Pioglitazone prevents smoking carcinogen-induced lung tumor development in mice

Current Cancer Drug Targets

Volumn 12, Issue 6, 2012, Pages 597-606

  Li, M Y ^a   Kong, A W Y ^a   Yuan, H ^a   Ma, L T ^a   Hsin, M K Y ^a   Wan, I Y P ^a   Underwood, M J ^a   Chen, G G ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

13(S) HODE; 15(S) HETE; Lung tumor development; Pioglitazone; PPAR ; Smoking carcinogen NNK

Indexed keywords

13 S HYDROXYOCTADECADIENOIC; 15 HYDROXYICOSATETRAENOIC ACID; 2 BUTANONE; 4 METHYLNITROSAMINO 3 PYRIDYL BUTANONE; ARACHIDONATE 15 LIPOXYGENASE; CARCINOGEN; ICOSANOID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; EARLY CANCER; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUNG CARCINOGENESIS; LUNG PARENCHYMA; LUNG TUMOR; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; SMOKING; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; HYPERPLASIA; LIGANDS; LINOLEIC ACIDS; LUNG NEOPLASMS; MICE; NITROSAMINES; PPAR GAMMA; PULMONARY ALVEOLI; SMOKING; THIAZOLIDINEDIONES; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 84862630157     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/156800912801784848     Document Type: Article

References (38)

1. Yuan, J. M.; Gao, Y. T.; Wang, R.; Chen, M.; Carmella, S. G.; Hecht, S. S. Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers. Carcinogenesis 2012, 33, 804-809.
2. Stepanov, I.; Upadhyaya, P.; Carmella, S. G.; Feuer, R.; Jensen, J.; Hatsukami, D. K.; Hecht, S. S. Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone in smokers. Cancer Epidemiol. Biomarkers Prev. 2008, 17, 1764-1773.
3. Jemal, A.; Bray, F.; Center, M. M.; Ferlay, J.; Ward, E.; Forman, D. Global cancer statistics. CA Cancer J. Clin. 2011, 61, 69-90.
4. Tontonoz, P.; Spiegelman, B. M. Fat and beyond: the diverse biology of PPARgamma. Annu. Rev. Biochem. 2008, 77, 289-312.
5. Nunez-Anita, R. E.; Cajero-Juarez, M.; Aceves, C. Peroxisome proliferator-activated receptors: role of isoform gamma in the antineoplastic effect of iodine in mammary cancer. Curr. Cancer Drug Targets 2011, 11, 775-786.
6. Huang, J. T.; Welch, J. S.; Ricote, M.; Binder, C. J.; Willson, T. M.; Kelly, C.; Witztum, J. L.; Funk, C. D.; Conrad, D.; Glass, C. K. Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. Nature 1999, 400, 378-382.
7. Yu, S.; Reddy, J. K. Transcription coactivators for peroxisome proliferator-activated receptors. Biochim. Biophys. Acta 2007, 1771, 936-951.
8. Zhang, Y.; Ba, Y.; Liu, C.; Sun, G.; Ding, L.; Gao, S.; Hao, J.; Yu, Z.; Zhang, J.; Zen, K.; Tong, Z.; Xiang, Y.; Zhang, C. Y. PGC- 1alpha induces apoptosis in human epithelial ovarian cancer cells through a PPARgamma-dependent pathway. Cell Res. 2007, 17, 363-373.
9. Li, M. Y.; Yuan, H.; Ma, L. T.; Kong, A. W.; Hsin, M. K.; Yip, J.; Underwood, M. J.; Chen, G. G. Roles of PPAR alpha and PPAR gamma in the development of non-small cell lung cancer. Am. J. Respir. Cell Mol. Biol. 2010, 43, 674-683.
10. Yuan, H.; Li, M. Y.; Ma, L. T.; Hsin, M. K.; Mok, T. S.; Underwood, M. J.; Chen, G. G. 15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer. Thorax 2010, 65, 321-326.
11. Li, M. Y.; Hsin, M. K.; Yip, J.; Mok, T. S.; Underwood, M. J.; Chen, G. G. PPAR{gamma} activation extinguishes smoking carcinogen by inhibiting NNK-mediated proliferation. Am. J. Respir. Cell Mol. Biol. 2010, 42, 113-122.
12. Fu, H.; Zhang, J.; Pan, J.; Zhang, Q.; Lu, Y.; Wen, W.; Lubet, R. A.; Szabo, E.; Chen, R.; Wang, Y.; Chen, D. R.; You, M. Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice. Mol. Carcinog. 2011, 50, 913-921.
13. Wang, Y.; James, M.; Wen, W.; Lu, Y.; Szabo, E.; Lubet, R. A.; You, M. Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice. Mol. Cancer Ther. 2010, 9, 3074-3082.
14. Kasono, K.; Nishida, J.; Tamemoto, H.; Fudaka, K.; Namai, K.; Kajio, H.; Masatoshi, K.; Kanazawa, Y.; Kawakami, M. Thiazolidinediones increase the number of platelets in immune thrombocytopenic purpura mice via inhibition of phagocytic activity of the reticulo-endothelial system. Life Sci. 2002, 71, 2037-2052.
15. Papi, A.; Tatenhorst, L.; Terwel, D.; Hermes, M.; Kummer, M. P.; Orlandi, M.; Heneka, M. T. PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models. J. Neurochem. 2009, 109, 1779-1790.
16. Li, M.; Lee, T. W.; Mok, T. S.; Warner, T. D.; Yim, A. P.; Chen, G. G. Activation of peroxisome proliferator-activated receptorgamma by troglitazone (TGZ) inhibits human lung cell growth. J. Cell Biochem. 2005, 96, 760-774.
17. Fujita, Y.; Yamada, Y.; Kusama, M.; Yamauchi, T.; Kamon, J.; Kadowaki, T.; Iga, T. Sex differences in the pharmacokinetics of pioglitazone in rats. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2003, 136, 85-94.
18. Mrowka, P.; Glodkowska, E.; Mlynarczuk-Bialy, I.; Bialy, L.; Kuckelkorn, U.; Nowis, D.; Makowski, M.; Legat, M.; Golab, J. Pioglitazone, a PPAR-gamma ligand, exerts cytostatic/cytotoxic effects against cancer cells, that do not result from inhibition of proteasome. Acta Biochim. Pol. 2008, 55, 75-84.
19. Li, M. Y.; Yip, J.; Hsin, M. K.; Mok, T. S.; Wu, Y.; Underwood, M. J.; Chen, G. G. Haem oxygenase-1 plays a central role in NNKmediated lung carcinogenesis. Eur. Respir. J. 2008, 32, 911-923.
20. Chen, G. G.; Lai, P. B.; Chak, E. C.; Xu, H.; Lee, K. M.; Lau, W. Y. Immunohistochemical analysis of pro-apoptotic Bid level in chronic hepatitis, hepatocellular carcinoma and liver metastases. Cancer Lett. 2001, 172, 75-82.
21. Foley, J. F.; Anderson, M. W.; Stoner, G. D.; Gaul, B. W.; Hardisty, J. F.; Maronpot, R. R. Proliferative lesions of the mouse lung: progression studies in strain A mice. Exp. Lung Res. 1991, 17, 157-168.
22. Belinsky, S. A.; Devereux, T. R.; Foley, J. F.; Maronpot, R. R.; Anderson, M. W. Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse. Cancer Res. 1992, 52, 3164-3173.
23. Kuhn, H.; Borngraber, S. Mammalian 15-lipoxygenases. Enzymatic properties and biological implications. Adv. Exp. Med. Biol. 1999, 447, 5-28.
24. Needleman, P.; Turk, J.; Jakschik, B. A.; Morrison, A. R.; Lefkowith, J. B. Arachidonic acid metabolism. Annu. Rev. Biochem. 1986, 55, 69-102.
25. Govindarajan, R.; Ratnasinghe, L.; Simmons, D. L.; Siegel, E. R.; Midathada, M. V.; Kim, L.; Kim, P. J.; Owens, R. J.; Lang, N. P. Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes. J. Clin. Oncol. 2007, 25, 1476-1481.
26. Girnun, G. D.; Smith, W. M.; Drori, S.; Sarraf, P.; Mueller, E.; Eng, C.; Nambiar, P.; Rosenberg, D. W.; Bronson, R. T.; Edelmann, W.; Kucherlapati, R.; Gonzalez, F. J.; Spiegelman, B. M. APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc. Natl. Acad. Sci. U. S. A. 2002, 99, 13771-13776.
27. Bao, B.; Wang, Z.; Li, Y.; Kong, D.; Ali, S.; Banerjee, S.; Ahmad, A.; Sarkar, F. H. The complexities of obesity and diabetes with the development and progression of pancreatic cancer. Biochim. Biophys. Acta 2011, 1815, 135-146.
28. Kliewer, S. A.; Lenhard, J. M.; Willson, T. M.; Patel, I.; Morris, D. C.; Lehmann, J. M. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 1995, 83, 813-819.
29. Forman, B. M.; Tontonoz, P.; Chen, J.; Brun, R. P.; Spiegelman, B. M.; Evans, R. M. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 1995, 83, 803-812.
30. Powell, W. S. 15-Deoxy-delta12,14-PGJ2: endogenous PPAR gamma ligand or minor eicosanoid degradation product? J. Clin. Invest. 2003, 112, 828-830.
31. Kliewer, S. A.; Sundseth, S. S.; Jones, S. A.; Brown, P. J.; Wisely, G. B.; Koble, C. S.; Devchand, P.; Wahli, W.; Willson, T. M.; Lenhard, J. M.; Lehmann, J. M. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc. Natl. Acad. Sci. U. S. A. 1997, 94, 4318-4323.
32. Krey, G.; Braissant, O.; L'Horset, F.; Kalkhoven, E.; Perroud, M.; Parker, M. G.; Wahli, W. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol. 1997, 11, 779-791.
33. Nagy, L.; Tontonoz, P.; Alvarez, J. G.; Chen, H.; Evans, R. M. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell 1998, 93, 229-240.
34. Shureiqi, I.; Wojno, K. J.; Poore, J. A.; Reddy, R. G.; Moussalli, M. J.; Spindler, S. A.; Greenson, J. K.; Normolle, D.; Hasan, A. A.; Lawrence, T. S.; Brenner, D. E. Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers. Carcinogenesis 1999, 20, 1985-1995.
35. Brash, A. R.; Boeglin, W. E.; Chang, M. S. Discovery of a second 15S-lipoxygenase in humans. Proc. Natl. Acad. Sci. U. S. A. 1997, 94, 6148-6152.
36. Chen, G. G.; Xu, H.; Lee, J. F.; Subramaniam, M.; Leung, K. L.; Wang, S. H.; Chan, U. P.; Spelsberg, T. C. 15-hydroxyeicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway. Int. J. Cancer 2003, 107, 837-843.
37. Subbarayan, V.; Xu, X. C.; Kim, J.; Yang, P.; Hoque, A.; Sabichi, A. L.; Llansa, N.; Mendoza, G.; Logothetis, C. J.; Newman, R. A.; Lippman, S. M.; Menter, D. G. Inverse relationship between 15- lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia. Neoplasia 2005, 7, 280-293.
38. Itoh, T.; Fairall, L.; Amin, K.; Inaba, Y.; Szanto, A.; Balint, B. L.; Nagy, L.; Yamamoto, K.; Schwabe, J. W. Structural basis for the activation of PPARgamma by oxidized fatty acids. Nat. Struct. Mol. Biol. 2008, 15, 924-931.