Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

Current Biology

Volumn 10, Issue 20, 2000, Pages 1247-1255

  Marsin, A S ^a   Bertrand, L ^a   Rider, M H ^a   Deprez, J ^a   Beauloye, C ^a   Vincent, M F ^a   Van den Berghe, G ^a   Carling, D ^b   Hue, L ^a  

^a DE DUVE INSTITUTE   (Belgium)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034687210     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00742-9     Document Type: Article

References (36)

1. Mechanisms of control of heart glycolysis
2. Glycolytic control mechanisms. II. Kinetics of intermediate changes during the aerobic-anoxic transition in perfused rat heart
3. Comparison of the effects of anoxia and whole heart ischaemia on carbohydrate utilization in isolated working rat hearts
4. Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase
5. Characterization of AMP-activated protein kinase β subunit and γ subunit - Assembly of the heterotrimeric complex in vitro
6. Mammalian AMP-activated protein kinase subfamily
7. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding
8. The AMP-activated protein kinase. Fuel gauge of the mammalian cell?
9. Purification and characterization of the AMP-activated protein kinase
10. Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICA riboside - An activator of AMP-activated protein kinase
11. Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle
12. 5'AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle
13. Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICA riboside
14. Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues
15. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: A metabolic signaling enzyme
16. Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades
17. Heart 6-phosphofructo-2-kinase activation by insulin results from Ser466 and Ser483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase B
18. AMP-activated protein kinase phosphorylation of endothelial NO synthase
19. The α1 and α2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro
20. Tissue distribution of AMP-activated protein kinase and lack of activation by cyclic AMP-dependant protein kinase, studied using a specific and sensitive peptide assay
21. An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: Role in tumor cell glycolysis and the Warburg effect
22. Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta
23. Protection against ischaemic injury by nonvasoactive concentrations of nitric oxide synthase inhibitors in the perfused rabbit heart
24. Role of fructose 2,6-bisphosphate in the control of heart glycolysis
25. 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
26. Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase
27. Cell-type specificity of inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside
28. Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase
29. Phosphorylation-dephosphorylation of enzymes
30. Role of fructose 2,6-bisphosphate in the stimulation of glycolysis by anoxia in isolated hepatocytes
31. Inhibition by AlCA riboside of gluconeogenesis in isolated rat hepatocytes
32. Fructose 2,6-bisphosphate in skeletal muscle during contraction
33. The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase
34. The regulation of AMP-activated protein kinase by phosphorylation
35. A kinetic study of pyrophosphate: Fructose 6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate
36. Rat muscle 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Study of the kinase domain by site-directed mutagenesis