. 87-108
    • Gibala, M.J.1
  • 41
    • 77955491433 scopus 로고    scopus 로고
    • Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise
    • Glynn EL, Fry CS, Drummond MJ, Dreyer HC, Dhanani S, Volpi E, Rasmussen BB. Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise. Am J Physiol Regul Integr Comp Physiol 299: R533-R540, 2010.
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.299 , pp. R533-R540
    • Glynn, E.L.1    Fry, C.S.2    Drummond, M.J.3    Dreyer, H.C.4    Dhanani, S.5    Volpi, E.6    Rasmussen, B.B.7
  • 42
    • 0014524556 scopus 로고
    • Effect of exercise and training on mitochondria of rat skeletal muscle
    • Gollnick PD, King DW. Effect of exercise and training on mitochondria of rat skeletal muscle. Am J Physiol 216: 1502-1509, 1969.
    • (1969) Am J Physiol , vol.216 , pp. 1502-1509
    • Gollnick, P.D.1    King, D.W.2
  • 43
    • 80053272231 scopus 로고    scopus 로고
    • Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass
    • Goodman CA, Mayhew DL, Hornberger TA. Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass. Cell Signal 23: 1896-1906, 2011.
    • (2011) Cell Signal , vol.23 , pp. 1896-1906
    • Goodman, C.A.1    Mayhew, D.L.2    Hornberger, T.A.3
  • 45
    • 82855169509 scopus 로고    scopus 로고
    • Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles
    • Grumati P, Coletto L, Schiavinato A, Castagnaro S, Bertaggia E, Sandri M, Bonaldo P. Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles. Autophagy 7: 1415-1423, 2011.
    • (2011) Autophagy , vol.7 , pp. 1415-1423
    • Grumati, P.1    Coletto, L.2    Schiavinato, A.3    Castagnaro, S.4    Bertaggia, E.5    Sandri, M.6    Bonaldo, P.7
  • 47
    • 0028786952 scopus 로고
    • Repression of capdependent translation by 4E-binding protein 1: Competition with p220 for binding to eukaryotic initiation factor-4E
    • Haghighat A, Mader S, Pause A, Sonenberg N. Repression of capdependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J 14: 5701-5709, 1995.
    • (1995) EMBO J , vol.14 , pp. 5701-5709
    • Haghighat, A.1    Mader, S.2    Pause, A.3    Sonenberg, N.4
  • 49
    • 0033634654 scopus 로고    scopus 로고
    • Regulated translation initiation controls stress-induced gene expression in mammalian cells
    • Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6: 1099-1108, 2000.
    • (2000) Mol Cell , vol.6 , pp. 1099-1108
    • Harding, H.P.1    Novoa, I.2    Zhang, Y.3    Zeng, H.4    Wek, R.5    Schapira, M.6    Ron, D.7
  • 51
  • 52
    • 27744569843 scopus 로고    scopus 로고
    • mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
    • Holz MK, Ballif BA, Gygi SP, Blenis J. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 123: 569-580, 2005.
    • (2005) Cell , vol.123 , pp. 569-580
    • Holz, M.K.1    Ballif, B.A.2    Gygi, S.P.3    Blenis, J.4
  • 53
    • 33645659052 scopus 로고    scopus 로고
    • Mechanical stimuli and nutrients regulate rapamycin-sensitive signaling through distinct mechanisms in skeletal muscle
    • Hornberger TA, Chien S. Mechanical stimuli and nutrients regulate rapamycin-sensitive signaling through distinct mechanisms in skeletal muscle. J Cell Biochem 97: 1207-1216, 2006.
    • (2006) J Cell Biochem , vol.97 , pp. 1207-1216
    • Hornberger, T.A.1    Chien, S.2
  • 54
    • 33645241260 scopus 로고    scopus 로고
    • The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle
    • Hornberger TA, Chu WK, Mak YW, Hsiung JW, Huang SA, Chien S. The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle. Proc Natl Acad Sci USA 103: 4741-4746, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4741-4746
    • Hornberger, T.A.1    Chu, W.K.2    Mak, Y.W.3    Hsiung, J.W.4    Huang, S.A.5    Chien, S.6
  • 55
    • 3042820402 scopus 로고    scopus 로고
    • Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase Band growth factor-independent mechanism
    • Hornberger TA, Stuppard R, Conley KE, Fedele MJ, Fiorotto ML, Chin ER, Esser KA. Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase Band growth factor-independent mechanism. Biochem J 380: 795-804, 2004.
    • (2004) Biochem J , vol.380 , pp. 795-804
    • Hornberger, T.A.1    Stuppard, R.2    Conley, K.E.3    Fedele, M.J.4    Fiorotto, M.L.5    Chin, E.R.6    Esser, K.A.7
  • 57
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115: 577-590, 2003.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 58
    • 84864885324 scopus 로고    scopus 로고
    • Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise
    • Jamart C, Benoit N, Raymackers JM, Kim HJ, Kim CK, Francaux M. Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise. Eur J Appl Physiol 112: 3173-3177, 2012.
    • (2012) Eur J Appl Physiol , vol.112 , pp. 3173-3177
    • Jamart, C.1    Benoit, N.2    Raymackers, J.M.3    Kim, H.J.4    Kim, C.K.5    Francaux, M.6
  • 59
    • 84862082711 scopus 로고
    • Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running
    • 2012
    • Jamart C, Francaux M, Millet GY, Deldicque L, Frère D, Féasson L. Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running. J Appl Physiol (1985) 112: 1529-1537, 2012.
    • (1985) J Appl Physiol , pp. 112-1537
    • Jamart, C.1    Francaux, M.2    Millet, G.Y.3    Deldicque, L.4    Frère, D.5    Féasson, L.6
  • 60
  • 61
    • 84885626734 scopus 로고    scopus 로고
    • Higher activation of autophagy in skeletal muscle of mice during endurance exercise in the fasted state
    • Jamart C, Naslain D, Gilson H, Francaux M. Higher activation of autophagy in skeletal muscle of mice during endurance exercise in the fasted state. Am J Physiol Endocrinol Metab 305: E964-E974, 2013.
    • (2013) Am J Physiol Endocrinol Metab , vol.305 , pp. E964-E974
    • Jamart, C.1    Naslain, D.2    Gilson, H.3    Francaux, M.4
  • 62
    • 84891756403 scopus 로고    scopus 로고
    • Exercise ameliorates the detrimental effect of chloroquine on skeletal muscles in mice via restoring autophagy flux
    • Jiang D, Chen K, Lu X, Gao HJ, Qin ZH, Lin F. Exercise ameliorates the detrimental effect of chloroquine on skeletal muscles in mice via restoring autophagy flux. Acta Pharmacol Sin 35: 135-142, 2014.
    • (2014) Acta Pharmacol Sin , vol.35 , pp. 135-142
    • Jiang, D.1    Chen, K.2    Lu, X.3    Gao, H.J.4    Qin, Z.H.5    Lin, F.6
  • 63
    • 69249222488 scopus 로고    scopus 로고
    • Identification of MAFbx as a myogenin-engaged F-box protein in SCF ubiquitin ligase
    • Jogo M, Shiraishi S, Tamura T. Identification of MAFbx as a myogenin-engaged F-box protein in SCF ubiquitin ligase. FEBS Lett 583: 2715-2719, 2009.
    • (2009) FEBS Lett , vol.583 , pp. 2715-2719
    • Jogo, M.1    Shiraishi, S.2    Tamura, T.3
  • 66
    • 4544358547 scopus 로고    scopus 로고
    • Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated type I (slow twitch/red muscle) fiber genes, and impaired glycemic control
    • Kamei Y, Miura S, Suzuki M, Kai Y, Mizukami J, Taniguchi T, Mochida K, Hata T, Matsuda J, Aburatani H, Nishino I, Ezaki O. Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated type I (slow twitch/red muscle) fiber genes, and impaired glycemic control. J Biol Chem 279: 41114-41123, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 41114-41123
    • Kamei, Y.1    Miura, S.2    Suzuki, M.3    Kai, Y.4    Mizukami, J.5    Taniguchi, T.6    Mochida, K.7    Hata, T.8    Matsuda, J.9    Aburatani, H.10    Nishino, I.11    Ezaki, O.12
  • 67
    • 0035032723 scopus 로고    scopus 로고
    • Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network
    • Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2: 330-335, 2001.
    • (2001) EMBO Rep , vol.2 , pp. 330-335
    • Kihara, A.1    Kabeya, Y.2    Ohsumi, Y.3    Yoshimori, T.4
  • 69
  • 71
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13: 132-141, 2011.
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 72
    • 84888428419 scopus 로고    scopus 로고
    • Autophagic response to exercise training in skeletal muscle with age
    • Kim YA, Kim YS, Oh SL, Kim HJ, Song W. Autophagic response to exercise training in skeletal muscle with age. J Physiol Biochem 69: 697-705, 2013.
    • (2013) J Physiol Biochem , vol.69 , pp. 697-705
    • Kim, Y.A.1    Kim, Y.S.2    Oh, S.L.3    Kim, H.J.4    Song, W.5
  • 73
    • 84864033090 scopus 로고    scopus 로고
    • Autophagic respon se to a single bout ofmoderate exercise in murine skeletal muscle
    • Kim YA, Kim YS, Song W. Autophagic respon se to a single bout ofmoderate exercise in murine skeletal muscle. J Physiol Biochem 68: 229-235, 2012.
    • (2012) J Physiol Biochem , vol.68 , pp. 229-235
    • Kim, Y.A.1    Kim, Y.S.2    Song, W.3
  • 74
    • 84862295360 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy
    • Klionsky DJ,.Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8: 445-544, 2012.
    • (2012) Autophagy , vol.8 , pp. 445-544
    • Klionsky, D.J.1
  • 77
    • 78149476877 scopus 로고    scopus 로고
    • The association of AMPK with ULK1 regulates autophagy
    • Lee JW, Park S, Takahashi Y, Wang HG. The association of AMPK with ULK1 regulates autophagy. PloS One 5: e15394, 2010.
    • (2010) PloS One , vol.5 , pp. e15394
    • Lee, J.W.1    Park, S.2    Takahashi, Y.3    Wang, H.G.4
  • 78
    • 0032806289 scopus 로고    scopus 로고
    • Hydroxyl radical generation during exercise increases mitochondrial protein oxidation and levels of urinary dityrosine
    • Leeuwenburgh C, Hansen PA, Holloszy JO, Heinecke JW. Hydroxyl radical generation during exercise increases mitochondrial protein oxidation and levels of urinary dityrosine. Free Radic Biol Med 27: 186-192, 1999.
    • (1999) Free Radic Biol Med , vol.27 , pp. 186-192
    • Leeuwenburgh, C.1    Hansen, P.A.2    Holloszy, J.O.3    Heinecke, J.W.4
  • 79
    • 84885145785 scopus 로고    scopus 로고
    • Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance
    • Lira VA, Okutsu M, Zhang M, Greene NP, Laker RC, Breen DS, Hoehn KL, Yan Z. Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. FASEB J 27: 4184-4193, 2013.
    • (2013) FASEB J , vol.27 , pp. 4184-4193
    • Lira, V.A.1    Okutsu, M.2    Zhang, M.3    Greene, N.P.4    Laker, R.C.5    Breen, D.S.6    Hoehn, K.L.7    Yan, Z.8
  • 84
    • 84874765168 scopus 로고    scopus 로고
    • Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats
    • Luo L, Lu AM, Wang Y, Hong A, Chen Y, Hu J, Li X, Qin ZH. Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats. Exp Gerontol 48: 427-436, 2013.
    • (2013) Exp Gerontol , vol.48 , pp. 427-436
    • Luo, L.1    Lu, A.M.2    Wang, Y.3    Hong, A.4    Chen, Y.5    Hu, J.6    Li, X.7    Qin, Z.H.8
  • 89
    • 34547683916 scopus 로고    scopus 로고
    • Changes in signalling pathways regulating protein synthesis in human muscle in the recovery period after endurance exercise
    • Mascher H, Andersson H, Nilsson PA, Ekblom B, Blomstrand E. Changes in signalling pathways regulating protein synthesis in human muscle in the recovery period after endurance exercise. Acta Physiol Oxf Engl 191: 67-75, 2007.
    • (2007) Acta Physiol Oxf Engl , vol.191 , pp. 67-75
    • Mascher, H.1    Andersson, H.2    Nilsson, P.A.3    Ekblom, B.4    Blomstrand, E.5
  • 90
    • 79955663097 scopus 로고    scopus 로고
    • Enhanced rates of muscle protein synthesis and elevated mTOR signalling following endurance exercise in human subjects
    • Mascher H, Ekblom B, Rooyackers O, Blomstrand E. Enhanced rates of muscle protein synthesis and elevated mTOR signalling following endurance exercise in human subjects. Acta Physiol Oxf Engl 202: 175-184, 2011.
    • (2011) Acta Physiol Oxf Engl , vol.202 , pp. 175-184
    • Mascher, H.1    Ekblom, B.2    Rooyackers, O.3    Blomstrand, E.4
  • 93
    • 0030983504 scopus 로고    scopus 로고
    • Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae
    • Matsuura A, Tsukada M, Wada Y, Ohsumi Y. Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Gene 192: 245-250, 1997.
    • (1997) Gene , vol.192 , pp. 245-250
    • Matsuura, A.1    Tsukada, M.2    Wada, Y.3    Ohsumi, Y.4
  • 95
    • 0031010050 scopus 로고    scopus 로고
    • Regulation of skeletal muscle mass in mice by a new TGFsuperfamily member
    • McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGFsuperfamily member. Nature 387: 83-90, 1997.
    • (1997) Nature , vol.387 , pp. 83-90
    • McPherron, A.C.1    Lawler, A.M.2    Lee, S.J.3
  • 96
    • 0031425839 scopus 로고    scopus 로고
    • AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
    • Merrill GF, Kurth EJ, Hardie DG, Winder WW. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol Endocrinol Metab 273: E1107-E1112, 1997.
    • (1997) Am J Physiol Endocrinol Metab , vol.273 , pp. E1107-E1112
    • Merrill, G.F.1    Kurth, E.J.2    Hardie, D.G.3    Winder, W.W.4
  • 97
    • 79953152152 scopus 로고    scopus 로고
    • Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling
    • Miyazaki M, McCarthy JJ, Fedele MJ, Esser KA. Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling. J Physiol 589: 1831-1846, 2011.
    • (2011) J Physiol , vol.589 , pp. 1831-1846
    • Miyazaki, M.1    McCarthy, J.J.2    Fedele, M.J.3    Esser, K.A.4
  • 98
    • 0033565655 scopus 로고    scopus 로고
    • Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway
    • Mizushima N, Noda T, Ohsumi Y. Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway. EMBO J 18: 3888-3896, 1999.
    • (1999) EMBO J , vol.18 , pp. 3888-3896
    • Mizushima, N.1    Noda, T.2    Ohsumi, Y.3
  • 99
    • 0032545292 scopus 로고    scopus 로고
    • new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy
    • Mizushima N, Sugita H, Yoshimori T, Ohsumi Y. A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. J Biol Chem 273: 33889-33892, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 33889-33892
    • Mizushima, N.1    Sugita, H.2    Yoshimori, T.3    Ohsumi, Y.A.4
  • 102
    • 0035055777 scopus 로고
    • Intracellular signaling specificity in skeletal muscle in response to different modes of exercise
    • 2001
    • Nader GA, Esser KA. Intracellular signaling specificity in skeletal muscle in response to different modes of exercise. J Appl Physiol (1985) 90: 1936-1942, 2001.
    • (1985) J Appl Physiol , vol.90 , pp. 1936-1942
    • Nader, G.A.1    Esser, K.A.2
  • 103
    • 0026476465 scopus 로고
    • Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans
    • Nair KS, Schwartz RG, Welle S. Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans. Am J Physiol Endocrinol Metab 263: E928-E934, 1992.
    • (1992) Am J Physiol Endocrinol Metab , vol.263 , pp. E928-E934
    • Nair, K.S.1    Schwartz, R.G.2    Welle, S.3
  • 104
    • 34548450714 scopus 로고    scopus 로고
    • AMPK activation stimulates myofibrillar protein degradation and expression of atrophy-related ubiquitin ligases by increasing FOXO transcription factors in C2C12 myotubes
    • Nakashima K, Yakabe Y. AMPK activation stimulates myofibrillar protein degradation and expression of atrophy-related ubiquitin ligases by increasing FOXO transcription factors in C2C12 myotubes. Biosci Biotechnol Biochem 71: 1650-1656, 2007.
    • (2007) Biosci Biotechnol Biochem , vol.71 , pp. 1650-1656
    • Nakashima, K.1    Yakabe, Y.2
  • 105
    • 34447099450 scopus 로고    scopus 로고
    • Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion
    • Nakatogawa H, Ichimura Y, Ohsumi Y. Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell 130: 165-178, 2007.
    • (2007) Cell , vol.130 , pp. 165-178
    • Nakatogawa, H.1    Ichimura, Y.2    Ohsumi, Y.3
  • 107
    • 84902546353 scopus 로고    scopus 로고
    • Autophagy and protein turnover signaling in slow-twitch muscle during exercise
    • Pagano AF, Py G, Bernardi H, Candau R., Sanchez AMJ. Autophagy and protein turnover signaling in slow-twitch muscle during exercise. Med Sci Sports Exerc 46: 1314-1325, 2014.
    • (2014) Med Sci Sports Exerc , vol.46 , pp. 1314-1325
    • Pagano, A.F.1    Py, G.2    Bernardi, H.3    Candau, R.4    Sanchez, M.J.5
  • 109
    • 54749088342 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1 D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle
    • Pruznak AM, Kazi AA, Frost RA, Vary TC, Lang CH. Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1 D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle. J Nutr 138: 1887-1894, 2008.
    • (2008) J Nutr , vol.138 , pp. 1887-1894
    • Pruznak, A.M.1    Kazi, A.A.2    Frost, R.A.3    Vary, T.C.4    Lang, C.H.5
  • 112
    • 0033834961 scopus 로고    scopus 로고
    • Protein and amino acid metabolism during and after exercise and the effects of nutrition
    • Rennie MJ, Tipton KD. Protein and amino acid metabolism during and after exercise and the effects of nutrition. Annu Rev Nutr 20: 457-483, 2000.
    • (2000) Annu Rev Nutr , vol.20 , pp. 457-483
    • Rennie, M.J.1    Tipton, K.D.2
  • 113
    • 84869210001 scopus 로고    scopus 로고
    • Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation
    • Romanov J, Walczak M, Ibiricu I, Schüchner S, Ogris E, Kraft C, Martens S. Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation. EMBO J 31: 4304-4317, 2012.
    • (2012) EMBO J , vol.31 , pp. 4304-4317
    • Romanov, J.1    Walczak, M.2    Ibiricu, I.3    Schüchner, S.4    Ogris, E.5    Kraft, C.6    Martens, S.7
  • 118
    • 0037205409 scopus 로고    scopus 로고
    • Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
    • Saitoh M, Pullen N, Brennan P, Cantrell D, Dennis PB, Thomas G. Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. J Biol Chem 277: 20104-20112, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 20104-20112
    • Saitoh, M.1    Pullen, N.2    Brennan, P.3    Cantrell, D.4    Dennis, P.B.5    Thomas, G.6
  • 120
    • 84893362301 scopus 로고    scopus 로고
    • p53 is necessary for the adaptive changes in cellular milieu subsequent to an acute bout of endurance exercise
    • Saleem A, Carter HN, Hood DA. p53 is necessary for the adaptive changes in cellular milieu subsequent to an acute bout of endurance exercise. Am J Physiol Cell Physiol 306: C241-C249, 2014.
    • (2014) Am J Physiol Cell Physiol , vol.306 , pp. C241-C249
    • Saleem, A.1    Carter, H.N.2    Hood, D.A.3
  • 121
    • 0021368054 scopus 로고
    • Autophagic response to strenuous exercise in mouse skeletal muscle fibers
    • Salminen A, Vihko V. Autophagic response to strenuous exercise in mouse skeletal muscle fibers. Virchows Arch B Cell Pathol Incl Mol Pathol 45: 97-106, 1984.
    • (1984) Virchows Arch B Cell Pathol Incl Mol Pathol , vol.45 , pp. 97-106
    • Salminen, A.1    Vihko, V.2
  • 122
    • 0032213768 scopus 로고    scopus 로고
    • AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release
    • Salt IP, Johnson G, Ashcroft SJ, Hardie DG. AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. Biochem J 335: 533-539, 1998.
    • (1998) Biochem J , vol.335 , pp. 533-539
    • Salt, I.P.1    Johnson, G.2    Ashcroft, S.J.3    Hardie, D.G.4
  • 124
    • 84899450195 scopus 로고    scopus 로고
    • FoxO transcription factors: Their roles in the maintenance of skeletal muscle homeostasis
    • Sanchez AMJ, Candau R., Bernardi H. FoxO transcription factors: their roles in the maintenance of skeletal muscle homeostasis. Cell Mol Life Sci 71: 1657-1671, 2014.
    • (2014) Cell Mol Life Sci , vol.71 , pp. 1657-1671
    • Sanchez, A.M.J.1    Candau, R.2    Bernardi, H.3
  • 125
    • 84865721346 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis
    • Sanchez AMJ, Candau R., Csibi A, Pagano AF, Raibon A, Bernardi H. The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis. Am J Physiol Cell Physiol 303: C475-C485, 2012.
    • (2012) Am J Physiol Cell Physiol , vol.303 , pp. C475-C485
    • Sanchez, A.M.J.1    Candau, R.2    Csibi, A.3    Pagano, A.F.4    Raibon, A.5    Bernardi, H.6
  • 126
    • 84855532023 scopus 로고    scopus 로고
    • AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1
    • Sanchez AMJ, Csibi A, Raibon A, Cornille K, Gay S, Bernardi H, Candau R. AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1. J Cell Biochem 113: 695-710, 2012.
    • (2012) J Cell Biochem , vol.113 , pp. 695-710
    • Sanchez, A.M.J.1    Csibi, A.2    Raibon, A.3    Cornille, K.4    Gay, S.5    Bernardi, H.6    Candau, R.7
  • 129
    • 77952626944 scopus 로고    scopus 로고
    • Autophagy in health and disease. 3. Involvement of autophagy in muscle atrophy
    • Sandri M. Autophagy in health and disease. 3. Involvement of autophagy in muscle atrophy. Am J Physiol Cell Physiol 298: C1291-C1297, 2010.
    • (2010) Am J Physiol Cell Physiol , vol.298 , pp. C1291-C1297
    • Sandri, M.1
  • 130
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, ErdjumentBromage H, Tempst P, Sabatini DM. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14: 1296-1302, 2004.
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjumentbromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 131
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101, 2005.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 132
    • 37749027195 scopus 로고    scopus 로고
    • A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy
    • Spangenburg EE, Le Roith D, Ward CW, Bodine SC. A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy. J Physiol 586: 283-291, 2008.
    • (2008) J Physiol , vol.586 , pp. 283-291
    • Spangenburg, E.E.1    Le Roith, D.2    Ward, C.W.3    Bodine, S.C.4
  • 135
    • 0035503594 scopus 로고    scopus 로고
    • The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation
    • Suzuki K, Kirisako T, Kamada Y, Mizushima N, Noda T, Ohsumi Y. The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J 20: 5971-5981, 2001.
    • (2001) EMBO J , vol.20 , pp. 5971-5981
    • Suzuki, K.1    Kirisako, T.2    Kamada, Y.3    Mizushima, N.4    Noda, T.5    Ohsumi, Y.6
  • 136
    • 84905106775 scopus 로고    scopus 로고
    • Autophagic cellular responses to physical exercise in skeletal muscle
    • Tam BT, Siu PM. Autophagic cellular responses to physical exercise in skeletal muscle. Sports Med Auckl NZ 44: 625-640, 2014.
    • (2014) Sports Med Auckl NZ , vol.44 , pp. 625-640
    • Tam, B.T.1    Siu, P.M.2
  • 137
    • 0023804355 scopus 로고
    • Skeletal muscle adaptations consequent to long-term heavy resistance exercise
    • Tesch PA. Skeletal muscle adaptations consequent to long-term heavy resistance exercise. Med Sci Sports Exerc 20: S132-S134, 1988
    • (1988) Med Sci Sports Exerc , vol.20 , pp. S132-S134
    • Tesch, P.A.1
  • 138
    • 17644368923 scopus 로고    scopus 로고
    • Mechanical signal transduction in skeletal muscle growth and adaptation
    • Tidball JG. Mechanical signal transduction in skeletal muscle growth and adaptation. J Appl Physiol 98: 1900-1908, 2005.
    • (2005) J Appl Physiol , vol.98 , pp. 1900-1908
    • Tidball, J.G.1
  • 142
    • 84894046982 scopus 로고    scopus 로고
    • Skeletal muscle, autophagy, and physical activity: The ménage à trois of metabolic regulation in health and disease
    • Vainshtein A, Grumati P, Sandri M, Bonaldo P. Skeletal muscle, autophagy, and physical activity: the ménage à trois of metabolic regulation in health and disease. J Mol Med 92: 127-137, 2014.
    • (2014) J Mol Med , vol.92 , pp. 127-137
    • Vainshtein, A.1    Grumati, P.2    Sandri, M.3    Bonaldo, P.4
  • 145
    • 84877656993 scopus 로고    scopus 로고
    • Differentiated mTOR but not AMPK signaling after strength vs endurance exercise in training-accustomed individuals
    • Vissing K, McGee SL, Farup J, Kjølhede T, Vendelbo MH, Jessen N. Differentiated mTOR but not AMPK signaling after strength vs endurance exercise in training-accustomed individuals. Scand J Med Sci Sports 23: 355-366, 2013.
    • (2013) Scand J Med Sci Sports , vol.23 , pp. 355-366
    • Vissing, K.1    McGee, S.L.2    Farup, J.3    Kjølhede, T.4    Vendelbo, M.H.5    Jessen, N.6
  • 148
    • 0031626826 scopus 로고    scopus 로고
    • Muscle amino acid metabolism at rest and during exercise: Role in human physiology and metabolism
    • Wagenmakers AJ. Muscle amino acid metabolism at rest and during exercise: role in human physiology and metabolism. Exerc Sport Sci Rev 26: 287-314, 1998.
    • (1998) Exerc Sport Sci Rev , vol.26 , pp. 287-314
    • Wagenmakers, A.J.1
  • 149
    • 70450210312 scopus 로고    scopus 로고
    • Padz ikJP, De Lisio M, Tang JE, Parise G, Rennie MJ, Baker SK, Phillips SM. Resistance exercise-induced increases in putative anabolic hormones do not enhance muscle protein synthesis or intracellular signalling in young men
    • West DWD, Kujbida GW, Moore DR, Atherton P, Burd NA, Padz ikJP, De Lisio M, Tang JE, Parise G, Rennie MJ, Baker SK, Phillips SM. Resistance exercise-induced increases in putative anabolic hormones do not enhance muscle protein synthesis or intracellular signalling in young men. J Physiol 587: 5239-5247, 2009.
    • (2009) J Physiol , vol.587 , pp. 5239-5247
    • West, D.W.D.1    Kujbida, G.W.2    Moore, D.R.3    Atherton, P.4    Burd, N.A.5
  • 150
    • 0029978799 scopus 로고    scopus 로고
    • Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
    • Winder WW, Hardie DG. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am J Physiol Endocrinol Metab 270: E299-E304, 1996.
    • (1996) Am J Physiol Endocrinol Metab , vol.270 , pp. E299-E304
    • Winder, W.W.1    Hardie, D.G.2
  • 153
    • 0034306362 scopus 로고    scopus 로고
    • Isoformspecific and exercise intensity-dependent activation of 5=-AMP-activated protein kinase in human skeletal muscle
    • Wojtaszewski JF, Nielsen P, Hansen BF, Richter EA, Kiens B. Isoformspecific and exercise intensity-dependent activation of 5=-AMP-activated protein kinase in human skeletal muscle. J Physiol 528: 221-226, 2000.
    • (2000) J Physiol , vol.528 , pp. 221-226
    • Wojtaszewski, J.F.1    Nielsen, P.2    Hansen, B.F.3    Richter, E.A.4    Kiens, B.5
  • 155
    • 85008952973 scopus 로고    scopus 로고
    • The truncated splice variants, NT-PGC-1 and PGC-1 4, increase with both endurance and resistance exercise in human skeletal muscle
    • Ydfors M, Fischer H, Mascher H, Blomstrand E, Norrbom J, Gustafsson T. The truncated splice variants, NT-PGC-1 and PGC-1 4, increase with both endurance and resistance exercise in human skeletal muscle. Physiol Rep 1: e00140, 2013.
    • (2013) Physiol Rep , vol.1 , pp. e00140
    • Ydfors, M.1    Fischer, H.2    Mascher, H.3    Blomstrand, E.4    Norrbom, J.5    Gustafsson, T.6
  • 156
    • 84855731134 scopus 로고    scopus 로고
    • Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
    • Yoon MS, Du G, Backer JM, Frohman MA, Chen J. Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J Cell Biol 195: 435-447, 2011.
    • (2011) J Cell Biol , vol.195 , pp. 435-447
    • Yoon, M.S.1    Du, G.2    Backer, J.M.3    Frohman, M.A.4    Chen, J.5
  • 157
    • 84892657844 scopus 로고    scopus 로고
    • The role of diacylglycerol kinase and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy
    • You JS, Lincoln HC, Kim CR, Frey JW, Goodman CA, Zhong XP, Hornberger TA. The role of diacylglycerol kinase and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy. J Biol Chem 289: 1551-1563, 2014.
    • (2014) J Biol Chem , vol.289 , pp. 1551-1563
    • You, J.S.1    Lincoln, H.C.2    Kim, C.R.3    Frey, J.W.4    Goodman, C.A.5    Zhong, X.P.6    Hornberger, T.A.7
  • 158
    • 84867525052 scopus 로고    scopus 로고
    • Mechanical stimulation inducesmTOR signaling via an ERK-independent mechanism: Implications for a direct activation of mTOR by phosphatidic acid
    • You JS, Frey JW, Hornberger TA. Mechanical stimulation inducesmTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid. PLoS One 7: e47258, 2012.
    • (2012) PLoS One , vol.7 , pp. e47258
    • You, J.S.1    Frey, J.W.2    Hornberger, T.A.3
  • 160
    • 0034069369 scopus 로고    scopus 로고
    • Regulation of human eIF4E by 4E-BP1: Binding analysis using surface plasmon resonance
    • Youtani T, Tomoo K, Ishida T, Miyoshi H, Miura K. Regulation of human eIF4E by 4E-BP1: binding analysis using surface plasmon resonance. IUBMB Life 49: 27-31, 2000.
    • (2000) IUBMB Life , vol.49 , pp. 27-31
    • Youtani, T.1    Tomoo, K.2    Ishida, T.3    Miyoshi, H.4    Miura, K.5
  • 161
    • 36448968532 scopus 로고    scopus 로고
    • FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
    • Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL. FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab 6: 472-483, 2007.
    • (2007) Cell Metab , vol.6 , pp. 472-483
    • Zhao, J.1    Brault, J.J.2    Schild, A.3    Cao, P.4    Sandri, M.5    Schiaffino, S.6    Lecker, S.H.7    Goldberg, A.L.8


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