메뉴 건너뛰기




Volumn 106, Issue 10, 2000, Pages 1221-1228

Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSE; INSULIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; ROSIGLITAZONE; THIAZOLIDINE DERIVATIVE; TRIACYLGLYCEROL; TROGLITAZONE;

EID: 0033708410     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI11245     Document Type: Article
Times cited : (345)

References (48)
  • 1
    • 0032532753 scopus 로고    scopus 로고
    • Life without white fat: A transgenic mouse
    • (1998) Genes Dev. , vol.12 , pp. 3168-3181
    • Moitra, J.1
  • 4
    • 0033965557 scopus 로고    scopus 로고
    • Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
    • (2000) J. Clin. Invest. , vol.105 , pp. 271-278
    • Gavrilova, O.1
  • 6
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 9
    • 0033857387 scopus 로고    scopus 로고
    • Treatment of insulin resistance with peroxisome proliferator-activated receptor γ agonists
    • (2000) J. Clin. Invest. , vol.106 , pp. 467-472
    • Olefsky, J.M.1
  • 10
    • 0028076266 scopus 로고
    • A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat
    • (1994) Diabetes , vol.43 , pp. 1203-1210
    • Oakes, N.D.1
  • 11
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1
  • 15
    • 0030811061 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gammal expression is induced during cyclic adenosine monophosphate-stimulated differentiation of alveolar type II pneumonocytes
    • (1997) Endocrinology , vol.138 , pp. 3695-3703
    • Michael, L.F.1    Lazar, M.A.2    Mendelson, C.R.3
  • 16
    • 0031844535 scopus 로고    scopus 로고
    • The nuclear eicosanoid receptor, PPARgamma, is aberrandy expressed in colonic cancers
    • (1998) Carcinogenesis , vol.19 , pp. 49-53
    • DuBois, R.N.1
  • 17
    • 0032006547 scopus 로고    scopus 로고
    • Skeletal muscle peroxisome proliferator-activated receptor-gamma expression in obesity and non-insulin-dependent diabetes mellitus
    • (1998) J Clin. Invest. , vol.101 , pp. 543-548
    • Kruszynska, Y.T.1
  • 19
    • 0032005178 scopus 로고    scopus 로고
    • Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial
    • (1998) Ann. Intern. Med. , vol.128 , pp. 176-185
    • Maggs, D.G.1
  • 21
    • 0032520921 scopus 로고    scopus 로고
    • Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
    • (1998) J. Clin. Invest. , vol.101 , pp. 1354-1361
    • Okuno, A.1
  • 24
    • 0028997684 scopus 로고
    • Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3012-3022
    • Lee, S.S.1
  • 25
    • 0019888474 scopus 로고
    • Identification of a DNA clone to phospho-enolpyruvate carboxykinase (GTP) from rat cytosol. Alterations in phosphoenolpyruvate carboxykinase RNA levels detectable by hybridization
    • (1981) J. Biol. Chem. , vol.256 , pp. 10224-10227
    • Yoo-Warren, H.1
  • 26
    • 0029797604 scopus 로고    scopus 로고
    • Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
    • (1996) J. Clin. Invest. , vol.98 , pp. 1575-1584
    • Shimano, H.1
  • 27
    • 0027988554 scopus 로고
    • [[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4 thiazolidinediones as potent antihyperglycemic agents
    • (1994) J. Med. Chem. , vol.37 , pp. 3977-3985
    • Cantello, B.C.1
  • 28
    • 0031054699 scopus 로고    scopus 로고
    • Cardiac and glycemic benefits of troglitazone treatment in NIDDM. The Troglitazone Study Group
    • (1997) Diabetes , vol.46 , pp. 433-439
    • Ghazzi, M.N.1
  • 32
    • 0034663140 scopus 로고    scopus 로고
    • Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes
    • (2000) Ann. Intern. Med. , vol.133 , pp. 263-274
    • Arioglu, E.1
  • 36
    • 0033636780 scopus 로고    scopus 로고
    • Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
    • (2000) Mol. Cell. , vol.6 , pp. 77-86
    • Shimomura, I.1
  • 37
    • 0033213637 scopus 로고    scopus 로고
    • PPAR gamma is required for placental, cardiac and adipose tissue development
    • (1999) Mol. Cell. , vol.4 , pp. 585-595
    • Barak, Y.1
  • 38
    • 0033212964 scopus 로고    scopus 로고
    • PPAR gamma mediates high-fat diet-induced adipocyre hypertrophy and insulin resistance
    • (1999) Mol. Cell. , vol.4 , pp. 597-609
    • Kubota, N.1
  • 39
    • 0033213631 scopus 로고    scopus 로고
    • PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro
    • (1999) Mol. Cell. , vol.4 , pp. 611-617
    • Rosen, E.D.1
  • 41
    • 0033849842 scopus 로고    scopus 로고
    • Insights inro insulin resistance and type 2 diabetes from knockout mouse models
    • (2000) J. Clin. Invest. , vol.106 , pp. 459-465
    • Kadowaki, T.1
  • 42
    • 0032532152 scopus 로고    scopus 로고
    • Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized lipodystrophy
    • (1998) Genes Dev. , vol.12 , pp. 3182-3194
    • Shimomura, I.1
  • 43
    • 0032587268 scopus 로고    scopus 로고
    • Rosiglitazone (BRL49653), a PPARgamma-selecrive agonist, causes peroxisome proliferator-like liver effects in obese mice
    • (1999) J. Lipid Res. , vol.40 , pp. 1177-1184
    • Edvardsson, U.1
  • 44
    • 0032491614 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis
    • (1998) J. Biol. Chem. , vol.273 , pp. 29577-29585
    • Costet, P.1
  • 45
    • 17744375160 scopus 로고    scopus 로고
    • The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
    • (2000) Mol. Endocrinol. , vol.14 , pp. 27-39
    • Jones, S.A.1
  • 46
    • 0034114625 scopus 로고    scopus 로고
    • Differential activation of peroxisome proliferator-activated receptor- gamma by troglitazone and rosiglitazone
    • (2000) Diabetes , vol.49 , pp. 539-547
    • Camp, H.S.1
  • 47
    • 0033766035 scopus 로고    scopus 로고
    • A selective peroxisome proliferator-activated receptor-gamma modulator blocks adipocyte differentiation but stimulates glucose uptake in 3T3-L1 adipocytes
    • (2000) Mol. Endocrinol. , vol.14 , pp. 1425-1433
    • Mukherjee, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.