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Volumn 11, Issue 4, 2009, Pages 275-284

Thiazolidinedione-induced skeletal fragility - Mechanisms and implications

Author keywords

Bone mineral density; Bone turnover; Fracture; Osteoporosis; Thiazolidinediones; Type 2 diabetes mellitus

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; BISPHOSPHONIC ACID DERIVATIVE; CORTICOSTEROID; DARGLITAZONE; ESTROGEN; GLIBENCLAMIDE; METFORMIN; NETOGLITAZONE; PARATHYROID HORMONE[1-34]; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PLACEBO; ROSIGLITAZONE; TROGLITAZONE; ANTIDIABETIC AGENT;

EID: 61549098167     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2008.00931.x     Document Type: Review
Times cited : (70)

References (84)
  • 1
    • 26244444319 scopus 로고    scopus 로고
    • The PROactive study: Some answers, many questions
    • Yki-Jarvinen H. The PROactive study: Some answers, many questions. Lancet 2005; 366: 1241-1242.
    • (2005) Lancet , vol.366 , pp. 1241-1242
    • Yki-Jarvinen, H.1
  • 2
    • 33748748644 scopus 로고    scopus 로고
    • Type 2 diabetes, thiazolidinediones: Bad to the bone?
    • Watts NB, D'Alessio DA. Type 2 diabetes, thiazolidinediones: Bad to the bone? J Clin Endocrinol Metab 2006; 91: 3276-3278.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3276-3278
    • Watts, N.B.1    D'Alessio, D.A.2
  • 3
    • 33845405222 scopus 로고    scopus 로고
    • Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    • Kahn SE, Haffner SM, Heise MA et al. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med 2006; 355: 2427-2443.
    • (2006) N Engl J Med , vol.355 , pp. 2427-2443
    • Kahn, S.E.1    Haffner, S.M.2    Heise, M.A.3
  • 4
    • 33748748206 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: A randomised controlled trial
    • The Dream Trial Investigators
    • The Dream Trial Investigators. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: A randomised controlled trial. Lancet 2006; 368: 1096-1105.
    • (2006) Lancet , vol.368 , pp. 1096-1105
  • 5
    • 13544274204 scopus 로고    scopus 로고
    • Thiazolidinediones for treatment of polycystic ovary syndrome
    • Stout DL, Fugate SE. Thiazolidinediones for treatment of polycystic ovary syndrome. Pharmacotherapy 2005; 25: 244-252.
    • (2005) Pharmacotherapy , vol.25 , pp. 244-252
    • Stout, D.L.1    Fugate, S.E.2
  • 6
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007; 356: 2457-2471.
    • (2007) N Engl J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 7
    • 34548580881 scopus 로고    scopus 로고
    • Long-term risk of cardiovascular events with rosiglitazone: A meta-analysis
    • Singh S, Loke YK, Furberg CD. Long-term risk of cardiovascular events with rosiglitazone: A meta-analysis. JAMA 2007; 298: 1189-1195.
    • (2007) JAMA , vol.298 , pp. 1189-1195
    • Singh, S.1    Loke, Y.K.2    Furberg, C.D.3
  • 8
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): A randomised controlled trial
    • Dormandy JA, Charbonnel B, Eckland DJA et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 2005; 366: 1279-1289.
    • (2005) Lancet , vol.366 , pp. 1279-1289
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.A.3
  • 9
    • 40849134281 scopus 로고    scopus 로고
    • Effects of pioglitazone on major adverse cardiovascular events in high-risk patients with type 2 diabetes: Results from PROspective pioglitAzone Clinical Trial In macro Vascular Events (PROactive 10)
    • Robert W, Stuart K, Erland E. Effects of pioglitazone on major adverse cardiovascular events in high-risk patients with type 2 diabetes: Results from PROspective pioglitAzone Clinical Trial In macro Vascular Events (PROactive 10). Am Heart J 2008; 155: 712-717.
    • (2008) Am Heart J , vol.155 , pp. 712-717
    • Robert, W.1    Stuart, K.2    Erland, E.3
  • 10
    • 34548590934 scopus 로고    scopus 로고
    • Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials
    • Lincoff AM, Wolski K, Nicholls SJ, Nissen SE. Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials. JAMA 2007; 298: 1180-1188.
    • (2007) JAMA , vol.298 , pp. 1180-1188
    • Lincoff, A.M.1    Wolski, K.2    Nicholls, S.J.3    Nissen, S.E.4
  • 11
    • 41649084422 scopus 로고    scopus 로고
    • Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: The PERISCOPE randomized controlled trial
    • Nissen SE, Nicholls SJ, Wolski K et al. Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: The PERISCOPE randomized controlled trial. JAMA 2008; 299: 1561-1573.
    • (2008) JAMA , vol.299 , pp. 1561-1573
    • Nissen, S.E.1    Nicholls, S.J.2    Wolski, K.3
  • 12
    • 33847629923 scopus 로고    scopus 로고
    • Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes - A meta-analysis
    • Vestergaard P. Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes - a meta-analysis. Osteoporos Int 2007; 18: 427-444.
    • (2007) Osteoporos Int , vol.18 , pp. 427-444
    • Vestergaard, P.1
  • 13
    • 33644828429 scopus 로고    scopus 로고
    • Elevated hip fracture risk in type 1 diabetic patients: A population-based cohort study in Sweden
    • Miao J, Brismar K, Nyren O, Ugarph-Morawski A, Ye W. Elevated hip fracture risk in type 1 diabetic patients: A population-based cohort study in Sweden. Diabetes Care 2005; 28: 2850-2855.
    • (2005) Diabetes Care , vol.28 , pp. 2850-2855
    • Miao, J.1    Brismar, K.2    Nyren, O.3    Ugarph-Morawski, A.4    Ye, W.5
  • 14
    • 23744512891 scopus 로고    scopus 로고
    • Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: The Health, Aging, and Body Composition study
    • Strotmeyer ES, Cauley JA, Schwartz AV et al. Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: The Health, Aging, and Body Composition study. Arch Intern Med 2005; 165: 1612-1617.
    • (2005) Arch Intern Med , vol.165 , pp. 1612-1617
    • Strotmeyer, E.S.1    Cauley, J.A.2    Schwartz, A.V.3
  • 15
    • 0035403830 scopus 로고    scopus 로고
    • Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women
    • Nicodemus KK, Folsom AR. Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women. Diabetes Care 2001; 24: 1192-1197.
    • (2001) Diabetes Care , vol.24 , pp. 1192-1197
    • Nicodemus, K.K.1    Folsom, A.R.2
  • 16
    • 0035143770 scopus 로고    scopus 로고
    • Older women with diabetes have an increased risk of fracture: A prospective study
    • Schwartz AV, Sellmeyer DE, Ensrud KE et al. Older women with diabetes have an increased risk of fracture: A prospective study. J Clin Endocrinol Metab 2001; 86: 32-38.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 32-38
    • Schwartz, A.V.1    Sellmeyer, D.E.2    Ensrud, K.E.3
  • 17
    • 23944490347 scopus 로고    scopus 로고
    • Relative fracture risk in patients with diabetes mellitus, and the impact of insulin and oral antidiabetic medication on relative fracture risk
    • Vestergaard P, Rejnmark L, Mosekilde L. Relative fracture risk in patients with diabetes mellitus, and the impact of insulin and oral antidiabetic medication on relative fracture risk. Diabetologia 2005; 48: 1292-1299.
    • (2005) Diabetologia , vol.48 , pp. 1292-1299
    • Vestergaard, P.1    Rejnmark, L.2    Mosekilde, L.3
  • 18
    • 33748740823 scopus 로고    scopus 로고
    • Risk of fracture in women with type 2 diabetes: The Women's Health Initiative Observational Study
    • Bonds DE, Larson JC, Schwartz AV et al. Risk of fracture in women with type 2 diabetes: The Women's Health Initiative Observational Study. J Clin Endocrinol Metab 2006; 91: 3404-3410.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3404-3410
    • Bonds, D.E.1    Larson, J.C.2    Schwartz, A.V.3
  • 20
    • 0035403173 scopus 로고    scopus 로고
    • Diabetes and risk of fracture: The Blue Mountains Eye Study
    • Ivers RQ, Cumming RG, Mitchell P, Peduto AJ. Diabetes and risk of fracture: The Blue Mountains Eye Study. Diabetes Care 2001; 24: 1198-1203.
    • (2001) Diabetes Care , vol.24 , pp. 1198-1203
    • Ivers, R.Q.1    Cumming, R.G.2    Mitchell, P.3    Peduto, A.J.4
  • 21
    • 34548017660 scopus 로고    scopus 로고
    • Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture
    • Janghorbani M, Van Dam RM, Willett WC, Hu FB. Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am J Epidemiol 2007; 166: 495-505.
    • (2007) Am J Epidemiol , vol.166 , pp. 495-505
    • Janghorbani, M.1    Van Dam, R.M.2    Willett, W.C.3    Hu, F.B.4
  • 22
    • 32844463801 scopus 로고    scopus 로고
    • Neuropathy-induced osteopenia in rats is not due to a reduction in weight borne on the affected limb
    • Whiteside GT, Boulet JM, Sellers R, Bunton TE, Walker K. Neuropathy-induced osteopenia in rats is not due to a reduction in weight borne on the affected limb. Bone 2006; 38: 387-393.
    • (2006) Bone , vol.38 , pp. 387-393
    • Whiteside, G.T.1    Boulet, J.M.2    Sellers, R.3    Bunton, T.E.4    Walker, K.5
  • 23
    • 0022392722 scopus 로고
    • Osteopenia and metatarsal fractures in diabetic neuropathy
    • Cundy TF, Edmonds ME, Watkins PJ. Osteopenia and metatarsal fractures in diabetic neuropathy. Diabet Med 1985; 2: 461-464.
    • (1985) Diabet Med , vol.2 , pp. 461-464
    • Cundy, T.F.1    Edmonds, M.E.2    Watkins, P.J.3
  • 24
    • 2642674421 scopus 로고    scopus 로고
    • High fatty acid content in rabbit serum is responsible for the differentiation of osteoblasts into adipocyte-like cells
    • Diascro DD, Vogel RL, Johnson TE et al. High fatty acid content in rabbit serum is responsible for the differentiation of osteoblasts into adipocyte-like cells. J Bone Miner Res 1998; 13: 96-106.
    • (1998) J Bone Miner Res , vol.13 , pp. 96-106
    • Diascro, D.D.1    Vogel, R.L.2    Johnson, T.E.3
  • 25
    • 0031953736 scopus 로고    scopus 로고
    • Human trabecular bone cells are able to express both osteoblastic and adipocytic phenotype: Implications for osteopenic disorders
    • Nuttall ME, Patton AJ, Olivera DL, Nadeau DP, Gowen M. Human trabecular bone cells are able to express both osteoblastic and adipocytic phenotype: Implications for osteopenic disorders. J Bone Miner Res 1998; 13: 371-382.
    • (1998) J Bone Miner Res , vol.13 , pp. 371-382
    • Nuttall, M.E.1    Patton, A.J.2    Olivera, D.L.3    Nadeau, D.P.4    Gowen, M.5
  • 26
    • 0034640397 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma pathway inhibits osteoclast differentiation
    • Mbalaviele G, Abu-Amer Y, Meng A et al. Activation of peroxisome proliferator-activated receptor-gamma pathway inhibits osteoclast differentiation. J Biol Chem 2000; 275: 14388-14393.
    • (2000) J Biol Chem , vol.275 , pp. 14388-14393
    • Mbalaviele, G.1    Abu-Amer, Y.2    Meng, A.3
  • 27
    • 0029847076 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells
    • Gimble JM, Robinson CE, Wu X et al. Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Mol Pharmacol 1996; 50: 1087-1094.
    • (1996) Mol Pharmacol , vol.50 , pp. 1087-1094
    • Gimble, J.M.1    Robinson, C.E.2    Wu, X.3
  • 28
    • 0033305164 scopus 로고    scopus 로고
    • Thiazolidinedione effects on glucocorticoid receptor-mediated gene transcription and differentiation in osteoblastic cells
    • Johnson TE, Vogel R, Rutledge SJ, Rodan G, Schmidt A. Thiazolidinedione effects on glucocorticoid receptor-mediated gene transcription and differentiation in osteoblastic cells. Endocrinology 1999; 140: 3245-3254.
    • (1999) Endocrinology , vol.140 , pp. 3245-3254
    • Johnson, T.E.1    Vogel, R.2    Rutledge, S.J.3    Rodan, G.4    Schmidt, A.5
  • 29
    • 0038607705 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma inhibits the Runx2-mediated transcription of osteocalcin in osteoblasts
    • Jeon MJ, Kim JA, Kwon SH et al. Activation of peroxisome proliferator-activated receptor-gamma inhibits the Runx2-mediated transcription of osteocalcin in osteoblasts. J Biol Chem 2003; 278: 23270-23277.
    • (2003) J Biol Chem , vol.278 , pp. 23270-23277
    • Jeon, M.J.1    Kim, J.A.2    Kwon, S.H.3
  • 30
    • 0034616069 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activators modulate the osteoblastic maturation of MC3T3-E1 preosteoblasts
    • Jackson SM, Demer LL. Peroxisome proliferator-activated receptor activators modulate the osteoblastic maturation of MC3T3-E1 preosteoblasts. FEBS Lett 2000; 471: 119-124.
    • (2000) FEBS Lett , vol.471 , pp. 119-124
    • Jackson, S.M.1    Demer, L.L.2
  • 31
    • 33751503186 scopus 로고    scopus 로고
    • PPAR agonists modulate human osteoclast formation and activity in vitro
    • Chan BY, Gartland A, Wilson PJM et al. PPAR agonists modulate human osteoclast formation and activity in vitro. Bone 2007; 40: 149-159.
    • (2007) Bone , vol.40 , pp. 149-159
    • Chan, B.Y.1    Gartland, A.2    Wilson, P.J.M.3
  • 32
    • 0033197899 scopus 로고    scopus 로고
    • Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2
    • Lecka-Czernik B, Gubrij I, Moerman EJ et al. Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2. J Cell Biochem 1999; 74: 357-371.
    • (1999) J Cell Biochem , vol.74 , pp. 357-371
    • Lecka-Czernik, B.1    Gubrij, I.2    Moerman, E.J.3
  • 33
    • 0041766341 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma inhibits differentiation of preosteoblasts
    • Khan E, Abu-Amer Y. Activation of peroxisome proliferator-activated receptor-gamma inhibits differentiation of preosteoblasts. J Lab Clin Med 2003; 142: 29-34.
    • (2003) J Lab Clin Med , vol.142 , pp. 29-34
    • Khan, E.1    Abu-Amer, Y.2
  • 34
    • 21044441395 scopus 로고    scopus 로고
    • Distinct effects of PPARgamma insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells
    • Kawaguchi H, Akune T, Yamaguchi M et al. Distinct effects of PPARgamma insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells. J Bone Miner Metab 2005; 23: 275-279.
    • (2005) J Bone Miner Metab , vol.23 , pp. 275-279
    • Kawaguchi, H.1    Akune, T.2    Yamaguchi, M.3
  • 35
    • 0036090467 scopus 로고    scopus 로고
    • Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation
    • Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL. Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. Endocrinology 2002; 143: 2376-2384.
    • (2002) Endocrinology , vol.143 , pp. 2376-2384
    • Lecka-Czernik, B.1    Moerman, E.J.2    Grant, D.F.3    Lehmann, J.M.4    Manolagas, S.C.5    Jilka, R.L.6
  • 36
    • 33746909073 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) induces cell death through MAPK-dependent mechanism in osteoblastic cells
    • Kim SH, Yoo CI, Kim HT, Park JY, Kwon CH, Kim YK. Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) induces cell death through MAPK-dependent mechanism in osteoblastic cells. Toxicol Appl Pharmacol 2006; 215: 198-207.
    • (2006) Toxicol Appl Pharmacol , vol.215 , pp. 198-207
    • Kim, S.H.1    Yoo, C.I.2    Kim, H.T.3    Park, J.Y.4    Kwon, C.H.5    Kim, Y.K.6
  • 37
    • 0033303538 scopus 로고    scopus 로고
    • Thiazolidinediones inhibit osteoclast-like cell formation and bone resorption in vitro
    • Okazaki R, Toriumi M, Fukumoto S et al. Thiazolidinediones inhibit osteoclast-like cell formation and bone resorption in vitro. Endocrinology 1999; 140: 5060-5065.
    • (1999) Endocrinology , vol.140 , pp. 5060-5065
    • Okazaki, R.1    Toriumi, M.2    Fukumoto, S.3
  • 40
    • 36849034568 scopus 로고    scopus 로고
    • PPARγ regulates osteoclastogenesis in mice
    • Wan Y, Chong L-W, Evans RM. PPARγ regulates osteoclastogenesis in mice. Nat Med 2007; 13: 1496-1503.
    • (2007) Nat Med , vol.13 , pp. 1496-1503
    • Wan, Y.1    Chong, L.-W.2    Evans, R.M.3
  • 41
    • 34548523808 scopus 로고    scopus 로고
    • PPARγ inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats
    • Lin T-H, Yang R-S, Tang C-H, Lin C-P, Fu W-M. PPARγ inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats. Bone 2007; 41: 562-574.
    • (2007) Bone , vol.41 , pp. 562-574
    • Lin, T.-H.1    Yang, R.-S.2    Tang, C.-H.3    Lin, C.-P.4    Fu, W.-M.5
  • 42
    • 14244250617 scopus 로고    scopus 로고
    • Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation
    • Ali AA, Weinstein RS, Stewart SA, Parfitt AM, Manolagas SC, Jilka RL. Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation. Endocrinology 2005; 146: 1226-1235.
    • (2005) Endocrinology , vol.146 , pp. 1226-1235
    • Ali, A.A.1    Weinstein, R.S.2    Stewart, S.A.3    Parfitt, A.M.4    Manolagas, S.C.5    Jilka, R.L.6
  • 43
    • 29344470714 scopus 로고    scopus 로고
    • Netoglitazone is a PPAR-gamma ligand with selective effects on bone and fat
    • Lazarenko OP, Rzonca SO, Suva LJ, Lecka-Czernik B. Netoglitazone is a PPAR-gamma ligand with selective effects on bone and fat. Bone 2006; 38: 74-84.
    • (2006) Bone , vol.38 , pp. 74-84
    • Lazarenko, O.P.1    Rzonca, S.O.2    Suva, L.J.3    Lecka-Czernik, B.4
  • 44
    • 12344255130 scopus 로고    scopus 로고
    • Rosiglitazone impacts negatively on bone by promoting osteoblast/ osteocyte apoptosis
    • Soroceanu MA, Miao D, Bai X-Y, Su H, Goltzman D, Karaplis AC. Rosiglitazone impacts negatively on bone by promoting osteoblast/ osteocyte apoptosis. J Endocrinol 2004; 183: 203-216.
    • (2004) J Endocrinol , vol.183 , pp. 203-216
    • Soroceanu, M.A.1    Miao, D.2    Bai, X.-Y.3    Su, H.4    Goltzman, D.5    Karaplis, A.C.6
  • 46
    • 33748157382 scopus 로고    scopus 로고
    • Surface-specific effects of a PPAR-gamma agonist, darglitazone, on bone in mice
    • Li M, Pan LC, Simmons HA et al. Surface-specific effects of a PPAR-gamma agonist, darglitazone, on bone in mice. Bone 2006; 39: 796-806.
    • (2006) Bone , vol.39 , pp. 796-806
    • Li, M.1    Pan, L.C.2    Simmons, H.A.3
  • 47
    • 37749034527 scopus 로고    scopus 로고
    • Skeletal consequences of thiazolidinedione therapy
    • Grey A. Skeletal consequences of thiazolidinedione therapy. Osteoporos Int 2008; 19: 129-137.
    • (2008) Osteoporos Int , vol.19 , pp. 129-137
    • Grey, A.1
  • 48
    • 31544457103 scopus 로고    scopus 로고
    • Mechanisms of disease: Is osteoporosis the obesity of bone?
    • Rosen CJ, Bouxsein ML. Mechanisms of disease: Is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol 2006; 2: 35-43.
    • (2006) Nat Clin Pract Rheumatol , vol.2 , pp. 35-43
    • Rosen, C.J.1    Bouxsein, M.L.2
  • 49
    • 11244346967 scopus 로고    scopus 로고
    • Enhanced marrow adipogenesis and bone resorption in estrogen-deprived rats treated with the PPARgamma agonist BRL49653 (rosiglitazone)
    • Sottile V, Seuwen K, Kneissel M. Enhanced marrow adipogenesis and bone resorption in estrogen-deprived rats treated with the PPARgamma agonist BRL49653 (rosiglitazone). Calcif Tissue Int 2004; 75: 329-337.
    • (2004) Calcif Tissue Int , vol.75 , pp. 329-337
    • Sottile, V.1    Seuwen, K.2    Kneissel, M.3
  • 50
    • 0034915161 scopus 로고    scopus 로고
    • Troglitazone treatment increases bone marrow adipose tissue volume but does not affect trabecular bone volume in mice
    • Tornvig L, Mosekilde LI, Justesen J, Falk E, Kassem M. Troglitazone treatment increases bone marrow adipose tissue volume but does not affect trabecular bone volume in mice. Calcif Tissue Int 2001; 69: 46-50.
    • (2001) Calcif Tissue Int , vol.69 , pp. 46-50
    • Tornvig, L.1    Mosekilde, L.I.2    Justesen, J.3    Falk, E.4    Kassem, M.5
  • 51
    • 2142652189 scopus 로고    scopus 로고
    • PPAR-gamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
    • Akune T, Ohba S, Kamekura S et al. PPAR-gamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 2004; 113: 846-855.
    • (2004) J Clin Invest , vol.113 , pp. 846-855
    • Akune, T.1    Ohba, S.2    Kamekura, S.3
  • 52
    • 9144272249 scopus 로고    scopus 로고
    • Regulation of bone mass in mice by the lipoxygenase gene Alox15
    • Klein RF, Allard J, Avnur Z et al. Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science 2004; 303: 229-232.
    • (2004) Science , vol.303 , pp. 229-232
    • Klein, R.F.1    Allard, J.2    Avnur, Z.3
  • 53
    • 33645357530 scopus 로고    scopus 로고
    • Nutrition-related peptides and bone homeostasis
    • Reid IR, Cornish J, Baldock PA. Nutrition-related peptides and bone homeostasis. J Bone Miner Res 2006; 21: 495-500.
    • (2006) J Bone Miner Res , vol.21 , pp. 495-500
    • Reid, I.R.1    Cornish, J.2    Baldock, P.A.3
  • 55
    • 0034455806 scopus 로고    scopus 로고
    • Leptin production in adipocytes from morbidly obese subjects: Stimulation by dexamethasone, inhibition with troglitazone, and influence of gender
    • Williams LB, Fawcett RL, Waechter AS et al. Leptin production in adipocytes from morbidly obese subjects: Stimulation by dexamethasone, inhibition with troglitazone, and influence of gender. J Clin Endocrinol Metab 2000; 85: 2678-2684.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2678-2684
    • Williams, L.B.1    Fawcett, R.L.2    Waechter, A.S.3
  • 56
    • 18744376564 scopus 로고    scopus 로고
    • Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo
    • Cornish J, Callon KE, Bava U et al. Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J Endocrinol 2002; 175: 405-415.
    • (2002) J Endocrinol , vol.175 , pp. 405-415
    • Cornish, J.1    Callon, K.E.2    Bava, U.3
  • 57
    • 0141737573 scopus 로고    scopus 로고
    • Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
    • Ducy P, Amling M, Takeda S et al. Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass. Cell 2000; 100: 197-207.
    • (2000) Cell , vol.100 , pp. 197-207
    • Ducy, P.1    Amling, M.2    Takeda, S.3
  • 58
    • 0035462629 scopus 로고    scopus 로고
    • PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    • Maeda N, Takahashi M, Funahashi T et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001; 50: 2094.
    • (2001) Diabetes , vol.50 , pp. 2094
    • Maeda, N.1    Takahashi, M.2    Funahashi, T.3
  • 59
    • 18044394024 scopus 로고    scopus 로고
    • Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast
    • Oshima K, Nampei A, Matsuda M et al. Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun 2005; 331: 520-526.
    • (2005) Biochem Biophys Res Commun , vol.331 , pp. 520-526
    • Oshima, K.1    Nampei, A.2    Matsuda, M.3
  • 61
    • 0029906854 scopus 로고    scopus 로고
    • Insulin increases histomorphometric indices of bone formation in vivo
    • Cornish J, Callon KE, Reid IR. Insulin increases histomorphometric indices of bone formation in vivo. Calcif Tissue Int 1996; 59: 492-495.
    • (1996) Calcif Tissue Int , vol.59 , pp. 492-495
    • Cornish, J.1    Callon, K.E.2    Reid, I.R.3
  • 62
    • 0031741159 scopus 로고    scopus 로고
    • Systemic administration of amylin increases bone mass, linear growth, and adiposity in adult male mice
    • Cornish J, Callon KE, King AR, Cooper GJS, Reid IR. Systemic administration of amylin increases bone mass, linear growth, and adiposity in adult male mice. Am J Physiol 1998; 38: E694-E699.
    • (1998) Am J Physiol , vol.38
    • Cornish, J.1    Callon, K.E.2    King, A.R.3    Cooper, G.J.S.4    Reid, I.R.5
  • 63
    • 10744220002 scopus 로고    scopus 로고
    • Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo
    • Dacquin R, Davey RA, Laplace C et al. Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J Cell Biol 2004; 164: 509-514.
    • (2004) J Cell Biol , vol.164 , pp. 509-514
    • Dacquin, R.1    Davey, R.A.2    Laplace, C.3
  • 64
    • 33846412672 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo
    • Lecka-Czernik B, Ackert-Bicknell C, Adamo ML et al. Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo. Endocrinology 2007; 148: 903-911.
    • (2007) Endocrinology , vol.148 , pp. 903-911
    • Lecka-Czernik, B.1    Ackert-Bicknell, C.2    Adamo, M.L.3
  • 65
    • 8844226036 scopus 로고    scopus 로고
    • Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen
    • Cock T-A, Back J, Elefteriou F et al. Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen. EMBO Reports 2004; 5: 1007-1012.
    • (2004) EMBO Reports , vol.5 , pp. 1007-1012
    • Cock, T.-A.1    Back, J.2    Elefteriou, F.3
  • 67
    • 34249905512 scopus 로고    scopus 로고
    • Thiazolidinediones treatment decreases bone mineral density in type 2 diabetic men
    • Yaturu S, Bryant B, Jain SK. Thiazolidinediones treatment decreases bone mineral density in type 2 diabetic men. Diabetes Care 2007; 30: 1574-1576.
    • (2007) Diabetes Care , vol.30 , pp. 1574-1576
    • Yaturu, S.1    Bryant, B.2    Jain, S.K.3
  • 68
    • 34147154970 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma agonist rosiglitazone decreases bone formation and bone mineral density in healthy postmenopausal women: A randomized, controlled trial
    • Grey A, Bolland M, Gamble G et al. The peroxisome proliferator-activated receptor-gamma agonist rosiglitazone decreases bone formation and bone mineral density in healthy postmenopausal women: A randomized, controlled trial. J Clin Endocrinol Metab 2007; 92: 1305-1310.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1305-1310
    • Grey, A.1    Bolland, M.2    Gamble, G.3
  • 70
    • 43249096938 scopus 로고    scopus 로고
    • Association of pioglitazone treatment with decreased bone mineral density in obese premenopausal patients with polycystic ovary syndrome: A randomized, placebo-controlled trial
    • Glintborg D, Andersen M, Hagen C, Heickendorff L, Hermann AP. Association of pioglitazone treatment with decreased bone mineral density in obese premenopausal patients with polycystic ovary syndrome: a randomized, placebo-controlled trial. J Clin Endocrinol Metab 2008; 93: 1696-1701.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1696-1701
    • Glintborg, D.1    Andersen, M.2    Hagen, C.3    Heickendorff, L.4    Hermann, A.P.5
  • 72
    • 38949182323 scopus 로고    scopus 로고
    • Bone fractures and hypoglycemic treatment in type 2 diabetic patients: A case-control study
    • Monami M, Cresci B, Colombini A et al. Bone fractures and hypoglycemic treatment in type 2 diabetic patients: A case-control study. Diabetes Care 2008; 31: 199-203.
    • (2008) Diabetes Care , vol.31 , pp. 199-203
    • Monami, M.1    Cresci, B.2    Colombini, A.3
  • 74
    • 84878640855 scopus 로고    scopus 로고
    • US Food and Drug Administration. Available from URL Accessed 14 April
    • US Food and Drug Administration. Available from URL: http://www.fda.gov/ medwatch/safety/2007/Avandia_GSK_Ltr.pdf. Accessed 14 April 2008.
    • (2008)
  • 75
    • 84878650641 scopus 로고    scopus 로고
    • US Food and Drug Administration. Available from URL Accessed 15 April
    • US Food and Drug Administration. Available from URL: http://www.fda.gov/ medwatch/safety/2007/Actosmar0807.pdf. Accessed 15 April 2008.
    • (2008)
  • 76
    • 0032875190 scopus 로고    scopus 로고
    • Age- and gender-specific rate of fractures in Australia: A population-based study
    • Sanders KM, Seeman E, Ugoni AM et al. Age- and gender-specific rate of fractures in Australia: A population-based study. Osteoporos Int 1999; 10: 240-247.
    • (1999) Osteoporos Int , vol.10 , pp. 240-247
    • Sanders, K.M.1    Seeman, E.2    Ugoni, A.M.3
  • 78
    • 43449091851 scopus 로고    scopus 로고
    • Available from URL Accessed 15 April 2008
    • FRAX: WHO fracture risk assessment tool. AvailablH from URL: http://www.shef.ac.uk/FRAX/index.htm. Accessed 15 April 2008.
    • FRAX: WHO Fracture Risk Assessment Tool
  • 79
    • 18244431006 scopus 로고    scopus 로고
    • Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis. Glucocorticoid-Induced Osteoporosis Intervention Study Group
    • Saag KG, Emkey R, Schnitzer TJ et al. Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis. Glucocorticoid-Induced Osteoporosis Intervention Study Group. N Engl J Med 1998; 339: 292-299.
    • (1998) N Engl J Med , vol.339 , pp. 292-299
    • Saag, K.G.1    Emkey, R.2    Schnitzer, T.J.3
  • 80
    • 0035147121 scopus 로고    scopus 로고
    • Two-year effects of alendronate on bone mineral density and vertebral fracture in patients receiving glucocorticoids: A randomized, double-blind, placebo-controlled extension trial
    • Adachi JD, Saag KG, Delmas PD et al. Two-year effects of alendronate on bone mineral density and vertebral fracture in patients receiving glucocorticoids: A randomized, double-blind, placebo-controlled extension trial. Arthritis Rheum 2001; 44: 202-211.
    • (2001) Arthritis Rheum , vol.44 , pp. 202-211
    • Adachi, J.D.1    Saag, K.G.2    Delmas, P.D.3
  • 81
    • 0028338252 scopus 로고
    • Continuous combined oestrogen/progestin therapy is well tolerated and increases bone density at the hip and spine in post-menopausal osteoporosis
    • Grey AB, Cundy TF, Reid IR. Continuous combined oestrogen/progestin therapy is well tolerated and increases bone density at the hip and spine in post-menopausal osteoporosis. Clin Endocrinol (Oxf) 1994; 40: 671-677.
    • (1994) Clin Endocrinol (Oxf) , vol.40 , pp. 671-677
    • Grey, A.B.1    Cundy, T.F.2    Reid, I.R.3
  • 82
    • 36148958951 scopus 로고    scopus 로고
    • Teriparatide or alendronate in glucocorticoid-induced osteoporosis
    • Saag KG, Shane E, Boonen S et al. Teriparatide or alendronate in glucocorticoid-induced osteoporosis. N Engl J Med 2007; 357: 2028-2039.
    • (2007) N Engl J Med , vol.357 , pp. 2028-2039
    • Saag, K.G.1    Shane, E.2    Boonen, S.3
  • 83
    • 61549141154 scopus 로고    scopus 로고
    • National Osteoporosis Foundation. Washington: National Osteoporosis Foundation
    • National Osteoporosis Foundation. Physician's Guide to Prevention and Treatment of Osteoporosis. Washington: National Osteoporosis Foundation, 2003.
    • (2003) Physician's Guide to Prevention and Treatment of Osteoporosis
  • 84
    • 1442285904 scopus 로고    scopus 로고
    • Medical guidelines for clinical practice for the prevention and treatment of postmenopausal osteoporosis
    • American Association of Clinical Endocrinologists
    • American Association of Clinical Endocrinologists. Medical guidelines for clinical practice for the prevention and treatment of postmenopausal osteoporosis. Endocrine Practice 2003; 9: 544-564.
    • (2003) Endocrine Practice , vol.9 , pp. 544-564


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