Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl) benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist

European Journal of Medicinal Chemistry

Volumn 58, Issue , 2012, Pages 355-360

  Bajare, Swapnil ^a   Anthony, Jessy ^a   Nair, Amrutha ^a   Marita, Rosalind ^a   Damre, Anagha ^a   Patel, Dharmeshkumar ^a   Rao, Chandrika ^a   Sivaramakrishnan, H ^a   Deka, Nabajyoti ^a  

^a Piramal Enterprises Limited   (India)

Author keywords

Adipocyte; Adipogenesis; PPAR ; Thiazolidinediones; Type 2 diabetes mellitus

Indexed keywords

2 CHLORO N ( 5 CHLORO 6 (QUINOLIN 3 YLOXY)PYRIDIN 3 YL) 4 (TRIFLUOROMETHYL)BENZENESULFONAMIDE; 2 CHLORO N ( 5 CHLORO 6 (QUINOLIN 3 YLOXY)PYRIDIN 3 YL) 4 FLUOROBENZENESULFONAMIDE; 3 CHLORO N ( 5 CHLORO 6 (QUINOLIN 3 YLOXY)PYRIDIN 3 YL) 4 FLUOROBENZENSULFONAMIDE; 3,4 DICHLORO N ( 5 CHLORO 6 (QUINOLIN 3 YLOXY)PYRIDIN 3 YL)BENZENESULFONAMIDE; ANTIOBESITY AGENT; BENZENESULFONAMIDE DERIVATIVE; N ( 5 CHLORO 6 (QUINOLIN 3 YLOXY)PYRIDIN 3 YL) 2 METHYLBENZENESULFONAMIDE; N ( 5 CHLORO 6 (QUINOLIN 3 YLOXY)PYRIDIN 3 YL) 2,4 DIFLUOROBENZENESULFONAMIDE; N ( 5 CHLORO 6 (QUINOLIN 3 YLOXY)PYRIDIN 3 YL) 2,4 DIMETHYLBENZENESULFONAMIDE; N ( 5 CHLORO 6 (QUINOLIN 3 YLOXY)PYRIDIN 3 YL) 2,5 DIMETHOXYBENZENESULFONAMIDE; N ( 5 CHLORO 6 (QUINOLIN 3 YLOXY)PYRIDIN 3 YL) 3 (TRIFLUOROMETHYL)BENZENESULFONAMIDE; N ( 5 CHLORO 6 (QUINOLIN 3 YLOXY)PYRIDIN 3 YL) 3 FLUOROBENZENESULFONAMIDE; N ( 5 CHLORO 6 (QUINOLIN 3 YLOXY)PYRIDIN 3 YL) 3 METHYLBENZENESULFONAMIDE; N ( 5 CHLORO 6 (QUINOLIN 3 YLOXY)PYRIDIN 3 YL) 3,4 DIFLUOROBENZENESULFONAMIDE; N ( 5 CHLORO 6 (QUINOLIN 3 YLOXY)PYRIDIN 3 YL) 3,4 DIMETHOXYBENZENESULFONAMIDE; N ( 5 CHLORO 6 (QUINOLIN 3 YLOXY)PYRIDIN 3 YL) 4 FLUORO 2 METHYLBENZENESULFONAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ADIPOGENESIS; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; DRUG SYNTHESIS; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; OBESITY;

DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PPAR GAMMA; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84868477903     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.10.027     Document Type: Article

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