Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise

European Journal of Applied Physiology

Volumn 112, Issue 8, 2012, Pages 3173-3177

  Jamart, Cȩcile ^a   Benoit, Nicolas ^a   Raymackers, Jean Marc ^a   Kim, Hyo Jeong ^b   Kim, Chang Keun ^b   Francaux, Marc ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b Korea National Sport University   (South Korea)

Author keywords

ATG; Autophagy; BNIP3; Endurance exercise; Gabarapl1; Lc3B

Indexed keywords

ATG12 PROTEIN, HUMAN; ATG4B PROTEIN, HUMAN; BNIP3 PROTEIN, HUMAN; BNIP3L PROTEIN, HUMAN; CATHEPSIN L; CTSL1 PROTEIN, HUMAN; CYSTEINE PROTEINASE; GABARAPL1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN; ONCOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SUMO PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ADULT; ARTICLE; AUTOPHAGY; BIOPSY; ENDURANCE; GENETIC MARKER; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; MUSCLE CONTRACTION; PATHOLOGY; QUADRICEPS FEMORIS MUSCLE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RUNNING; TIME; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AUTOPHAGY; BIOPSY; CATHEPSIN L; CYSTEINE ENDOPEPTIDASES; GENETIC MARKERS; HUMANS; MALE; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; MUSCLE CONTRACTION; PHYSICAL ENDURANCE; PROTO-ONCOGENE PROTEINS; QUADRICEPS MUSCLE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RUNNING; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; TIME FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 84864885324     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-011-2287-3     Document Type: Article

References (25)

1. Cabrera S, Marino G, Fernandez AF, Lopez-Otin C (2010) Autophagy, proteases and the sense of balance. Autophagy 6:961-963.
2. De Lange P, Moreno M, Silvestri E, Lombardi A, Goglia F, Lanni A (2007) Fuel economy in food-deprived skeletal muscle: Signaling pathways and regulatory mechanisms. Faseb J 21:3431-3441. (Pubitemid 350075134)
3. Deldicque L, Atherton P, Patel R, Theisen D, Nielens H, Rennie MJ, Francaux M (2008) Effects of resistance exercise with and without creatine supplementation on gene expression and cell signaling in human skeletal muscle. J Appl Physiol 104:371-378. (Pubitemid 351231483)
4. Dobrowolny G, Aucello M, Rizzuto E, Beccafico S, Mammucari C, Boncompagni S, Belia S, Wannenes F, Nicoletti C, Del Prete Z, Rosenthal N, Molinaro M, Protasi F, Fano G, Sandri M, Musaro A (2008) Skeletal muscle is a primary target of SOD1G93A-mediated toxicity. Cell Metab 8:425-436.
5. Eskelinen EL, Saftig P (2009) Autophagy: A lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta 1793:664-673.
6. Feng Z, Bai L, Yan J, Li Y, Shen W, Wang Y, Wertz K, Weber P, Zhang Y, Chen Y, Liu J (2011) Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: Regulatory effects of hydroxytyrosol. Free Radic Biol Med 50:1437-1446.
7. Finn PF, Dice JF (2006) Proteolytic and lipolytic responses to starvation. Nutrition 22:830-844. (Pubitemid 43947502)
8. Hamacher-Brady A, Brady NR, Logue SE, Sayen MR, Jinno M, Kirshenbaum LA, Gottlieb RA, Gustafsson AB (2007) Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Cell Death Differ 14:146-157. (Pubitemid 44911902)
9. Kim HJ, Jamart C, Deldicque L, An GL, Lee YH, Kim CK, Raymackers JM, Francaux M (2011) Endoplasmic reticulum stress markers and ubiquitin-proteasome pathway activity in response to a 200-km run. Med Sci Sports Exerc 43:18-25.
10. Klionsky DJ, Cregg JM, Dunn WA Jr, Emr SD, Sakai Y, Sandoval IV, Sibirny A, Subramani S, Thumm M, Veenhuis M, Ohsumi Y (2003) A unified nomenclature for yeast autophagy-related genes. Dev Cell 5:539-545. (Pubitemid 37243044)
11. Lee EJ, Tournier C (2011) The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. Autophagy 7:689-695.
12. Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, Burden SJ, Di Lisi R, Sandri C, Zhao J, Goldberg AL, Schiaffino S, Sandri M (2007) FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab 6:458-471. (Pubitemid 350163055)
13. Mammucari C, Schiaffino S, Sandri M (2008) Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle. Autophagy 4:524-526. (Pubitemid 351705153)
14. McCully KK, Faulkner JA (1985) Injury to skeletal muscle fibers of mice following lengthening contractions. J Appl Physiol 59:119-126. (Pubitemid 15230302)
15. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y (2004) In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15:1101-1111. (Pubitemid 38316219)
16. Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, Shiosaka S, Hammarback JA, Urano F, Imaizumi K (2006) Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 26:9220-9231. (Pubitemid 44904418)
17. Sahlin K, Shabalina IG, Mattsson CM, Bakkman L, Fernstrom M, Rozhdestvenskaya Z, Enqvist JK, Nedergaard J, Ekblom B, Tonkonogi M (2010) Ultraendurance exercise increases the production of reactive oxygen species in isolated mitochondria from human skeletal muscle. J Appl Physiol 108:780-787.
18. Salminen A (1985) Lysosomal changes in skeletal muscles during the repair of exercise injuries in muscle fibers. Acta Physiol Scand Suppl 539:1-31.
19. Salminen A, Vihko V (1984) Autophagic response to strenuous exercise in mouse skeletal muscle fibers. Virchows Arch B Cell Pathol Incl Mol Pathol 45:97-106. (Pubitemid 14175489)
20. Sandri M (2010) Autophagy in skeletal muscle. FEBS Lett 584:1411-1416.
21. Tarnopolsky M (2004) Protein requirements for endurance athletes. Nutrition 20:662-668. (Pubitemid 38798083)
22. Tracy K, Macleod KF (2007) Regulation of mitochondrial integrity, autophagy and cell survival by BNIP3. Autophagy 3:616-619. (Pubitemid 350060062)
23. Wang CW, Klionsky DJ (2003) The molecular mechanism of autophagy. Mol Med 9:65-76. (Pubitemid 36819962)
24. Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL (2007) FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab 6:472-483. (Pubitemid 350163056)
25. Zhao J, Brault JJ, Schild A, Goldberg AL (2008) Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor. Autophagy 4:378-380. (Pubitemid 351458106)