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Volumn 17, Issue 4, 2009, Pages 665-673

PPAR-γ AF-2 domain functions as a component of a ubiquitin-dependent degradation signal

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEASOME; UBIQUITIN;

EID: 63049133308     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2008.616     Document Type: Article
Times cited : (43)

References (37)
  • 1
    • 50649097541 scopus 로고    scopus 로고
    • Fat and beyond: The diverse biology of PRARγ
    • Tontonoz P, Spiegelman BM. Fat and beyond: the diverse biology of PRARγ. Annu Rev Biochem 2008;77:289-312.
    • (2008) Annu Rev Biochem , vol.77 , pp. 289-312
    • Tontonoz, P.1    Spiegelman, B.M.2
  • 2
    • 0030000088 scopus 로고    scopus 로고
    • Regulation of PPAR γ gene expression by nutrition and obesity in rodents
    • Vidal-Puig A, Jimenez-Linan M, Lowell BB et al. Regulation of PPAR γ gene expression by nutrition and obesity in rodents. J Clin Invest 1996;97:2553-2561.
    • (1996) J Clin Invest , vol.97 , pp. 2553-2561
    • Vidal-Puig, A.1    Jimenez-Linan, M.2    Lowell, B.B.3
  • 3
    • 33744497272 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor N-terminal domain controls isotype-selective gene expression and adipogenesis
    • Hummasti S, Tontonoz P. The peroxisome proliferator-activated receptor N-terminal domain controls isotype-selective gene expression and adipogenesis. Mol Endocrinol 2006;20:1261-1275.
    • (2006) Mol Endocrinol , vol.20 , pp. 1261-1275
    • Hummasti, S.1    Tontonoz, P.2
  • 4
    • 34247636362 scopus 로고    scopus 로고
    • PPAR γ 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
    • Medina-Gomez G, Gray SL, Yetukuri L et al. PPAR γ 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet 2007;3:e64.
    • (2007) PLoS Genet , vol.3
    • Medina-Gomez, G.1    Gray, S.L.2    Yetukuri, L.3
  • 5
    • 0033212964 scopus 로고    scopus 로고
    • PPAR γ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
    • Kubota N, Terauchi Y, Miki H et al. PPAR γ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 1999;4:597-609.
    • (1999) Mol Cell , vol.4 , pp. 597-609
    • Kubota, N.1    Terauchi, Y.2    Miki, H.3
  • 6
    • 0033973843 scopus 로고    scopus 로고
    • Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency
    • Miles PD, Barak Y, He W, Evans RM, Olefsky JM: Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency. J Clin Invest 2000;105: 287-292.
    • (2000) J Clin Invest , vol.105 , pp. 287-292
    • Miles, P.D.1    Barak, Y.2    He, W.3    Evans, R.M.4    Olefsky, J.M.5
  • 7
    • 0037364560 scopus 로고    scopus 로고
    • Effect of heterozygous PPARγ deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding
    • Miles PD, Barak Y, Evans RM, Olefsky JM. Effect of heterozygous PPARγ deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding. Am J Physiol Endocrinol Metab 2003;284:E618-E626.
    • (2003) Am J Physiol Endocrinol Metab , vol.284
    • Miles, P.D.1    Barak, Y.2    Evans, R.M.3    Olefsky, J.M.4
  • 9
    • 5044234664 scopus 로고    scopus 로고
    • Altered growth in male peroxisome proliferator-actlvated receptor γ (PPARγ) heterozygous mice: Involvement of PPARγ in a negative feedback regulation of growth hormone action
    • Rieusset J, Seydoux J, Anghel SI et al. Altered growth in male peroxisome proliferator-actlvated receptor γ (PPARγ) heterozygous mice: involvement of PPARγ in a negative feedback regulation of growth hormone action. Mol Endocrinol 2004;18:2363-2377.
    • (2004) Mol Endocrinol , vol.18 , pp. 2363-2377
    • Rieusset, J.1    Seydoux, J.2    Anghel, S.I.3
  • 10
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
    • He W, Barak Y, Hevener A et al. Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci USA 2003;100:15712-15717.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15712-15717
    • He, W.1    Barak, Y.2    Hevener, A.3
  • 11
    • 20944439189 scopus 로고    scopus 로고
    • Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance
    • Jones JR, Barrick C, Kim KA et al. Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci USA 2005;102:6207-6212.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 6207-6212
    • Jones, J.R.1    Barrick, C.2    Kim, K.A.3
  • 12
    • 0034674567 scopus 로고    scopus 로고
    • Degradation of the peroxisome proliferator-actlvated receptor γ is linked to ligand-dependent activation
    • Hauser S, Adelmant G, Sarraf P et al. Degradation of the peroxisome proliferator-actlvated receptor γ is linked to ligand-dependent activation. J Biol Chem 2000;275:18527-18533.
    • (2000) J Biol Chem , vol.275 , pp. 18527-18533
    • Hauser, S.1    Adelmant, G.2    Sarraf, P.3
  • 13
    • 0037040272 scopus 로고    scopus 로고
    • Interferon-γ-mediated activation and ubiquitin-proteasome-dependent degradation of PPARγ in adipocytes
    • Floyd ZE, Stephens JM. Interferon-γ-mediated activation and ubiquitin-proteasome-dependent degradation of PPARγ in adipocytes. J Biol Chem 2002;277:4062-4068.
    • (2002) J Biol Chem , vol.277 , pp. 4062-4068
    • Floyd, Z.E.1    Stephens, J.M.2
  • 14
    • 0035831494 scopus 로고    scopus 로고
    • Interferon-γ- Induced regulation of peroxisome proliferator-actlvated receptor γ and STATs in adipocytes
    • Waite KJ, Floyd ZE, Arbour-Reily P, Stephens JM. Interferon-γ- Induced regulation of peroxisome proliferator-actlvated receptor γ and STATs in adipocytes. J Biol Chem 2001;276:7062-7068.
    • (2001) J Biol Chem , vol.276 , pp. 7062-7068
    • Waite, K.J.1    Floyd, Z.E.2    Arbour-Reily, P.3    Stephens, J.M.4
  • 15
    • 33749346301 scopus 로고    scopus 로고
    • Modification of proteins by ubiquitin and ubiquitin-like proteins
    • Keracher O, Felberbaum R, Hochstrasser M. Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu Rev Cell Dev Biol 2006;22: 159-180.
    • (2006) Annu Rev Cell Dev Biol , vol.22 , pp. 159-180
    • Keracher, O.1    Felberbaum, R.2    Hochstrasser, M.3
  • 16
    • 4644257496 scopus 로고    scopus 로고
    • Control of peroxisome proliferator-activated receptor γ2 stability and activity by SUMOylation
    • Floyd ZE, Stephens JM. Control of peroxisome proliferator-activated receptor γ2 stability and activity by SUMOylation. Obes Res 2004; 12: 921-928.
    • (2004) Obes Res , vol.12 , pp. 921-928
    • Floyd, Z.E.1    Stephens, J.M.2
  • 18
    • 0035979738 scopus 로고    scopus 로고
    • Regulation of transcriptional activation domain function by ubiquitin
    • Salghetti SE, Caudy AA, Chenoweth JG, Tansey WP. Regulation of transcriptional activation domain function by ubiquitin. Science 2001;293:1651-1653.
    • (2001) Science , vol.293 , pp. 1651-1653
    • Salghetti, S.E.1    Caudy, A.A.2    Chenoweth, J.G.3    Tansey, W.P.4
  • 19
    • 0034724166 scopus 로고    scopus 로고
    • Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis
    • Salghetti SE, Muratani M, Wijnen H, Futcher B, Tansey WP. Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis. Proc Natl Acad Sci USA 2000;97: 3118-3123.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3118-3123
    • Salghetti, S.E.1    Muratani, M.2    Wijnen, H.3    Futcher, B.4    Tansey, W.P.5
  • 20
    • 0036087244 scopus 로고    scopus 로고
    • Downregulated IRS-1 and PPARγ in obese women with gestational diabetes: Relationship to FFA during pregnancy
    • Catalano PM, Nizielski SE, Shao J et al. Downregulated IRS-1 and PPARγ in obese women with gestational diabetes: relationship to FFA during pregnancy. Am J Physiol Endocrinol Metab 2002;282: E522-E533.
    • (2002) Am J Physiol Endocrinol Metab , vol.282
    • Catalano, P.M.1    Nizielski, S.E.2    Shao, J.3
  • 21
    • 0035851187 scopus 로고    scopus 로고
    • PPARγ: A nuclear regulator of metabolism, differentiation, and cell growth
    • Rosen ED, Spiegelman BM. PPARγ: a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem 2001;276:37731-37734.
    • (2001) J Biol Chem , vol.276 , pp. 37731-37734
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 22
    • 33646841837 scopus 로고    scopus 로고
    • Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate
    • Kisselev AF, Callard A, Goldberg AL. Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate. J Biol Chem 2006;281:8582-8590.
    • (2006) J Biol Chem , vol.281 , pp. 8582-8590
    • Kisselev, A.F.1    Callard, A.2    Goldberg, A.L.3
  • 23
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 24
    • 35148886143 scopus 로고    scopus 로고
    • Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics
    • Yang Y, Kitagaki J, Dai RM et al. Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res 2007;67:9472-9481.
    • (2007) Cancer Res , vol.67 , pp. 9472-9481
    • Yang, Y.1    Kitagaki, J.2    Dai, R.M.3
  • 25
    • 0028146192 scopus 로고
    • Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant
    • Finley D, Sadis S, Monia BP et al. Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant. Mol Cell Biol 1994;14:5501-5509.
    • (1994) Mol Cell Biol , vol.14 , pp. 5501-5509
    • Finley, D.1    Sadis, S.2    Monia, B.P.3
  • 26
    • 0026803107 scopus 로고
    • Expression of a ubiquitin derivative that conjugates to protein irreversibly produces phenotypes consistent with a ubiquitin deficiency
    • Hodgins RR, Ellison KS, Ellison MJ. Expression of a ubiquitin derivative that conjugates to protein irreversibly produces phenotypes consistent with a ubiquitin deficiency. J Biol Chem 1992;267:8807-8812.
    • (1992) J Biol Chem , vol.267 , pp. 8807-8812
    • Hodgins, R.R.1    Ellison, K.S.2    Ellison, M.J.3
  • 27
    • 0842303313 scopus 로고    scopus 로고
    • Back to the future with ubiquitin
    • Pickart CM. Back to the future with ubiquitin. Cell 2004;116:181-190.
    • (2004) Cell , vol.116 , pp. 181-190
    • Pickart, C.M.1
  • 28
    • 0024448046 scopus 로고
    • Degradation of ornithine decarboxylase in mammalian cells is ATP dependent but ubiquitin independent
    • Rosenberg-Hasson Y, Bercovich Z, Ciechanover A, Kahana C. Degradation of ornithine decarboxylase in mammalian cells is ATP dependent but ubiquitin independent. Eur J Biochem 1989;185:469-474.
    • (1989) Eur J Biochem , vol.185 , pp. 469-474
    • Rosenberg-Hasson, Y.1    Bercovich, Z.2    Ciechanover, A.3    Kahana, C.4
  • 29
    • 0034114625 scopus 로고    scopus 로고
    • Differential activation of peroxisome proliferator-activated receptor-γ by troglitazone and rosiglitazone
    • Camp HS, Li O, Wise SC et al. Differential activation of peroxisome proliferator-activated receptor-γ by troglitazone and rosiglitazone. Diabetes 2000;49:539-547.
    • (2000) Diabetes , vol.49 , pp. 539-547
    • Camp, H.S.1    Li, O.2    Wise, S.C.3
  • 30
    • 0037335034 scopus 로고    scopus 로고
    • How the ubiquitin-proteasome system controls transcription
    • Muratani M, Tansey WP. How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol 2003;4:192-201.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 192-201
    • Muratani, M.1    Tansey, W.P.2
  • 31
    • 1542297619 scopus 로고    scopus 로고
    • Urban renewal in the nucleus: Is protein turnover by proteasomes absolutely required for nuclear receptor-regulated transcription?
    • Nawaz Z, O'Malley BW. Urban renewal in the nucleus: is protein turnover by proteasomes absolutely required for nuclear receptor-regulated transcription? Mol Endocrinol 2004;18:493-499.
    • (2004) Mol Endocrinol , vol.18 , pp. 493-499
    • Nawaz, Z.1    O'Malley, B.W.2
  • 32
    • 31044449824 scopus 로고    scopus 로고
    • The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGγ proteasome
    • Li X, Lonard DM, Jung SY et al. The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGγ proteasome. Cell 2006;124:381-392.
    • (2006) Cell , vol.124 , pp. 381-392
    • Li, X.1    Lonard, D.M.2    Jung, S.Y.3
  • 33
    • 31044439969 scopus 로고    scopus 로고
    • Zhou P. REGγ: a shortcut to destruction. Cell 2006;124:256-257.
    • Zhou P. REGγ: a shortcut to destruction. Cell 2006;124:256-257.
  • 34
    • 0344630205 scopus 로고    scopus 로고
    • Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR γ hypomorphic mice
    • Koutnikova H, Cock TA, Watanabe M et al. Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR γ hypomorphic mice. Proc Natl Acad Sci USA 2003;100: 14457-14462.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14457-14462
    • Koutnikova, H.1    Cock, T.A.2    Watanabe, M.3
  • 35
    • 20044380758 scopus 로고    scopus 로고
    • The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-γ2 isoform
    • Medina-Gomez G, Virtue S, Lelliott C et al. The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-γ2 isoform. Diabetes 2005;54:1706-1716.
    • (2005) Diabetes , vol.54 , pp. 1706-1716
    • Medina-Gomez, G.1    Virtue, S.2    Lelliott, C.3
  • 36
    • 0037020156 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor a (PPARα) turnover by the ubiquitin-proteasome system controls the ligand-induced expression level of its target genes
    • Blanquart C, Barbier O, Fruchart JC, Staels B, Glineur C. Peroxisome proliferator-activated receptor a (PPARα) turnover by the ubiquitin-proteasome system controls the ligand-induced expression level of its target genes. J Biol Chem 2002;277: 37254-37259.
    • (2002) J Biol Chem , vol.277 , pp. 37254-37259
    • Blanquart, C.1    Barbier, O.2    Fruchart, J.C.3    Staels, B.4    Glineur, C.5
  • 37
    • 34249696521 scopus 로고    scopus 로고
    • Block of nuclear receptor ubiquitination. A mechanism of ligand-dependent control of peroxisome proliferator-activated receptor delta activity
    • Genini D, Catapano CV. Block of nuclear receptor ubiquitination. A mechanism of ligand-dependent control of peroxisome proliferator-activated receptor delta activity. J Biol Chem 2007;282:11776-11785.
    • (2007) J Biol Chem , vol.282 , pp. 11776-11785
    • Genini, D.1    Catapano, C.V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.