Cohort study of pioglitazone and cancer incidence in patients with diabetes

Diabetes Care

Volumn 34, Issue 4, 2011, Pages 923-929

  Ferrara, Assiamira ^a   Lewis, James D ^b   Quesenberry Jr , Charles P ^a   Peng, Tiffany ^a   Strom, Brian L ^b   Van Den Eeden, Stephen K ^a   Ehrlich, Samantha F ^a   Habel, Laurel A ^a  

^a DIVISION OF RESEARCH   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; CREATININE; PIOGLITAZONE;

ADULT; AGE; AGED; ARTICLE; BREAST CANCER; BRONCHUS CANCER; CANCER INCIDENCE; CANCER LOCALIZATION; CANCER RISK; COHORT ANALYSIS; COLON CANCER; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETES CONTROL; DISEASE DURATION; DRUG DOSE INCREASE; DRUG USE; ENDOMETRIUM CANCER; FEMALE; GENDER; HUMAN; INCOME; KIDNEY CANCER; KIDNEY PELVIS; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MELANOMA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHODGKIN LYMPHOMA; PANCREAS CANCER; PRESCRIPTION; PROSTATE CANCER; RACE; RECTUM CANCER; REGISTER; SIDE EFFECT; SMOKING; UNITED STATES;

ADULT; AGED; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MIDDLE AGED; NEOPLASMS; PROPORTIONAL HAZARDS MODELS; THIAZOLIDINEDIONES;

EID: 79956226830     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc10-1067     Document Type: Article

References (23)

1. Nathan DM, Buse JB, Davidson MB, et al.; American Diabetes Association; European Association for Study of Diabetes. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009;32:193-203
2. Ohta K, Endo T, Haraguchi K, Hershman JM, Onaya T. Ligands for peroxisome proliferator-activated receptor gamma inhibit growth and induce apoptosis of human papillary thyroid carcinoma cells. J Clin Endocrinol Metab 2001;86:2170-2177 (Pubitemid 32472935)
3. Elstner E, Müller C, Koshizuka K, et al. Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci USA 1998; 95:8806-8811
4. Takano S, Kubota T, Nishibori H, et al. Pioglitazone, a ligand for peroxisome proliferator-activated receptor-gamma acts as an inhibitor of colon cancer liver metastasis. Anticancer Res 2008;28(6A):3593-3599
5. Shen D, Deng C, Zhang M. Peroxisome proliferator-activated receptor gamma agonists inhibit the proliferation and invasion of human colon cancer cells. Postgrad Med J 2007;83:414-419 (Pubitemid 46960828)
6. Liu H, Zang C, Fenner MH, Possinger K, Elstner E. PPARgamma ligands and ATRA inhibit the invasion of human breast cancer cells in vitro. Breast Cancer Res Treat 2003; 79:63-74 (Pubitemid 36561044)
7. Magenta G, Borenstein X, Rolando R, Jasnis MA: Rosiglitazone inhibits metastasis development of a murine mammary tumor cell line LMM3. BMC Cancer 2008: 47-57
8. Rubenstrunk A, Hanf R, Hum DW, Fruchart JC, Staels B. Safety issues and prospects for future generations of PPAR modulators. Biochim Biophys Acta 2007; 1771:1065-1081 (Pubitemid 47208546)
9. Clay CE, Monjazeb A, Thorburn J, Chilton FH, High KP. 15-Deoxydelta12,14- prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells. J Lipid Res 2002;43: 1818-1828 (Pubitemid 35315799)
10. Palakurthi SS, Aktas H, Grubissich LM, Mortensen RM, Halperin JA. Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation. Cancer Res 2001;61:6213-6218 (Pubitemid 32762559)
11. Ramos-Nino ME, MacLean CD, Littenberg B. Association between cancer prevalence and use of thiazolidinediones: results from the Vermont Diabetes Information System. BMC Med 2007;5:17
12. Govindarajan R, Ratnasinghe L, Simmons DL, et al. Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes. J Clin Oncol 2007; 25:1476-1481 (Pubitemid 46733074)
13. Koro C, Barrett S, Qizilbash N. Cancer risks in thiazolidinedione users compared to other anti-diabetic agents. Pharmacoepidemiol Drug Saf 2007;16:485-492 (Pubitemid 46824269)
14. Monami M, Lamanna C, Marchionni N, Mannucci E. Rosiglitazone and risk of cancer: a meta-analysis of randomized clinical trials. Diabetes Care 2008;31: 1455-1460
15. Actos (Pioglitazone Hydrochloride) Tablets: Full Prescribing Information. Deerfield, Illinois. Takeda Pharmaceuticals America, Inc., 2009
16. Cohen SM. Effects of PPARgamma and combined agonists on the urinary tract of rats and other species. Toxicol Sci 2005; 87:322-327 (Pubitemid 41300679)
17. Dormandy JA, Charbonnel B, Eckland DJ, et al.; PROactive investigators. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 2005;366:1279-1289
18. Selby JV, Ray GT, Zhang D, Colby CJ. Excess costs of medical care for patients with diabetes in a managed care population. Diabetes Care 1997;20:1396-1402 (Pubitemid 27366814)
19. Karter AJ, Ferrara A, Liu JY, Moffet HH, Ackerson LM, Selby JV. Ethnic disparities in diabetic complications in an insured population. JAMA 2002;287:2519-2527 (Pubitemid 34517197)
20. Huxley R, Ansary-Moghaddam A, Berrington de González A, Barzi F, Woodward M. Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer 2005;92:2076-2083 (Pubitemid 40897433)
21. Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD. Metformin and reduced risk of cancer in diabetic patients. BMJ 2005;330:1304-1305 (Pubitemid 40813563)
22. Currie CJ, Poole CD, Gale EA. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia 2009;52:1766-1777
23. Oliveria SA, Koro CE, Ulcickas Yood M, Sowell M. Cancer incidence among patients treated with antidiabetic pharmacotherapy. Diabetes Metab Syndr 2008;2:47-57 (Pubitemid 351194192)