메뉴 건너뛰기




Volumn 5, Issue 11, 2010, Pages

The association of AMPK with ULK1 regulates autophagy

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROLINE; PROTEIN 14 3 3; PROTEIN 14 3 3 TAU; REGULATOR PROTEIN; RIBONUCLEOTIDE; RIBONUCLEOTIDE ACIR; SERINE; TUBERIN; UNC 51 LIKE KINASE 1; UNCLASSIFIED DRUG; MTORC1 COMPLEX, HUMAN; PRKAA2 PROTEIN, HUMAN; PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN SUBUNIT; RPTOR PROTEIN, HUMAN; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; ULK1 PROTEIN, HUMAN;

EID: 78149476877     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015394     Document Type: Article
Times cited : (417)

References (39)
  • 1
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451: 1069-1075.
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 2
    • 67649467294 scopus 로고    scopus 로고
    • Dynamics and diversity in autophagy mechanisms: Lessons from yeast
    • Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y (2009) Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol 10: 458-467.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 458-467
    • Nakatogawa, H.1    Suzuki, K.2    Kamada, Y.3    Ohsumi, Y.4
  • 3
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124: 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 4
    • 77951221542 scopus 로고    scopus 로고
    • The role of the Atg1/ULK1 complex in autophagy regulation
    • Mizushima N (2010) The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol.
    • (2010) Curr Opin Cell Biol
    • Mizushima, N.1
  • 6
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
    • Shackelford DB, Shaw RJ (2009) The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 9: 563-575.
    • (2009) Nat Rev Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 7
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115: 577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 8
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki K, Li Y, Xu T, Guan KL (2003) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17: 1829-1834.
    • (2003) Genes Dev , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 10
    • 0027424777 scopus 로고
    • Isolation and characterization of autophagydefective mutants of Saccharomyces cerevisiae
    • Tsukada M, Ohsumi Y (1993) Isolation and characterization of autophagydefective mutants of Saccharomyces cerevisiae. FEBS Lett 333: 169-174.
    • (1993) FEBS Lett , vol.333 , pp. 169-174
    • Tsukada, M.1    Ohsumi, Y.2
  • 11
    • 0030983504 scopus 로고    scopus 로고
    • Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae
    • Matsuura A, Tsukada M, Wada Y, Ohsumi Y (1997) Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Gene 192: 245-250.
    • (1997) Gene , vol.192 , pp. 245-250
    • Matsuura, A.1    Tsukada, M.2    Wada, Y.3    Ohsumi, Y.4
  • 12
    • 0034683568 scopus 로고    scopus 로고
    • Tormediated induction of autophagy via an Apg1 protein kinase complex
    • Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, et al. (2000) Tormediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 150: 1507-1513.
    • (2000) J Cell Biol , vol.150 , pp. 1507-1513
    • Kamada, Y.1    Funakoshi, T.2    Shintani, T.3    Nagano, K.4    Ohsumi, M.5
  • 13
    • 65249155441 scopus 로고    scopus 로고
    • An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation
    • Chang YY, Neufeld TP (2009) An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. Mol Biol Cell 20: 2004-2014.
    • (2009) Mol Biol Cell , vol.20 , pp. 2004-2014
    • Chang, Y.Y.1    Neufeld, T.P.2
  • 14
    • 43149090064 scopus 로고    scopus 로고
    • FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
    • Hara T, Takamura A, Kishi C, Iemura S, Natsume T, et al. (2008) FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol 181: 497-510.
    • (2008) J Cell Biol , vol.181 , pp. 497-510
    • Hara, T.1    Takamura, A.2    Kishi, C.3    Iemura, S.4    Natsume, T.5
  • 15
    • 65249176304 scopus 로고    scopus 로고
    • ULK-Atg13- FIP200 complexes mediate mTOR signaling to the autophagy machinery
    • Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, et al. (2009) ULK-Atg13- FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 20: 1992-2003.
    • (2009) Mol Biol Cell , vol.20 , pp. 1992-2003
    • Jung, C.H.1    Jun, C.B.2    Ro, S.H.3    Kim, Y.M.4    Otto, N.M.5
  • 16
    • 66449083078 scopus 로고    scopus 로고
    • ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
    • Ganley IG, Lam du H, Wang J, Ding X, Chen S, et al. (2009) ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 284: 12297-12305.
    • (2009) J Biol Chem , vol.284 , pp. 12297-12305
    • Ganley, I.G.1    Lam du, H.2    Wang, J.3    Ding, X.4    Chen, S.5
  • 17
    • 65249119430 scopus 로고    scopus 로고
    • Nutrientdependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
    • Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, et al. (2009) Nutrientdependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 20: 1981-1991.
    • (2009) Mol Biol Cell , vol.20 , pp. 1981-1991
    • Hosokawa, N.1    Hara, T.2    Kaizuka, T.3    Kishi, C.4    Takamura, A.5
  • 18
    • 0034727876 scopus 로고    scopus 로고
    • Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: Possible role of vesicular transport in axonal elongation
    • Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, et al. (2000) Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. Brain Res Mol Brain Res 85: 1-12.
    • (2000) Brain Res Mol Brain Res , vol.85 , pp. 1-12
    • Okazaki, N.1    Yan, J.2    Yuasa, S.3    Ueno, T.4    Kominami, E.5
  • 19
    • 1642417689 scopus 로고    scopus 로고
    • Role of Unc51.1 and its binding partners in CNS axon outgrowth
    • Tomoda T, Kim JH, Zhan C, Hatten ME (2004) Role of Unc51.1 and its binding partners in CNS axon outgrowth. Genes Dev 18: 541-558.
    • (2004) Genes Dev , vol.18 , pp. 541-558
    • Tomoda, T.1    Kim, J.H.2    Zhan, C.3    Hatten, M.E.4
  • 20
    • 70349644856 scopus 로고    scopus 로고
    • Atg101, a novel mammalian autophagy protein interacting with Atg13
    • Hosokawa N, Sasaki T, Iemura S, Natsume T, Hara T, et al. (2009) Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy 5: 973-979.
    • (2009) Autophagy , vol.5 , pp. 973-979
    • Hosokawa, N.1    Sasaki, T.2    Iemura, S.3    Natsume, T.4    Hara, T.5
  • 21
    • 67549110195 scopus 로고    scopus 로고
    • A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy
    • Mercer CA, Kaliappan A, Dennis PB (2009) A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy 5: 649-662.
    • (2009) Autophagy , vol.5 , pp. 649-662
    • Mercer, C.A.1    Kaliappan, A.2    Dennis, P.B.3
  • 22
    • 66449099052 scopus 로고    scopus 로고
    • p53 acetylation is crucial for its transcription-independent proapoptotic functions
    • Yamaguchi H, Woods NT, Piluso LG, Lee HH, Chen J, et al. (2009) p53 acetylation is crucial for its transcription-independent proapoptotic functions. J Biol Chem 284: 11171-11183.
    • (2009) J Biol Chem , vol.284 , pp. 11171-11183
    • Yamaguchi, H.1    Woods, N.T.2    Piluso, L.G.3    Lee, H.H.4    Chen, J.5
  • 23
    • 77954237882 scopus 로고    scopus 로고
    • Network organization of the human autophagy system
    • Behrends C, Sowa ME, Gygi SP, Harper JW (2010) Network organization of the human autophagy system. Nature 466: 68-76.
    • (2010) Nature , vol.466 , pp. 68-76
    • Behrends, C.1    Sowa, M.E.2    Gygi, S.P.3    Harper, J.W.4
  • 24
    • 0032508564 scopus 로고    scopus 로고
    • Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase
    • Samari HR, Seglen PO (1998) Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase. J Biol Chem 273: 23758-23763.
    • (1998) J Biol Chem , vol.273 , pp. 23758-23763
    • Samari, H.R.1    Seglen, P.O.2
  • 25
    • 34248593475 scopus 로고    scopus 로고
    • AMP-activated protein kinase and autophagy
    • Meijer AJ, Codogno P (2007) AMP-activated protein kinase and autophagy. Autophagy 3: 238-240.
    • (2007) Autophagy , vol.3 , pp. 238-240
    • Meijer, A.J.1    Codogno, P.2
  • 26
    • 35448938087 scopus 로고    scopus 로고
    • Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration
    • Komatsu M, Wang QJ, Holstein GR, Friedrich VL, Jr., Iwata J, et al. (2007) Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A 104: 14489-14494.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 14489-14494
    • Komatsu, M.1    Wang, Q.J.2    Holstein, G.R.3    Friedrich Jr., V.L.4    Iwata, J.5
  • 27
    • 33748154216 scopus 로고    scopus 로고
    • Induction of autophagy in axonal dystrophy and degeneration
    • Wang QJ, Ding Y, Kohtz DS, Mizushima N, Cristea IM, et al. (2006) Induction of autophagy in axonal dystrophy and degeneration. J Neurosci 26: 8057-8068.
    • (2006) J Neurosci , vol.26 , pp. 8057-8068
    • Wang, Q.J.1    Ding, Y.2    Kohtz, D.S.3    Mizushima, N.4    Cristea, I.M.5
  • 28
    • 23744454765 scopus 로고    scopus 로고
    • Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control
    • Gan B, Melkoumian ZK, Wu X, Guan KL, Guan JL (2005) Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. J Cell Biol 170: 379-389.
    • (2005) J Cell Biol , vol.170 , pp. 379-389
    • Gan, B.1    Melkoumian, Z.K.2    Wu, X.3    Guan, K.L.4    Guan, J.L.5
  • 29
    • 18244394277 scopus 로고    scopus 로고
    • Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy
    • Kabeya Y, Kamada Y, Baba M, Takikawa H, Sasaki M, et al. (2005) Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Mol Biol Cell 16: 2544-2553.
    • (2005) Mol Biol Cell , vol.16 , pp. 2544-2553
    • Kabeya, Y.1    Kamada, Y.2    Baba, M.3    Takikawa, H.4    Sasaki, M.5
  • 30
    • 14844366592 scopus 로고    scopus 로고
    • Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagysuppressive toxins
    • Samari HR, Moller MT, Holden L, Asmyhr T, Seglen PO (2005) Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagysuppressive toxins. Biochem J 386: 237-244.
    • (2005) Biochem J , vol.386 , pp. 237-244
    • Samari, H.R.1    Moller, M.T.2    Holden, L.3    Asmyhr, T.4    Seglen, P.O.5
  • 31
    • 33947250696 scopus 로고    scopus 로고
    • The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
    • Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, et al. (2007) The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 9: 218-224.
    • (2007) Nat Cell Biol , vol.9 , pp. 218-224
    • Liang, J.1    Shao, S.H.2    Xu, Z.X.3    Hennessy, B.4    Ding, Z.5
  • 32
  • 34
    • 34547114031 scopus 로고    scopus 로고
    • Systemic treatment with the antidiabetic drug metformin selectively impairs p53- deficient tumor cell growth
    • Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, et al. (2007) Systemic treatment with the antidiabetic drug metformin selectively impairs p53- deficient tumor cell growth. Cancer Res 67: 6745-6752.
    • (2007) Cancer Res , vol.67 , pp. 6745-6752
    • Buzzai, M.1    Jones, R.G.2    Amaravadi, R.K.3    Lum, J.J.4    Deberardinis, R.J.5
  • 35
    • 34047154536 scopus 로고    scopus 로고
    • ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase
    • Lee SB, Kim S, Lee J, Park J, Lee G, et al. (2007) ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase. EMBO Rep 8: 360-365.
    • (2007) EMBO Rep , vol.8 , pp. 360-365
    • Lee, S.B.1    Kim, S.2    Lee, J.3    Park, J.4    Lee, G.5
  • 36
    • 33845874899 scopus 로고    scopus 로고
    • Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death
    • Scott RC, Juhasz G, Neufeld TP (2007) Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol 17: 1-11.
    • (2007) Curr Biol , vol.17 , pp. 1-11
    • Scott, R.C.1    Juhasz, G.2    Neufeld, T.P.3
  • 37
    • 2942637332 scopus 로고    scopus 로고
    • Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak
    • Wang G, Barrett JW, Nazarian SH, Everett H, Gao X, et al. (2004) Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak. J Virol 78: 7097-7111.
    • (2004) J Virol , vol.78 , pp. 7097-7111
    • Wang, G.1    Barrett, J.W.2    Nazarian, S.H.3    Everett, H.4    Gao, X.5
  • 38
    • 33947264077 scopus 로고    scopus 로고
    • PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
    • Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, et al. (2007) PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 25: 903-915.
    • (2007) Mol Cell , vol.25 , pp. 903-915
    • Sancak, Y.1    Thoreen, C.C.2    Peterson, T.R.3    Lindquist, R.A.4    Kang, S.A.5
  • 39
    • 0037178786 scopus 로고    scopus 로고
    • mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, et al. (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110: 163-175.
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.