PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

Open Biology

Volumn 2, Issue MAY, 2012, Pages

  Kondapalli, Chandana ^a   Kazlauskaite, Agne ^a   Zhang, Ning ^a   Woodroof, Helen I ^a   Campbell, David G ^a   Gourlay, Robert ^a   Burchell, Lynn ^b   Walden, Helen ^b   MacArtney, Thomas J ^a   Deak, Maria ^a   Knebel, Axel ^a   Alessi, Dario R ^a   Muqit, Miratul M K ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Parkin; Parkinson's disease; PINK1

Indexed keywords

HEXAPODA;

CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; HYBRID PROTEIN; INSECT PROTEIN; PARKIN; PHOSPHOSERINE; PHOSPHOTHREONINE; PROTEIN KINASE; PTEN INDUCED PUTATIVE KINASE; PTEN-INDUCED PUTATIVE KINASE; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE;

ANIMAL; ARTICLE; CELL STRAIN HEK293; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PARKINSON DISEASE; PHOSPHORYLATION; PHYSIOLOGY; PINK1; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; RNA INTERFERENCE; TRIBOLIUM;

PARKIN; PARKINSON'S DISEASE; PINK1;

ANIMALS; CARBONYL CYANIDE M-CHLOROPHENYL HYDRAZONE; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; INSECT PROTEINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PARKINSON DISEASE; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTHREONINE; PROTEIN KINASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 2; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRIBOLIUM; UBIQUITIN-PROTEIN LIGASES;

EID: 84864267876     PISSN: None     EISSN: 20462441     Source Type: Journal    
DOI: 10.1098/rsob.120080     Document Type: Article

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