An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein

American Journal of Physiology - Endocrinology and Metabolism

Volumn 273, Issue 1 36-1, 1997, Pages

  Biolo, Gianni ^a,b   Tipton, Kevin D ^a   Klein, Samuel ^a,c   Wolfe, Robert R ^a,d  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b UNIVERSITY OF TRIESTE   (Italy)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

Alanine; Blood flow; Leucine; Lysine; Phenylalanine; Stable isotopes

Indexed keywords

ALANINE; LEUCINE; LYSINE; MUSCLE PROTEIN; PHENYLALANINE;

ADULT; AMINO ACID TRANSPORT; AMINOACIDEMIA; ARTICLE; EXERCISE; HUMAN; HUMAN EXPERIMENT; MALE; METABOLIC REGULATION; MUSCLE BIOPSY; MUSCLE HYPERTROPHY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTAKE; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS REGULATION; SKELETAL MUSCLE;

EID: 0030859081     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.273.1.e122     Document Type: Article

References (20)

1. Baron, A. D., H. Steinberg, G. Brechtel, and A. Johnson. Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E248-E253, 1994.
2. 13C]leucine. Clin. Sci. (Colch.) 76: 447-454, 1989.
3. Bergström, J., F. Fürst, L.-O. Norée, and E. Vinnars. Intracellular free amino acid concentration in human muscle tissue. J. Appl. Physiol. 36: 693-697, 1974.
4. Biolo, G., D. Chinkes, X.-J. Zhang, and R. R. Wolfe. A new model to determine in vivo the relationship between amino acid transmembrane transport and protein kinetics in muscle. J. Paren. Enter. Nutr. 16: 305-315, 1992.
5. Biolo, G., R. Y. D. Fleming, S. P. Maggi, and R. R. Wolfe. Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E75-E84, 1995.
6. Biolo, G., S. P. Maggi, B. D. Williams, K. D. Tipton, and R. R. Wolfe. Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E514-E520, 1995.
7. Butterfield, G., and D. H. Calloway. Physical activity improves protein utilization in young men. Br. J. Nutr. 51: 171-184, 1984.
8. Calloway, D. H., and H. Spector. Nitrogen balance as related to caloric and protein intake in active young men. Am. J. Clin. Nutr. 2: 405-411, 1954.
9. 14C]leucine kinetics in splanchnic and leg tissues in man. Diabetes 37: 1365-1372, 1990.
10. Goldberg, A. L. Protein synthesis during work-induced growth of skeletal muscle. J. Cell Biol. 36: 653-658, 1968.
11. Hundal, H. S., M. J. Rennie, and P. W. Watt. Characteristics of acid, basic and neutral amino acid transport in the perfused rat hindlimb. J. Physiol. (Lond.) 408: 93-114, 1989.
12. Jones, D. A., and O. M. Rutherford. Human muscle strength training: the effects of three different regimes and the nature of the resultant changes. J. Physiol. (Lond.) 391: 1-11, 1987.
13. Jorfeld, L., and J. Warren. Leg blood flow during exercise in man. Clin. Sci. (Colch.) 41: 459-473, 1978.
14. Lundholm, K., K. Bennegård, H. Zachrisson, F. Lundgren, E. Edén, and A. C. Möller-Loswick. Transport kinetics of amino acids across the resting human leg. J. Clin. Invest. 80: 763-771, 1987.
15. Maggs, D. G., R. Jacob, F. Rife, R. Lange, P. Leone, M. J. During, W. V. Tamborlane, and R. S. Sherwin. Interstitial fluid concentrations of glycerol, glucose, and amino acids in human quadriceps mucle and adipose tissue. Evidence for significant lipolysis in skeletal muscle. J. Clin. Invest. 96: 370-377, 1995.
16. Miller, L. L. The role of the liver and the non-hepatic tissues in the regulation of free amino acid levels in the blood. In: Amino Acid Pools, edited by J. T. Holden. Amsterdam: Elsevier, 1962, p. 708-722.
17. Mortimore, G. E., A. R. Pogo, M. Kudowaki, and J. J. West, Jr. Multiphasic control of protein degradation by regulatory amino acids: general features and hormonal modulation. J. Biol. Chem. 262: 19322-19327, 1987.
18. Rosenblatt, J., D. Chinkes, M. Wolfe, and R. R. Wolfe. Stable isotope tracer analysis by GC-MS, including quantification of isotopomer effects. Am. J. Physiol. 263 (Endocrinol. Metab. 26): E584-E596, 1992.
19. Williams, B. D., I. Plag, J. Troup, and R. R. Wolfe. Isotopic determination of glycolytic flux during intense exercise in humans. J. Appl. Physiol. 78: 483-490, 1995.
20. Wolfe, R. R. Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis. New York: Wiley-Liss, 1992, p. 417.